Author: John A. Todd

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Preprints

Within-host genomics of SARS-CoV-2

• Downloaded 4,793 times
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  • Site-wide: 2,106
  • In genomics: 221
• Year to date:
  • Site-wide: 1,136
• Since beginning of last month:
  • Site-wide: 1,837

Consequences Of Natural Perturbations In The Human Plasma Proteome

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  • Site-wide: 2,491
  • In genomics: 275
• Year to date:
  • Site-wide: 87,261
• Since beginning of last month:
  • Site-wide: 96,686

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

• Downloaded 3,368 times
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  • Site-wide: 3,508
  • In immunology: 102
• Year to date:
  • Site-wide: 12,756
• Since beginning of last month:
  • Site-wide: 15,084

An integrated platform to systematically identify causal variants and genes for polygenic human traits

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  • Site-wide: 7,686
  • In genetics: 358
• Year to date:
  • Site-wide: 11,190
• Since beginning of last month:
  • Site-wide: 12,530

The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides new insights into the genetics of type 1 diabetes

• Downloaded 1,474 times
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  • Site-wide: 11,724
  • In genomics: 1,280
• Year to date:
  • Site-wide: 44,575
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  • Site-wide: 46,292

Fine-mapping identifies causal variants for RA and T1D in DNASE1L3, SIRPG, MEG3, TNFAIP3 and CD28/CTLA4 loci

• Downloaded 1,450 times
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  • Site-wide: 12,030
  • In genetics: 587
• Year to date:
  • Site-wide: 88,351
• Since beginning of last month:
  • Site-wide: 78,508

Open Targets Genetics: An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci

• Downloaded 1,437 times
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  • Site-wide: 12,182
  • In genetics: 596
• Year to date:
  • Site-wide: 8,214
• Since beginning of last month:
  • Site-wide: 7,349

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

• Downloaded 1,409 times
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  • Site-wide: 12,573
  • In genomics: 1,358
• Year to date:
  • Site-wide: 94,428
• Since beginning of last month:
  • Site-wide: 118,003

A method for identifying genetic heterogeneity within phenotypically-defined disease subgroups

• Downloaded 1,212 times
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  • Site-wide: 15,823
  • In genomics: 1,629
• Year to date:
  • Site-wide: 93,019
• Since beginning of last month:
  • Site-wide: 117,527

Dissection of a complex disease susceptibility region using a Bayesian stochastic search approach to fine mapping

• Downloaded 886 times
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  • Site-wide: 25,044
  • In genetics: 1,213
• Year to date:
  • Site-wide: 90,405
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  • Site-wide: 120,557

Early Analysis of a potential link between viral load and the N501Y mutation in the SARS-COV-2 spike protein

• Downloaded 876 times
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  • Site-wide: 25,437
  • In infectious diseases: 1,891
• Year to date:
  • Site-wide: 1,326
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  • Site-wide: 1,767

A rare IL2RA haplotype identifies SNP rs61839660 as causal for autoimmunity

• Downloaded 716 times
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  • Site-wide: 33,591
  • In genetics: 1,628
• Year to date:
  • Site-wide: 83,506
• Since beginning of last month:
  • Site-wide: 74,991

Cells With Treg-Specific FOXP3 Demethylation But Low CD25 Are Prevalent In Autoimmunity

• Downloaded 711 times
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  • Site-wide: 33,899
  • In immunology: 968
• Year to date:
  • Site-wide: 95,915
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  • Site-wide: 72,608

Dexi disruption depletes gut microbial metabolites and accelerates autoimmune diabetes

• Downloaded 492 times
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  • Site-wide: 53,803
  • In genetics: 2,490
• Year to date:
  • Site-wide: 86,240
• Since beginning of last month:
  • Site-wide: 107,909

Specific type 1 diabetes risk genes underpin age-at-diagnosis and indicate joint defects in immunity, beta-cell fragility and responses to viral infections in early-onset disease

• Downloaded 492 times
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  • Site-wide: 53,779
  • In genetics: 2,488
• Year to date:
  • Site-wide: 77,134
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  • Site-wide: 72,313

Analysis of overlapping genetic association in type 1 and type 2 diabetes

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  • Site-wide: 61,434
  • In genetics: 2,855
• Year to date:
  • Site-wide: 13,651
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  • Site-wide: 47,907

Using de novo assembly to identify structural variation of complex immune system gene regions

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  • Site-wide: 84,890
  • In bioinformatics: 7,640
• Year to date:
  • Site-wide: 6,129
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  • Site-wide: 16,259

Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease

• Downloaded 143 times
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  • Site-wide: 119,342
  • In genetics: 5,089
• Year to date:
  • Site-wide: 16,955
• Since beginning of last month:
  • Site-wide: 30,107

Successful incorporation of a genetic risk prediction research platform into routine newborn screening

• Downloaded 136 times
• Download rankings, all-time:
  • Site-wide: 120,530
  • In genetic and genomic medicine: 560
• Year to date:
  • Site-wide: 18,092
• Since beginning of last month:
  • Site-wide: 5,342