Author: Jian Wang

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Preprints

Temporal dynamics in viral shedding and transmissibility of COVID-19

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  • Site-wide: 162
  • In infectious diseases: 64
• Year to date:
  • Site-wide: 902
• Since beginning of last month:
  • Site-wide: 902

An exploratory randomized, controlled study on the efficacy and safety of lopinavir/ritonavir or arbidol treating adult patients hospitalized with mild/moderate COVID-19 (ELACOI)

• Downloaded 7,742 times
• Download rankings, all-time:
  • Site-wide: 1,039
  • In infectious diseases: 295
• Year to date:
  • Site-wide: 5,960
• Since beginning of last month:
  • Site-wide: 5,960

Efficient long single molecule sequencing for cost effective and accurate sequencing, haplotyping, and de novo assembly

• Downloaded 5,809 times
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  • Site-wide: 1,506
  • In genomics: 144
• Year to date:
  • Site-wide: 11,019
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  • Site-wide: 11,019

Large field of view-spatially resolved transcriptomics at nanoscale resolution

• Downloaded 5,059 times
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  • Site-wide: 1,817
  • In cell biology: 26
• Year to date:
  • Site-wide: 86
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  • Site-wide: 86

Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

• Downloaded 4,442 times
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  • Site-wide: 2,194
  • In cell biology: 39
• Year to date:
  • Site-wide: 3,465
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  • Site-wide: 3,465

SARS-CoV-2 detection using digital PCR for COVID-19 diagnosis, treatment monitoring and criteria for discharge

• Downloaded 4,244 times
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  • Site-wide: 2,329
  • In infectious diseases: 491
• Year to date:
  • Site-wide: 4,464
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  • Site-wide: 4,464

CoolMPS™: Advanced massively parallel sequencing using antibodies specific to each natural nucleobase

• Downloaded 3,754 times
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  • Site-wide: 2,777
  • In genomics: 330
• Year to date:
  • Site-wide: 4,083
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  • Site-wide: 4,083

Celebrex adjuvant therapy on COVID-19: An experimental study

• Downloaded 3,482 times
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  • Site-wide: 3,120
  • In public and global health: 92
• Year to date:
  • Site-wide: 8,352
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  • Site-wide: 8,352

Multiple approaches for massively parallel sequencing of HCoV-19 (SARS-CoV-2) genomes directly from clinical samples

• Downloaded 2,815 times
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  • Site-wide: 4,181
  • In genomics: 486
• Year to date:
  • Site-wide: 15,861
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  • Site-wide: 15,861

Associations of clinical characteristics and antiviral drugs with viral RNA clearance in patients with COVID-19 in Guangzhou, China: a retrospective cohort study

• Downloaded 2,153 times
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  • Site-wide: 6,216
  • In infectious diseases: 885
• Year to date:
  • Site-wide: 39,285
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  • Site-wide: 39,285

A Single-Cell Immune Atlas of Triple Negative Breast Cancer Reveals Novel Immune Cell Subsets

• Downloaded 2,150 times
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  • Site-wide: 6,231
  • In immunology: 168
• Year to date:
  • Site-wide: 9,221
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  • Site-wide: 9,221

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

• Downloaded 2,031 times
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  • Site-wide: 6,759
  • In cell biology: 145
• Year to date:
  • Site-wide: 12,622
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  • Site-wide: 12,622

Rapid Automated Large Structural Variation Detection in a Diploid Genome by NanoChannel Based Next-Generation Mapping

• Downloaded 1,959 times
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  • Site-wide: 7,125
  • In genomics: 797
• Year to date:
  • Site-wide: 53,358
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  • Site-wide: 53,358

A multi-omic cohort as a reference point for promoting a healthy human gut microbiome

• Downloaded 1,771 times
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  • Site-wide: 8,321
  • In microbiology: 456
• Year to date:
  • Site-wide: 27,670
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  • Site-wide: 27,670

Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

• Downloaded 1,755 times
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  • Site-wide: 8,427
  • In genomics: 953
• Year to date:
  • Site-wide: 45,410
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  • Site-wide: 45,410

Critical Care for Patients with Severe Covid-2019 in Sichuan Province, China: Provincial Cohort Study

• Downloaded 1,751 times
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  • Site-wide: 8,450
  • In intensive care and critical care medicine: 37
• Year to date:
  • Site-wide: 30,664
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  • Site-wide: 30,664

Reliable Multiplex Sequencing with Rare Index Mis-Assignment on DNB-Based NGS Platform

• Downloaded 1,709 times
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  • Site-wide: 8,788
  • In genomics: 989
• Year to date:
  • Site-wide: 35,282
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  • Site-wide: 35,282

The HLA Ligand Atlas. A resource of natural HLA ligands presented on benign tissues.

• Downloaded 1,558 times
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  • Site-wide: 10,093
  • In immunology: 281
• Year to date:
  • Site-wide: 12,703
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  • Site-wide: 12,703

Initial Study of Human Genetic Contribution to COVID-19 Severity and Susceptibility

• Downloaded 1,516 times
• Download rankings, all-time:
  • Site-wide: 10,513
  • In genetic and genomic medicine: 35
• Year to date:
  • Site-wide: 9,309
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  • Site-wide: 9,309

PIRD: Pan immune repertoire database

• Downloaded 1,389 times
• Download rankings, all-time:
  • Site-wide: 11,963
  • In immunology: 325
• Year to date:
  • Site-wide: 17,295
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  • Site-wide: 17,295

Recent origin of an XX/XY sex-determination system in the ancient plant lineage Ginkgo biloba

• Downloaded 1,338 times
• Download rankings, all-time:
  • Site-wide: 12,653
  • In evolutionary biology: 470
• Year to date:
  • Site-wide: 11,015
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  • Site-wide: 11,015

A new massively parallel nanoball sequencing platform for whole exome research

• Downloaded 1,306 times
• Download rankings, all-time:
  • Site-wide: 13,099
  • In genomics: 1,432
• Year to date:
  • Site-wide: 70,661
• Since beginning of last month:
  • Site-wide: 70,661

Circularization of genes and chromosome by CRISPR in human cells

• Downloaded 1,282 times
• Download rankings, all-time:
  • Site-wide: 13,484
  • In genomics: 1,466
• Year to date:
  • Site-wide: 53,217
• Since beginning of last month:
  • Site-wide: 53,217

A catalog of microbial genes from the bovine rumen unveils a specialized and diverse biomass-degrading environment

• Downloaded 1,213 times
• Download rankings, all-time:
  • Site-wide: 14,659
  • In microbiology: 822
• Year to date:
  • Site-wide: 38,458
• Since beginning of last month:
  • Site-wide: 38,458

The Trans-omics Landscape of COVID-19

• Downloaded 1,176 times
• Download rankings, all-time:
  • Site-wide: 15,354
  • In infectious diseases: 1,403
• Year to date:
  • Site-wide: 17,996
• Since beginning of last month:
  • Site-wide: 17,996

Life history recorded in the vagino-cervical microbiome

• Downloaded 1,145 times
• Download rankings, all-time:
  • Site-wide: 16,004
  • In microbiology: 894
• Year to date:
  • Site-wide: 34,015
• Since beginning of last month:
  • Site-wide: 34,015

Gene Panel Sequencing in a Chinese High-risk Breast Cancer Cohort

• Downloaded 1,132 times
• Download rankings, all-time:
  • Site-wide: 16,276
  • In cancer biology: 368
• Year to date:
  • Site-wide: 22,706
• Since beginning of last month:
  • Site-wide: 22,706

Gene-centric intra- and inter-clade recombination in a context of Escherichia coli subpopulations

• Downloaded 1,113 times
• Download rankings, all-time:
  • Site-wide: 16,710
  • In microbiology: 929
• Year to date:
  • Site-wide: 66,679
• Since beginning of last month:
  • Site-wide: 66,679

Fecal microbiota transplantation brings about bacterial strain displacement in patients with inflammatory bowel diseases

• Downloaded 1,078 times
• Download rankings, all-time:
  • Site-wide: 17,513
  • In clinical trials: 36
• Year to date:
  • Site-wide: 35,164
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  • Site-wide: 35,164

Over 50000 metagenomically assembled draft genomes for the human oral microbiome reveal new taxa

• Downloaded 1,030 times
• Download rankings, all-time:
  • Site-wide: 18,785
  • In microbiology: 1,045
• Year to date:
  • Site-wide: None
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  • Site-wide: None

Massively parallel quantification of CRISPR editing in cells by TRAP-seq enables better design of Cas9, ABE, CBE gRNAs of high efficiency and accuracy

• Downloaded 1,030 times
• Download rankings, all-time:
  • Site-wide: 18,779
  • In systems biology: 389
• Year to date:
  • Site-wide: 22,478
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  • Site-wide: 22,478

Characterization of Microbial Co-infections in the Respiratory Tract of hospitalized COVID-19 patients

• Downloaded 991 times
• Download rankings, all-time:
  • Site-wide: 19,820
  • In infectious diseases: 1,579
• Year to date:
  • Site-wide: 25,653
• Since beginning of last month:
  • Site-wide: 25,653

Small effect size leads to reproducibility failure in resting-state fMRI studies

• Downloaded 969 times
• Download rankings, all-time:
  • Site-wide: 20,472
  • In neuroscience: 2,632
• Year to date:
  • Site-wide: 38,386
• Since beginning of last month:
  • Site-wide: 38,386

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

• Downloaded 948 times
• Download rankings, all-time:
  • Site-wide: 21,121
  • In developmental biology: 393
• Year to date:
  • Site-wide: 42,963
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  • Site-wide: 42,963

Intra-host Variation and Evolutionary Dynamics of SARS-CoV-2 Population in COVID-19 Patients

• Downloaded 934 times
• Download rankings, all-time:
  • Site-wide: 21,576
  • In genomics: 2,153
• Year to date:
  • Site-wide: 24,712
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  • Site-wide: 24,712

Integration of gut microbiome, host biomarkers, and urine metabolome data reveals networks of interactions associated with distinct clinical phenotypes

• Downloaded 858 times
• Download rankings, all-time:
  • Site-wide: 24,405
  • In microbiology: 1,395
• Year to date:
  • Site-wide: 72,862
• Since beginning of last month:
  • Site-wide: 72,862

Enhance genome editing efficiency and specificity by a quick CRISPR/Cas9 system

• Downloaded 844 times
• Download rankings, all-time:
  • Site-wide: 24,973
  • In genetics: 1,238
• Year to date:
  • Site-wide: 24,265
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  • Site-wide: 24,265

Identification of gut microbiome markers for schizophrenia delineates a potential role of Streptococcus

• Downloaded 838 times
• Download rankings, all-time:
  • Site-wide: 25,226
  • In microbiology: 1,454
• Year to date:
  • Site-wide: 27,897
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  • Site-wide: 27,897

Integrated Analysis Revealed Hub Genes in Breast Cancer

• Downloaded 833 times
• Download rankings, all-time:
  • Site-wide: 25,420
  • In bioinformatics: 3,012
• Year to date:
  • Site-wide: 114,162
• Since beginning of last month:
  • Site-wide: 114,162

Base editing in Streptomyces with Cas9-deaminase fusions

• Downloaded 789 times
• Download rankings, all-time:
  • Site-wide: 27,392
  • In microbiology: 1,603
• Year to date:
  • Site-wide: 38,572
• Since beginning of last month:
  • Site-wide: 38,572

The landscape of somatic mutation in sporadic Chinese colorectal cancer

• Downloaded 777 times
• Download rankings, all-time:
  • Site-wide: 27,989
  • In genomics: 2,614
• Year to date:
  • Site-wide: 73,057
• Since beginning of last month:
  • Site-wide: 73,057

Age-dependent sexual dimorphism in the adult human gut microbiota

• Downloaded 743 times
• Download rankings, all-time:
  • Site-wide: 29,797
  • In genomics: 2,725
• Year to date:
  • Site-wide: 86,010
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  • Site-wide: 86,010

A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth

• Downloaded 740 times
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  • Site-wide: 29,956
  • In genomics: 2,734
• Year to date:
  • Site-wide: 47,623
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  • Site-wide: 47,623

The mitochondrial DNA content can not predict the embryo viability

• Downloaded 734 times
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  • Site-wide: 30,287
  • In ecology: 678
• Year to date:
  • Site-wide: 37,383
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  • Site-wide: 37,383

Draft genome sequence of the Solanum aethiopicum provides insights into disease resistance, drought tolerance and the evolution of the genome

• Downloaded 705 times
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  • Site-wide: 32,016
  • In genomics: 2,870
• Year to date:
  • Site-wide: 109,222
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  • Site-wide: 109,222

Calorie restriction intervention induces enterotype-associated BMI loss in nonobese individuals

• Downloaded 647 times
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  • Site-wide: 35,955
  • In microbiology: 2,140
• Year to date:
  • Site-wide: 48,628
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  • Site-wide: 48,628

Identification of Variable and Joining germline genes and alleles for Rhesus macaque from B-cell receptor repertoires

• Downloaded 642 times
• Download rankings, all-time:
  • Site-wide: 36,314
  • In immunology: 990
• Year to date:
  • Site-wide: 37,358
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  • Site-wide: 37,358

PALM-Seq: simultaneous sequencing of cell-free long RNA and small RNA

• Downloaded 641 times
• Download rankings, all-time:
  • Site-wide: 36,402
  • In molecular biology: 1,030
• Year to date:
  • Site-wide: 47,747
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  • Site-wide: 47,747

Time-series plasma cell-free DNA analysis reveals disease severity of COVID-19 patients

• Downloaded 633 times
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  • Site-wide: 36,975
  • In epidemiology: 1,764
• Year to date:
  • Site-wide: 23,331
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  • Site-wide: 23,331

Dynamic chromosome rearrangements of the white-spotted bamboo shark shed light on cartilaginous fish diversification mechanisms

• Downloaded 632 times
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  • Site-wide: 37,092
  • In genomics: 3,191
• Year to date:
  • Site-wide: 50,991
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  • Site-wide: 50,991

Impact of anxiety associated with COVID 19 on tinnitus

• Downloaded 618 times
• Download rankings, all-time:
  • Site-wide: 38,144
  • In otolaryngology: 18
• Year to date:
  • Site-wide: 16,276
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  • Site-wide: 16,276

M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases

• Downloaded 590 times
• Download rankings, all-time:
  • Site-wide: 40,425
  • In genetics: 1,954
• Year to date:
  • Site-wide: 32,286
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  • Site-wide: 32,286

TCR repertoire analysis reveals effector memory T cells differentiation into Th17 cells in rheumatoid arthritis

• Downloaded 567 times
• Download rankings, all-time:
  • Site-wide: 42,510
  • In immunology: 1,153
• Year to date:
  • Site-wide: 32,614
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  • Site-wide: 32,614

Engineering of Chimeric Antigen Receptor T Cells with integrin αEβ7 Results in Augmented Therapeutic Efficacy against E-cadherin positive tumor

• Downloaded 563 times
• Download rankings, all-time:
  • Site-wide: 42,909
  • In immunology: 1,162
• Year to date:
  • Site-wide: 47,781
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  • Site-wide: 47,781

Nationwide population genetic screening improves outcomes of newborn screening for hearing loss in China

• Downloaded 558 times
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  • Site-wide: 43,348
  • In genetics: 2,092
• Year to date:
  • Site-wide: 72,942
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  • Site-wide: 72,942

St. Jude Cloud a Pediatric Cancer Genomic Data Sharing Ecosystem

• Downloaded 537 times
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  • Site-wide: 45,458
  • In cancer biology: 1,267
• Year to date:
  • Site-wide: 24,888
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  • Site-wide: 24,888

Spreading predictability in complex networks

• Downloaded 502 times
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  • Site-wide: 49,145
  • In bioinformatics: 5,124
• Year to date:
  • Site-wide: 94,181
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  • Site-wide: 94,181

The female urinary microbiota in relation to the reproductive tract microbiota

• Downloaded 454 times
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  • Site-wide: 55,146
  • In microbiology: 3,576
• Year to date:
  • Site-wide: 37,250
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  • Site-wide: 37,250

Insulin/IGF signaling and TOR promote vitellogenesis via inducing juvenile hormone biosynthesis

• Downloaded 415 times
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  • Site-wide: 60,434
  • In developmental biology: 1,537
• Year to date:
  • Site-wide: 35,743
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  • Site-wide: 35,743

Prefusion spike protein stabilization through computational mutagenesis

• Downloaded 409 times
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  • Site-wide: 61,327
  • In biophysics: 2,207
• Year to date:
  • Site-wide: 64,051
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  • Site-wide: 64,051

Detection of Ovarian Cancer Using Samples Sourced from the Vaginal Microenvironment

• Downloaded 382 times
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  • Site-wide: 65,544
  • In cancer biology: 1,879
• Year to date:
  • Site-wide: 31,222
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  • Site-wide: 31,222

Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics

• Downloaded 376 times
• Download rankings, all-time:
  • Site-wide: 66,606
  • In microbiology: 4,487
• Year to date:
  • Site-wide: 109,944
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  • Site-wide: 109,944

TET1-DNA Hydroxymethylation Mediated Oligodendrocyte Homeostasis is Required for CNS Myelination and Remyelination

• Downloaded 368 times
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  • Site-wide: 67,934
  • In neuroscience: 10,397
• Year to date:
  • Site-wide: 34,650
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  • Site-wide: 34,650

Sequencing of the MHC region defines HLA-DQA1 as the major independent risk for anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis in Han population

• Downloaded 349 times
• Download rankings, all-time:
  • Site-wide: 71,157
  • In genetics: 3,316
• Year to date:
  • Site-wide: 96,840
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  • Site-wide: 96,840

Smartphone overuse and visual impairment in children and young adults: a systematic review and meta-analysis

• Downloaded 344 times
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  • Site-wide: 71,843
  • In ophthalmology: 40
• Year to date:
  • Site-wide: 44,389
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  • Site-wide: 44,389

New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin

• Downloaded 320 times
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  • Site-wide: 76,214
  • In genetics: 3,549
• Year to date:
  • Site-wide: 111,026
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  • Site-wide: 111,026

The Amyloid Structure of Mouse RIPK3 (Receptor Interacting Protein Kinase 3) in Cell Necroptosis

• Downloaded 310 times
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  • Site-wide: 78,189
  • In biochemistry: 2,219
• Year to date:
  • Site-wide: 25,719
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  • Site-wide: 25,719

The landscape and diagnostic potential of T and B cell repertoire in Immunoglobulin A Nephropathy

• Downloaded 306 times
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  • Site-wide: 78,954
  • In immunology: 2,145
• Year to date:
  • Site-wide: 109,103
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  • Site-wide: 109,103

Inter-determination of blood metabolite levels and gut microbiome supported by Mendelian randomization

• Downloaded 305 times
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  • Site-wide: 79,256
  • In genetics: 3,669
• Year to date:
  • Site-wide: 18,978
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  • Site-wide: 18,978

Cdc42 is required for lymphatic branching, maturation and valve formation during embryonic development

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  • Site-wide: 79,290
  • In developmental biology: 2,145
• Year to date:
  • Site-wide: 63,763
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  • Site-wide: 63,763

SOAPTyping: an open-source and cross-platform tool for Sanger sequence-based typing for HLA class I and II alleles

• Downloaded 289 times
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  • Site-wide: 82,472
  • In bioinformatics: 7,471
• Year to date:
  • Site-wide: 86,086
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  • Site-wide: 86,086

Tau Accumulation via Reduced BAG3-mediated Autophagy Is Required for GGGGCC Repeat Expansion-Induced Neurodegeneration

• Downloaded 270 times
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  • Site-wide: 86,284
  • In neuroscience: 13,430
• Year to date:
  • Site-wide: 100,639
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  • Site-wide: 100,639

WinnerTakeAlmostAll: A parsimony approach integrating multi-targets improves marker gene profiling

• Downloaded 252 times
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  • Site-wide: 90,224
  • In bioinformatics: 7,968
• Year to date:
  • Site-wide: 85,781
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  • Site-wide: 85,781

Expression, Purification, and Functional Reconstitution of 19F-labeled Cytochrome b5 in Peptide Nanodiscs for NMR Studies

• Downloaded 229 times
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  • Site-wide: 95,101
  • In biochemistry: 2,779
• Year to date:
  • Site-wide: 76,820
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  • Site-wide: 76,820

Integrative framework of cross-module deep biomarker for the prognosis of clear cell renal cell carcinoma: A retrospective TCGA project

• Downloaded 215 times
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  • Site-wide: 98,189
  • In bioinformatics: 8,475
• Year to date:
  • Site-wide: 114,257
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  • Site-wide: 114,257

A yeast BiFC-seq method for genome-wide interactome mapping

• Downloaded 205 times
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  • Site-wide: 100,407
  • In genomics: 5,971
• Year to date:
  • Site-wide: 52,523
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  • Site-wide: 52,523

Various miRNAs are involved in efficient HCV replication

• Downloaded 169 times
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  • Site-wide: 107,863
  • In microbiology: 8,101
• Year to date:
  • Site-wide: 93,649
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  • Site-wide: 93,649

Personalized vagino-cervical microbiome dynamics after oral probiotics

• Downloaded 160 times
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  • Site-wide: 109,588
  • In microbiology: 8,268
• Year to date:
  • Site-wide: 64,100
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  • Site-wide: 64,100

Src/FAK complex phosphorylates cardiac myosin binding protein c (cMyBP-C) in vitro and in vivo

• Downloaded 147 times
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  • Site-wide: 112,274
  • In molecular biology: 3,372
• Year to date:
  • Site-wide: 89,700
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  • Site-wide: 89,700

Fibroblast growth factor-2 prevents synaptic pathology in minimal hepatic encephalopathy via NRG1/ErbB4 signaling

• Downloaded 143 times
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  • Site-wide: 113,032
  • In neuroscience: 17,589
• Year to date:
  • Site-wide: 75,496
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  • Site-wide: 75,496

Maternal perception of child weight and concern about child overweight mediates the relationship between child weight and non-responsive feeding practices

• Downloaded 128 times
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  • Site-wide: 115,852
  • In pediatrics: 151
• Year to date:
  • Site-wide: 25,120
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  • Site-wide: 25,120

The inverse relationship between fibronectin and neuroligins in the embryonic rat colon

• Downloaded 125 times
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  • Site-wide: 116,366
  • In cell biology: 5,403
• Year to date:
  • Site-wide: 117,247
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  • Site-wide: 117,247

Comprehensive genome sequencing analysis as a promising option in the prenatal diagnosis of fetal structural anomalies: a prospective study.

• Downloaded 124 times
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  • Site-wide: 116,448
  • In genomics: 6,444
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Chinese medicine (Q-14) in the Treatment of Patients with Coronavirus Disease 2019 (COVID-19): A Single-center, Open label, Randomised Controlled Trial

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JAK/STAT pathway promotes Drosophila neuroblast proliferation via the direct CycE regulation

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Evaluation method of ecosystem service value under complex ecological environment: A case study of Gansu Province, China

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