Author: Yi Zhang

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Preprints

eccDNA purification, full-length sequencing, and genomic mapping

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Favipiravir versus Arbidol for COVID-19: A Randomized Clinical Trial

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  • Site-wide: 1,155
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  • Site-wide: 1,960

The respiratory sound features of COVID-19 patients fill gaps between clinical data and screening methods

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SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

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  • Site-wide: 263
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TBtools - an integrative toolkit developed for interactive analyses of big biological data

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  • Site-wide: 597
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From SARS-CoV to Wuhan 2019-nCoV Outbreak: Similarity of Early Epidemic and Prediction of Future Trends

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  • Site-wide: 1,028
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  • Site-wide: 42,730

LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

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  • Site-wide: 1,401
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Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing

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  • Site-wide: 5,535
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Immune Correlates of Protection by mRNA-1273 Immunization against SARS-CoV-2 Infection in Nonhuman Primates

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Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates

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Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates

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  • Site-wide: 9,599
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In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target

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  • Site-wide: 9,752
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  • Site-wide: 10,878

Antibodies with potent and broad neutralizing activity against antigenically diverse and highly transmissible SARS-CoV-2 variants

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  • Site-wide: 9,925
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  • Site-wide: 14,307
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Machine learning modeling of protein-intrinsic features predicts tractability of targeted protein degradation

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Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529

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Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants

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Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

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Genetic analysis of the Arabidopsis TIR1/AFB auxin receptors reveals both overlapping and specialized functions

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  • Site-wide: 14,974
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Efficacy and Safety of Leflunomide for Refractory COVID-19: An Open-label Controlled Study

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Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

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  • Site-wide: 19,206
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Tn5 transposase-based epigenomic profiling methods are prone to open chromatin bias

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Rapid cost-effective viral genome sequencing by V-seq

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Species composition and environmental adaptation of indigenous Chinese cattle

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Mechanism of β-Aminobutyric Acid-Induced Resistance in Wheat to the Grain Aphid, Sitobion avenae

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  • Site-wide: 28,252
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  • Site-wide: 133,118

Effectiveness of Convalescent Plasma for Treatment of COVID-19 Patients

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  • Site-wide: 30,314
  • In respiratory medicine: 82
• Year to date:
  • Site-wide: 64,660
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  • Site-wide: 55,066

Deep Unfolded Robust PCA with Application to Clutter Suppression in Ultrasound

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  • Site-wide: 30,629
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  • Site-wide: 39,136
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  • Site-wide: 30,421

Antibody Resistance of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2 and BA.3 Sub-lineages

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  • Site-wide: 30,665
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  • Site-wide: 1,517
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  • Site-wide: 2,434

MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets

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  • Site-wide: 30,822
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  • Site-wide: 24,931
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  • Site-wide: 44,563

The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice

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  • Site-wide: 30,849
  • In neuroscience: 3,777
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  • Site-wide: 63,633
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  • Site-wide: 117,059

Renin Angiotensin System Inhibition and Susceptibility and Outcomes from COVID-19: A Systematic Review and Meta-analysis of 69,200 COVID-19 Patients

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  • Site-wide: 33,997
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• Year to date:
  • Site-wide: 19,774
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  • Site-wide: 17,462

Natural copy number differences of tandemly repeated small nucleolar RNAs in the Prader-Willi syndrome genomic region regulate individual behavioral responses in mammals

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  • Site-wide: 35,210
  • In evolutionary biology: 1,411
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  • Site-wide: 72,008
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  • Site-wide: 85,536

The Arabidopsis Auxin F-box proteins AFB4 and AFB5 are Required for Response to the Synthetic Auxin Picloram

• Downloaded 961 times
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  • Site-wide: 36,019
  • In plant biology: 576
• Year to date:
  • Site-wide: 140,014
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  • Site-wide: 76,564

Engineering of Chimeric Antigen Receptor T Cells with integrin αEβ7 Results in Augmented Therapeutic Efficacy against E-cadherin positive tumor

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  • Site-wide: 38,420
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  • Site-wide: 51,302
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  • Site-wide: 29,194

Developmentally Delayed Epigenetic Reprogramming Underlying the Pathogenesis of Preeclampsia

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  • Site-wide: 42,766

Decoding molecular and cellular heterogeneity of nucleus accumbens with high-throughput scRNA-seq and MERFISH

• Downloaded 908 times
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  • Site-wide: 39,223
  • In neuroscience: 5,770
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  • Site-wide: 19,935
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  • Site-wide: 25,075

Selective auxin agonists induce specific AUX/IAA protein degradation to modulate plant development

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  • Site-wide: 39,588
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• Year to date:
  • Site-wide: 126,222
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  • Site-wide: 162,018

Broadly neutralizing antibodies target the coronavirus fusion peptide

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  • Site-wide: 41,021
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  • Site-wide: 2,065
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  • Site-wide: 980

Mapping and Inheritance analysis of a novel dominant rice male sterility mutant, OsDMS-1

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  • Site-wide: 42,549
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  • Site-wide: 143,051

Single-cell RNA-seq reveals early heterogeneity during ageing in yeast

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  • Site-wide: 45,672
  • In genomics: 3,700
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  • Site-wide: 30,201
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  • Site-wide: 19,517

SequencEnG: an Interactive Knowledge Base of Sequencing Techniques

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  • Site-wide: 46,894
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  • Site-wide: 178,439

RSVdb: A comprehensive database of transcriptome RNA structure

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  • Site-wide: 48,396
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  • Site-wide: 86,254

Strategic release of lockdowns in a COVID infection model

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  • Site-wide: 49,075
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SeqOthello: Query over RNA-seq experiments at scale

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  • Site-wide: 51,412
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  • Site-wide: 160,158

Metagenomic Study Revealed the Potential Role of the Gut Microbiome in Gout

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  • Site-wide: 109,347

A Reproducibility Analysis-based Statistical Framework for Residue-Residue Evolutionary Coupling Detection

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Metatranscriptome profiling of the dynamic transcription of mRNA and sRNA of a probiotic Lactobacillus strain in human gut

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A novel germline EGFR variant p.R831H causes predisposition to familial CDK12-mutant prostate cancer with tandem duplicator phenotype

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An effective, safe and cost-effective cell-based chimeric vaccine against SARS-CoV2

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  • Site-wide: 61,276
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  • Site-wide: 151,649

PI3K Activation In Neural Stem Cells Drives Tumorigenesis Which Can Be Suppressed By Targeting CREB

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Deleterious effects of SARS-CoV-2 infection on human pancreatic cells

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  • Site-wide: 17,612

Can cancer GWAS variants modulate immune cells in the tumor microenvironment?

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  • Site-wide: 184,978

Molecular mechanisms behind global distribution of earthworm revealed by the genome

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  • Site-wide: 66,973
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  • Site-wide: 152,059
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  • Site-wide: 149,656

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

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  • Site-wide: 67,339
  • In immunology: 2,844
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  • Site-wide: 3,569
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  • Site-wide: 13,774

ClusterEnG: An interactive educational web resource for clustering big data

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  • Site-wide: 68,943
  • In bioinformatics: 6,141
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  • Site-wide: 184,255
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  • Site-wide: 149,273

Real-time denoising of fluorescence time-lapse imaging enables high-sensitivity observations of biological dynamics beyond the shot-noise limit

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  • Site-wide: 69,990
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  • Site-wide: 3,780

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

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  • Site-wide: 70,004
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  • Site-wide: 4,953
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  • Site-wide: 48,291

Deciphering the rules of mRNA structure differentiation in vivo and in vitro with deep neural networks in Saccharomyces cerevisiae

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  • Site-wide: 144,605

Low-dose IFN-γ induces tumor cell stemness in tumor microenvironment of non-small cell lung cancer

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  • Site-wide: 71,550
  • In cancer biology: 1,987
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  • Site-wide: 114,233

Transmembrane Kinases are essential for plant development

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  • Site-wide: 73,843
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  • Site-wide: 30,116
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  • Site-wide: 21,469

Basic reproduction number of 2019 Novel Coronavirus Disease in Major Endemic Areas of China: A latent profile analysis

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  • Site-wide: 77,467
  • In epidemiology: 3,335
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  • Site-wide: 129,206
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  • Site-wide: 88,673

Construction of high-density genetic maps and detection of QTLs associated with Huanglongbing infection in citrus

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  • Site-wide: 78,687
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  • Site-wide: 154,422
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  • Site-wide: 146,778

Retinoic acid promotes in vitro development of haploid germ cells from pre-pubertal porcine spermatogenic cells

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  • In developmental biology: 1,869
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  • Site-wide: 139,494

Reconstituting human somitogenesis in vitro

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  • Site-wide: 79,110
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  • Site-wide: 4,334
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  • Site-wide: 529

Tracking single cell evolution via clock-like chromatin accessibility

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  • Site-wide: 80,710
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  • Site-wide: 4,442
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  • Site-wide: 543

Genomic epidemiology of the Los Angeles COVID-19 outbreak

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  • Site-wide: 81,960
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  • Site-wide: 83,655
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  • Site-wide: 121,413

Structural characterization of cocktail-like targeting polysaccharides from Ecklonia kurome Okam and their anti-SARS-CoV-2 activities in vitro

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  • Site-wide: 82,485
  • In biochemistry: 2,290
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  • Site-wide: 69,989

Mapping fetal brain development based on automated segmentation and 4D brain atlasing

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  • Site-wide: 83,436
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  • Site-wide: 67,058
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  • Site-wide: 73,865

Risk assessment and prediction of severe or critical illness of COVID-19 in the elderly

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  • Site-wide: 88,877
  • In public and global health: 1,232
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  • Site-wide: 148,366
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  • Site-wide: 136,673

DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and preimplantation development

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  • Site-wide: 91,552
  • In developmental biology: 2,423
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  • Site-wide: 49,905
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  • Site-wide: 60,247

Broad and Long-lasting Immune Response against SARS-CoV-2 Omicron and Other Variants by PIKA-Adjuvanted Recombinant SARS-CoV-2 Spike (S) Protein Subunit Vaccine (YS-SC2-010)

• Downloaded 470 times
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  • Site-wide: 93,896
  • In immunology: 3,211
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  • Site-wide: 13,842
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  • Site-wide: 43,266

3D Printed Microheater Sensor-Integrated, Drug-Encapsulated Microneedle Patch System for Pain Management

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  • Site-wide: 96,588
  • In bioengineering: 1,761
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  • Site-wide: 132,248
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  • Site-wide: 101,301

Cancer SIGVAR: A semi-automated interpretation tool for germline variants of hereditary cancer-related genes

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  • Site-wide: 96,642
  • In genetics: 3,855
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  • Site-wide: 95,585
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  • Site-wide: 127,072

Design of nanoparticulate group 2 influenza hemagglutinin stem antigens that activate unmutated ancestor B cell receptors of broadly neutralizing antibody lineages

• Downloaded 455 times
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  • Site-wide: 97,068
  • In immunology: 2,801
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  • Site-wide: 176,542
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  • Site-wide: 160,759

Rapid visual CRISPR assay: a naked-eye colorimetric detection method for nucleic acids based on CRISPR/Cas12a and convolutional neural network

• Downloaded 455 times
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  • Site-wide: 97,204
  • In molecular biology: 2,872
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  • Site-wide: 75,127
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  • Site-wide: 80,792

Convergent epitope specificities, V gene usage and public clones elicited by primary exposure to SARS-CoV-2 variants

• Downloaded 453 times
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  • Site-wide: 97,610
  • In immunology: None
• Year to date:
  • Site-wide: 5,725
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  • Site-wide: 6,555

Artificial intelligence assisted standard white light endoscopy accurately characters early colorectal cancer: a multicenter diagnostic study

• Downloaded 446 times
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  • Site-wide: 99,222
  • In oncology: 206
• Year to date:
  • Site-wide: 95,366
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  • Site-wide: 118,409

Accurate Name Entity Recognition for Biomedical Literatures: A Combined High-quality Manual Annotation and Deep-learning Natural Language Processing Study

• Downloaded 431 times
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  • Site-wide: 102,770
  • In bioinformatics: 9,550
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  • Site-wide: 28,886
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  • Site-wide: 69,734

A population-based seroprevalence survey of severe acute respiratory syndrome coronavirus 2 infection in Beijing, China

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  • Site-wide: 108,149
  • In epidemiology: 4,392
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  • Site-wide: 127,097
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  • Site-wide: 138,525

Pressure overload leads to coronary plaque formation, progression and myocardial events in ApoE-/- mice

• Downloaded 400 times
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  • Site-wide: 110,143
  • In pathology: 529
• Year to date:
  • Site-wide: 170,541
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  • Site-wide: 147,515

A novel antiviral lncRNA EDAL shields a T309 O-GlcNAcylation site to promote EZH2 degradation

• Downloaded 395 times
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  • Site-wide: 111,420
  • In microbiology: 7,295
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  • Site-wide: 137,844
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  • Site-wide: 87,018

Setting Standards to Promote Artificial Intelligence in Colon Mass Endoscopic Sampling

• Downloaded 370 times
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  • Site-wide: 117,950
  • In oncology: 277
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  • Site-wide: 131,985
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  • Site-wide: 150,133

Impact of Vaccination and Testing in an Urban Campus model for the SARS-CoV-2 Pandemic

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  • Site-wide: 119,020
  • In health policy: 360
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  • Site-wide: 38,122
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  • Site-wide: 7,397

Accurate inference of genome-wide spatial expression with iSpatial

• Downloaded 346 times
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  • Site-wide: 124,547
  • In bioinformatics: None
• Year to date:
  • Site-wide: 8,632
• Since beginning of last month:
  • Site-wide: 1,071

Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variation

• Downloaded 342 times
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  • Site-wide: 125,698
  • In bioinformatics: 10,496
• Year to date:
  • Site-wide: 48,203
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  • Site-wide: 155,280

A high-precision hybrid algorithm for predicting eukaryotic protein subcellular localization

• Downloaded 339 times
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  • Site-wide: 126,732
  • In bioinformatics: 9,782
• Year to date:
  • Site-wide: 155,739
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  • Site-wide: 141,842

Predicting the Impact of the COVID-19 Pandemic for the Low- and Middle-Income Countries

• Downloaded 326 times
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  • Site-wide: 130,457
  • In infectious diseases: 5,776
• Year to date:
  • Site-wide: 127,052
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  • Site-wide: 99,422

Hidden Parameters impacting resurgence of SARS-CoV-2 Pandemic

• Downloaded 318 times
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  • Site-wide: 132,579
  • In health policy: 336
• Year to date:
  • Site-wide: 108,554
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  • Site-wide: 97,263

Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution

• Downloaded 300 times
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  • Site-wide: 138,096
  • In cancer biology: 4,291
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  • Site-wide: 39,353
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  • Site-wide: 109,911

The physiological adaptation for the “fore-mid” four-legged walking behavior of the pygmy mole cricket Xya sichuanensis

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  • Site-wide: 138,650
  • In evolutionary biology: 6,280
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  • Site-wide: 156,957
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  • Site-wide: 149,695

Performance Comparison of Computational Prediction Methods for the Function and Pathogenicity of Non-coding Variants

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  • Site-wide: 138,908
  • In bioinformatics: 10,794
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  • Site-wide: 64,403
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  • Site-wide: 169,033

Computational optical sectioning by phase-space imaging with an incoherent multiscale scattering model

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  • Site-wide: 139,679
  • In cell biology: 6,251
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  • Site-wide: 98,335

Genomic profiling of cell lines reveals hidden research bias and caveats

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  • Site-wide: 142,842
  • In cancer biology: 4,132
• Year to date:
  • Site-wide: 142,295
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  • Site-wide: 120,584

Deciphering the developmental order and microstructural patterns of early white matter pathways in a diffusion MRI based fetal brain atlas

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  • Site-wide: 143,900
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• Year to date:
  • Site-wide: 11,807
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  • Site-wide: 22,645

CLE42 Delays Leaf Senescence by Antagonizing Ethylene Pathway in Arabidopsis

• Downloaded 278 times
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  • Site-wide: 144,791
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• Year to date:
  • Site-wide: 11,994
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  • Site-wide: 43,627

Comparative analysis of temporal transcriptome reveals the relationship between pectin degradation and pathogenicity of defoliating Verticillium dahliae to Upland cotton (Gossypium hirsutum)

• Downloaded 270 times
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  • Site-wide: 147,107
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  • Site-wide: 106,324
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  • Site-wide: 78,844

Crosstalk in oxygen homeostasis networks: SKN-1/NRF inhibits the HIF-1 hypoxia-inducible factor in Caenorhabditis elegans

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  • Site-wide: 149,638
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  • Site-wide: 37,607
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  • Site-wide: 10,169

Hfq Globally Binds and Destabilizes the bound sRNAs and mRNAs in Yersinia pestis

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  • Site-wide: 153,832
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  • Site-wide: 165,161

Structural insights into the viral proteins binding by TRIM7 reveal a general C-terminal glutamine recognition mechanism

• Downloaded 225 times
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  • Site-wide: 160,151
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• Year to date:
  • Site-wide: 16,419
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  • Site-wide: 16,529

Two Ubiquitin-Activating Systems Occur in Plants with One Playing a Major Role in Plant Immunity

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  • Site-wide: 163,050
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  • Site-wide: 98,202

Telmisartan potentiates insulin secretion via ion channels, independent of the AT1 receptor and PPARγ

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  • Site-wide: 173,052
  • In cell biology: 7,459
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  • Site-wide: 178,739

Impaired KDM2B-mediated PRC1 recruitment to chromatin causes neural stem cell senescence and ASD/ID-like behavioral deficits

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  • Site-wide: 174,203
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  • Site-wide: 169,001

Development of visual cortex in human neonates are selectively modified by postnatal experience

• Downloaded 157 times
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  • Site-wide: 176,650
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• Year to date:
  • Site-wide: 27,008
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  • Site-wide: 72,466

Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells

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  • Site-wide: 177,179
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  • Site-wide: 78,660
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  • Site-wide: 75,267

Modeling Vaccinations, Virus Variants and Lockdown: Early guidance for Sars-Cov-2 health policies in India

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  • Site-wide: 179,254
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  • Site-wide: 30,374
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  • Site-wide: 79,488

MAPK cascades mediating Trichoderma brevicrassum strain TC967 against phytopathogen Rhizoctonia solani

• Downloaded 132 times
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  • Site-wide: 181,258
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  • Site-wide: 156,034

Survival intravascular photoacoustic imaging of lipid-rich plaque in cholesterol fed rabbits

• Downloaded 53 times
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  • Site-wide: 189,723
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• Year to date:
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  • Site-wide: 22,722