Author: Gilbran Hemani

Downloads per author, site-wide

Preprints

Collider bias undermines our understanding of COVID-19 disease risk and severity

• Downloaded 12,270 times
• Download rankings, all-time:
  • Site-wide: 670
  • In epidemiology: 99
• Year to date:
  • Site-wide: 2,683
• Since beginning of last month:
  • Site-wide: 2,983

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

• Downloaded 10,737 times
• Download rankings, all-time:
  • Site-wide: 810
  • In genomics: 59
• Year to date:
  • Site-wide: 1,141
• Since beginning of last month:
  • Site-wide: 932

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

• Downloaded 7,341 times
• Download rankings, all-time:
  • Site-wide: 1,307
  • In bioinformatics: 80
• Year to date:
  • Site-wide: 32,680
• Since beginning of last month:
  • Site-wide: 45,287

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,581 times
• Download rankings, all-time:
  • Site-wide: 2,472
  • In genetics: 87
• Year to date:
  • Site-wide: 36,008
• Since beginning of last month:
  • Site-wide: 40,130

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

• Downloaded 4,079 times
• Download rankings, all-time:
  • Site-wide: 2,915
  • In epidemiology: 303
• Year to date:
  • Site-wide: 26,147
• Since beginning of last month:
  • Site-wide: 26,651

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

• Downloaded 3,961 times
• Download rankings, all-time:
  • Site-wide: 3,057
  • In genetics: 112
• Year to date:
  • Site-wide: 9,875
• Since beginning of last month:
  • Site-wide: 11,253

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

• Downloaded 3,570 times
• Download rankings, all-time:
  • Site-wide: 3,554
  • In epidemiology: 345
• Year to date:
  • Site-wide: 11,024
• Since beginning of last month:
  • Site-wide: 13,571

Why are education, socioeconomic position and intelligence genetically correlated?

• Downloaded 2,474 times
• Download rankings, all-time:
  • Site-wide: 6,016
  • In genetics: 269
• Year to date:
  • Site-wide: 48,574
• Since beginning of last month:
  • Site-wide: 50,696

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

• Downloaded 2,228 times
• Download rankings, all-time:
  • Site-wide: 6,997
  • In genetics: 325
• Year to date:
  • Site-wide: 24,864
• Since beginning of last month:
  • Site-wide: 27,582

Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

• Downloaded 1,883 times
• Download rankings, all-time:
  • Site-wide: 8,956
  • In genetics: 402
• Year to date:
  • Site-wide: 63,621
• Since beginning of last month:
  • Site-wide: 88,930

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

• Downloaded 1,631 times
• Download rankings, all-time:
  • Site-wide: 11,079
  • In genetics: 515
• Year to date:
  • Site-wide: 125,254
• Since beginning of last month:
  • Site-wide: 114,049

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,434 times
• Download rankings, all-time:
  • Site-wide: 13,442
  • In genetics: 630
• Year to date:
  • Site-wide: 89,126
• Since beginning of last month:
  • Site-wide: 115,393

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 1,342 times
• Download rankings, all-time:
  • Site-wide: 14,816
  • In genetics: 705
• Year to date:
  • Site-wide: 6,514
• Since beginning of last month:
  • Site-wide: 8,683

Bayesian reassessment of the epigenetic architecture of complex traits

• Downloaded 1,334 times
• Download rankings, all-time:
  • Site-wide: 14,965
  • In genomics: 1,524
• Year to date:
  • Site-wide: 128,784
• Since beginning of last month:
  • Site-wide: 138,560

Meffil: efficient normalisation and analysis of very large DNA methylation samples

• Downloaded 1,321 times
• Download rankings, all-time:
  • Site-wide: 15,163
  • In bioinformatics: 1,804
• Year to date:
  • Site-wide: 72,513
• Since beginning of last month:
  • Site-wide: 90,005

High COVID-19 transmission potential associated with re-opening universities can be mitigated with layered interventions

• Downloaded 1,282 times
• Download rankings, all-time:
  • Site-wide: 15,887
  • In infectious diseases: 1,629
• Year to date:
  • Site-wide: 22,907
• Since beginning of last month:
  • Site-wide: 29,006

Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

• Downloaded 1,271 times
• Download rankings, all-time:
  • Site-wide: 16,085
  • In genetics: 765
• Year to date:
  • Site-wide: 140,270
• Since beginning of last month:
  • Site-wide: 132,662

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

• Downloaded 1,223 times
• Download rankings, all-time:
  • Site-wide: 17,043
  • In epidemiology: 1,087
• Year to date:
  • Site-wide: 102,709
• Since beginning of last month:
  • Site-wide: 121,068

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

• Downloaded 1,200 times
• Download rankings, all-time:
  • Site-wide: 17,507
  • In genetics: 830
• Year to date:
  • Site-wide: 85,466
• Since beginning of last month:
  • Site-wide: 83,333

Within-sibship GWAS improve estimates of direct genetic effects

• Downloaded 1,174 times
• Download rankings, all-time:
  • Site-wide: 18,079
  • In genetics: 860
• Year to date:
  • Site-wide: 1,753
• Since beginning of last month:
  • Site-wide: 2,221

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

• Downloaded 1,081 times
• Download rankings, all-time:
  • Site-wide: 20,467
  • In bioinformatics: 2,383
• Year to date:
  • Site-wide: 70,876
• Since beginning of last month:
  • Site-wide: 80,989

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

• Downloaded 1,060 times
• Download rankings, all-time:
  • Site-wide: 21,054
  • In genetics: 987
• Year to date:
  • Site-wide: 99,795
• Since beginning of last month:
  • Site-wide: 108,529

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

• Downloaded 1,016 times
• Download rankings, all-time:
  • Site-wide: 22,430
  • In genetics: 1,048
• Year to date:
  • Site-wide: 9,527
• Since beginning of last month:
  • Site-wide: 5,658

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

• Downloaded 990 times
• Download rankings, all-time:
  • Site-wide: 23,234
  • In epidemiology: 1,346
• Year to date:
  • Site-wide: 69,581
• Since beginning of last month:
  • Site-wide: 51,750

COVID-19 transmission in a university setting: a rapid review of modelling studies

• Downloaded 907 times
• Download rankings, all-time:
  • Site-wide: 26,405
  • In health policy: 73
• Year to date:
  • Site-wide: 19,748
• Since beginning of last month:
  • Site-wide: 25,162

Tendency towards being a "Morning person" increases risk of Parkinson's disease: evidence from Mendelian randomisation

• Downloaded 874 times
• Download rankings, all-time:
  • Site-wide: 27,796
  • In epidemiology: 1,502
• Year to date:
  • Site-wide: 43,854
• Since beginning of last month:
  • Site-wide: 15,200

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 874 times
• Download rankings, all-time:
  • Site-wide: 27,799
  • In genetic and genomic medicine: 100
• Year to date:
  • Site-wide: 8,185
• Since beginning of last month:
  • Site-wide: 7,634

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes

• Downloaded 853 times
• Download rankings, all-time:
  • Site-wide: 28,763
  • In genomics: 2,603
• Year to date:
  • Site-wide: 67,463
• Since beginning of last month:
  • Site-wide: 80,155

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

• Downloaded 814 times
• Download rankings, all-time:
  • Site-wide: 30,727
  • In bioinformatics: 3,454
• Year to date:
  • Site-wide: 69,754
• Since beginning of last month:
  • Site-wide: 45,652

The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

• Downloaded 793 times
• Download rankings, all-time:
  • Site-wide: 31,875
  • In epidemiology: 1,648
• Year to date:
  • Site-wide: 89,204
• Since beginning of last month:
  • Site-wide: 121,064

The variant call format provides efficient and robust storage of GWAS summary statistics

• Downloaded 723 times
• Download rankings, all-time:
  • Site-wide: 36,190
  • In genetics: 1,692
• Year to date:
  • Site-wide: 23,010
• Since beginning of last month:
  • Site-wide: 23,549

The MRC IEU OpenGWAS data infrastructure

• Downloaded 711 times
• Download rankings, all-time:
  • Site-wide: 37,064
  • In genetics: 1,727
• Year to date:
  • Site-wide: 9,612
• Since beginning of last month:
  • Site-wide: 8,341

Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

• Downloaded 659 times
• Download rankings, all-time:
  • Site-wide: 40,993
  • In systems biology: 911
• Year to date:
  • Site-wide: 131,582
• Since beginning of last month:
  • Site-wide: 128,717

Using genetic instruments to estimate interactions in Mendelian Randomization studies

• Downloaded 657 times
• Download rankings, all-time:
  • Site-wide: 41,125
  • In epidemiology: 1,987
• Year to date:
  • Site-wide: 43,797
• Since beginning of last month:
  • Site-wide: 31,592

Appraising the causal relevance of DNA methylation for risk of lung cancer

• Downloaded 656 times
• Download rankings, all-time:
  • Site-wide: 41,216
  • In epidemiology: 1,989
• Year to date:
  • Site-wide: 101,755
• Since beginning of last month:
  • Site-wide: 98,108

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 585 times
• Download rankings, all-time:
  • Site-wide: 47,546
  • In epidemiology: 2,218
• Year to date:
  • Site-wide: 117,176
• Since beginning of last month:
  • Site-wide: 128,773

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 516 times
• Download rankings, all-time:
  • Site-wide: 55,305
  • In neuroscience: 8,074
• Year to date:
  • Site-wide: 127,027
• Since beginning of last month:
  • Site-wide: 136,861

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

• Downloaded 510 times
• Download rankings, all-time:
  • Site-wide: 56,098
  • In epidemiology: 2,488
• Year to date:
  • Site-wide: 133,871
• Since beginning of last month:
  • Site-wide: 129,783

Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

• Downloaded 503 times
• Download rankings, all-time:
  • Site-wide: 56,930
  • In genetics: 2,576
• Year to date:
  • Site-wide: 68,400
• Since beginning of last month:
  • Site-wide: 80,691

Prenatal alcohol exposure and facial morphology in a UK cohort

• Downloaded 471 times
• Download rankings, all-time:
  • Site-wide: 61,195
  • In epidemiology: 2,691
• Year to date:
  • Site-wide: 78,895
• Since beginning of last month:
  • Site-wide: 55,366

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

• Downloaded 465 times
• Download rankings, all-time:
  • Site-wide: 62,104
  • In genetics: 2,801
• Year to date:
  • Site-wide: 135,546
• Since beginning of last month:
  • Site-wide: 129,948

Schizophrenia risk and reproductive success: A Mendelian randomization study.

• Downloaded 437 times
• Download rankings, all-time:
  • Site-wide: 66,360
  • In evolutionary biology: 3,550
• Year to date:
  • Site-wide: 120,686
• Since beginning of last month:
  • Site-wide: 114,833

Does Neuroticism Cause Depression? A Mendelian Randomization Study

• Downloaded 424 times
• Download rankings, all-time:
  • Site-wide: 68,420
  • In genetics: 3,091
• Year to date:
  • Site-wide: 141,969
• Since beginning of last month:
  • Site-wide: 138,199

The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: A two-step, two-sample Mendelian randomization study

• Downloaded 422 times
• Download rankings, all-time:
  • Site-wide: 68,697
  • In epidemiology: 2,960
• Year to date:
  • Site-wide: 112,441
• Since beginning of last month:
  • Site-wide: 76,307

Assortative mating and within-spouse pair comparisons

• Downloaded 414 times
• Download rankings, all-time:
  • Site-wide: 70,121
  • In genetics: 3,149
• Year to date:
  • Site-wide: 53,279
• Since beginning of last month:
  • Site-wide: 32,714

The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

• Downloaded 411 times
• Download rankings, all-time:
  • Site-wide: 70,626
  • In genetics: 3,169
• Year to date:
  • Site-wide: 63,795
• Since beginning of last month:
  • Site-wide: 85,532

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

• Downloaded 374 times
• Download rankings, all-time:
  • Site-wide: 77,015
  • In epidemiology: 3,254
• Year to date:
  • Site-wide: 120,468
• Since beginning of last month:
  • Site-wide: 118,085

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

• Downloaded 372 times
• Download rankings, all-time:
  • Site-wide: 77,420
  • In genetics: 3,464
• Year to date:
  • Site-wide: 132,438
• Since beginning of last month:
  • Site-wide: 99,224

DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

• Downloaded 351 times
• Download rankings, all-time:
  • Site-wide: 81,338
  • In genetics: 3,630
• Year to date:
  • Site-wide: 126,694
• Since beginning of last month:
  • Site-wide: 129,877

Investigating DNA methylation as a potential mediator between pigmentation genes, pigmentary traits and skin cancer

• Downloaded 311 times
• Download rankings, all-time:
  • Site-wide: 89,727
  • In genetics: 3,959
• Year to date:
  • Site-wide: 53,343
• Since beginning of last month:
  • Site-wide: 62,211

Contacts and behaviours of university students during the COVID-19 pandemic at the start of the 2020/21 academic year

• Downloaded 302 times
• Download rankings, all-time:
  • Site-wide: 91,519
  • In public and global health: 1,095
• Year to date:
  • Site-wide: 20,694
• Since beginning of last month:
  • Site-wide: 41,150

University students and staff able to maintain low daily contact numbers during various COVID-19 guideline periods

• Downloaded 299 times
• Download rankings, all-time:
  • Site-wide: 92,198
  • In epidemiology: 3,834
• Year to date:
  • Site-wide: 12,448
• Since beginning of last month:
  • Site-wide: 26,891

Modelling pooling strategies for SARS-CoV-2 testing in a university setting

• Downloaded 279 times
• Download rankings, all-time:
  • Site-wide: 96,873
  • In infectious diseases: 4,014
• Year to date:
  • Site-wide: 13,818
• Since beginning of last month:
  • Site-wide: 43,952

EpiGraphDB: a database and data mining platform for health data science

• Downloaded 251 times
• Download rankings, all-time:
  • Site-wide: 103,299
  • In bioinformatics: 8,778
• Year to date:
  • Site-wide: 105,284
• Since beginning of last month:
  • Site-wide: 86,113

The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers

• Downloaded 197 times
• Download rankings, all-time:
  • Site-wide: 116,019
  • In genetics: 4,940
• Year to date:
  • Site-wide: 137,869
• Since beginning of last month:
  • Site-wide: 112,031

Limits of lockdown: characterising essential contacts during strict physical distancing

• Downloaded 141 times
• Download rankings, all-time:
  • Site-wide: 128,511
  • In epidemiology: 5,281
• Year to date:
  • Site-wide: 32,892
• Since beginning of last month:
  • Site-wide: 56,000

Exploring the variance in complex traits captured by DNA methylation assays

• Downloaded 120 times
• Download rankings, all-time:
  • Site-wide: 132,749
  • In genetics: 5,452
• Year to date:
  • Site-wide: 114,120
• Since beginning of last month:
  • Site-wide: 131,299