Author: Xun Xu

Downloads per author, site-wide

Preprints

Efficient long single molecule sequencing for cost effective and accurate sequencing, haplotyping, and de novo assembly

• Downloaded 5,220 times
• Download rankings, all-time:
  • Site-wide: 508 out of 77,122
  • In genomics: 119 out of 5,066
• Year to date:
  • Site-wide: 3,044 out of 77,122
• Since beginning of last month:
  • Site-wide: 3,507 out of 77,122

Construction of the third generation Zea mays haplotype map

• Downloaded 4,004 times
• Download rankings, all-time:
  • Site-wide: 843 out of 77,122
  • In bioinformatics: 161 out of 7,446
• Year to date:
  • Site-wide: 26,516 out of 77,122
• Since beginning of last month:
  • Site-wide: 22,572 out of 77,122

A portable and cost-effective microfluidic system for massively parallel single-cell transcriptome profiling

• Downloaded 3,380 times
• Download rankings, all-time:
  • Site-wide: 1,154 out of 77,122
  • In genomics: 260 out of 5,066
• Year to date:
  • Site-wide: 1,187 out of 77,122
• Since beginning of last month:
  • Site-wide: 1,376 out of 77,122

Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity

• Downloaded 2,350 times
• Download rankings, all-time:
  • Site-wide: 2,197 out of 77,122
  • In genomics: 448 out of 5,066
• Year to date:
  • Site-wide: 25,192 out of 77,122
• Since beginning of last month:
  • Site-wide: 25,263 out of 77,122

CoolMPS™: Advanced massively parallel sequencing using antibodies specific to each natural nucleobase

• Downloaded 2,182 times
• Download rankings, all-time:
  • Site-wide: 2,509 out of 77,122
  • In genomics: 504 out of 5,066
• Year to date:
  • Site-wide: 123 out of 77,122
• Since beginning of last month:
  • Site-wide: 101 out of 77,122

Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

• Downloaded 1,521 times
• Download rankings, all-time:
  • Site-wide: 4,641 out of 77,122
  • In genomics: 822 out of 5,066
• Year to date:
  • Site-wide: 15,573 out of 77,122
• Since beginning of last month:
  • Site-wide: 14,732 out of 77,122

Reliable Multiplex Sequencing with Rare Index Mis-Assignment on DNB-Based NGS Platform

• Downloaded 1,485 times
• Download rankings, all-time:
  • Site-wide: 4,825 out of 77,122
  • In genomics: 847 out of 5,066
• Year to date:
  • Site-wide: 17,909 out of 77,122
• Since beginning of last month:
  • Site-wide: 16,603 out of 77,122

A multi-omic cohort as a reference point for promoting a healthy human gut microbiome

• Downloaded 1,300 times
• Download rankings, all-time:
  • Site-wide: 6,024 out of 77,122
  • In microbiology: 266 out of 6,386
• Year to date:
  • Site-wide: 9,477 out of 77,122
• Since beginning of last month:
  • Site-wide: 9,666 out of 77,122

Circularization of genes and chromosome by CRISPR in human cells

• Downloaded 1,153 times
• Download rankings, all-time:
  • Site-wide: 7,368 out of 77,122
  • In genomics: 1,167 out of 5,066
• Year to date:
  • Site-wide: 44,241 out of 77,122
• Since beginning of last month:
  • Site-wide: 44,325 out of 77,122

Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiation

• Downloaded 1,148 times
• Download rankings, all-time:
  • Site-wide: 7,410 out of 77,122
  • In developmental biology: 151 out of 2,319
• Year to date:
  • Site-wide: 22,384 out of 77,122
• Since beginning of last month:
  • Site-wide: 18,672 out of 77,122

PIRD: Pan immune repertoire database

• Downloaded 1,019 times
• Download rankings, all-time:
  • Site-wide: 9,055 out of 77,122
  • In immunology: 164 out of 2,071
• Year to date:
  • Site-wide: 19,848 out of 77,122
• Since beginning of last month:
  • Site-wide: 18,909 out of 77,122

Recent origin of an XX/XY sex-determination system in the ancient plant lineage Ginkgo biloba

• Downloaded 1,010 times
• Download rankings, all-time:
  • Site-wide: 9,203 out of 77,122
  • In evolutionary biology: 538 out of 4,915
• Year to date:
  • Site-wide: 14,339 out of 77,122
• Since beginning of last month:
  • Site-wide: 17,294 out of 77,122

A catalog of microbial genes from the bovine rumen unveils a specialized and diverse biomass-degrading environment

• Downloaded 954 times
• Download rankings, all-time:
  • Site-wide: 10,105 out of 77,122
  • In microbiology: 478 out of 6,386
• Year to date:
  • Site-wide: 14,071 out of 77,122
• Since beginning of last month:
  • Site-wide: 14,386 out of 77,122

Advanced Whole Genome Sequencing Using a Complete PCR-free Massively Parallel Sequencing (MPS) Workflow

• Downloaded 913 times
• Download rankings, all-time:
  • Site-wide: 10,767 out of 77,122
  • In genomics: 1,553 out of 5,066
• Year to date:
  • Site-wide: 503 out of 77,122
• Since beginning of last month:
  • Site-wide: 398 out of 77,122

3′ Branch Ligation: A Novel Method to Ligate Non-Complementary DNA to Recessed or Internal 3′ OH Ends in DNA or RNA

• Downloaded 909 times
• Download rankings, all-time:
  • Site-wide: 10,857 out of 77,122
  • In molecular biology: 334 out of 2,538
• Year to date:
  • Site-wide: 19,822 out of 77,122
• Since beginning of last month:
  • Site-wide: 20,361 out of 77,122

Life history recorded in the vagino-cervical microbiome

• Downloaded 898 times
• Download rankings, all-time:
  • Site-wide: 11,075 out of 77,122
  • In microbiology: 540 out of 6,386
• Year to date:
  • Site-wide: 14,046 out of 77,122
• Since beginning of last month:
  • Site-wide: 18,925 out of 77,122

Initial data release and announcement of the Fish10K: Fish 10,000 Genomes Project

• Downloaded 798 times
• Download rankings, all-time:
  • Site-wide: 13,284 out of 77,122
  • In genomics: 1,789 out of 5,066
• Year to date:
  • Site-wide: 9,822 out of 77,122
• Since beginning of last month:
  • Site-wide: 11,613 out of 77,122

LFMD: detecting low-frequency mutations in high-depth genome sequencing data without molecular tags

• Downloaded 724 times
• Download rankings, all-time:
  • Site-wide: 15,361 out of 77,122
  • In bioinformatics: 2,414 out of 7,446
• Year to date:
  • Site-wide: 10,144 out of 77,122
• Since beginning of last month:
  • Site-wide: 9,954 out of 77,122

Integration of gut microbiome, host biomarkers, and urine metabolome data reveals networks of interactions associated with distinct clinical phenotypes

• Downloaded 656 times
• Download rankings, all-time:
  • Site-wide: 17,786 out of 77,122
  • In microbiology: 952 out of 6,386
• Year to date:
  • Site-wide: 16,894 out of 77,122
• Since beginning of last month:
  • Site-wide: 14,554 out of 77,122

Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson's disease mouse brain

• Downloaded 634 times
• Download rankings, all-time:
  • Site-wide: 18,707 out of 77,122
  • In cell biology: 792 out of 3,828
• Year to date:
  • Site-wide: 662 out of 77,122
• Since beginning of last month:
  • Site-wide: 374 out of 77,122

Development of Coupling Controlled Polymerizations by Adapter-ligation in Mate-pair Sequencing for Detection of Various Genomic Variants in One Single Assay

• Downloaded 626 times
• Download rankings, all-time:
  • Site-wide: 19,039 out of 77,122
  • In genomics: 2,263 out of 5,066
• Year to date:
  • Site-wide: 30,229 out of 77,122
• Since beginning of last month:
  • Site-wide: 23,315 out of 77,122

Age-dependent sexual dimorphism in the adult human gut microbiota

• Downloaded 618 times
• Download rankings, all-time:
  • Site-wide: 19,432 out of 77,122
  • In genomics: 2,302 out of 5,066
• Year to date:
  • Site-wide: 59,980 out of 77,122
• Since beginning of last month:
  • Site-wide: 50,872 out of 77,122

Over 50000 metagenomically assembled draft genomes for the human oral microbiome reveal new taxa

• Downloaded 607 times
• Download rankings, all-time:
  • Site-wide: 19,901 out of 77,122
  • In microbiology: 1,091 out of 6,386
• Year to date:
  • Site-wide: 11,291 out of 77,122
• Since beginning of last month:
  • Site-wide: 11,083 out of 77,122

Draft genome sequence of the Solanum aethiopicum provides insights into disease resistance, drought tolerance and the evolution of the genome

• Downloaded 598 times
• Download rankings, all-time:
  • Site-wide: 20,319 out of 77,122
  • In genomics: 2,368 out of 5,066
• Year to date:
  • Site-wide: 50,759 out of 77,122
• Since beginning of last month:
  • Site-wide: 55,211 out of 77,122

Identification of gut microbiome markers for schizophrenia delineates a potential role of Streptococcus

• Downloaded 572 times
• Download rankings, all-time:
  • Site-wide: 21,567 out of 77,122
  • In microbiology: 1,208 out of 6,386
• Year to date:
  • Site-wide: 7,887 out of 77,122
• Since beginning of last month:
  • Site-wide: 8,706 out of 77,122

Enhance genome editing efficiency and specificity by a quick CRISPR/Cas9 system

• Downloaded 570 times
• Download rankings, all-time:
  • Site-wide: 21,680 out of 77,122
  • In genetics: 1,411 out of 4,163
• Year to date:
  • Site-wide: 16,007 out of 77,122
• Since beginning of last month:
  • Site-wide: 18,544 out of 77,122

A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth

• Downloaded 532 times
• Download rankings, all-time:
  • Site-wide: 23,778 out of 77,122
  • In genomics: 2,620 out of 5,066
• Year to date:
  • Site-wide: 26,245 out of 77,122
• Since beginning of last month:
  • Site-wide: 24,481 out of 77,122

De novo assembly of the Mongolian gerbil genome and transcriptome

• Downloaded 493 times
• Download rankings, all-time:
  • Site-wide: 26,152 out of 77,122
  • In genomics: 2,776 out of 5,066
• Year to date:
  • Site-wide: 24,148 out of 77,122
• Since beginning of last month:
  • Site-wide: 22,855 out of 77,122

Sequencing of Panax notoginseng genome reveals genes involved in disease resistance and ginsenoside biosynthesis

• Downloaded 476 times
• Download rankings, all-time:
  • Site-wide: 27,294 out of 77,122
  • In genomics: 2,847 out of 5,066
• Year to date:
  • Site-wide: 24,439 out of 77,122
• Since beginning of last month:
  • Site-wide: 18,522 out of 77,122

Dynamic chromosome rearrangements of the white-spotted bamboo shark shed light on cartilaginous fish diversification mechanisms

• Downloaded 379 times
• Download rankings, all-time:
  • Site-wide: 35,341 out of 77,122
  • In genomics: 3,356 out of 5,066
• Year to date:
  • Site-wide: 20,151 out of 77,122
• Since beginning of last month:
  • Site-wide: 16,909 out of 77,122

PALM-Seq: simultaneous sequencing of cell-free long RNA and small RNA

• Downloaded 370 times
• Download rankings, all-time:
  • Site-wide: 36,194 out of 77,122
  • In molecular biology: 1,107 out of 2,538
• Year to date:
  • Site-wide: 20,236 out of 77,122
• Since beginning of last month:
  • Site-wide: 17,155 out of 77,122

Towards Practical and Robust DNA-based Data Archiving by Codec System Named ‘Yin-Yang’

• Downloaded 356 times
• Download rankings, all-time:
  • Site-wide: 37,600 out of 77,122
  • In synthetic biology: 543 out of 732
• Year to date:
  • Site-wide: 8,655 out of 77,122
• Since beginning of last month:
  • Site-wide: 6,239 out of 77,122

Nationwide population genetic screening improves outcomes of newborn screening for hearing loss in China

• Downloaded 353 times
• Download rankings, all-time:
  • Site-wide: 37,962 out of 77,122
  • In genetics: 2,276 out of 4,163
• Year to date:
  • Site-wide: 33,692 out of 77,122
• Since beginning of last month:
  • Site-wide: 27,641 out of 77,122

SLR-superscaffolder: a de novo scaffolding tool for synthetic long reads using a top-to-bottom scheme

• Downloaded 352 times
• Download rankings, all-time:
  • Site-wide: 38,005 out of 77,122
  • In bioinformatics: 4,641 out of 7,446
• Year to date:
  • Site-wide: 14,393 out of 77,122
• Since beginning of last month:
  • Site-wide: 15,211 out of 77,122

TGS-GapCloser: fast and accurately passing through the Bermuda in large genome using error-prone third-generation long reads

• Downloaded 345 times
• Download rankings, all-time:
  • Site-wide: 38,694 out of 77,122
  • In bioinformatics: 4,711 out of 7,446
• Year to date:
  • Site-wide: 7,093 out of 77,122
• Since beginning of last month:
  • Site-wide: 7,904 out of 77,122

Integrated multi-omics analysis to study the effects of simulated weightlessness on rhesus macaques (Macaca mulatta)

• Downloaded 323 times
• Download rankings, all-time:
  • Site-wide: 41,176 out of 77,122
  • In immunology: 939 out of 2,071
• Year to date:
  • Site-wide: 49,099 out of 77,122
• Since beginning of last month:
  • Site-wide: 52,939 out of 77,122

Single cell atlas of domestic pig brain illuminates the conservation and divergence of cell types at spatial and species levels

• Downloaded 314 times
• Download rankings, all-time:
  • Site-wide: 42,187 out of 77,122
  • In bioinformatics: 5,010 out of 7,446
• Year to date:
  • Site-wide: 11,620 out of 77,122
• Since beginning of last month:
  • Site-wide: 13,274 out of 77,122

Intratumor Heterogeneity and Evolution of Colorectal Cancer

• Downloaded 309 times
• Download rankings, all-time:
  • Site-wide: 42,956 out of 77,122
  • In genetics: 2,553 out of 4,163
• Year to date:
  • Site-wide: 2,160 out of 77,122
• Since beginning of last month:
  • Site-wide: 5,192 out of 77,122

Single cell atlas of trisomy 21 cerebral cortex

• Downloaded 291 times
• Download rankings, all-time:
  • Site-wide: 45,214 out of 77,122
  • In neuroscience: 8,010 out of 13,826
• Year to date:
  • Site-wide: 2,409 out of 77,122
• Since beginning of last month:
  • Site-wide: 6,565 out of 77,122

Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics

• Downloaded 281 times
• Download rankings, all-time:
  • Site-wide: 46,550 out of 77,122
  • In microbiology: 3,199 out of 6,386
• Year to date:
  • Site-wide: 37,247 out of 77,122
• Since beginning of last month:
  • Site-wide: 29,816 out of 77,122

Shotgun Metagenomics of 361 elderly women reveals gut microbiome change in bone mass loss

• Downloaded 266 times
• Download rankings, all-time:
  • Site-wide: 48,582 out of 77,122
  • In microbiology: 3,394 out of 6,386
• Year to date:
  • Site-wide: 33,149 out of 77,122
• Since beginning of last month:
  • Site-wide: 30,284 out of 77,122

Sequencing of the MHC region defines HLA-DQA1 as the major independent risk for anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis in Han population

• Downloaded 264 times
• Download rankings, all-time:
  • Site-wide: 48,852 out of 77,122
  • In genetics: 2,872 out of 4,163
• Year to date:
  • Site-wide: 49,308 out of 77,122
• Since beginning of last month:
  • Site-wide: 44,069 out of 77,122

M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases

• Downloaded 251 times
• Download rankings, all-time:
  • Site-wide: 50,639 out of 77,122
  • In genetics: 2,960 out of 4,163
• Year to date:
  • Site-wide: 24,196 out of 77,122
• Since beginning of last month:
  • Site-wide: 24,266 out of 77,122

Three genomes of Osteoglossidae shed light on ancient teleost evolution

• Downloaded 243 times
• Download rankings, all-time:
  • Site-wide: 51,740 out of 77,122
  • In genomics: 4,183 out of 5,066
• Year to date:
  • Site-wide: 3,232 out of 77,122
• Since beginning of last month:
  • Site-wide: 8,035 out of 77,122

Sequencing and comparative analysis of three Chlorella genomes provide insights into strain-specific adaptation to wastewater

• Downloaded 238 times
• Download rankings, all-time:
  • Site-wide: 52,536 out of 77,122
  • In genomics: 4,215 out of 5,066
• Year to date:
  • Site-wide: 55,684 out of 77,122
• Since beginning of last month:
  • Site-wide: 58,491 out of 77,122

New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin

• Downloaded 237 times
• Download rankings, all-time:
  • Site-wide: 52,710 out of 77,122
  • In genetics: 3,076 out of 4,163
• Year to date:
  • Site-wide: 51,811 out of 77,122
• Since beginning of last month:
  • Site-wide: 48,856 out of 77,122

Genomic analyses reveal the origin of domestic ducks and identify different genetic underpinnings of wild ducks

• Downloaded 231 times
• Download rankings, all-time:
  • Site-wide: 53,550 out of 77,122
  • In genomics: 4,257 out of 5,066
• Year to date:
  • Site-wide: 3,530 out of 77,122
• Since beginning of last month:
  • Site-wide: 1,881 out of 77,122

DNB-Based On-Chip Motif Finding (DocMF): a High-Throughput Method to Profile Different Types of Protein-DNA Interactions

• Downloaded 225 times
• Download rankings, all-time:
  • Site-wide: 54,377 out of 77,122
  • In molecular biology: 1,712 out of 2,538
• Year to date:
  • Site-wide: 14,382 out of 77,122
• Since beginning of last month:
  • Site-wide: 18,751 out of 77,122

Multiple approaches for massively parallel sequencing of HCoV-19 (SARS-CoV-2) genomes directly from clinical samples

• Downloaded 223 times
• Download rankings, all-time:
  • Site-wide: 54,726 out of 77,122
  • In genomics: 4,297 out of 5,066
• Year to date:
  • Site-wide: 3,737 out of 77,122
• Since beginning of last month:
  • Site-wide: 1,977 out of 77,122

Recovered and dead outcome patients caused by influenza A (H7N9) virus infection show different pro-inflammatory cytokine dynamics during disease progress and its application in real-time prognosis

• Downloaded 222 times
• Download rankings, all-time:
  • Site-wide: 54,924 out of 77,122
  • In immunology: 1,331 out of 2,071
• Year to date:
  • Site-wide: 38,121 out of 77,122
• Since beginning of last month:
  • Site-wide: 30,749 out of 77,122

The Urinary Microbiota in Relation to the Reproductive Tract Microbiota

• Downloaded 221 times
• Download rankings, all-time:
  • Site-wide: 55,087 out of 77,122
  • In microbiology: 4,026 out of 6,386
• Year to date:
  • Site-wide: 60,912 out of 77,122
• Since beginning of last month:
  • Site-wide: 61,437 out of 77,122

Slicing the genome of star-fruit (Averrhoa carambola L.)

• Downloaded 194 times
• Download rankings, all-time:
  • Site-wide: 59,236 out of 77,122
  • In genomics: 4,474 out of 5,066
• Year to date:
  • Site-wide: 12,924 out of 77,122
• Since beginning of last month:
  • Site-wide: 15,682 out of 77,122

Draft Genomes of two Artocarpus plants, Jackfruit (A. heterophyllus) and Breadfruit (A. altilis)

• Downloaded 162 times
• Download rankings, all-time:
  • Site-wide: 64,521 out of 77,122
  • In genomics: 4,666 out of 5,066
• Year to date:
  • Site-wide: 29,154 out of 77,122
• Since beginning of last month:
  • Site-wide: 34,992 out of 77,122

Complete chloroplast genomes of 14 mangroves: phylogenetic and genomic comparative analyses

• Downloaded 158 times
• Download rankings, all-time:
  • Site-wide: 65,130 out of 77,122
  • In genomics: 4,694 out of 5,066
• Year to date:
  • Site-wide: 29,139 out of 77,122
• Since beginning of last month:
  • Site-wide: 25,430 out of 77,122

Single cell chromatin accessibility of the developmental cephalochordate

• Downloaded 103 times
• Download rankings, all-time:
  • Site-wide: 72,508 out of 77,122
  • In developmental biology: 2,212 out of 2,319
• Year to date:
  • Site-wide: 12,031 out of 77,122
• Since beginning of last month:
  • Site-wide: 6,630 out of 77,122

Independent domestications shape the genetic pattern of a reproductive isolation system in rice

• Downloaded 55 times
• Download rankings, all-time:
  • Site-wide: 75,283 out of 77,122
  • In evolutionary biology: 4,826 out of 4,915
• Year to date:
  • Site-wide: 25,757 out of 77,122
• Since beginning of last month:
  • Site-wide: 58,025 out of 77,122