Author: Wei Li

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Preprints

Fast 2-photon stimulation using holographic patterns

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Bioconda: A sustainable and comprehensive software distribution for the life sciences

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  • Site-wide: 2,196
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  • Site-wide: 4,272
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  • Site-wide: 5,994

Multi-omics analysis of chromatin accessibility and interactions with transcriptome by HiCAR

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  • Site-wide: 5,157
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• Year to date:
  • Site-wide: 17,210
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  • Site-wide: 24,165

Rapid selection of a human monoclonal antibody that potently neutralizes SARS-CoV-2 in two animal models

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  • Site-wide: 5,512
  • In microbiology: 370
• Year to date:
  • Site-wide: 86,832
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  • Site-wide: 81,132

Detecting Tumor Specific Antigen-Reactive T cells from Tumor Infiltrating Lymphocytes via Interaction Dependent Fucosyl-biotinylation

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  • Site-wide: 6,694
  • In immunology: 271
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Click-ExM enables expansion microscopy for all biomolecules

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  • Site-wide: 10,440
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  • Site-wide: 44,223
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  • Site-wide: 39,665

Reducing False Positives in CRISPR/Cas9 Screens from Copy Number Variations

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  • Site-wide: 10,878
  • In bioinformatics: 1,162
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  • Site-wide: 91,903

A Cell Type-Specific Class of Chromatin Loops Anchored at Large DNA Methylation Nadirs

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  • Site-wide: 11,199
  • In genomics: 1,031
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  • Site-wide: 59,445

SARS-CoV-2 detection with CRISPR diagnostics

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  • Site-wide: 11,503
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A new method for rapid genome classification, clustering, visualization, and novel taxa discovery from metagenome

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  • Site-wide: 12,247
  • In bioinformatics: 1,315
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  • Site-wide: 120,626

Clipper: p-value-free FDR control on high-throughput data from two conditions

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  • Site-wide: 16,000
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Metagenomic Next-generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Central Nervous System Infections: A Multicentre Prospective Study

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  • Site-wide: 17,026
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  • Site-wide: 171,171
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  • Site-wide: 89,151

Identification of novel rare sequence variation underlying heritable pulmonary arterial hypertension

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  • Site-wide: 17,655
  • In genetics: 709
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  • Site-wide: 198,484

Linking genotypes with multiple phenotypes in single-cell CRISPR screens

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  • Site-wide: 19,146
  • In bioinformatics: 2,098
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  • Site-wide: 112,683
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  • Site-wide: 118,006

Diversification of molecularly defined myenteric neuron classes revealed by single cell RNA-sequencing

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  • Site-wide: 21,045
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  • Site-wide: 77,392

Resurrection of human endogenous retroviruses during aging reinforces senescence

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  • Site-wide: 23,918
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  • Site-wide: 497
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Genetic Basis of Alternative Polyadenylation is an Emerging Molecular Phenotype for Human Traits and Diseases

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  • Site-wide: 25,363
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  • Site-wide: 60,780
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  • Site-wide: 91,397

SMRT sequencing yields the chromosome-scale reference genome of tea tree, Camellia sinensis var. sinensis

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  • Site-wide: 27,035
  • In genomics: 2,291
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  • Site-wide: 80,060
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  • Site-wide: 131,803

Integrative analysis and refined design of CRISPR knockout screens

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  • Site-wide: 27,213
  • In bioinformatics: 3,074
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  • Site-wide: 3,156
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  • Site-wide: 61,323

Single cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina

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  • Site-wide: 28,605
  • In cell biology: 1,037
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  • Site-wide: 36,008
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  • Site-wide: 181,923

Exploring functional variation affecting ceRNA regulation in humans

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  • Site-wide: 28,851
  • In genetics: 1,144
• Year to date:
  • Site-wide: 93,220
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  • Site-wide: 198,110

SMRT sequencing generates the chromosome-scale reference genome of tropical fruit mango, Mangifera indica

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  • Site-wide: 32,321
  • In genomics: 2,689
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  • Site-wide: 28,380
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  • Site-wide: 127,737

Potential microenvironment of SARS-CoV-2 infection in airway epithelial cells revealed by Human Protein Atlas database analysis

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  • Site-wide: 33,389
  • In cell biology: 1,233
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  • Site-wide: 153,853
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  • Site-wide: 185,342

Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis

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  • Site-wide: 33,478
  • In biochemistry: 785
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  • Site-wide: 193,525
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  • Site-wide: 42,979

CRISPR/Cas9 screens Reveal Dasatinib Targets of Inhibiting T cell Activation and Proliferation

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  • Site-wide: 34,312
  • In cancer biology: 948
• Year to date:
  • Site-wide: 25,755
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  • Site-wide: 32,799

Radial contractility of Actomyosin-II rings facilitates cargo trafficking and maintains axonal structural stability following cargo-induced transient axonal expansion

• Downloaded 1,091 times
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  • Site-wide: 34,865
  • In neuroscience: 4,408
• Year to date:
  • Site-wide: 136,887
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  • Site-wide: 154,547

Poly(A)-ClickSeq: click-chemistry for next-generation 3′-end sequencing without RNA enrichment or fragmentation

• Downloaded 1,012 times
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  • Site-wide: 39,132
  • In molecular biology: 1,076
• Year to date:
  • Site-wide: 172,842
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  • Site-wide: 178,394

Intrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems

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  • Site-wide: 39,474
  • In molecular biology: 1,125
• Year to date:
  • Site-wide: 35,057
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  • Site-wide: 8,836

Modeling CRISPR-Cas13d on-target and off-target effects using machine learning approaches

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  • Site-wide: 46,864
  • In bioinformatics: 5,453
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  • Site-wide: None
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  • Site-wide: 15,102

Dual functions of Intraflagellar Transport Protein IFT20 in spermiogenesis: formation of sperm flagella and removal of cytoplasm by autophagy

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  • Site-wide: 47,983
  • In developmental biology: 1,024
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  • Site-wide: 72,660
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  • Site-wide: 203,912

Lactate Increases Stemness of CD8+ T Cells to Augment Anti-Tumor Immunity

• Downloaded 885 times
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  • Site-wide: 48,188
  • In immunology: 1,661
• Year to date:
  • Site-wide: 74,325
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  • Site-wide: 29,413

GCNA preserves genome integrity and fertility across species

• Downloaded 879 times
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  • Site-wide: 48,709
  • In developmental biology: 1,036
• Year to date:
  • Site-wide: 191,761
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  • Site-wide: 181,336

Single cell RNA sequencing reveals cellular diversity of trisomy 21 retina

• Downloaded 877 times
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  • Site-wide: 48,882
  • In cell biology: 1,972
• Year to date:
  • Site-wide: 169,054
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  • Site-wide: 181,881

The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double strand break repair

• Downloaded 854 times
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  • Site-wide: 50,870
  • In developmental biology: 1,116
• Year to date:
  • Site-wide: 94,003
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  • Site-wide: 76,467

m6A Regulates Liver Metabolic Disorders and Hepatogenous Diabetes

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  • Site-wide: 53,845
  • In genetics: 2,122
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  • Site-wide: 45,303
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  • Site-wide: 52,753

A large-sample crisis? Exaggerated false positives by popular differential expression methods

• Downloaded 812 times
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  • Site-wide: 54,849
  • In bioinformatics: 5,511
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  • Site-wide: 180,085
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  • Site-wide: 29,655

Single cell atlas of trisomy 21 cerebral cortex

• Downloaded 808 times
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  • Site-wide: 55,244
  • In neuroscience: 7,525
• Year to date:
  • Site-wide: 119,640
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  • Site-wide: 184,314

Cone mitochondria act as microlenses to enhance light delivery and confer Stiles-Crawford-like direction sensitivity

• Downloaded 796 times
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  • Site-wide: 56,449
  • In neuroscience: 7,824
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  • Site-wide: 37,750
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  • Site-wide: 84,157

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

• Downloaded 779 times
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  • Site-wide: 58,320
  • In cell biology: 2,507
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  • Site-wide: 53,843

Progressive lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence of mouse embryonic fibroblasts

• Downloaded 755 times
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  • Site-wide: 61,081
  • In genomics: 4,237
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  • Site-wide: 174,963

PCA outperforms popular hidden variable inference methods for QTL mapping

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  • Site-wide: 62,382
  • In bioinformatics: 6,004
• Year to date:
  • Site-wide: 79,111
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  • Site-wide: 69,051

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains

• Downloaded 710 times
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  • Site-wide: 66,863
  • In immunology: 2,221
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  • Site-wide: 55,231
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  • Site-wide: 48,740

Extensive alternative splicing transitions during postnatal skeletal muscle development are required for Ca2+ handling

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  • Site-wide: 68,021
  • In cell biology: 2,974
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  • Site-wide: 92,287
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  • Site-wide: 204,230

Coordinate Enhancer Reprogramming by GATA3 and AP1 Promotes Phenotypic Plasticity to Achieve Breast Cancer Endocrine Resistance

• Downloaded 693 times
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  • Site-wide: 69,128
  • In cancer biology: 2,015
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  • Site-wide: 215,452

Identification of transcription factors involved in the specification of photoreceptor subtypes

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  • Site-wide: 71,496
  • In neuroscience: 9,927
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  • Site-wide: None
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  • Site-wide: 33,133

Diagnostic Whole Exome Sequencing in Patients with Short Stature

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  • Site-wide: 72,144
  • In genetics: 2,776
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  • Site-wide: 111,782
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  • Site-wide: 90,257

Differences in GluN2B-containing NMDA receptors result in opposite long-term plasticity and dopaminergic modulation at ipsilateral vs. contralateral cortico-striatal synapses

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  • Site-wide: 75,684
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  • Site-wide: 153,238

Pre-implantation genetic diagnosis for a family with Usher syndrome through targeted sequencing and haplotype analysis

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  • Site-wide: 76,832
  • In genetics: 2,949
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  • Site-wide: 136,516
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  • Site-wide: 144,245

HiAlc Klebsiella pneumonia, one of potential chief culprits of non-alcoholic fatty liver disease: through generation of endogenous ethanol

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  • Site-wide: 82,953
  • In microbiology: 5,161
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Discovery of a novel human antibody VH domain with potent activity against mesothelin expressing cancer cells in both CAR T-cell and antibody drug conjugate formats

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  • Site-wide: 84,926
  • In cancer biology: 2,869
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  • Site-wide: 2,430
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  • Site-wide: 8,885

Cyclin B3 is specifically required for metaphase to anaphase transition in mouse oocyte meiosis I

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  • Site-wide: 85,690
  • In cell biology: 3,833
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Long-Term Potentiation Induces Extrasynaptic Exocytosis of Glun2A-containing NMDA Receptors that is Mainly Controlled by SNAP23

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  • Site-wide: 87,680
  • In cell biology: 4,075
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  • Site-wide: 26,145
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  • Site-wide: 116,713

Rapid Detection of Burkholderia pseudomallei with a Lateral Flow Recombinase Polymerase Amplification Assay

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  • Site-wide: 88,181
  • In microbiology: 5,677
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  • Site-wide: None
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  • Site-wide: 89,911

Essential role of Bone morphogenetic protein 15 in porcine ovarian and follicular development and ovulation

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  • Site-wide: 88,596
  • In developmental biology: 2,237
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  • Site-wide: 90,182

Circulating BMP9 protects the pulmonary endothelium during inflammation-induced lung injury in mice

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  • Site-wide: 89,501
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Global lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence

• Downloaded 554 times
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  • Site-wide: 92,393
  • In genomics: 5,764
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  • Site-wide: 94,493
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Long Non-Coding RNA LncKdm2b Regulates Cortical Neuronal Differentiation by Cis-Activating Kdm2b

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  • Site-wide: 92,416
  • In molecular biology: 2,658
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  • Site-wide: 179,902

ABLs and TMKs are co-receptors for extracellular auxin

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  • Site-wide: 93,423
  • In plant biology: 2,790
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  • Site-wide: 2,310
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  • Site-wide: 1,271

Temporal regulation of prenatal embryonic development by paternal imprinted loci

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  • Site-wide: 99,356
  • In developmental biology: 2,598
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  • Site-wide: 94,366
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  • Site-wide: 43,421

Effect of arbuscular mycorrhizal fungi (AMF) and plant growth promoting rhizobacteria (PGPR) on microbial community structure of phenanthrene and pyrene contaminated soils using Illumina HiSeq sequencing.

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  • Site-wide: 99,677
  • In ecology: 2,562
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  • Site-wide: 49,667
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  • Site-wide: 185,250

Hsa_circ_0001947 suppresses acute myeloid leukemia progression by sponging hsa-miR-329-5p and regulating CREBRF expression

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  • Site-wide: 101,003
  • In cancer biology: 3,071
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  • Site-wide: 114,046
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  • Site-wide: 163,929

SLFL Genes Participate in the Ubiquitination and Degradation of S-RNase in Self-Compatible Chinese Peach

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  • Site-wide: 102,522
  • In molecular biology: 2,987
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  • Site-wide: 92,392

SMRT sequencing of the Oryza rufipogon genome reveals the genomic basis of rice adaptation

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  • Site-wide: 103,807
  • In genomics: 6,180
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  • Site-wide: 214,661

True S-cones are concentrated in the ventral mouse retina for color detection in the upper visual field

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  • Site-wide: 105,196
  • In evolutionary biology: 4,851
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  • Site-wide: 121,545

Structural variability and functional association in the epiphytic bacteria assemblies of freshwater macrophytes (Myriophyllum spicatum)

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  • Site-wide: 106,002
  • In microbiology: 6,927
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  • Site-wide: 173,650

Deciphering tea tree chloroplast and mitochondrial genomes of Camellia sinensis var. assamica

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  • Site-wide: 107,397
  • In genomics: 6,357
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  • Site-wide: 116,541

Emerging SARS-CoV-2 Variants of Concern: Spike Protein Mutational Analysis and Epitope for Broad Neutralization

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  • Site-wide: 109,262
  • In biochemistry: 3,153
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  • Site-wide: 112,345

Numerical Investigation of Drug Transport from Blood Vessels to Tumor Tissue Using a Tumor-Vasculature-on-a-Chip

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  • Site-wide: 114,206
  • In bioengineering: 2,303
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  • Site-wide: 147,856

Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization

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  • Site-wide: 114,778
  • In developmental biology: 2,989
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  • Site-wide: 160,776
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  • Site-wide: 163,385

Noninvasive prenatal test of methylmalonic academia cblC type through targeted sequencing of cell-free DNA in maternal plasma

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  • Site-wide: 117,742
  • In genetics: 4,406
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  • Site-wide: 201,333

Clinical diagnosis of single-gene disorders and chromosomal abnormalities based on BGISEQ-500 platform

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  • Site-wide: 130,986
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  • Site-wide: 117,553

Cellular heterogeneity-adjusted clonal methylation (CHALM) provides better prediction of gene expression

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  • Site-wide: 133,240
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BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor

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  • Site-wide: 133,514
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Wilcoxon rank-sum test still outperforms dearseq after accounting for the normalization impact in semi-synthetic RNA-seq data simulation

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  • Site-wide: 133,649
  • In bioinformatics: 11,487
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  • Site-wide: 8,431

Identification of TTN as a novel candidate gene for atrioventricular block in a Chinese pedigree by whole-exome sequencing

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  • Site-wide: 133,928
  • In genetics: 5,029
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  • Site-wide: 137,071
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  • Site-wide: 75,003

Targeting against HIV/HCV Co-infection using Machine Learning-based multitarget-quantitative structure-activity relationships (mt-QSAR) Methods

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  • Site-wide: 135,748
  • In bioinformatics: 10,869
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  • Site-wide: 208,771

Enabling in vivo Analysis Via Nanoparticle-mediated Intracellular Assay Probe Delivery: Using RAS as the Prototype

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  • Site-wide: 137,943
  • In biochemistry: 4,168
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  • Site-wide: 53,173

ATM and ATR Influence Meiotic Crossover Formation Through Antagonistic and Overlapping Functions in C. elegans

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  • Site-wide: 181,757

Decoding the IGF1 Signaling Gene Regulatory Network Behind Alveologenesis from A Mouse Model of Bronchopulmonary Dysplasia

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  • Site-wide: 141,224
  • In developmental biology: 3,783
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  • Site-wide: 68,742

A Reference Feature based method for Quantification and Identification of LC-MS based untargeted metabolomics

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  • Site-wide: 142,035
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  • Site-wide: 129,532

Influence of isolation by environment and landscape heterogeneity on genetic structure of wild rice Zizania latifolia along a latitudinal gradient

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  • Site-wide: 144,401
  • In ecology: 4,343
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Spectrin-based Membrane Mechanics Is Asymmetric and Remodels during Neural Development

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  • In developmental biology: 3,924
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  • Site-wide: 121,230
• Since beginning of last month:
  • Site-wide: 102,672

The draft genome sequence of herbaceous diploid bamboo Raddia distichophylla

• Downloaded 311 times
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  • Site-wide: 156,580
  • In genomics: 8,047
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  • Site-wide: 87,662
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  • Site-wide: 128,402

DORGE: Discovery of Oncogenes and Tumor SuppressoR Genes Using Genetic and Epigenetic Features

• Downloaded 311 times
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  • Site-wide: 156,564
  • In bioinformatics: 12,183
• Year to date:
  • Site-wide: 150,911
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  • Site-wide: 184,200

Whole-genome-based Helicobacter pylori geographic surveillance: a visualized and expandable webtool

• Downloaded 292 times
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  • Site-wide: 162,373
  • In genomics: 8,209
• Year to date:
  • Site-wide: 106,785
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  • Site-wide: 171,104

Intra-protein binding peptide fragments have specific and intrinsic sequence patterns

• Downloaded 292 times
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  • Site-wide: 162,504
  • In bioinformatics: 12,472
• Year to date:
  • Site-wide: 190,290
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  • Site-wide: 202,641

Specific Pupylation as IDEntity Reporter (SPIDER) for the identification of Protein-Biomolecule interactions

• Downloaded 292 times
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  • Site-wide: 162,549
  • In systems biology: 3,316
• Year to date:
  • Site-wide: 26,984
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  • Site-wide: 22,743

Combinatorial phosphorylation modulates the structure and function of the G protein gamma subunit in yeast

• Downloaded 285 times
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  • Site-wide: 164,557
  • In molecular biology: 4,868
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  • Site-wide: 160,221
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  • Site-wide: 166,382

Discovery and pre-clinical evaluation of antibodies to the NKG2A inhibitory receptor

• Downloaded 277 times
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  • Site-wide: 167,026
  • In immunology: 5,434
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  • Site-wide: 16,250
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  • Site-wide: 28,827

The key miRNAs for metastasis and survival of colon adenocarcinoma

• Downloaded 272 times
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  • Site-wide: 168,307
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  • Site-wide: 114,651
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  • Site-wide: 190,403

Single-Cell RNA-seq of Heart Reveals Intercellular Communication Drivers of Myocardial Fibrosis in Diabetic Mice

• Downloaded 269 times
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  • Site-wide: 169,205
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  • Site-wide: 36,575

Decoding herbal materials of representative TCM preparations with the multi-barcoding approach

• Downloaded 261 times
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  • Site-wide: 171,572
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  • Site-wide: 183,393
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  • Site-wide: 160,370

Ccdc38 is required for sperm flagellum biogenesis and male fertility in mouse

• Downloaded 256 times
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  • Site-wide: 173,161
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  • Site-wide: 168,009

Comparative analyses and phylogenetic relationships of 15 Trapa (Trapaceae) species based on Complete Chloroplast Genomes

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  • Site-wide: 173,647
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  • Site-wide: 97,281

Novel Vβ specific germline contacts shape an elite controller T cell response

• Downloaded 253 times
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  • Site-wide: 173,805
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  • Site-wide: 121,761
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  • Site-wide: 188,674

Impact of ultrasonography on identifying noninvasive prenatal screening false-negative aneuploidy

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  • Site-wide: 176,707
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  • Site-wide: 163,578
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  • Site-wide: 200,412

Oral Azvudine (FNC) Tablets in Patients infected with SARS-CoV-2 Omicron Variant: A Retrospective Cohort Study

• Downloaded 241 times
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  • Site-wide: 177,178
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  • Site-wide: 237
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Integrated Regulation of PKA by Fast and Slow Neurotransmission in the Nucleus Accumbens Controls Plasticity and Stress Responses

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  • Site-wide: 189,332
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  • Site-wide: None

The Western Lake Erie Culture Collection: A promising resource for evaluating the physiological and genetic diversity of Microcystis and its associated microbiome

• Downloaded 191 times
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  • Site-wide: 189,509
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  • Site-wide: 27,243

Near telomere-to-telomere nuclear phased chromosomes of the dikaryotic wheat fungus Rhizoctonia cerealis

• Downloaded 185 times
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  • Site-wide: 190,972
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  • Site-wide: 177,649
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  • Site-wide: 167,798

Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathy

• Downloaded 169 times
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  • Site-wide: 194,435
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  • Site-wide: 27,294
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  • Site-wide: 99,697

LRP-1 Commands Two Parallel Signalling Mechanisms to Support Constitutive Tumour Cell Motility in the Absence of Blood Supply

• Downloaded 165 times
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  • Site-wide: 195,139
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  • Site-wide: 108,315
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  • Site-wide: 159,164

MEIG1/PACRG associated and non-associated functions of axonemal dynein light intermediate polypeptide 1 (DNALI1) in mammalian spermatogenesis

• Downloaded 161 times
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  • Site-wide: 195,998
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  • Site-wide: 170,882

Biosynthetic diversification of peptaibol mediates fungus-mycohost interactions

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  • Site-wide: 198,727
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  • Site-wide: 58,308

A Versatile Deep Graph Contrastive Learning Framework for Single-cell Proteomics Embedding

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  • Site-wide: 4,415
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  • Site-wide: 2,005

A novel PLS1 c.981+1G>A variant causes autosomal-dominant hereditary hearing loss in a family via up-regulation of the PI3K-Akt signaling pathway

• Downloaded 137 times
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  • Site-wide: 200,747
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  • Site-wide: 195,214

MAP4Ks inhibition promotes retinal neuron regeneration from Muumlller glia in adult mice

• Downloaded 136 times
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  • Site-wide: 200,908
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  • Site-wide: 31,690

Unplanned ICU transfer from post-anesthesia care unit following cerebral surgery: A retrospective study

• Downloaded 126 times
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  • Site-wide: 202,825
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  • Site-wide: 181,346
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  • Site-wide: 169,299

A novel antidepressant acting via allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons

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  • Site-wide: 203,532
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  • Site-wide: 174,046
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  • Site-wide: 35,055

Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting Mycobacterium tuberculosis

• Downloaded 112 times
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  • Site-wide: 205,420
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  • Site-wide: 11,804
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  • Site-wide: 17,823

Influence of residual microbial nucleic acid in instruments for hip joint arthroplasty on false-positive results of metagenomic sequencing

• Downloaded 93 times
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  • Site-wide: 208,752
  • In genomics: 9,452
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  • Site-wide: 181,641
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  • Site-wide: 169,082

Characterization of N distribution in different organs of winter wheat using UAV-based remote sensing

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  • Site-wide: 213,157
  • In bioengineering: 4,687
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  • Site-wide: 68,093
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  • Site-wide: 31,858

Extreme diversity of mycoviruses present in four strains of Rhizoctonia cerealis, the pathogen of wheat sharp eyespot

• Downloaded 54 times
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  • Site-wide: 215,408
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  • Site-wide: 46,751