Author: Wei Li

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Preprints

Bioconda: A sustainable and comprehensive software distribution for the life sciences

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  • Site-wide: 1,759
  • In bioinformatics: 122
• Year to date:
  • Site-wide: 9,645
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  • Site-wide: 8,605

Rapid selection of a human monoclonal antibody that potently neutralizes SARS-CoV-2 in two animal models

• Downloaded 3,167 times
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  • Site-wide: 4,371
  • In microbiology: 283
• Year to date:
  • Site-wide: 9,709
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  • Site-wide: 12,996

Detecting Tumor Specific Antigen-Reactive T cells from Tumor Infiltrating Lymphocytes via Interaction Dependent Fucosyl-biotinylation

• Downloaded 2,678 times
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  • Site-wide: 5,532
  • In immunology: 189
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  • Site-wide: 3,545
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  • Site-wide: 4,748

Multi-omics analysis of chromatin accessibility and interactions with transcriptome by HiCAR

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  • Site-wide: 6,614
  • In genomics: 712
• Year to date:
  • Site-wide: 2,647
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  • Site-wide: 2,605

A Cell Type-Specific Class of Chromatin Loops Anchored at Large DNA Methylation Nadirs

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  • Site-wide: 8,131
  • In genomics: 853
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  • Site-wide: 33,235
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  • Site-wide: 43,796

SARS-CoV-2 detection with CRISPR diagnostics

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  • Site-wide: 8,192
  • In molecular biology: 196
• Year to date:
  • Site-wide: 43,775
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  • Site-wide: 34,167

Reducing False Positives in CRISPR/Cas9 Screens from Copy Number Variations

• Downloaded 1,960 times
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  • Site-wide: 8,782
  • In bioinformatics: 1,026
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  • Site-wide: 27,485
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  • Site-wide: 53,025

Click-ExM enables expansion microscopy for all biomolecules

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  • Site-wide: 8,886
  • In bioengineering: 143
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  • Site-wide: 13,454
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  • Site-wide: 18,631

A new method for rapid genome classification, clustering, visualization, and novel taxa discovery from metagenome

• Downloaded 1,862 times
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  • Site-wide: 9,477
  • In bioinformatics: 1,109
• Year to date:
  • Site-wide: 18,149
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  • Site-wide: 37,162

Identification of novel rare sequence variation underlying heritable pulmonary arterial hypertension

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  • Site-wide: 12,438
  • In genetics: 576
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  • Site-wide: 76,901
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  • Site-wide: 97,254

Linking genotypes with multiple phenotypes in single-cell CRISPR screens

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  • Site-wide: 13,818
  • In bioinformatics: 1,609
• Year to date:
  • Site-wide: 101,159
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  • Site-wide: 102,300

Metagenomic Next-generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Central Nervous System Infections: A Multicentre Prospective Study

• Downloaded 1,397 times
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  • Site-wide: 14,490
  • In genomics: 1,481
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  • Site-wide: 27,754
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  • Site-wide: 19,566

Diversification of molecularly defined myenteric neuron classes revealed by single cell RNA-sequencing

• Downloaded 1,262 times
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  • Site-wide: 16,888
  • In neuroscience: 2,016
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  • Site-wide: 22,479
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  • Site-wide: 31,177

Exploring functional variation affecting ceRNA regulation in humans

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  • Site-wide: 20,119
  • In genetics: 941
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  • Site-wide: 126,360
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  • Site-wide: 101,939

Genetic Basis of Alternative Polyadenylation is an Emerging Molecular Phenotype for Human Traits and Diseases

• Downloaded 1,087 times
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  • Site-wide: 21,022
  • In bioinformatics: 2,432
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  • Site-wide: 40,980
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  • Site-wide: 57,744

Integrative analysis and refined design of CRISPR knockout screens

• Downloaded 1,081 times
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  • Site-wide: 21,183
  • In bioinformatics: 2,446
• Year to date:
  • Site-wide: 74,429
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  • Site-wide: 61,708

SMRT sequencing yields the chromosome-scale reference genome of tea tree, Camellia sinensis var. sinensis

• Downloaded 1,060 times
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  • Site-wide: 21,803
  • In genomics: 2,098
• Year to date:
  • Site-wide: 53,426
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  • Site-wide: 42,632

Single cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina

• Downloaded 1,059 times
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  • Site-wide: 21,861
  • In cell biology: 740
• Year to date:
  • Site-wide: 40,978
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  • Site-wide: 24,832

Potential microenvironment of SARS-CoV-2 infection in airway epithelial cells revealed by Human Protein Atlas database analysis

• Downloaded 994 times
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  • Site-wide: 23,998
  • In cell biology: 845
• Year to date:
  • Site-wide: 53,397
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  • Site-wide: 39,657

Radial contractility of Actomyosin-II rings facilitates cargo trafficking and maintains axonal structural stability following cargo-induced transient axonal expansion

• Downloaded 930 times
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  • Site-wide: 26,401
  • In neuroscience: 3,389
• Year to date:
  • Site-wide: 68,829
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  • Site-wide: 46,230

Poly(A)-ClickSeq: click-chemistry for next-generation 3′-end sequencing without RNA enrichment or fragmentation

• Downloaded 911 times
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  • Site-wide: 27,162
  • In molecular biology: 737
• Year to date:
  • Site-wide: 85,359
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  • Site-wide: 96,670

Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis

• Downloaded 905 times
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  • Site-wide: 27,421
  • In biochemistry: 632
• Year to date:
  • Site-wide: 75,732
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  • Site-wide: 57,098

CRISPR/Cas9 screens Reveal Dasatinib Targets of Inhibiting T cell Activation and Proliferation

• Downloaded 858 times
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  • Site-wide: 29,576
  • In cancer biology: 765
• Year to date:
  • Site-wide: 68,070
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  • Site-wide: 53,080

SMRT sequencing generates the chromosome-scale reference genome of tropical fruit mango, Mangifera indica

• Downloaded 825 times
• Download rankings, all-time:
  • Site-wide: 31,262
  • In genomics: 2,759
• Year to date:
  • Site-wide: 40,608
• Since beginning of last month:
  • Site-wide: 55,041

GCNA preserves genome integrity and fertility across species

• Downloaded 799 times
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  • Site-wide: 32,635
  • In developmental biology: 650
• Year to date:
  • Site-wide: 97,660
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  • Site-wide: 112,372

Clipper: p-value-free FDR control on high-throughput data from two conditions

• Downloaded 791 times
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  • Site-wide: 33,100
  • In bioinformatics: 3,671
• Year to date:
  • Site-wide: 10,431
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  • Site-wide: 29,545

Dual functions of Intraflagellar Transport Protein IFT20 in spermiogenesis: formation of sperm flagella and removal of cytoplasm by autophagy

• Downloaded 776 times
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  • Site-wide: 34,017
  • In developmental biology: 688
• Year to date:
  • Site-wide: 127,854
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  • Site-wide: 95,934

Single cell RNA sequencing reveals cellular diversity of trisomy 21 retina

• Downloaded 671 times
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  • Site-wide: 41,462
  • In cell biology: 1,688
• Year to date:
  • Site-wide: 103,453
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  • Site-wide: 101,452

The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double strand break repair

• Downloaded 669 times
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  • Site-wide: 41,575
  • In developmental biology: 902
• Year to date:
  • Site-wide: 73,792
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  • Site-wide: 88,644

Progressive lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence of mouse embryonic fibroblasts

• Downloaded 647 times
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  • Site-wide: 43,460
  • In genomics: 3,503
• Year to date:
  • Site-wide: 100,105
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  • Site-wide: 86,820

m6A Regulates Liver Metabolic Disorders and Hepatogenous Diabetes

• Downloaded 634 times
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  • Site-wide: 44,582
  • In genetics: 2,021
• Year to date:
  • Site-wide: 65,378
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  • Site-wide: 53,637

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

• Downloaded 621 times
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  • Site-wide: 45,685
  • In cell biology: 1,912
• Year to date:
  • Site-wide: 98,489
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  • Site-wide: 91,103

Extensive alternative splicing transitions during postnatal skeletal muscle development are required for Ca2+ handling

• Downloaded 577 times
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  • Site-wide: 50,084
  • In cell biology: 2,160
• Year to date:
  • Site-wide: 118,990
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  • Site-wide: 116,684

Single cell atlas of trisomy 21 cerebral cortex

• Downloaded 569 times
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  • Site-wide: 50,994
  • In neuroscience: 7,314
• Year to date:
  • Site-wide: 56,470
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  • Site-wide: 33,720

Diagnostic Whole Exome Sequencing in Patients with Short Stature

• Downloaded 540 times
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  • Site-wide: 54,306
  • In genetics: 2,425
• Year to date:
  • Site-wide: 92,213
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  • Site-wide: 94,822

Differences in GluN2B-containing NMDA receptors result in opposite long-term plasticity and dopaminergic modulation at ipsilateral vs. contralateral cortico-striatal synapses

• Downloaded 529 times
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  • Site-wide: 55,632
  • In neuroscience: 8,075
• Year to date:
  • Site-wide: 95,722
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  • Site-wide: 112,618

Pre-implantation genetic diagnosis for a family with Usher syndrome through targeted sequencing and haplotype analysis

• Downloaded 518 times
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  • Site-wide: 57,104
  • In genetics: 2,554
• Year to date:
  • Site-wide: 111,531
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  • Site-wide: 116,420

Coordinate Enhancer Reprogramming by GATA3 and AP1 Promotes Phenotypic Plasticity to Achieve Breast Cancer Endocrine Resistance

• Downloaded 492 times
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  • Site-wide: 60,537
  • In cancer biology: 1,722
• Year to date:
  • Site-wide: 97,950
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  • Site-wide: 108,127

Long Non-Coding RNA LncKdm2b Regulates Cortical Neuronal Differentiation by Cis-Activating Kdm2b

• Downloaded 476 times
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  • Site-wide: 62,702
  • In molecular biology: 1,785
• Year to date:
  • Site-wide: 77,270
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  • Site-wide: 97,696

HiAlc Klebsiella pneumonia, one of potential chief culprits of non-alcoholic fatty liver disease: through generation of endogenous ethanol

• Downloaded 467 times
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  • Site-wide: 64,030
  • In microbiology: 4,181
• Year to date:
  • Site-wide: 93,928
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  • Site-wide: 123,523

Global lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence

• Downloaded 462 times
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  • Site-wide: 64,783
  • In genomics: 4,627
• Year to date:
  • Site-wide: 112,108
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  • Site-wide: 86,845

Cyclin B3 is specifically required for metaphase to anaphase transition in mouse oocyte meiosis I

• Downloaded 454 times
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  • Site-wide: 66,030
  • In cell biology: 2,935
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  • Site-wide: 87,172
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  • Site-wide: 34,996

SMRT sequencing of the Oryza rufipogon genome reveals the genomic basis of rice adaptation

• Downloaded 419 times
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  • Site-wide: 71,656
  • In genomics: 4,930
• Year to date:
  • Site-wide: 146,966
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  • Site-wide: 118,881

Essential role of Bone morphogenetic protein 15 in porcine ovarian and follicular development and ovulation

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  • Site-wide: 73,802
  • In developmental biology: 1,860
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  • Site-wide: 63,958
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  • Site-wide: 66,620

Long-Term Potentiation Induces Extrasynaptic Exocytosis of Glun2A-containing NMDA Receptors that is Mainly Controlled by SNAP23

• Downloaded 405 times
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  • Site-wide: 74,033
  • In cell biology: 3,364
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  • Site-wide: 61,014
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  • Site-wide: 31,993

Deciphering tea tree chloroplast and mitochondrial genomes of Camellia sinensis var. assamica

• Downloaded 398 times
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  • Site-wide: 75,383
  • In genomics: 5,088
• Year to date:
  • Site-wide: 141,389
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  • Site-wide: 142,096

Circulating BMP9 protects the pulmonary endothelium during inflammation-induced lung injury in mice

• Downloaded 389 times
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  • Site-wide: 76,939
  • In physiology: 577
• Year to date:
  • Site-wide: 48,008
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  • Site-wide: 58,671

Rapid Detection of Burkholderia pseudomallei with a Lateral Flow Recombinase Polymerase Amplification Assay

• Downloaded 387 times
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  • Site-wide: 77,317
  • In microbiology: 5,245
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  • Site-wide: 109,736
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  • Site-wide: 131,804

Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization

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  • Site-wide: 77,461
  • In developmental biology: 1,986
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  • Site-wide: 65,037
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  • Site-wide: 54,202

Numerical Investigation of Drug Transport from Blood Vessels to Tumor Tissue Using a Tumor-Vasculature-on-a-Chip

• Downloaded 372 times
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  • Site-wide: 80,152
  • In bioengineering: 1,505
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  • Site-wide: 86,838
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  • Site-wide: 102,220

SLFL Genes Participate in the Ubiquitination and Degradation of S-RNase in Self-Compatible Chinese Peach

• Downloaded 370 times
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  • Site-wide: 80,414
  • In molecular biology: 2,367
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  • Site-wide: 130,749
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  • Site-wide: 125,612

Structural variability and functional association in the epiphytic bacteria assemblies of freshwater macrophytes (Myriophyllum spicatum)

• Downloaded 370 times
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  • Site-wide: 80,413
  • In microbiology: 5,515
• Year to date:
  • Site-wide: 120,534
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  • Site-wide: 93,604

Effect of arbuscular mycorrhizal fungi (AMF) and plant growth promoting rhizobacteria (PGPR) on microbial community structure of phenanthrene and pyrene contaminated soils using Illumina HiSeq sequencing.

• Downloaded 350 times
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  • Site-wide: 84,305
  • In ecology: 2,448
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  • Site-wide: 76,051
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  • Site-wide: 90,339

True S-cones are concentrated in the ventral mouse retina for color detection in the upper visual field

• Downloaded 342 times
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  • Site-wide: 85,916
  • In evolutionary biology: 4,529
• Year to date:
  • Site-wide: 106,469
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  • Site-wide: 104,916

Noninvasive prenatal test of methylmalonic academia cblC type through targeted sequencing of cell-free DNA in maternal plasma

• Downloaded 330 times
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  • Site-wide: 88,597
  • In genetics: 3,884
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  • Site-wide: 122,871
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  • Site-wide: 101,449

Temporal regulation of prenatal embryonic development by paternal imprinted loci

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  • Site-wide: 96,647
  • In developmental biology: 2,604
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  • Site-wide: 78,447
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  • Site-wide: 49,902

Clinical diagnosis of single-gene disorders and chromosomal abnormalities based on BGISEQ-500 platform

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  • Site-wide: 97,578
  • In genomics: 5,948
• Year to date:
  • Site-wide: 143,656
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  • Site-wide: 142,185

Targeting against HIV/HCV Co-infection using Machine Learning-based multitarget-quantitative structure-activity relationships (mt-QSAR) Methods

• Downloaded 277 times
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  • Site-wide: 100,286
  • In bioinformatics: 8,616
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  • Site-wide: 138,934
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  • Site-wide: 117,460

ATM and ATR Influence Meiotic Crossover Formation Through Antagonistic and Overlapping Functions in C. elegans

• Downloaded 276 times
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  • Site-wide: 100,698
  • In genetics: 4,330
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  • Site-wide: 145,600
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  • Site-wide: 132,526

Cellular heterogeneity-adjusted clonal methylation (CHALM) provides better prediction of gene expression

• Downloaded 272 times
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  • Site-wide: 101,575
  • In bioinformatics: 8,695
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  • Site-wide: 110,808
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  • Site-wide: 108,148

BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor

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  • Site-wide: 101,816
  • In cell biology: 4,720
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  • Site-wide: 113,019
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  • Site-wide: 145,026

Identification of TTN as a novel candidate gene for atrioventricular block in a Chinese pedigree by whole-exome sequencing

• Downloaded 271 times
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  • Site-wide: 101,695
  • In genetics: 4,383
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  • Site-wide: 98,896
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  • Site-wide: 49,321

Hsa_circ_0001947 suppresses acute myeloid leukemia progression by sponging hsa-miR-329-5p and regulating CREBRF expression

• Downloaded 237 times
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  • Site-wide: 109,923
  • In cancer biology: 3,331
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  • Site-wide: 96,496
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  • Site-wide: 106,873

Intra-protein binding peptide fragments have specific and intrinsic sequence patterns

• Downloaded 234 times
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  • Site-wide: 110,710
  • In bioinformatics: 9,264
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  • Site-wide: 146,808
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  • Site-wide: 112,982

A Reference Feature based method for Quantification and Identification of LC-MS based untargeted metabolomics

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  • Site-wide: 113,401
  • In bioinformatics: 9,423
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  • Site-wide: 108,433

DORGE: Discovery of Oncogenes and Tumor SuppressoR Genes Using Genetic and Epigenetic Features

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  • Site-wide: 113,499
  • In bioinformatics: 9,413
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  • Site-wide: 139,489

Spectrin-based Membrane Mechanics Is Asymmetric and Remodels during Neural Development

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  • Site-wide: 114,333
  • In developmental biology: 3,082
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  • Site-wide: 133,789
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  • Site-wide: 98,362

Influence of isolation by environment and landscape heterogeneity on genetic structure of wild rice Zizania latifolia along a latitudinal gradient

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  • Site-wide: 116,200
  • In ecology: 3,824
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  • Site-wide: 73,343

The draft genome sequence of herbaceous diploid bamboo Raddia distichophylla

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  • Site-wide: 119,528
  • In genomics: 6,666
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  • Site-wide: 102,414
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  • Site-wide: 75,455

Impact of ultrasonography on identifying noninvasive prenatal screening false-negative aneuploidy

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  • Site-wide: 120,988
  • In genetics: 5,070
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  • Site-wide: 103,850

Combinatorial phosphorylation modulates the structure and function of the G protein gamma subunit in yeast

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  • Site-wide: 123,131
  • In molecular biology: 3,653
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  • Site-wide: 104,946

The key miRNAs for metastasis and survival of colon adenocarcinoma

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  • Site-wide: 125,704
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  • Site-wide: 122,504
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Enabling in vivo Analysis Via Nanoparticle-mediated Intracellular Assay Probe Delivery: Using RAS as the Prototype

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  • Site-wide: 130,930
  • In biochemistry: 3,941
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Novel Vβ specific germline contacts shape an elite controller T cell response

• Downloaded 141 times
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  • Site-wide: 132,594
  • In immunology: 3,900
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  • Site-wide: 114,671
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  • Site-wide: 104,849

Decoding herbal materials of representative TCM preparations with the multi-barcoding approach

• Downloaded 136 times
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  • Site-wide: 133,657
  • In bioinformatics: 10,517
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  • Site-wide: 110,505
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  • Site-wide: 82,274

Whole-genome-based Helicobacter pylori geographic surveillance: a visualized and expandable webtool

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  • Site-wide: 142,940
  • In genomics: 7,340
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  • Site-wide: 63,476
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  • Site-wide: 70,527

Comparative analyses and phylogenetic relationships of 15 Trapa (Trapaceae) species based on Complete Chloroplast Genomes

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  • In genomics: 7,403
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