Author: Yi Zhang

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Preprints

A Reproducibility Analysis-based Statistical Framework for Residue-Residue Evolutionary Coupling Detection

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Accurate Name Entity Recognition for Biomedical Literatures: A Combined High-quality Manual Annotation and Deep-learning Natural Language Processing Study

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Impaired KDM2B-mediated PRC1 recruitment to chromatin causes neural stem cell senescence and ASD/ID-like behavioral deficits

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Two Ubiquitin-Activating Systems Occur in Plants with One Playing a Major Role in Plant Immunity

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MAPK cascades mediating Trichoderma brevicrassum strain TC967 against phytopathogen Rhizoctonia solani

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Favipiravir versus Arbidol for COVID-19: A Randomized Clinical Trial

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The respiratory sound features of COVID-19 patients fill gaps between clinical data and screening methods

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SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

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TBtools - an integrative toolkit developed for interactive analyses of big biological data

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  • Site-wide: 632
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  • Site-wide: 738
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From SARS-CoV to Wuhan 2019-nCoV Outbreak: Similarity of Early Epidemic and Prediction of Future Trends

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  • Site-wide: 796
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Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing

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  • Site-wide: 2,076
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  • Site-wide: 2,717
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  • Site-wide: 16,539

Immune Correlates of Protection by mRNA-1273 Immunization against SARS-CoV-2 Infection in Nonhuman Primates

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LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

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Antibodies with potent and broad neutralizing activity against antigenically diverse and highly transmissible SARS-CoV-2 variants

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  • Site-wide: 10,642
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Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates

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  • Site-wide: 10,683
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Genetic analysis of the Arabidopsis TIR1/AFB auxin receptors reveals both overlapping and specialized functions

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  • Site-wide: 12,410
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  • Site-wide: 115,965

Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants

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  • Site-wide: 14,986
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Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates

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Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

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Efficacy and Safety of Leflunomide for Refractory COVID-19: An Open-label Controlled Study

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Species composition and environmental adaptation of indigenous Chinese cattle

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In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target

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  • Site-wide: 22,121
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Mechanism of β-Aminobutyric Acid-Induced Resistance in Wheat to the Grain Aphid, Sitobion avenae

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  • Site-wide: 22,733
  • In ecology: 400
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Rapid cost-effective viral genome sequencing by V-seq

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  • Site-wide: 23,705
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  • Site-wide: 24,453
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The Arabidopsis Auxin F-box proteins AFB4 and AFB5 are Required for Response to the Synthetic Auxin Picloram

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  • Site-wide: 28,275
  • In plant biology: 468
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Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

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  • Site-wide: 28,519
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  • Site-wide: 3,767
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  • Site-wide: 20,163

The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice

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  • Site-wide: 30,560
  • In neuroscience: 3,975
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  • Site-wide: 63,793
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Effectiveness of Convalescent Plasma for Treatment of COVID-19 Patients

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  • Site-wide: 30,821
  • In respiratory medicine: 77
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  • Site-wide: 49,830
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  • Site-wide: 23,031

Selective auxin agonists induce specific AUX/IAA protein degradation to modulate plant development

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  • Site-wide: 32,090
  • In plant biology: 575
• Year to date:
  • Site-wide: 120,983
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  • Site-wide: 105,504

Natural copy number differences of tandemly repeated small nucleolar RNAs in the Prader-Willi syndrome genomic region regulate individual behavioral responses in mammals

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  • Site-wide: 35,003
  • In evolutionary biology: 1,605
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  • Site-wide: 34,310
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Tn5 transposase-based epigenomic profiling methods are prone to open chromatin bias

• Downloaded 769 times
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  • Site-wide: 35,715
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  • Site-wide: 4,736
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  • Site-wide: 962

Deep Unfolded Robust PCA with Application to Clutter Suppression in Ultrasound

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  • Site-wide: 35,732
  • In bioengineering: 664
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  • Site-wide: 37,127
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  • Site-wide: 32,356

Engineering of Chimeric Antigen Receptor T Cells with integrin αEβ7 Results in Augmented Therapeutic Efficacy against E-cadherin positive tumor

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  • Site-wide: 36,275
  • In immunology: 1,139
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  • Site-wide: 27,627
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  • Site-wide: 7,637

Mapping and Inheritance analysis of a novel dominant rice male sterility mutant, OsDMS-1

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  • Site-wide: 36,483
  • In genetics: 1,655
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  • Site-wide: 74,075

SequencEnG: an Interactive Knowledge Base of Sequencing Techniques

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  • Site-wide: 38,422
  • In bioinformatics: 4,137
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  • Site-wide: 148,045
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  • Site-wide: 110,791

SeqOthello: Query over RNA-seq experiments at scale

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  • Site-wide: 41,161
  • In bioinformatics: 4,396
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  • Site-wide: 108,530

Strategic release of lockdowns in a COVID infection model

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  • Site-wide: 41,180
  • In epidemiology: 2,034
• Year to date:
  • Site-wide: 91,031
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  • Site-wide: 92,951

Developmentally Delayed Epigenetic Reprogramming Underlying the Pathogenesis of Preeclampsia

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  • Site-wide: 43,485
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Renin Angiotensin System Inhibition and Susceptibility and Outcomes from COVID-19: A Systematic Review and Meta-analysis of 69,200 COVID-19 Patients

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  • Site-wide: 44,869
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  • Site-wide: 3,132

Metatranscriptome profiling of the dynamic transcription of mRNA and sRNA of a probiotic Lactobacillus strain in human gut

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PI3K Activation In Neural Stem Cells Drives Tumorigenesis Which Can Be Suppressed By Targeting CREB

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  • Site-wide: 47,203
  • In cancer biology: 1,324
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Metagenomic Study Revealed the Potential Role of the Gut Microbiome in Gout

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  • Site-wide: 47,800
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  • Site-wide: 30,339

MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets

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  • In genomics: 3,736
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  • Site-wide: 25,093

RSVdb: A comprehensive database of transcriptome RNA structure

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  • Site-wide: 48,707
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An effective, safe and cost-effective cell-based chimeric vaccine against SARS-CoV2

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  • Site-wide: 51,669
  • In immunology: 1,561
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  • Site-wide: 10,198

Can cancer GWAS variants modulate immune cells in the tumor microenvironment?

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  • Site-wide: 114,897

ClusterEnG: An interactive educational web resource for clustering big data

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  • Site-wide: 52,645
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  • Site-wide: 150,160
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Molecular mechanisms behind global distribution of earthworm revealed by the genome

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Single-cell RNA-seq reveals early heterogeneity during ageing in yeast

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Deciphering the rules of mRNA structure differentiation in vivo and in vitro with deep neural networks in Saccharomyces cerevisiae

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  • Site-wide: 110,363

Low-dose IFN-γ induces tumor cell stemness in tumor microenvironment of non-small cell lung cancer

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A novel germline EGFR variant p.R831H causes predisposition to familial CDK12-mutant prostate cancer with tandem duplicator phenotype

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Retinoic acid promotes in vitro development of haploid germ cells from pre-pubertal porcine spermatogenic cells

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Construction of high-density genetic maps and detection of QTLs associated with Huanglongbing infection in citrus

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Basic reproduction number of 2019 Novel Coronavirus Disease in Major Endemic Areas of China: A latent profile analysis

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  • Site-wide: 67,991
  • In epidemiology: 2,984
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Risk assessment and prediction of severe or critical illness of COVID-19 in the elderly

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  • Site-wide: 70,893
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  • Site-wide: 110,771
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  • Site-wide: 48,122

Design of nanoparticulate group 2 influenza hemagglutinin stem antigens that activate unmutated ancestor B cell receptors of broadly neutralizing antibody lineages

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  • Site-wide: 76,769
  • In immunology: 2,281
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  • Site-wide: 78,539

Genomic epidemiology of the Los Angeles COVID-19 outbreak

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  • Site-wide: 77,233
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  • Site-wide: 67,785

Mapping fetal brain development based on automated segmentation and 4D brain atlasing

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  • Site-wide: 79,135
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  • Site-wide: 55,609
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Deleterious effects of SARS-CoV-2 infection on human pancreatic cells

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  • Site-wide: 79,753
  • In infectious diseases: 3,821
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  • Site-wide: 12,786
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  • Site-wide: 89,250

3D Printed Microheater Sensor-Integrated, Drug-Encapsulated Microneedle Patch System for Pain Management

• Downloaded 384 times
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  • Site-wide: 80,804
  • In bioengineering: 1,529
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  • Site-wide: 79,037
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  • Site-wide: 21,478

Pressure overload leads to coronary plaque formation, progression and myocardial events in ApoE-/- mice

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  • Site-wide: 84,197
  • In pathology: 424
• Year to date:
  • Site-wide: 150,320
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Cancer SIGVAR: A semi-automated interpretation tool for germline variants of hereditary cancer-related genes

• Downloaded 352 times
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  • Site-wide: 87,111
  • In genetics: 3,787
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  • Site-wide: 50,451
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  • Site-wide: 34,673

Transmembrane Kinases are essential for plant development

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  • Site-wide: 87,137
  • In plant biology: 2,287
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  • Site-wide: 14,800
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  • Site-wide: 4,486

Structural characterization of cocktail-like targeting polysaccharides from Ecklonia kurome Okam and their anti-SARS-CoV-2 activities in vitro

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  • Site-wide: 88,392
  • In biochemistry: 2,511
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  • Site-wide: 15,174
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  • Site-wide: 67,187

Artificial intelligence assisted standard white light endoscopy accurately characters early colorectal cancer: a multicenter diagnostic study

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  • Site-wide: 90,806
  • In oncology: 168
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  • Site-wide: 67,532
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  • Site-wide: 35,602

A novel antiviral lncRNA EDAL shields a T309 O-GlcNAcylation site to promote EZH2 degradation

• Downloaded 310 times
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  • Site-wide: 96,280
  • In microbiology: 6,817
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  • Site-wide: 130,124
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  • Site-wide: 105,762

A population-based seroprevalence survey of severe acute respiratory syndrome coronavirus 2 infection in Beijing, China

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  • Site-wide: 96,736
  • In epidemiology: 4,078
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  • Site-wide: 46,275
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  • Site-wide: 46,654

Setting Standards to Promote Artificial Intelligence in Colon Mass Endoscopic Sampling

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  • Site-wide: 104,665
  • In oncology: 227
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  • Site-wide: 99,165
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  • Site-wide: 35,871

A high-precision hybrid algorithm for predicting eukaryotic protein subcellular localization

• Downloaded 271 times
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  • Site-wide: 105,512
  • In bioinformatics: 8,931
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  • Site-wide: 126,942
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  • Site-wide: 119,057

Predicting the Impact of the COVID-19 Pandemic for the Low- and Middle-Income Countries

• Downloaded 225 times
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  • Site-wide: 116,972
  • In infectious diseases: 4,809
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  • Site-wide: 99,459
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Genomic profiling of cell lines reveals hidden research bias and caveats

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  • Site-wide: 117,146
  • In cancer biology: 3,527
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  • Site-wide: 103,675
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  • Site-wide: 17,167

Decoding molecular and cellular heterogeneity of nucleus accumbens with high-throughput scRNA-seq and MERFISH

• Downloaded 221 times
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  • Site-wide: 117,792
  • In neuroscience: 17,893
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  • Site-wide: 27,857
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  • Site-wide: 36,038

Hidden Parameters impacting resurgence of SARS-CoV-2 Pandemic

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  • Site-wide: 120,020
  • In health policy: 288
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  • Site-wide: 29,287
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The physiological adaptation for the “fore-mid” four-legged walking behavior of the pygmy mole cricket Xya sichuanensis

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  • Site-wide: 121,649
  • In evolutionary biology: 6,092
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  • Site-wide: 97,450
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  • Site-wide: 113,072

Hfq Globally Binds and Destabilizes the bound sRNAs and mRNAs in Yersinia pestis

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  • Site-wide: 122,711
  • In genomics: 6,784
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  • Site-wide: 145,447
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  • Site-wide: 43,717

Rapid visual CRISPR assay: a naked-eye colorimetric detection method for nucleic acids based on CRISPR/Cas12a and convolutional neural network

• Downloaded 194 times
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  • Site-wide: 124,463
  • In molecular biology: 3,694
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  • Site-wide: 32,660
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  • Site-wide: 58,777

Comparative analysis of temporal transcriptome reveals the relationship between pectin degradation and pathogenicity of defoliating Verticillium dahliae to Upland cotton (Gossypium hirsutum)

• Downloaded 179 times
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  • Site-wide: 128,273
  • In microbiology: 9,604
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  • Site-wide: 100,718
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  • Site-wide: 68,467

Impact of Vaccination and Testing in an Urban Campus model for the SARS-CoV-2 Pandemic

• Downloaded 171 times
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  • Site-wide: 130,102
  • In health policy: 326
• Year to date:
  • Site-wide: 38,054
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Computational optical sectioning by phase-space imaging with an incoherent multiscale scattering model

• Downloaded 168 times
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  • Site-wide: 130,817
  • In cell biology: 6,012
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  • Site-wide: 77,090
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  • Site-wide: 89,015

Telmisartan potentiates insulin secretion via ion channels, independent of the AT1 receptor and PPARγ

• Downloaded 108 times
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  • Site-wide: 143,515
  • In cell biology: 6,545
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  • Site-wide: 122,950
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  • Site-wide: 82,812

Crosstalk in oxygen homeostasis networks: SKN-1/NRF inhibits the HIF-1 hypoxia-inducible factor in Caenorhabditis elegans

• Downloaded 86 times
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  • Site-wide: 147,162
  • In genetics: 5,795
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  • Site-wide: 75,021
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  • Site-wide: 68,047

Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variation

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  • Site-wide: 149,577
  • In bioinformatics: 11,361
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  • Site-wide: 91,498
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  • Site-wide: 3,240

DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and preimplantation development

• Downloaded 5 times
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  • Site-wide: 154,271
  • In developmental biology: 4,003
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  • Site-wide: 51,711