Author: Jian Wang

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Preprints

Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome

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Plasma cell-free DNA promise disease monitoring and tissue injury assessment of COVID-19

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Yuel: Compound-Protein Interaction Prediction with High Generalizability

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EpicPCR-Directed Cultivation of a Candidatus Saccharibacteria Symbiont Reveals a Type IV Pili-dependent Epibiotic Lifestyle

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GM1 mediates the formation and maintenance of cytotoxic Aβ oligomers

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Transcriptional and Post-transcriptional Regulation of Ethylene Biosynthesis by Salicyclic Acid in Kiwifruit

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Temporal dynamics in viral shedding and transmissibility of COVID-19

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  • Site-wide: 187
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  • Site-wide: 1,209
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  • Site-wide: 1,958

An exploratory randomized, controlled study on the efficacy and safety of lopinavir/ritonavir or arbidol treating adult patients hospitalized with mild/moderate COVID-19 (ELACOI)

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  • Site-wide: 1,185
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  • Site-wide: 5,610
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  • Site-wide: 9,786

Large field of view-spatially resolved transcriptomics at nanoscale resolution

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  • Site-wide: 1,200
  • In cell biology: 14
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Efficient long single molecule sequencing for cost effective and accurate sequencing, haplotyping, and de novo assembly

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  • Site-wide: 1,800
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  • Site-wide: 23,101

Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

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  • Site-wide: 2,327
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  • Site-wide: 6,755

SARS-CoV-2 detection using digital PCR for COVID-19 diagnosis, treatment monitoring and criteria for discharge

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  • Site-wide: 2,362
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  • Site-wide: 3,464
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  • Site-wide: 4,300

CoolMPS™: Advanced massively parallel sequencing using antibodies specific to each natural nucleobase

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  • Site-wide: 3,032
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  • Site-wide: 7,050

Celebrex adjuvant therapy on COVID-19: An experimental study

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  • Site-wide: 3,443
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  • Site-wide: 10,493
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  • Site-wide: 15,844

Multiple approaches for massively parallel sequencing of HCoV-19 (SARS-CoV-2) genomes directly from clinical samples

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  • Site-wide: 4,876
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A Single-Cell Immune Atlas of Triple Negative Breast Cancer Reveals Novel Immune Cell Subsets

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  • Site-wide: 6,560
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Associations of clinical characteristics and antiviral drugs with viral RNA clearance in patients with COVID-19 in Guangzhou, China: a retrospective cohort study

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  • Site-wide: 7,250
  • In infectious diseases: 1,103
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  • Site-wide: 49,573
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  • Site-wide: 35,814

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

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  • Site-wide: 7,307
  • In cell biology: 159
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Rapid Automated Large Structural Variation Detection in a Diploid Genome by NanoChannel Based Next-Generation Mapping

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  • Site-wide: 57,083

A multi-omic cohort as a reference point for promoting a healthy human gut microbiome

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  • Site-wide: 9,093
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  • Site-wide: 29,132
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  • Site-wide: 37,065

Critical Care for Patients with Severe Covid-2019 in Sichuan Province, China: Provincial Cohort Study

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  • Site-wide: 9,448
  • In intensive care and critical care medicine: 42
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  • Site-wide: 36,311
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  • Site-wide: 37,169

Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

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  • Site-wide: 9,757
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  • Site-wide: 50,426

The HLA Ligand Atlas. A resource of natural HLA ligands presented on benign tissues.

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  • Site-wide: 9,867
  • In immunology: 326
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  • Site-wide: 23,380

Reliable Multiplex Sequencing with Rare Index Mis-Assignment on DNB-Based NGS Platform

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  • Site-wide: 10,142
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  • Site-wide: 67,725

Initial Study of Human Genetic Contribution to COVID-19 Severity and Susceptibility

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  • Site-wide: 10,870
  • In genetic and genomic medicine: 44
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  • Site-wide: 16,035
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  • Site-wide: 27,093

PIRD: Pan immune repertoire database

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  • Site-wide: 11,819
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  • Site-wide: 18,314

Recent origin of an XX/XY sex-determination system in the ancient plant lineage Ginkgo biloba

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  • Site-wide: 12,333
  • In evolutionary biology: 398
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  • Site-wide: 14,729
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  • Site-wide: 18,936

The Trans-omics Landscape of COVID-19

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  • Site-wide: 14,977
  • In infectious diseases: 1,627
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  • Site-wide: 19,350
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  • Site-wide: 19,643

A new massively parallel nanoball sequencing platform for whole exome research

• Downloaded 1,338 times
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  • Site-wide: 15,457
  • In genomics: 1,557
• Year to date:
  • Site-wide: 99,264
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  • Site-wide: 111,493

Circularization of genes and chromosome by CRISPR in human cells

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  • Site-wide: 15,556
  • In genomics: 1,570
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  • Site-wide: 74,585
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  • Site-wide: 67,952

Fecal microbiota transplantation brings about bacterial strain displacement in patients with inflammatory bowel diseases

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  • Site-wide: 16,303
  • In clinical trials: 33
• Year to date:
  • Site-wide: 20,099
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  • Site-wide: 49,881

Gene Panel Sequencing in a Chinese High-risk Breast Cancer Cohort

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  • Site-wide: 16,667
  • In cancer biology: 361
• Year to date:
  • Site-wide: 27,772
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  • Site-wide: 43,943

A catalog of microbial genes from the bovine rumen unveils a specialized and diverse biomass-degrading environment

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  • Site-wide: 17,471
  • In microbiology: 1,014
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  • Site-wide: 95,431
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  • Site-wide: 146,976

Characterization of Microbial Co-infections in the Respiratory Tract of hospitalized COVID-19 patients

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  • Site-wide: 17,690
  • In infectious diseases: 1,765
• Year to date:
  • Site-wide: 17,357
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  • Site-wide: 17,271

Life history recorded in the vagino-cervical microbiome

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  • Site-wide: 17,743
  • In microbiology: 1,026
• Year to date:
  • Site-wide: 51,285
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  • Site-wide: 39,200

Over 50000 metagenomically assembled draft genomes for the human oral microbiome reveal new taxa

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  • Site-wide: 17,989
  • In microbiology: 1,047
• Year to date:
  • Site-wide: 30,371
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  • Site-wide: 33,719

Gene-centric intra- and inter-clade recombination in a context of Escherichia coli subpopulations

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  • Site-wide: 18,605
  • In microbiology: 1,070
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  • Site-wide: 64,791
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  • Site-wide: 56,776

Massively parallel quantification of CRISPR editing in cells by TRAP-seq enables better design of Cas9, ABE, CBE gRNAs of high efficiency and accuracy

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  • Site-wide: 19,433
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  • Site-wide: 30,812

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

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  • Site-wide: 21,569
  • In developmental biology: 374
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  • Site-wide: 21,606

Small effect size leads to reproducibility failure in resting-state fMRI studies

• Downloaded 1,032 times
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  • Site-wide: 22,736
  • In neuroscience: 2,835
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  • Site-wide: 59,312
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  • Site-wide: 35,248

Intra-host Variation and Evolutionary Dynamics of SARS-CoV-2 Population in COVID-19 Patients

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  • Site-wide: 23,550
  • In genomics: 2,239
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  • Site-wide: 41,460

Enhance genome editing efficiency and specificity by a quick CRISPR/Cas9 system

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  • Site-wide: 25,112
  • In genetics: 1,162
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  • Site-wide: 32,552
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Identification of gut microbiome markers for schizophrenia delineates a potential role of Streptococcus

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  • Site-wide: 25,899
  • In microbiology: 1,517
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  • Site-wide: 32,206

Integration of gut microbiome, host biomarkers, and urine metabolome data reveals networks of interactions associated with distinct clinical phenotypes

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  • Site-wide: 26,524
  • In microbiology: 1,562
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  • Site-wide: 57,754

Base editing in Streptomyces with Cas9-deaminase fusions

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  • Site-wide: 28,986
  • In microbiology: 1,717
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Integrated Analysis Revealed Hub Genes in Breast Cancer

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  • Site-wide: 30,165
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  • Site-wide: 123,500

The landscape of somatic mutation in sporadic Chinese colorectal cancer

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  • Site-wide: 32,323
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Age-dependent sexual dimorphism in the adult human gut microbiota

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  • Site-wide: 33,172
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The mitochondrial DNA content can not predict the embryo viability

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A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth

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Draft genome sequence of the Solanum aethiopicum provides insights into disease resistance, drought tolerance and the evolution of the genome

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Time-series plasma cell-free DNA analysis reveals disease severity of COVID-19 patients

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  • Site-wide: 37,048
  • In epidemiology: 1,861
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Engineering of Chimeric Antigen Receptor T Cells with integrin αEβ7 Results in Augmented Therapeutic Efficacy against E-cadherin positive tumor

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Impact of anxiety associated with COVID 19 on tinnitus

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PALM-Seq: simultaneous sequencing of cell-free long RNA and small RNA

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  • Site-wide: 38,488
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Calorie restriction intervention induces enterotype-associated BMI loss in nonobese individuals

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  • Site-wide: 39,726
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Identification of Variable and Joining germline genes and alleles for Rhesus macaque from B-cell receptor repertoires

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  • Site-wide: 40,736
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M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases

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  • Site-wide: 42,201
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Dynamic chromosome rearrangements of the white-spotted bamboo shark shed light on cartilaginous fish diversification mechanisms

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TCR repertoire analysis reveals effector memory T cells differentiation into Th17 cells in rheumatoid arthritis

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St. Jude Cloud a Pediatric Cancer Genomic Data Sharing Ecosystem

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Nationwide population genetic screening improves outcomes of newborn screening for hearing loss in China

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Spreading predictability in complex networks

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The female urinary microbiota in relation to the reproductive tract microbiota

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Prefusion spike protein stabilization through computational mutagenesis

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Insulin/IGF signaling and TOR promote vitellogenesis via inducing juvenile hormone biosynthesis

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TET1-DNA Hydroxymethylation Mediated Oligodendrocyte Homeostasis is Required for CNS Myelination and Remyelination

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Detection of Ovarian Cancer Using Samples Sourced from the Vaginal Microenvironment

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Smartphone overuse and visual impairment in children and young adults: a systematic review and meta-analysis

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Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics

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Sequencing of the MHC region defines HLA-DQA1 as the major independent risk for anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis in Han population

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Inter-determination of blood metabolite levels and gut microbiome supported by Mendelian randomization

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The Clinical Genome Resource (ClinGen) Familial Hypercholesterolemia Variant Curation Expert Panel consensus guidelines for LDLR variant classification

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SingleChannelNet: A Model for Automatic Sleep Stage Classification with Raw Single-Channel EEG

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The Amyloid Structure of Mouse RIPK3 (Receptor Interacting Protein Kinase 3) in Cell Necroptosis

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New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin

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Cdc42 is required for lymphatic branching, maturation and valve formation during embryonic development

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The landscape and diagnostic potential of T and B cell repertoire in Immunoglobulin A Nephropathy

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SOAPTyping: an open-source and cross-platform tool for Sanger sequence-based typing for HLA class I and II alleles

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Tau Accumulation via Reduced BAG3-mediated Autophagy Is Required for GGGGCC Repeat Expansion-Induced Neurodegeneration

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Expression, Purification, and Functional Reconstitution of 19F-labeled Cytochrome b5 in Peptide Nanodiscs for NMR Studies

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WinnerTakeAlmostAll: A parsimony approach integrating multi-targets improves marker gene profiling

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A yeast BiFC-seq method for genome-wide interactome mapping

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Genomic epidemiology of SARS-CoV-2 in the United Arab Emirates reveals novel virus mutation, patterns of co-infection and tissue specific host innate immune response

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Integrative framework of cross-module deep biomarker for the prognosis of clear cell renal cell carcinoma: A retrospective TCGA project

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TGF-beta promotes microtube formation in glioblastoma through Thrombospondin 1

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A Chinese host genetic study discovered type I interferons and causality of cholesterol levels and WBC counts on COVID-19 severity

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Personalized vagino-cervical microbiome dynamics after oral probiotics

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Chinese medicine (Q-14) in the Treatment of Patients with Coronavirus Disease 2019 (COVID-19): A Single-center, Open label, Randomised Controlled Trial

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Src/FAK complex phosphorylates cardiac myosin binding protein c (cMyBP-C) in vitro and in vivo

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Various miRNAs are involved in efficient HCV replication

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Maternal perception of child weight and concern about child overweight mediates the relationship between child weight and non-responsive feeding practices

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Fibroblast growth factor-2 prevents synaptic pathology in minimal hepatic encephalopathy via NRG1/ErbB4 signaling

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JAK/STAT pathway promotes Drosophila neuroblast proliferation via the direct CycE regulation

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Comprehensive genome sequencing analysis as a promising option in the prenatal diagnosis of fetal structural anomalies: a prospective study.

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Evaluation method of ecosystem service value under complex ecological environment: A case study of Gansu Province, China

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The inverse relationship between fibronectin and neuroligins in the embryonic rat colon

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Microfluidic Streptomyces Cultivation for Whole Lifecycle Characterization and Phenotypic Assays Enabled by Nanogap-stabilized Air-Water Interface

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Evolutionary trajectories and transmission dynamics of multidrug-resistant Mycobacterium tuberculosis in Tibet, China

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Temperature Evolution Following Joint Loading Promotes Chondrogenesis by Synergistic Cues via Calcium Signaling

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