Author: Jian Wang

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Preprints

Temporal dynamics in viral shedding and transmissibility of COVID-19

• Downloaded 39,032 times
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  • Site-wide: 255
  • In infectious diseases: 96
• Year to date:
  • Site-wide: 1,551
• Since beginning of last month:
  • Site-wide: 4,175

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

• Downloaded 18,758 times
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  • Site-wide: 612
  • In cell biology: 4
• Year to date:
  • Site-wide: 262
• Since beginning of last month:
  • Site-wide: 1,239

An exploratory randomized, controlled study on the efficacy and safety of lopinavir/ritonavir or arbidol treating adult patients hospitalized with mild/moderate COVID-19 (ELACOI)

• Downloaded 9,039 times
• Download rankings, all-time:
  • Site-wide: 1,537
  • In infectious diseases: 463
• Year to date:
  • Site-wide: 17,233
• Since beginning of last month:
  • Site-wide: 19,556

Efficient long single molecule sequencing for cost effective and accurate sequencing, haplotyping, and de novo assembly

• Downloaded 6,296 times
• Download rankings, all-time:
  • Site-wide: 2,499
  • In genomics: 184
• Year to date:
  • Site-wide: 55,668
• Since beginning of last month:
  • Site-wide: 107,020

Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

• Downloaded 6,152 times
• Download rankings, all-time:
  • Site-wide: 2,577
  • In cell biology: 37
• Year to date:
  • Site-wide: 7,491
• Since beginning of last month:
  • Site-wide: 11,260

SARS-CoV-2 detection using digital PCR for COVID-19 diagnosis, treatment monitoring and criteria for discharge

• Downloaded 5,560 times
• Download rankings, all-time:
  • Site-wide: 2,957
  • In infectious diseases: 739
• Year to date:
  • Site-wide: 26,852
• Since beginning of last month:
  • Site-wide: 33,371

CoolMPS™: Advanced massively parallel sequencing using antibodies specific to each natural nucleobase

• Downloaded 5,219 times
• Download rankings, all-time:
  • Site-wide: 3,223
  • In genomics: 292
• Year to date:
  • Site-wide: 5,483
• Since beginning of last month:
  • Site-wide: 4,767

Celebrex adjuvant therapy on COVID-19: An experimental study

• Downloaded 4,388 times
• Download rankings, all-time:
  • Site-wide: 4,055
  • In public and global health: 138
• Year to date:
  • Site-wide: 23,109
• Since beginning of last month:
  • Site-wide: 16,254

Spatially-resolved transcriptomics analyses of invasive fronts in solid tumors

• Downloaded 3,989 times
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  • Site-wide: 4,661
  • In cancer biology: 77
• Year to date:
  • Site-wide: 938
• Since beginning of last month:
  • Site-wide: 1,027

Spatiotemporal transcriptome at single-cell resolution reveals key radial glial cell population in axolotl telencephalon development and regeneration

• Downloaded 3,724 times
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  • Site-wide: 5,185
  • In developmental biology: 55
• Year to date:
  • Site-wide: 1,593
• Since beginning of last month:
  • Site-wide: 7,684

Single-cell Stereo-seq enables cell type-specific spatial transcriptome characterization in Arabidopsis leaves

• Downloaded 3,482 times
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  • Site-wide: 5,717
  • In plant biology: 36
• Year to date:
  • Site-wide: 1,066
• Since beginning of last month:
  • Site-wide: 2,874

Multiple approaches for massively parallel sequencing of HCoV-19 (SARS-CoV-2) genomes directly from clinical samples

• Downloaded 3,094 times
• Download rankings, all-time:
  • Site-wide: 6,810
  • In genomics: 619
• Year to date:
  • Site-wide: 103,470
• Since beginning of last month:
  • Site-wide: 99,842

A Single-Cell Immune Atlas of Triple Negative Breast Cancer Reveals Novel Immune Cell Subsets

• Downloaded 3,072 times
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  • Site-wide: 6,873
  • In immunology: 273
• Year to date:
  • Site-wide: 14,514
• Since beginning of last month:
  • Site-wide: 11,810

Recent origin of an XX/XY sex-determination system in the ancient plant lineage Ginkgo biloba

• Downloaded 2,809 times
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  • Site-wide: 7,772
  • In evolutionary biology: 177
• Year to date:
  • Site-wide: 12,999
• Since beginning of last month:
  • Site-wide: 8,932

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

• Downloaded 2,778 times
• Download rankings, all-time:
  • Site-wide: 7,905
  • In cell biology: 162
• Year to date:
  • Site-wide: 27,952
• Since beginning of last month:
  • Site-wide: 24,289

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

• Downloaded 2,549 times
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  • Site-wide: 9,015
  • In cell biology: 276
• Year to date:
  • Site-wide: 812
• Since beginning of last month:
  • Site-wide: 2,305

Associations of clinical characteristics and antiviral drugs with viral RNA clearance in patients with COVID-19 in Guangzhou, China: a retrospective cohort study

• Downloaded 2,437 times
• Download rankings, all-time:
  • Site-wide: 9,642
  • In infectious diseases: 1,538
• Year to date:
  • Site-wide: 103,337
• Since beginning of last month:
  • Site-wide: 100,873

A multi-omic cohort as a reference point for promoting a healthy human gut microbiome

• Downloaded 2,254 times
• Download rankings, all-time:
  • Site-wide: 10,858
  • In microbiology: 621
• Year to date:
  • Site-wide: 63,396
• Since beginning of last month:
  • Site-wide: 146,904

Critical Care for Patients with Severe Covid-2019 in Sichuan Province, China: Provincial Cohort Study

• Downloaded 2,220 times
• Download rankings, all-time:
  • Site-wide: 11,113
  • In intensive care and critical care medicine: 49
• Year to date:
  • Site-wide: 54,065
• Since beginning of last month:
  • Site-wide: 33,259

Rapid Automated Large Structural Variation Detection in a Diploid Genome by NanoChannel Based Next-Generation Mapping

• Downloaded 2,218 times
• Download rankings, all-time:
  • Site-wide: 11,126
  • In genomics: 1,012
• Year to date:
  • Site-wide: 88,625
• Since beginning of last month:
  • Site-wide: 27,972

PIRD: Pan immune repertoire database

• Downloaded 2,131 times
• Download rankings, all-time:
  • Site-wide: 11,839
  • In immunology: 458
• Year to date:
  • Site-wide: 25,820
• Since beginning of last month:
  • Site-wide: 14,969

The HLA Ligand Atlas. A resource of natural HLA ligands presented on benign tissues.

• Downloaded 2,106 times
• Download rankings, all-time:
  • Site-wide: 12,056
  • In immunology: 441
• Year to date:
  • Site-wide: 80,737
• Since beginning of last month:
  • Site-wide: 46,868

Initial Study of Human Genetic Contribution to COVID-19 Severity and Susceptibility

• Downloaded 1,967 times
• Download rankings, all-time:
  • Site-wide: 13,330
  • In genetic and genomic medicine: 72
• Year to date:
  • Site-wide: 85,605
• Since beginning of last month:
  • Site-wide: 119,878

Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

• Downloaded 1,959 times
• Download rankings, all-time:
  • Site-wide: 13,422
  • In genomics: 1,189
• Year to date:
  • Site-wide: 112,570
• Since beginning of last month:
  • Site-wide: 109,755

Reliable Multiplex Sequencing with Rare Index Mis-Assignment on DNB-Based NGS Platform

• Downloaded 1,913 times
• Download rankings, all-time:
  • Site-wide: 13,909
  • In genomics: 1,242
• Year to date:
  • Site-wide: 136,455
• Since beginning of last month:
  • Site-wide: 68,374

Gene Panel Sequencing in a Chinese High-risk Breast Cancer Cohort

• Downloaded 1,711 times
• Download rankings, all-time:
  • Site-wide: 16,466
  • In cancer biology: 358
• Year to date:
  • Site-wide: 32,819
• Since beginning of last month:
  • Site-wide: 21,974

Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome

• Downloaded 1,608 times
• Download rankings, all-time:
  • Site-wide: 18,174
  • In genetics: 1,825
• Year to date:
  • Site-wide: 3,259
• Since beginning of last month:
  • Site-wide: 400

Fecal microbiota transplantation brings about bacterial strain displacement in patients with inflammatory bowel diseases

• Downloaded 1,603 times
• Download rankings, all-time:
  • Site-wide: 18,261
  • In clinical trials: 35
• Year to date:
  • Site-wide: 48,296
• Since beginning of last month:
  • Site-wide: 34,523

Transcriptomic Profiling Reveals Cancer-Associated Fibroblasts as Potential Targets for the Prognosis and Treatment of Cervical Squamous Cell Carcinoma

• Downloaded 1,589 times
• Download rankings, all-time:
  • Site-wide: 18,521
  • In cancer biology: 483
• Year to date:
  • Site-wide: 2,039
• Since beginning of last month:
  • Site-wide: 10,763

The Trans-omics Landscape of COVID-19

• Downloaded 1,571 times
• Download rankings, all-time:
  • Site-wide: 18,837
  • In infectious diseases: 2,191
• Year to date:
  • Site-wide: 106,377
• Since beginning of last month:
  • Site-wide: 99,284

Over 50000 metagenomically assembled draft genomes for the human oral microbiome reveal new taxa

• Downloaded 1,523 times
• Download rankings, all-time:
  • Site-wide: 19,774
  • In microbiology: 1,119
• Year to date:
  • Site-wide: 66,950
• Since beginning of last month:
  • Site-wide: 57,689

Characterization of Microbial Co-infections in the Respiratory Tract of hospitalized COVID-19 patients

• Downloaded 1,495 times
• Download rankings, all-time:
  • Site-wide: 20,386
  • In infectious diseases: 2,294
• Year to date:
  • Site-wide: 77,133
• Since beginning of last month:
  • Site-wide: 47,186

A new massively parallel nanoball sequencing platform for whole exome research

• Downloaded 1,494 times
• Download rankings, all-time:
  • Site-wide: 20,411
  • In genomics: 1,774
• Year to date:
  • Site-wide: 126,760
• Since beginning of last month:
  • Site-wide: 148,955

Massively parallel quantification of CRISPR editing in cells by TRAP-seq enables better design of Cas9, ABE, CBE gRNAs of high efficiency and accuracy

• Downloaded 1,484 times
• Download rankings, all-time:
  • Site-wide: 20,643
  • In systems biology: 357
• Year to date:
  • Site-wide: 43,449
• Since beginning of last month:
  • Site-wide: 58,162

Circularization of genes and chromosome by CRISPR in human cells

• Downloaded 1,457 times
• Download rankings, all-time:
  • Site-wide: 21,237
  • In genomics: 1,828
• Year to date:
  • Site-wide: 141,341
• Since beginning of last month:
  • Site-wide: 107,187

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

• Downloaded 1,413 times
• Download rankings, all-time:
  • Site-wide: 22,325
  • In developmental biology: 364
• Year to date:
  • Site-wide: 59,351
• Since beginning of last month:
  • Site-wide: 37,293

Septins Enable T Cells Adaptive Circumnavigation and Migration-Transmigration Transition Within Structurally Complex Microenvironments

• Downloaded 1,412 times
• Download rankings, all-time:
  • Site-wide: 22,351
  • In biophysics: 832
• Year to date:
  • Site-wide: 1,968
• Since beginning of last month:
  • Site-wide: 3,641

Life history recorded in the vagino-cervical microbiome

• Downloaded 1,411 times
• Download rankings, all-time:
  • Site-wide: 22,366
  • In microbiology: 1,250
• Year to date:
  • Site-wide: 86,414
• Since beginning of last month:
  • Site-wide: 196,617

Reference genomes of 545 silkworms enable high-throughput exploring genotype-phenotype relationships

• Downloaded 1,375 times
• Download rankings, all-time:
  • Site-wide: 23,307
  • In genomics: 2,124
• Year to date:
  • Site-wide: 8,623
• Since beginning of last month:
  • Site-wide: 18,255

A catalog of microbial genes from the bovine rumen unveils a specialized and diverse biomass-degrading environment

• Downloaded 1,354 times
• Download rankings, all-time:
  • Site-wide: 23,877
  • In microbiology: 1,346
• Year to date:
  • Site-wide: 131,243
• Since beginning of last month:
  • Site-wide: 186,991

Gene-centric intra- and inter-clade recombination in a context of Escherichia coli subpopulations

• Downloaded 1,328 times
• Download rankings, all-time:
  • Site-wide: 24,620
  • In microbiology: 1,379
• Year to date:
  • Site-wide: 141,662
• Since beginning of last month:
  • Site-wide: 130,836

Enhance genome editing efficiency and specificity by a quick CRISPR/Cas9 system

• Downloaded 1,254 times
• Download rankings, all-time:
  • Site-wide: 27,019
  • In genetics: 1,091
• Year to date:
  • Site-wide: 56,911
• Since beginning of last month:
  • Site-wide: 52,995

Base editing in Streptomyces with Cas9-deaminase fusions

• Downloaded 1,211 times
• Download rankings, all-time:
  • Site-wide: 28,477
  • In microbiology: 1,693
• Year to date:
  • Site-wide: 42,026
• Since beginning of last month:
  • Site-wide: 37,176

The Clinical Genome Resource (ClinGen) Familial Hypercholesterolemia Variant Curation Expert Panel consensus guidelines for LDLR variant classification

• Downloaded 1,207 times
• Download rankings, all-time:
  • Site-wide: 28,606
  • In genetic and genomic medicine: 178
• Year to date:
  • Site-wide: 13,039
• Since beginning of last month:
  • Site-wide: 12,961

Small effect size leads to reproducibility failure in resting-state fMRI studies

• Downloaded 1,198 times
• Download rankings, all-time:
  • Site-wide: 28,973
  • In neuroscience: 3,408
• Year to date:
  • Site-wide: 122,405
• Since beginning of last month:
  • Site-wide: 166,635

Integration of gut microbiome, host biomarkers, and urine metabolome data reveals networks of interactions associated with distinct clinical phenotypes

• Downloaded 1,141 times
• Download rankings, all-time:
  • Site-wide: 31,258
  • In microbiology: 1,798
• Year to date:
  • Site-wide: 93,307
• Since beginning of last month:
  • Site-wide: 89,380

Intra-host Variation and Evolutionary Dynamics of SARS-CoV-2 Population in COVID-19 Patients

• Downloaded 1,134 times
• Download rankings, all-time:
  • Site-wide: 31,609
  • In genomics: 2,590
• Year to date:
  • Site-wide: 150,748
• Since beginning of last month:
  • Site-wide: 161,560

Identification of gut microbiome markers for schizophrenia delineates a potential role of Streptococcus

• Downloaded 1,131 times
• Download rankings, all-time:
  • Site-wide: 31,737
  • In microbiology: 1,816
• Year to date:
  • Site-wide: 101,894
• Since beginning of last month:
  • Site-wide: 120,461

PALM-Seq: simultaneous sequencing of cell-free long RNA and small RNA

• Downloaded 1,123 times
• Download rankings, all-time:
  • Site-wide: 32,083
  • In molecular biology: 840
• Year to date:
  • Site-wide: 30,910
• Since beginning of last month:
  • Site-wide: 54,019

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

• Downloaded 1,024 times
• Download rankings, all-time:
  • Site-wide: 36,888
  • In cell biology: 1,540
• Year to date:
  • Site-wide: 6,803
• Since beginning of last month:
  • Site-wide: 41,838

Engineering of Chimeric Antigen Receptor T Cells with integrin αEβ7 Results in Augmented Therapeutic Efficacy against E-cadherin positive tumor

• Downloaded 999 times
• Download rankings, all-time:
  • Site-wide: 38,371
  • In immunology: 1,347
• Year to date:
  • Site-wide: 56,386
• Since beginning of last month:
  • Site-wide: 44,258

Integrated Analysis Revealed Hub Genes in Breast Cancer

• Downloaded 959 times
• Download rankings, all-time:
  • Site-wide: 40,839
  • In bioinformatics: 4,154
• Year to date:
  • Site-wide: 133,910
• Since beginning of last month:
  • Site-wide: 89,071

Age-dependent sexual dimorphism in the adult human gut microbiota

• Downloaded 942 times
• Download rankings, all-time:
  • Site-wide: 41,988
  • In genomics: 3,218
• Year to date:
  • Site-wide: 122,796
• Since beginning of last month:
  • Site-wide: 54,178

Impact of anxiety associated with COVID 19 on tinnitus

• Downloaded 938 times
• Download rankings, all-time:
  • Site-wide: 42,271
  • In otolaryngology: 28
• Year to date:
  • Site-wide: 83,581
• Since beginning of last month:
  • Site-wide: 33,598

The mitochondrial DNA content can not predict the embryo viability

• Downloaded 932 times
• Download rankings, all-time:
  • Site-wide: 42,649
  • In ecology: 825
• Year to date:
  • Site-wide: 136,360
• Since beginning of last month:
  • Site-wide: 68,259

Time-series plasma cell-free DNA analysis reveals disease severity of COVID-19 patients

• Downloaded 918 times
• Download rankings, all-time:
  • Site-wide: 43,655
  • In epidemiology: 2,233
• Year to date:
  • Site-wide: 109,972
• Since beginning of last month:
  • Site-wide: 57,830

A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth

• Downloaded 914 times
• Download rankings, all-time:
  • Site-wide: 43,955
  • In genomics: 3,303
• Year to date:
  • Site-wide: 93,309
• Since beginning of last month:
  • Site-wide: 89,586

The landscape of somatic mutation in sporadic Chinese colorectal cancer

• Downloaded 903 times
• Download rankings, all-time:
  • Site-wide: 44,730
  • In genomics: 3,380
• Year to date:
  • Site-wide: 136,943
• Since beginning of last month:
  • Site-wide: 69,162

M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases

• Downloaded 887 times
• Download rankings, all-time:
  • Site-wide: 45,973
  • In genetics: 1,891
• Year to date:
  • Site-wide: 81,464
• Since beginning of last month:
  • Site-wide: 18,930

Calorie restriction intervention induces enterotype-associated BMI loss in nonobese individuals

• Downloaded 871 times
• Download rankings, all-time:
  • Site-wide: 47,300
  • In microbiology: 2,765
• Year to date:
  • Site-wide: 86,521
• Since beginning of last month:
  • Site-wide: 61,009

Lactate Increases Stemness of CD8+ T Cells to Augment Anti-Tumor Immunity

• Downloaded 854 times
• Download rankings, all-time:
  • Site-wide: 48,694
  • In immunology: 1,786
• Year to date:
  • Site-wide: 12,461
• Since beginning of last month:
  • Site-wide: 49,515

Draft genome sequence of the Solanum aethiopicum provides insights into disease resistance, drought tolerance and the evolution of the genome

• Downloaded 839 times
• Download rankings, all-time:
  • Site-wide: 50,084
  • In genomics: 3,607
• Year to date:
  • Site-wide: 135,917
• Since beginning of last month:
  • Site-wide: 110,047

Ten-eleven translocation 1 Mediated-DNA Hydroxymethylation is Required for Myelination and Remyelination in the Mouse Brain

• Downloaded 815 times
• Download rankings, all-time:
  • Site-wide: 52,350
  • In neuroscience: 8,012
• Year to date:
  • Site-wide: 57,825
• Since beginning of last month:
  • Site-wide: 29,076

Dynamic chromosome rearrangements of the white-spotted bamboo shark shed light on cartilaginous fish diversification mechanisms

• Downloaded 806 times
• Download rankings, all-time:
  • Site-wide: 53,152
  • In genomics: 3,838
• Year to date:
  • Site-wide: 117,992
• Since beginning of last month:
  • Site-wide: 79,878

SingleChannelNet: A Model for Automatic Sleep Stage Classification with Raw Single-Channel EEG

• Downloaded 800 times
• Download rankings, all-time:
  • Site-wide: 53,808
  • In bioengineering: 1,080
• Year to date:
  • Site-wide: 26,860
• Since beginning of last month:
  • Site-wide: 38,910

Genomic epidemiology of SARS-CoV-2 in the United Arab Emirates reveals novel virus mutation, patterns of co-infection and tissue specific host innate immune response

• Downloaded 782 times
• Download rankings, all-time:
  • Site-wide: 55,576
  • In epidemiology: 2,685
• Year to date:
  • Site-wide: 17,298
• Since beginning of last month:
  • Site-wide: 136,049

St. Jude Cloud a Pediatric Cancer Genomic Data Sharing Ecosystem

• Downloaded 765 times
• Download rankings, all-time:
  • Site-wide: 57,329
  • In cancer biology: 1,594
• Year to date:
  • Site-wide: 129,820
• Since beginning of last month:
  • Site-wide: 178,627

Identification of Variable and Joining germline genes and alleles for Rhesus macaque from B-cell receptor repertoires

• Downloaded 741 times
• Download rankings, all-time:
  • Site-wide: 60,182
  • In immunology: 1,902
• Year to date:
  • Site-wide: 203,868
• Since beginning of last month:
  • Site-wide: 150,579

TCR repertoire analysis reveals effector memory T cells differentiation into Th17 cells in rheumatoid arthritis

• Downloaded 740 times
• Download rankings, all-time:
  • Site-wide: 60,262
  • In immunology: 1,932
• Year to date:
  • Site-wide: 141,399
• Since beginning of last month:
  • Site-wide: 80,314

The female urinary microbiota in relation to the reproductive tract microbiota

• Downloaded 718 times
• Download rankings, all-time:
  • Site-wide: 62,870
  • In microbiology: 3,711
• Year to date:
  • Site-wide: 95,664
• Since beginning of last month:
  • Site-wide: 78,083

Smartphone overuse and visual impairment in children and young adults: a systematic review and meta-analysis

• Downloaded 677 times
• Download rankings, all-time:
  • Site-wide: 68,393
  • In ophthalmology: 51
• Year to date:
  • Site-wide: 72,343
• Since beginning of last month:
  • Site-wide: 47,362

Nationwide population genetic screening improves outcomes of newborn screening for hearing loss in China

• Downloaded 675 times
• Download rankings, all-time:
  • Site-wide: 68,702
  • In genetics: 2,618
• Year to date:
  • Site-wide: 170,055
• Since beginning of last month:
  • Site-wide: 166,824

Spreading predictability in complex networks

• Downloaded 642 times
• Download rankings, all-time:
  • Site-wide: 73,520
  • In bioinformatics: 6,633
• Year to date:
  • Site-wide: 190,633
• Since beginning of last month:
  • Site-wide: 183,425

EpicPCR-Directed Cultivation of a Candidatus Saccharibacteria Symbiont Reveals a Type IV Pili-dependent Epibiotic Lifestyle

• Downloaded 638 times
• Download rankings, all-time:
  • Site-wide: 74,174
  • In microbiology: 5,169
• Year to date:
  • Site-wide: 40,592
• Since beginning of last month:
  • Site-wide: 46,303

Enhanced competitive protein exchange at the nano-bio interface enables ultra-deep coverage of the human plasma proteome

• Downloaded 587 times
• Download rankings, all-time:
  • Site-wide: 82,313
  • In biophysics: 3,229
• Year to date:
  • Site-wide: 8,158
• Since beginning of last month:
  • Site-wide: 26,721

Yuel: Compound-Protein Interaction Prediction with High Generalizability

• Downloaded 586 times
• Download rankings, all-time:
  • Site-wide: 82,689
  • In bioinformatics: 7,626
• Year to date:
  • Site-wide: 34,600
• Since beginning of last month:
  • Site-wide: 72,126

Different structures and pathologies of alpha-synuclein fibrils derived from preclinical and postmortem patients of Parkinson's disease

• Downloaded 585 times
• Download rankings, all-time:
  • Site-wide: 82,728
  • In biophysics: 3,158
• Year to date:
  • Site-wide: 41,463
• Since beginning of last month:
  • Site-wide: 38,556

Prefusion spike protein stabilization through computational mutagenesis

• Downloaded 575 times
• Download rankings, all-time:
  • Site-wide: 84,566
  • In biophysics: 2,956
• Year to date:
  • Site-wide: 145,760
• Since beginning of last month:
  • Site-wide: 120,137

Cdc42 is required for lymphatic branching, maturation and valve formation during embryonic development

• Downloaded 559 times
• Download rankings, all-time:
  • Site-wide: 87,622
  • In developmental biology: 2,399
• Year to date:
  • Site-wide: 91,284
• Since beginning of last month:
  • Site-wide: 21,797

Detection of Ovarian Cancer Using Samples Sourced from the Vaginal Microenvironment

• Downloaded 549 times
• Download rankings, all-time:
  • Site-wide: 89,643
  • In cancer biology: 2,606
• Year to date:
  • Site-wide: 139,062
• Since beginning of last month:
  • Site-wide: 69,207

TGF-beta promotes microtube formation in glioblastoma through Thrombospondin 1

• Downloaded 544 times
• Download rankings, all-time:
  • Site-wide: 90,629
  • In cancer biology: 2,640
• Year to date:
  • Site-wide: 36,628
• Since beginning of last month:
  • Site-wide: 188,730

Insulin/IGF signaling and TOR promote vitellogenesis via inducing juvenile hormone biosynthesis

• Downloaded 543 times
• Download rankings, all-time:
  • Site-wide: 90,728
  • In developmental biology: 2,220
• Year to date:
  • Site-wide: 177,900
• Since beginning of last month:
  • Site-wide: 181,646

AlphaFold Models Illuminate Half of Dark Human Proteins

• Downloaded 542 times
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  • Site-wide: 90,923
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  • Site-wide: 28,256
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  • Site-wide: 38,406

Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome

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Adaptation-proof SARS-CoV-2 vaccine design

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  • Site-wide: 101,922
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  • Site-wide: 10,960
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  • Site-wide: 21,637

Sequencing of the MHC region defines HLA-DQA1 as the major independent risk for anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis in Han population

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The Amyloid Structure of Mouse RIPK3 (Receptor Interacting Protein Kinase 3) in Cell Necroptosis

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  • Site-wide: 180,673

Local and long-distance organization of prefrontal cortex circuits in the marmoset brain

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  • Site-wide: 12,029
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  • Site-wide: None

Spatiotemporal landscape of SARS-CoV-2 pulmonary infection reveals Slamf9+Spp1+ macrophages promoting viral clearance and inflammation resolution

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  • Site-wide: 106,490
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New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin

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  • Site-wide: 127,866

Tau Accumulation via Reduced BAG3-mediated Autophagy Is Required for GGGGCC Repeat Expansion-Induced Neurodegeneration

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  • Site-wide: 172,311

The landscape and diagnostic potential of T and B cell repertoire in Immunoglobulin A Nephropathy

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Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics

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Peptide-centric analyses of human plasma enable increased resolution of biological insights into non-small cell lung cancer relative to protein-centric analysis

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Predicting 3D RNA structure from solely the nucleotide sequence using Euclidean distance neural networks

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  • Site-wide: 12,754
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  • Site-wide: 22,367

Expression, Purification, and Functional Reconstitution of 19F-labeled Cytochrome b5 in Peptide Nanodiscs for NMR Studies

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A Chinese host genetic study discovered type I interferons and causality of cholesterol levels and WBC counts on COVID-19 severity

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  • Site-wide: 82,411

Chinese medicine (Q-14) in the Treatment of Patients with Coronavirus Disease 2019 (COVID-19): A Single-center, Open label, Randomised Controlled Trial

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  • Site-wide: 98,639

A yeast BiFC-seq method for genome-wide interactome mapping

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NeuralDock: Rapid and conformation-agnostic docking of small molecules

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A BERT-Based Hybrid System for Chemical Identification and Indexing in Full-Text Articles

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Plasma cell-free DNA promise disease monitoring and tissue injury assessment of COVID-19

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  • Site-wide: 57,478
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  • Site-wide: 85,010

SOAPTyping: an open-source and cross-platform tool for Sanger sequence-based typing for HLA class I and II alleles

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WinnerTakeAlmostAll: A parsimony approach integrating multi-targets improves marker gene profiling

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Microfluidic Streptomyces Cultivation for Whole Lifecycle Characterization and Phenotypic Assays Enabled by Nanogap-stabilized Air-Water Interface

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Personalized vagino-cervical microbiome dynamics after oral probiotics

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Maternal perception of child weight and concern about child overweight mediates the relationship between child weight and non-responsive feeding practices

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Integrative framework of cross-module deep biomarker for the prognosis of clear cell renal cell carcinoma: A retrospective TCGA project

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Evolutionary trajectories and transmission dynamics of multidrug-resistant Mycobacterium tuberculosis in Tibet, China

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Comprehensive genome sequencing analysis as a promising option in the prenatal diagnosis of fetal structural anomalies: a prospective study.

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Various miRNAs are involved in efficient HCV replication

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JAK/STAT pathway promotes Drosophila neuroblast proliferation via the direct CycE regulation

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Src/FAK complex phosphorylates cardiac myosin binding protein c (cMyBP-C) in vitro and in vivo

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Evaluation method of ecosystem service value under complex ecological environment: A case study of Gansu Province, China

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Denoising diffusion weighted imaging data using convolutional neural networks

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A pangenome analysis pipeline (PSVCP) provides insights into rice functional gene identification

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Fibroblast growth factor-2 prevents synaptic pathology in minimal hepatic encephalopathy via NRG1/ErbB4 signaling

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The inverse relationship between fibronectin and neuroligins in the embryonic rat colon

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GM1 mediates the formation and maintenance of cytotoxic Aβ oligomers

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Transcriptional and Post-transcriptional Regulation of Ethylene Biosynthesis by Salicyclic Acid in Kiwifruit

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Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast

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Temperature Evolution Following Joint Loading Promotes Chondrogenesis by Synergistic Cues via Calcium Signaling

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Sex differences in the nasal microbiome of healthy young adults

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Human iPSC-derived neuron of 16p11.2 deletion reveals haplotype-specific expression of MAPK3 and its contribution to variable NDD phenotypes

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Development and validation of radiomics nomograms for preoperative prediction of characteristics in non-small cell lung cancer and circulating tumor cells

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Construction of a High-Density Genetic Map Based on Large-Scale Marker Development in Coix lacryma-jobi L . Using Specifific-Locus Amplifified Fragment Sequencing (SLAF-seq)

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Bordetella spp. block eosinophil recruitment to suppress lung iBALT formation

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