Author: Wei Li

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Preprints

Bioconda: A sustainable and comprehensive software distribution for the life sciences

• Downloaded 5,859 times
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  • Site-wide: 1,665
  • In bioinformatics: 122
• Year to date:
  • Site-wide: 13,162
• Since beginning of last month:
  • Site-wide: 29,220

Rapid selection of a human monoclonal antibody that potently neutralizes SARS-CoV-2 in two animal models

• Downloaded 3,036 times
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  • Site-wide: 4,197
  • In microbiology: 266
• Year to date:
  • Site-wide: 8,764
• Since beginning of last month:
  • Site-wide: 9,617

Detecting Tumor Specific Antigen-Reactive T cells from Tumor Infiltrating Lymphocytes via Interaction Dependent Fucosyl-biotinylation

• Downloaded 2,443 times
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  • Site-wide: 5,761
  • In immunology: 173
• Year to date:
  • Site-wide: 3,023
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  • Site-wide: 3,493

Multi-omics analysis of chromatin accessibility and interactions with transcriptome by HiCAR

• Downloaded 2,020 times
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  • Site-wide: 7,584
  • In genomics: 817
• Year to date:
  • Site-wide: 2,600
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  • Site-wide: 4,877

A Cell Type-Specific Class of Chromatin Loops Anchored at Large DNA Methylation Nadirs

• Downloaded 2,009 times
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  • Site-wide: 7,641
  • In genomics: 824
• Year to date:
  • Site-wide: 28,326
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  • Site-wide: 20,914

SARS-CoV-2 detection with CRISPR diagnostics

• Downloaded 1,998 times
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  • Site-wide: 7,717
  • In molecular biology: 186
• Year to date:
  • Site-wide: 41,196
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  • Site-wide: 45,956

Reducing False Positives in CRISPR/Cas9 Screens from Copy Number Variations

• Downloaded 1,915 times
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  • Site-wide: 8,212
  • In bioinformatics: 979
• Year to date:
  • Site-wide: 20,920
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  • Site-wide: 12,361

Click-ExM enables expansion microscopy for all biomolecules

• Downloaded 1,852 times
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  • Site-wide: 8,648
  • In bioengineering: 139
• Year to date:
  • Site-wide: 11,223
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  • Site-wide: 12,405

A new method for rapid genome classification, clustering, visualization, and novel taxa discovery from metagenome

• Downloaded 1,793 times
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  • Site-wide: 9,079
  • In bioinformatics: 1,094
• Year to date:
  • Site-wide: 14,524
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  • Site-wide: 12,555

Identification of novel rare sequence variation underlying heritable pulmonary arterial hypertension

• Downloaded 1,526 times
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  • Site-wide: 11,488
  • In genetics: 547
• Year to date:
  • Site-wide: 59,874
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  • Site-wide: 41,013

Linking genotypes with multiple phenotypes in single-cell CRISPR screens

• Downloaded 1,425 times
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  • Site-wide: 12,763
  • In bioinformatics: 1,534
• Year to date:
  • Site-wide: 93,628
• Since beginning of last month:
  • Site-wide: 111,797

Metagenomic Next-generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Central Nervous System Infections: A Multicentre Prospective Study

• Downloaded 1,300 times
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  • Site-wide: 14,658
  • In genomics: 1,530
• Year to date:
  • Site-wide: 34,457
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  • Site-wide: 38,563

Diversification of molecularly defined myenteric neuron classes revealed by single cell RNA-sequencing

• Downloaded 1,173 times
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  • Site-wide: 17,111
  • In neuroscience: 2,108
• Year to date:
  • Site-wide: 23,000
• Since beginning of last month:
  • Site-wide: 50,189

Exploring functional variation affecting ceRNA regulation in humans

• Downloaded 1,110 times
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  • Site-wide: 18,557
  • In genetics: 902
• Year to date:
  • Site-wide: 115,078
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  • Site-wide: 126,730

Integrative analysis and refined design of CRISPR knockout screens

• Downloaded 1,061 times
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  • Site-wide: 19,803
  • In bioinformatics: 2,338
• Year to date:
  • Site-wide: 59,935
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  • Site-wide: 99,260

Genetic Basis of Alternative Polyadenylation is an Emerging Molecular Phenotype for Human Traits and Diseases

• Downloaded 1,051 times
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  • Site-wide: 20,106
  • In bioinformatics: 2,376
• Year to date:
  • Site-wide: 32,309
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  • Site-wide: 23,341

SMRT sequencing yields the chromosome-scale reference genome of tea tree, Camellia sinensis var. sinensis

• Downloaded 1,022 times
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  • Site-wide: 20,952
  • In genomics: 2,077
• Year to date:
  • Site-wide: 47,963
• Since beginning of last month:
  • Site-wide: 31,876

Single cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina

• Downloaded 1,007 times
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  • Site-wide: 21,409
  • In cell biology: 737
• Year to date:
  • Site-wide: 38,680
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  • Site-wide: 20,080

Potential microenvironment of SARS-CoV-2 infection in airway epithelial cells revealed by Human Protein Atlas database analysis

• Downloaded 954 times
• Download rankings, all-time:
  • Site-wide: 23,165
  • In cell biology: 827
• Year to date:
  • Site-wide: 48,960
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  • Site-wide: 51,736

Radial contractility of Actomyosin-II rings facilitates cargo trafficking and maintains axonal structural stability following cargo-induced transient axonal expansion

• Downloaded 898 times
• Download rankings, all-time:
  • Site-wide: 25,294
  • In neuroscience: 3,291
• Year to date:
  • Site-wide: 66,013
• Since beginning of last month:
  • Site-wide: 91,023

Poly(A)-ClickSeq: click-chemistry for next-generation 3′-end sequencing without RNA enrichment or fragmentation

• Downloaded 893 times
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  • Site-wide: 25,486
  • In molecular biology: 693
• Year to date:
  • Site-wide: 71,683
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  • Site-wide: 101,334

Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis

• Downloaded 879 times
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  • Site-wide: 26,003
  • In biochemistry: 604
• Year to date:
  • Site-wide: 69,063
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  • Site-wide: 67,625

CRISPR/Cas9 screens Reveal Dasatinib Targets of Inhibiting T cell Activation and Proliferation

• Downloaded 832 times
• Download rankings, all-time:
  • Site-wide: 28,083
  • In cancer biology: 723
• Year to date:
  • Site-wide: 58,794
• Since beginning of last month:
  • Site-wide: 49,048

GCNA preserves genome integrity and fertility across species

• Downloaded 784 times
• Download rankings, all-time:
  • Site-wide: 30,565
  • In developmental biology: 618
• Year to date:
  • Site-wide: 83,034
• Since beginning of last month:
  • Site-wide: 98,186

SMRT sequencing generates the chromosome-scale reference genome of tropical fruit mango, Mangifera indica

• Downloaded 773 times
• Download rankings, all-time:
  • Site-wide: 31,165
  • In genomics: 2,788
• Year to date:
  • Site-wide: 38,044
• Since beginning of last month:
  • Site-wide: 28,087

Dual functions of Intraflagellar Transport Protein IFT20 in spermiogenesis: formation of sperm flagella and removal of cytoplasm by autophagy

• Downloaded 765 times
• Download rankings, all-time:
  • Site-wide: 31,614
  • In developmental biology: 645
• Year to date:
  • Site-wide: 120,659
• Since beginning of last month:
  • Site-wide: 88,062

Clipper: p-value-free FDR control on high-throughput data from two conditions

• Downloaded 693 times
• Download rankings, all-time:
  • Site-wide: 36,215
  • In bioinformatics: 4,003
• Year to date:
  • Site-wide: 8,269
• Since beginning of last month:
  • Site-wide: 3,466

Single cell RNA sequencing reveals cellular diversity of trisomy 21 retina

• Downloaded 659 times
• Download rankings, all-time:
  • Site-wide: 38,696
  • In cell biology: 1,571
• Year to date:
  • Site-wide: 87,466
• Since beginning of last month:
  • Site-wide: 68,454

The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double strand break repair

• Downloaded 650 times
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  • Site-wide: 39,390
  • In developmental biology: 863
• Year to date:
  • Site-wide: 58,164
• Since beginning of last month:
  • Site-wide: 129,891

Progressive lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence of mouse embryonic fibroblasts

• Downloaded 626 times
• Download rankings, all-time:
  • Site-wide: 41,347
  • In genomics: 3,406
• Year to date:
  • Site-wide: 99,919
• Since beginning of last month:
  • Site-wide: 90,475

m6A Regulates Liver Metabolic Disorders and Hepatogenous Diabetes

• Downloaded 611 times
• Download rankings, all-time:
  • Site-wide: 42,583
  • In genetics: 2,002
• Year to date:
  • Site-wide: 52,778
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  • Site-wide: 38,755

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

• Downloaded 605 times
• Download rankings, all-time:
  • Site-wide: 43,126
  • In cell biology: 1,797
• Year to date:
  • Site-wide: 86,550
• Since beginning of last month:
  • Site-wide: 108,075

Extensive alternative splicing transitions during postnatal skeletal muscle development are required for Ca2+ handling

• Downloaded 567 times
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  • Site-wide: 46,783
  • In cell biology: 1,995
• Year to date:
  • Site-wide: 104,319
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  • Site-wide: 96,525

Diagnostic Whole Exome Sequencing in Patients with Short Stature

• Downloaded 525 times
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  • Site-wide: 51,269
  • In genetics: 2,370
• Year to date:
  • Site-wide: 77,711
• Since beginning of last month:
  • Site-wide: 54,631

Single cell atlas of trisomy 21 cerebral cortex

• Downloaded 524 times
• Download rankings, all-time:
  • Site-wide: 51,336
  • In neuroscience: 7,508
• Year to date:
  • Site-wide: 57,848
• Since beginning of last month:
  • Site-wide: 62,907

Differences in GluN2B-containing NMDA receptors result in opposite long-term plasticity and dopaminergic modulation at ipsilateral vs. contralateral cortico-striatal synapses

• Downloaded 515 times
• Download rankings, all-time:
  • Site-wide: 52,477
  • In neuroscience: 7,696
• Year to date:
  • Site-wide: 80,219
• Since beginning of last month:
  • Site-wide: 86,320

Pre-implantation genetic diagnosis for a family with Usher syndrome through targeted sequencing and haplotype analysis

• Downloaded 508 times
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  • Site-wide: 53,313
  • In genetics: 2,464
• Year to date:
  • Site-wide: 92,611
• Since beginning of last month:
  • Site-wide: 85,862

Coordinate Enhancer Reprogramming by GATA3 and AP1 Promotes Phenotypic Plasticity to Achieve Breast Cancer Endocrine Resistance

• Downloaded 484 times
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  • Site-wide: 56,383
  • In cancer biology: 1,584
• Year to date:
  • Site-wide: 72,567
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  • Site-wide: 50,814

Long Non-Coding RNA LncKdm2b Regulates Cortical Neuronal Differentiation by Cis-Activating Kdm2b

• Downloaded 460 times
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  • Site-wide: 59,454
  • In molecular biology: 1,704
• Year to date:
  • Site-wide: 60,108
• Since beginning of last month:
  • Site-wide: 55,612

HiAlc Klebsiella pneumonia, one of potential chief culprits of non-alcoholic fatty liver disease: through generation of endogenous ethanol

• Downloaded 452 times
• Download rankings, all-time:
  • Site-wide: 60,672
  • In microbiology: 3,961
• Year to date:
  • Site-wide: 78,045
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  • Site-wide: 89,024

Global lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 62,161
  • In genomics: 4,507
• Year to date:
  • Site-wide: 121,439
• Since beginning of last month:
  • Site-wide: 115,564

Cyclin B3 is specifically required for metaphase to anaphase transition in mouse oocyte meiosis I

• Downloaded 422 times
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  • Site-wide: 65,090
  • In cell biology: 2,907
• Year to date:
  • Site-wide: 99,364
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  • Site-wide: 83,816

SMRT sequencing of the Oryza rufipogon genome reveals the genomic basis of rice adaptation

• Downloaded 413 times
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  • Site-wide: 66,438
  • In genomics: 4,703
• Year to date:
  • Site-wide: 136,965
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  • Site-wide: 132,077

Deciphering tea tree chloroplast and mitochondrial genomes of Camellia sinensis var. assamica

• Downloaded 393 times
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  • Site-wide: 69,733
  • In genomics: 4,847
• Year to date:
  • Site-wide: 127,402
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  • Site-wide: 128,195

Essential role of Bone morphogenetic protein 15 in porcine ovarian and follicular development and ovulation

• Downloaded 376 times
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  • Site-wide: 72,620
  • In developmental biology: 1,873
• Year to date:
  • Site-wide: 56,836
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  • Site-wide: 53,375

Rapid Detection of Burkholderia pseudomallei with a Lateral Flow Recombinase Polymerase Amplification Assay

• Downloaded 373 times
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  • Site-wide: 73,214
  • In microbiology: 4,974
• Year to date:
  • Site-wide: 99,273
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  • Site-wide: 100,569

Numerical Investigation of Drug Transport from Blood Vessels to Tumor Tissue Using a Tumor-Vasculature-on-a-Chip

• Downloaded 363 times
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  • Site-wide: 74,971
  • In bioengineering: 1,399
• Year to date:
  • Site-wide: 62,904
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  • Site-wide: 59,616

Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization

• Downloaded 362 times
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  • Site-wide: 75,129
  • In developmental biology: 1,949
• Year to date:
  • Site-wide: 52,811
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  • Site-wide: 92,800

Long-Term Potentiation Induces Extrasynaptic Exocytosis of Glun2A-containing NMDA Receptors that is Mainly Controlled by SNAP23

• Downloaded 362 times
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  • Site-wide: 75,293
  • In cell biology: 3,434
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  • Site-wide: 64,501
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  • Site-wide: 76,942

SLFL Genes Participate in the Ubiquitination and Degradation of S-RNase in Self-Compatible Chinese Peach

• Downloaded 360 times
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  • Site-wide: 75,571
  • In molecular biology: 2,220
• Year to date:
  • Site-wide: 122,816
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  • Site-wide: 109,775

Structural variability and functional association in the epiphytic bacteria assemblies of freshwater macrophytes (Myriophyllum spicatum)

• Downloaded 355 times
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  • Site-wide: 76,470
  • In microbiology: 5,227
• Year to date:
  • Site-wide: 118,499
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  • Site-wide: 89,311

Circulating BMP9 protects the pulmonary endothelium during inflammation-induced lung injury in mice

• Downloaded 355 times
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  • Site-wide: 76,624
  • In physiology: 597
• Year to date:
  • Site-wide: 39,265
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  • Site-wide: 20,654

Effect of arbuscular mycorrhizal fungi (AMF) and plant growth promoting rhizobacteria (PGPR) on microbial community structure of phenanthrene and pyrene contaminated soils using Illumina HiSeq sequencing.

• Downloaded 336 times
• Download rankings, all-time:
  • Site-wide: 80,211
  • In ecology: 2,382
• Year to date:
  • Site-wide: 56,750
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  • Site-wide: 35,533

True S-cones are concentrated in the ventral mouse retina for color detection in the upper visual field

• Downloaded 323 times
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  • Site-wide: 82,660
  • In evolutionary biology: 4,463
• Year to date:
  • Site-wide: 105,179
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  • Site-wide: 104,802

Noninvasive prenatal test of methylmalonic academia cblC type through targeted sequencing of cell-free DNA in maternal plasma

• Downloaded 315 times
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  • Site-wide: 84,257
  • In genetics: 3,787
• Year to date:
  • Site-wide: 122,299
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  • Site-wide: 97,766

Clinical diagnosis of single-gene disorders and chromosomal abnormalities based on BGISEQ-500 platform

• Downloaded 287 times
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  • Site-wide: 90,434
  • In genomics: 5,657
• Year to date:
  • Site-wide: 128,233
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  • Site-wide: 120,437

ATM and ATR Influence Meiotic Crossover Formation Through Antagonistic and Overlapping Functions in C. elegans

• Downloaded 270 times
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  • Site-wide: 93,996
  • In genetics: 4,190
• Year to date:
  • Site-wide: 136,271
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  • Site-wide: 135,716

BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor

• Downloaded 267 times
• Download rankings, all-time:
  • Site-wide: 94,800
  • In cell biology: 4,379
• Year to date:
  • Site-wide: 84,029
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  • Site-wide: 92,689

Targeting against HIV/HCV Co-infection using Machine Learning-based multitarget-quantitative structure-activity relationships (mt-QSAR) Methods

• Downloaded 266 times
• Download rankings, all-time:
  • Site-wide: 94,999
  • In bioinformatics: 8,261
• Year to date:
  • Site-wide: 134,654
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  • Site-wide: None

Temporal regulation of prenatal embryonic development by paternal imprinted loci

• Downloaded 265 times
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  • Site-wide: 95,050
  • In developmental biology: 2,569
• Year to date:
  • Site-wide: 77,341
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  • Site-wide: 53,714

Cellular heterogeneity-adjusted clonal methylation (CHALM) provides better prediction of gene expression

• Downloaded 260 times
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  • Site-wide: 96,136
  • In bioinformatics: 8,358
• Year to date:
  • Site-wide: 95,894
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  • Site-wide: 122,052

Identification of TTN as a novel candidate gene for atrioventricular block in a Chinese pedigree by whole-exome sequencing

• Downloaded 245 times
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  • Site-wide: 99,570
  • In genetics: 4,400
• Year to date:
  • Site-wide: 108,365
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  • Site-wide: 68,955

Intra-protein binding peptide fragments have specific and intrinsic sequence patterns

• Downloaded 227 times
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  • Site-wide: 103,731
  • In bioinformatics: 8,801
• Year to date:
  • Site-wide: 137,355
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  • Site-wide: 132,890

Hsa_circ_0001947 suppresses acute myeloid leukemia progression by sponging hsa-miR-329-5p and regulating CREBRF expression

• Downloaded 227 times
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  • Site-wide: 103,590
  • In cancer biology: 3,134
• Year to date:
  • Site-wide: 74,328
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  • Site-wide: 80,592

DORGE: Discovery of Oncogenes and Tumor SuppressoR Genes Using Genetic and Epigenetic Features

• Downloaded 219 times
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  • Site-wide: 105,538
  • In bioinformatics: 8,914
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  • Site-wide: 84,576
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  • Site-wide: 106,653

A Reference Feature based method for Quantification and Identification of LC-MS based untargeted metabolomics

• Downloaded 211 times
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  • Site-wide: 107,363
  • In bioinformatics: 9,029
• Year to date:
  • Site-wide: 98,314
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  • Site-wide: 79,595

Spectrin-based Membrane Mechanics Is Asymmetric and Remodels during Neural Development

• Downloaded 208 times
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  • Site-wide: 108,077
  • In developmental biology: 2,935
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  • Site-wide: 126,664
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  • Site-wide: 102,626

Influence of isolation by environment and landscape heterogeneity on genetic structure of wild rice Zizania latifolia along a latitudinal gradient

• Downloaded 185 times
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  • Site-wide: 113,107
  • In ecology: 3,877
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  • Site-wide: 55,308
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  • Site-wide: 62,199

The draft genome sequence of herbaceous diploid bamboo Raddia distichophylla

• Downloaded 182 times
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  • Site-wide: 113,803
  • In genomics: 6,405
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  • Site-wide: 91,968
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  • Site-wide: 77,200

Impact of ultrasonography on identifying noninvasive prenatal screening false-negative aneuploidy

• Downloaded 181 times
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  • Site-wide: 113,946
  • In genetics: 4,924
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  • Site-wide: 91,431
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  • Site-wide: 88,070

Combinatorial phosphorylation modulates the structure and function of the G protein gamma subunit in yeast

• Downloaded 172 times
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  • Site-wide: 116,018
  • In molecular biology: 3,454
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  • Site-wide: 74,859
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  • Site-wide: 121,246

The key miRNAs for metastasis and survival of colon adenocarcinoma

• Downloaded 151 times
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  • Site-wide: 120,554
  • In bioinformatics: 9,767
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  • Site-wide: 132,858
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  • Site-wide: 105,888

Enabling in vivo Analysis Via Nanoparticle-mediated Intracellular Assay Probe Delivery: Using RAS as the Prototype

• Downloaded 133 times
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  • Site-wide: 124,229
  • In biochemistry: 3,755
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  • Site-wide: 84,192
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  • Site-wide: 56,312

Novel Vβ specific germline contacts shape an elite controller T cell response

• Downloaded 132 times
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  • Site-wide: 124,483
  • In immunology: 3,582
• Year to date:
  • Site-wide: 95,393
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  • Site-wide: 92,149

Decoding herbal materials of representative TCM preparations with the multi-barcoding approach

• Downloaded 120 times
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  • Site-wide: 126,846
  • In bioinformatics: 10,086
• Year to date:
  • Site-wide: 104,941
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  • Site-wide: 78,054

Whole-genome-based Helicobacter pylori geographic surveillance: a visualized and expandable webtool

• Downloaded 46 times
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  • Site-wide: 136,975
  • In genomics: 7,063
• Year to date:
  • Site-wide: 66,557
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  • Site-wide: 32,269