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Author: Kirk E. Lohmueller

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  • All-time downloads: 26,879 (rank: 5,795 )
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    • evolutionary biology: 13,335 (rank: 101 )
    • genetics: 9,248 (rank: 1,897 )
    • genomics: 4,296 (rank: 5,555 )

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Preprints

High-quality genome and methylomes illustrate features underlying evolutionary success of oaks

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Population history of the Sardinian people inferred from whole-genome sequencing

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Strongly deleterious mutations are a primary determinant of extinction risk due to inbreeding depression

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A community-maintained standard library of population genetic models

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The distribution of deleterious genetic variation in human populations

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Fitting the Balding-Nichols model to forensic databases

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Genome-wide patterns of de novo tandem repeat mutations and their contribution to autism spectrum disorders.

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Natural selection reduces linked neutral divergence between distantly related species

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Negative selection on complex traits limits genetic risk prediction accuracy between populations

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Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared to mice and Drosophila melanogaster

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Gene expression drives the evolution of dominance

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Extreme distribution of deleterious variation in a historically small and isolated population-insights from the Greenlandic Inuit

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Haplotype-based inference of the distribution of fitness effects

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Deleterious variation mimics signatures of genomic incompatibility and adaptive introgression

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Genomic signatures of extensive inbreeding in Isle Royale wolves, a population on the threshold of extinction

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Understanding the Hidden Complexity of Latin American Population Isolates

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Comparison of single genome and allele frequency data reveals discordant demographic histories

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Complex patterns of sex-biased demography in canines

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Determining the factors driving selective effects of new nonsynonymous mutations

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Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome

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Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution

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Leveraging ancestry to improve causal variant identification in exome sequencing for monogenic disorders

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Inference of the distribution of selection coefficients for new nonsynonymous mutations using large samples

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Recessive deleterious variation has a limited impact on signals of adaptive introgression in human populations

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Identification and characterization of constrained non-exonic bases lacking predictive epigenomic and transcription factor binding annotations

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The impact of identity-by-descent on fitness and disease in natural and domesticated Canid populations

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A signature of Neanderthal introgression on molecular mechanisms of environmental responses

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