Author: Gibran Hemani

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Preprints

Collider bias undermines our understanding of COVID-19 disease risk and severity

• Downloaded 11,758 times
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  • Site-wide: 602
  • In epidemiology: 89
• Year to date:
  • Site-wide: 2,057
• Since beginning of last month:
  • Site-wide: 1,770

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

• Downloaded 9,365 times
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  • Site-wide: 817
  • In genomics: 68
• Year to date:
  • Site-wide: 3,343
• Since beginning of last month:
  • Site-wide: None

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

• Downloaded 7,253 times
• Download rankings, all-time:
  • Site-wide: 1,142
  • In bioinformatics: 71
• Year to date:
  • Site-wide: 24,526
• Since beginning of last month:
  • Site-wide: 14,312

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,504 times
• Download rankings, all-time:
  • Site-wide: 2,160
  • In genetics: 83
• Year to date:
  • Site-wide: 25,034
• Since beginning of last month:
  • Site-wide: 19,067

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

• Downloaded 3,985 times
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  • Site-wide: 2,557
  • In epidemiology: 266
• Year to date:
  • Site-wide: 16,180
• Since beginning of last month:
  • Site-wide: 70,631

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

• Downloaded 3,737 times
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  • Site-wide: 2,821
  • In genetics: 112
• Year to date:
  • Site-wide: 8,559
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  • Site-wide: 6,381

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

• Downloaded 3,359 times
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  • Site-wide: 3,297
  • In epidemiology: 324
• Year to date:
  • Site-wide: 9,851
• Since beginning of last month:
  • Site-wide: 7,588

Why are education, socioeconomic position and intelligence genetically correlated?

• Downloaded 2,412 times
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  • Site-wide: 5,328
  • In genetics: 252
• Year to date:
  • Site-wide: 38,491
• Since beginning of last month:
  • Site-wide: 25,027

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

• Downloaded 2,118 times
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  • Site-wide: 6,414
  • In genetics: 318
• Year to date:
  • Site-wide: 18,832
• Since beginning of last month:
  • Site-wide: 16,406

Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

• Downloaded 1,840 times
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  • Site-wide: 7,890
  • In genetics: 382
• Year to date:
  • Site-wide: 46,267
• Since beginning of last month:
  • Site-wide: 57,819

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

• Downloaded 1,619 times
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  • Site-wide: 9,608
  • In genetics: 477
• Year to date:
  • Site-wide: 92,792
• Since beginning of last month:
  • Site-wide: None

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,401 times
• Download rankings, all-time:
  • Site-wide: 11,886
  • In genetics: 597
• Year to date:
  • Site-wide: 86,160
• Since beginning of last month:
  • Site-wide: 87,047

Bayesian reassessment of the epigenetic architecture of complex traits

• Downloaded 1,321 times
• Download rankings, all-time:
  • Site-wide: 12,977
  • In genomics: 1,417
• Year to date:
  • Site-wide: 104,426
• Since beginning of last month:
  • Site-wide: 62,067

Meffil: efficient normalisation and analysis of very large DNA methylation samples

• Downloaded 1,281 times
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  • Site-wide: 13,618
  • In bioinformatics: 1,676
• Year to date:
  • Site-wide: 63,094
• Since beginning of last month:
  • Site-wide: 62,197

Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

• Downloaded 1,265 times
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  • Site-wide: 13,856
  • In genetics: 708
• Year to date:
  • Site-wide: 109,971
• Since beginning of last month:
  • Site-wide: 73,478

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

• Downloaded 1,198 times
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  • Site-wide: 15,043
  • In epidemiology: 947
• Year to date:
  • Site-wide: 96,347
• Since beginning of last month:
  • Site-wide: None

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

• Downloaded 1,171 times
• Download rankings, all-time:
  • Site-wide: 15,557
  • In genetics: 794
• Year to date:
  • Site-wide: 62,743
• Since beginning of last month:
  • Site-wide: 36,637

High COVID-19 transmission potential associated with re-opening universities can be mitigated with layered interventions

• Downloaded 1,168 times
• Download rankings, all-time:
  • Site-wide: 15,614
  • In infectious diseases: 1,425
• Year to date:
  • Site-wide: 16,284
• Since beginning of last month:
  • Site-wide: 20,332

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

• Downloaded 1,037 times
• Download rankings, all-time:
  • Site-wide: 18,702
  • In genetics: 933
• Year to date:
  • Site-wide: 80,376
• Since beginning of last month:
  • Site-wide: 62,518

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

• Downloaded 1,035 times
• Download rankings, all-time:
  • Site-wide: 18,743
  • In bioinformatics: 2,263
• Year to date:
  • Site-wide: 74,400
• Since beginning of last month:
  • Site-wide: 73,462

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 1,026 times
• Download rankings, all-time:
  • Site-wide: 19,027
  • In genetics: 947
• Year to date:
  • Site-wide: 6,692
• Since beginning of last month:
  • Site-wide: 7,094

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

• Downloaded 951 times
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  • Site-wide: 21,168
  • In epidemiology: 1,207
• Year to date:
  • Site-wide: 51,457
• Since beginning of last month:
  • Site-wide: 51,096

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes

• Downloaded 817 times
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  • Site-wide: 26,284
  • In genomics: 2,483
• Year to date:
  • Site-wide: 43,778
• Since beginning of last month:
  • Site-wide: 41,938

Tendency towards being a "Morning person" increases risk of Parkinson's disease: evidence from Mendelian randomisation

• Downloaded 790 times
• Download rankings, all-time:
  • Site-wide: 27,535
  • In epidemiology: 1,437
• Year to date:
  • Site-wide: 55,682
• Since beginning of last month:
  • Site-wide: 73,015

COVID-19 transmission in a university setting: a rapid review of modelling studies

• Downloaded 770 times
• Download rankings, all-time:
  • Site-wide: 28,509
  • In health policy: 70
• Year to date:
  • Site-wide: 16,272
• Since beginning of last month:
  • Site-wide: 15,588

The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

• Downloaded 760 times
• Download rankings, all-time:
  • Site-wide: 29,038
  • In epidemiology: 1,493
• Year to date:
  • Site-wide: 85,067
• Since beginning of last month:
  • Site-wide: None

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

• Downloaded 751 times
• Download rankings, all-time:
  • Site-wide: 29,538
  • In bioinformatics: 3,389
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

• Downloaded 730 times
• Download rankings, all-time:
  • Site-wide: 30,780
  • In genetics: 1,526
• Year to date:
  • Site-wide: 16,275
• Since beginning of last month:
  • Site-wide: 23,970

Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

• Downloaded 644 times
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  • Site-wide: 36,422
  • In systems biology: 854
• Year to date:
  • Site-wide: 119,422
• Since beginning of last month:
  • Site-wide: None

Appraising the causal relevance of DNA methylation for risk of lung cancer

• Downloaded 628 times
• Download rankings, all-time:
  • Site-wide: 37,612
  • In epidemiology: 1,804
• Year to date:
  • Site-wide: 106,946
• Since beginning of last month:
  • Site-wide: None

The variant call format provides efficient and robust storage of GWAS summary statistics

• Downloaded 609 times
• Download rankings, all-time:
  • Site-wide: 39,105
  • In genetics: 1,898
• Year to date:
  • Site-wide: 16,354
• Since beginning of last month:
  • Site-wide: 24,135

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 602 times
• Download rankings, all-time:
  • Site-wide: 39,633
  • In genetic and genomic medicine: 113
• Year to date:
  • Site-wide: 8,328
• Since beginning of last month:
  • Site-wide: 12,888

Using genetic instruments to estimate interactions in Mendelian Randomization studies

• Downloaded 576 times
• Download rankings, all-time:
  • Site-wide: 41,927
  • In epidemiology: 1,960
• Year to date:
  • Site-wide: 49,818
• Since beginning of last month:
  • Site-wide: 28,314

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 569 times
• Download rankings, all-time:
  • Site-wide: 42,530
  • In epidemiology: 1,985
• Year to date:
  • Site-wide: 93,005
• Since beginning of last month:
  • Site-wide: 93,846

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 507 times
• Download rankings, all-time:
  • Site-wide: 48,925
  • In neuroscience: 7,253
• Year to date:
  • Site-wide: 82,001
• Since beginning of last month:
  • Site-wide: 72,915

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

• Downloaded 500 times
• Download rankings, all-time:
  • Site-wide: 49,749
  • In epidemiology: 2,198
• Year to date:
  • Site-wide: 107,171
• Since beginning of last month:
  • Site-wide: 89,750

The MRC IEU OpenGWAS data infrastructure

• Downloaded 481 times
• Download rankings, all-time:
  • Site-wide: 52,007
  • In genetics: 2,472
• Year to date:
  • Site-wide: 8,437
• Since beginning of last month:
  • Site-wide: 9,485

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

• Downloaded 456 times
• Download rankings, all-time:
  • Site-wide: 55,131
  • In genetics: 2,614
• Year to date:
  • Site-wide: 105,158
• Since beginning of last month:
  • Site-wide: 93,237

Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

• Downloaded 451 times
• Download rankings, all-time:
  • Site-wide: 55,778
  • In genetics: 2,637
• Year to date:
  • Site-wide: 85,360
• Since beginning of last month:
  • Site-wide: 73,642

Prenatal alcohol exposure and facial morphology in a UK cohort

• Downloaded 426 times
• Download rankings, all-time:
  • Site-wide: 59,219
  • In epidemiology: 2,530
• Year to date:
  • Site-wide: 106,950
• Since beginning of last month:
  • Site-wide: None

Schizophrenia risk and reproductive success: A Mendelian randomization study.

• Downloaded 423 times
• Download rankings, all-time:
  • Site-wide: 59,659
  • In evolutionary biology: 3,343
• Year to date:
  • Site-wide: 91,571
• Since beginning of last month:
  • Site-wide: 76,625

Does Neuroticism Cause Depression? A Mendelian Randomization Study

• Downloaded 417 times
• Download rankings, all-time:
  • Site-wide: 60,540
  • In genetics: 2,871
• Year to date:
  • Site-wide: 119,583
• Since beginning of last month:
  • Site-wide: 105,499

The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: A two-step, two-sample Mendelian randomization study

• Downloaded 400 times
• Download rankings, all-time:
  • Site-wide: 63,146
  • In epidemiology: 2,665
• Year to date:
  • Site-wide: 107,200
• Since beginning of last month:
  • Site-wide: 76,552

The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

• Downloaded 366 times
• Download rankings, all-time:
  • Site-wide: 68,642
  • In genetics: 3,199
• Year to date:
  • Site-wide: 49,952
• Since beginning of last month:
  • Site-wide: 56,352

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

• Downloaded 361 times
• Download rankings, all-time:
  • Site-wide: 69,460
  • In epidemiology: 2,891
• Year to date:
  • Site-wide: 85,205
• Since beginning of last month:
  • Site-wide: 76,455

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

• Downloaded 360 times
• Download rankings, all-time:
  • Site-wide: 69,574
  • In genetics: 3,250
• Year to date:
  • Site-wide: 108,405
• Since beginning of last month:
  • Site-wide: 88,668

Assortative mating and within-spouse pair comparisons

• Downloaded 339 times
• Download rankings, all-time:
  • Site-wide: 73,274
  • In genetics: 3,404
• Year to date:
  • Site-wide: 89,940
• Since beginning of last month:
  • Site-wide: 85,485

DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

• Downloaded 337 times
• Download rankings, all-time:
  • Site-wide: 73,539
  • In genetics: 3,424
• Year to date:
  • Site-wide: 105,156
• Since beginning of last month:
  • Site-wide: 88,909

Investigating DNA methylation as a potential mediator between pigmentation genes, pigmentary traits and skin cancer

• Downloaded 271 times
• Download rankings, all-time:
  • Site-wide: 86,714
  • In genetics: 3,976
• Year to date:
  • Site-wide: 28,204
• Since beginning of last month:
  • Site-wide: 40,653

EpiGraphDB: a database and data mining platform for health data science

• Downloaded 230 times
• Download rankings, all-time:
  • Site-wide: 95,365
  • In bioinformatics: 8,302
• Year to date:
  • Site-wide: 84,543
• Since beginning of last month:
  • Site-wide: 81,838

The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers

• Downloaded 187 times
• Download rankings, all-time:
  • Site-wide: 104,735
  • In genetics: 4,676
• Year to date:
  • Site-wide: 115,165
• Since beginning of last month:
  • Site-wide: 96,634

Modelling pooling strategies for SARS-CoV-2 testing in a university setting

• Downloaded 183 times
• Download rankings, all-time:
  • Site-wide: 105,498
  • In infectious diseases: 3,690
• Year to date:
  • Site-wide: 5,427
• Since beginning of last month:
  • Site-wide: 8,985

Contacts and behaviours of university students during the COVID-19 pandemic at the start of the 2020/21 academic year

• Downloaded 167 times
• Download rankings, all-time:
  • Site-wide: 108,888
  • In public and global health: 1,154
• Year to date:
  • Site-wide: 17,809
• Since beginning of last month:
  • Site-wide: 20,035

University students and staff able to maintain low daily contact numbers during various COVID-19 guideline periods

• Downloaded 124 times
• Download rankings, all-time:
  • Site-wide: 117,123
  • In epidemiology: 4,744
• Year to date:
  • Site-wide: 9,087
• Since beginning of last month:
  • Site-wide: 4,432

Exploring the variance in complex traits captured by DNA methylation assays

• Downloaded 111 times
• Download rankings, all-time:
  • Site-wide: 119,519
  • In genetics: 5,137
• Year to date:
  • Site-wide: 59,811
• Since beginning of last month:
  • Site-wide: 38,374