Author: Gib Hemani

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Preprints

Collider bias undermines our understanding of COVID-19 disease risk and severity

• Downloaded 12,488 times
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  • Site-wide: 708
  • In epidemiology: 101
• Year to date:
  • Site-wide: 2,765
• Since beginning of last month:
  • Site-wide: 3,165

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

• Downloaded 11,087 times
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  • Site-wide: 829
  • In genomics: 60
• Year to date:
  • Site-wide: 1,249
• Since beginning of last month:
  • Site-wide: 1,942

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

• Downloaded 7,376 times
• Download rankings, all-time:
  • Site-wide: 1,396
  • In bioinformatics: 84
• Year to date:
  • Site-wide: 35,232
• Since beginning of last month:
  • Site-wide: 31,508

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,611 times
• Download rankings, all-time:
  • Site-wide: 2,635
  • In genetics: 86
• Year to date:
  • Site-wide: 39,443
• Since beginning of last month:
  • Site-wide: 81,529

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

• Downloaded 4,100 times
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  • Site-wide: 3,124
  • In epidemiology: 326
• Year to date:
  • Site-wide: 31,384
• Since beginning of last month:
  • Site-wide: 61,911

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

• Downloaded 4,030 times
• Download rankings, all-time:
  • Site-wide: 3,207
  • In genetics: 109
• Year to date:
  • Site-wide: 10,910
• Since beginning of last month:
  • Site-wide: 23,447

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

• Downloaded 3,671 times
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  • Site-wide: 3,638
  • In epidemiology: 359
• Year to date:
  • Site-wide: 10,680
• Since beginning of last month:
  • Site-wide: 59,158

Why are education, socioeconomic position and intelligence genetically correlated?

• Downloaded 2,497 times
• Download rankings, all-time:
  • Site-wide: 6,321
  • In genetics: 274
• Year to date:
  • Site-wide: 53,942
• Since beginning of last month:
  • Site-wide: 67,003

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

• Downloaded 2,264 times
• Download rankings, all-time:
  • Site-wide: 7,291
  • In genetics: 323
• Year to date:
  • Site-wide: 27,657
• Since beginning of last month:
  • Site-wide: 84,981

Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

• Downloaded 1,901 times
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  • Site-wide: 9,426
  • In genetics: 409
• Year to date:
  • Site-wide: 70,256
• Since beginning of last month:
  • Site-wide: 73,017

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

• Downloaded 1,641 times
• Download rankings, all-time:
  • Site-wide: 11,730
  • In genetics: 533
• Year to date:
  • Site-wide: 128,787
• Since beginning of last month:
  • Site-wide: 84,097

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 1,443 times
• Download rankings, all-time:
  • Site-wide: 14,155
  • In genetics: 650
• Year to date:
  • Site-wide: 6,966
• Since beginning of last month:
  • Site-wide: 99,398

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,440 times
• Download rankings, all-time:
  • Site-wide: 14,202
  • In genetics: 652
• Year to date:
  • Site-wide: 103,642
• Since beginning of last month:
  • Site-wide: 60,337

Within-sibship GWAS improve estimates of direct genetic effects

• Downloaded 1,414 times
• Download rankings, all-time:
  • Site-wide: 14,589
  • In genetics: 673
• Year to date:
  • Site-wide: 1,909
• Since beginning of last month:
  • Site-wide: 10,469

Meffil: efficient normalisation and analysis of very large DNA methylation samples

• Downloaded 1,348 times
• Download rankings, all-time:
  • Site-wide: 15,686
  • In bioinformatics: 1,840
• Year to date:
  • Site-wide: 71,412
• Since beginning of last month:
  • Site-wide: None

Bayesian reassessment of the epigenetic architecture of complex traits

• Downloaded 1,339 times
• Download rankings, all-time:
  • Site-wide: 15,851
  • In genomics: 1,579
• Year to date:
  • Site-wide: 139,202
• Since beginning of last month:
  • Site-wide: None

High COVID-19 transmission potential associated with re-opening universities can be mitigated with layered interventions

• Downloaded 1,319 times
• Download rankings, all-time:
  • Site-wide: 16,236
  • In infectious diseases: 1,724
• Year to date:
  • Site-wide: 25,594
• Since beginning of last month:
  • Site-wide: None

Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

• Downloaded 1,280 times
• Download rankings, all-time:
  • Site-wide: 16,990
  • In genetics: 793
• Year to date:
  • Site-wide: 144,426
• Since beginning of last month:
  • Site-wide: 73,175

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

• Downloaded 1,226 times
• Download rankings, all-time:
  • Site-wide: 18,079
  • In epidemiology: 1,154
• Year to date:
  • Site-wide: 121,005
• Since beginning of last month:
  • Site-wide: 75,392

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

• Downloaded 1,213 times
• Download rankings, all-time:
  • Site-wide: 18,363
  • In genetics: 853
• Year to date:
  • Site-wide: 92,853
• Since beginning of last month:
  • Site-wide: 80,797

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

• Downloaded 1,135 times
• Download rankings, all-time:
  • Site-wide: 20,289
  • In genetics: 937
• Year to date:
  • Site-wide: 9,000
• Since beginning of last month:
  • Site-wide: 66,836

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

• Downloaded 1,089 times
• Download rankings, all-time:
  • Site-wide: 21,529
  • In bioinformatics: 2,485
• Year to date:
  • Site-wide: 84,546
• Since beginning of last month:
  • Site-wide: None

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

• Downloaded 1,069 times
• Download rankings, all-time:
  • Site-wide: 22,115
  • In genetics: 1,014
• Year to date:
  • Site-wide: 110,596
• Since beginning of last month:
  • Site-wide: None

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

• Downloaded 1,007 times
• Download rankings, all-time:
  • Site-wide: 24,129
  • In epidemiology: 1,407
• Year to date:
  • Site-wide: 75,748
• Since beginning of last month:
  • Site-wide: 75,386

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 970 times
• Download rankings, all-time:
  • Site-wide: 25,542
  • In genetic and genomic medicine: 102
• Year to date:
  • Site-wide: 8,563
• Since beginning of last month:
  • Site-wide: 27,395

COVID-19 transmission in a university setting: a rapid review of modelling studies

• Downloaded 950 times
• Download rankings, all-time:
  • Site-wide: 26,308
  • In health policy: 74
• Year to date:
  • Site-wide: 21,844
• Since beginning of last month:
  • Site-wide: 38,013

Tendency towards being a "Morning person" increases risk of Parkinson's disease: evidence from Mendelian randomisation

• Downloaded 886 times
• Download rankings, all-time:
  • Site-wide: 29,020
  • In epidemiology: 1,570
• Year to date:
  • Site-wide: 53,900
• Since beginning of last month:
  • Site-wide: 75,320

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes

• Downloaded 867 times
• Download rankings, all-time:
  • Site-wide: 29,904
  • In genomics: 2,649
• Year to date:
  • Site-wide: 76,869
• Since beginning of last month:
  • Site-wide: None

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

• Downloaded 830 times
• Download rankings, all-time:
  • Site-wide: 31,798
  • In bioinformatics: 3,553
• Year to date:
  • Site-wide: 77,016
• Since beginning of last month:
  • Site-wide: 23,812

The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

• Downloaded 805 times
• Download rankings, all-time:
  • Site-wide: 33,165
  • In epidemiology: 1,715
• Year to date:
  • Site-wide: 96,828
• Since beginning of last month:
  • Site-wide: 75,393

The MRC IEU OpenGWAS data infrastructure

• Downloaded 792 times
• Download rankings, all-time:
  • Site-wide: 33,915
  • In genetics: 1,550
• Year to date:
  • Site-wide: 10,222
• Since beginning of last month:
  • Site-wide: 38,371

The variant call format provides efficient and robust storage of GWAS summary statistics

• Downloaded 768 times
• Download rankings, all-time:
  • Site-wide: 35,409
  • In genetics: 1,616
• Year to date:
  • Site-wide: 24,437
• Since beginning of last month:
  • Site-wide: 12,598

Using genetic instruments to estimate interactions in Mendelian Randomization studies

• Downloaded 691 times
• Download rankings, all-time:
  • Site-wide: 40,899
  • In epidemiology: 2,017
• Year to date:
  • Site-wide: 45,073
• Since beginning of last month:
  • Site-wide: 33,741

Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

• Downloaded 670 times
• Download rankings, all-time:
  • Site-wide: 42,572
  • In systems biology: 931
• Year to date:
  • Site-wide: 132,941
• Since beginning of last month:
  • Site-wide: None

Appraising the causal relevance of DNA methylation for risk of lung cancer

• Downloaded 663 times
• Download rankings, all-time:
  • Site-wide: 43,236
  • In epidemiology: 2,101
• Year to date:
  • Site-wide: 115,127
• Since beginning of last month:
  • Site-wide: 75,318

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 588 times
• Download rankings, all-time:
  • Site-wide: 50,296
  • In epidemiology: 2,345
• Year to date:
  • Site-wide: 132,797
• Since beginning of last month:
  • Site-wide: 66,452

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 523 times
• Download rankings, all-time:
  • Site-wide: 58,002
  • In neuroscience: 8,490
• Year to date:
  • Site-wide: 134,118
• Since beginning of last month:
  • Site-wide: 84,992

Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

• Downloaded 515 times
• Download rankings, all-time:
  • Site-wide: 59,107
  • In genetics: 2,616
• Year to date:
  • Site-wide: 79,016
• Since beginning of last month:
  • Site-wide: 79,846

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

• Downloaded 513 times
• Download rankings, all-time:
  • Site-wide: 59,367
  • In epidemiology: 2,657
• Year to date:
  • Site-wide: 144,970
• Since beginning of last month:
  • Site-wide: None

Prenatal alcohol exposure and facial morphology in a UK cohort

• Downloaded 495 times
• Download rankings, all-time:
  • Site-wide: 61,772
  • In epidemiology: 2,741
• Year to date:
  • Site-wide: 78,117
• Since beginning of last month:
  • Site-wide: 24,398

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

• Downloaded 468 times
• Download rankings, all-time:
  • Site-wide: 65,668
  • In genetics: 2,887
• Year to date:
  • Site-wide: 146,260
• Since beginning of last month:
  • Site-wide: 73,112

Schizophrenia risk and reproductive success: A Mendelian randomization study.

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 69,935
  • In evolutionary biology: 3,654
• Year to date:
  • Site-wide: 134,603
• Since beginning of last month:
  • Site-wide: None

The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

• Downloaded 433 times
• Download rankings, all-time:
  • Site-wide: 71,323
  • In genetics: 3,147
• Year to date:
  • Site-wide: 67,697
• Since beginning of last month:
  • Site-wide: 21,092

Does Neuroticism Cause Depression? A Mendelian Randomization Study

• Downloaded 428 times
• Download rankings, all-time:
  • Site-wide: 72,131
  • In genetics: 3,171
• Year to date:
  • Site-wide: 150,461
• Since beginning of last month:
  • Site-wide: None

Assortative mating and within-spouse pair comparisons

• Downloaded 427 times
• Download rankings, all-time:
  • Site-wide: 72,300
  • In genetics: 3,178
• Year to date:
  • Site-wide: 63,248
• Since beginning of last month:
  • Site-wide: 95,826

The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: A two-step, two-sample Mendelian randomization study

• Downloaded 422 times
• Download rankings, all-time:
  • Site-wide: 73,117
  • In epidemiology: 3,158
• Year to date:
  • Site-wide: 133,220
• Since beginning of last month:
  • Site-wide: None

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

• Downloaded 377 times
• Download rankings, all-time:
  • Site-wide: 81,271
  • In epidemiology: 3,443
• Year to date:
  • Site-wide: 136,126
• Since beginning of last month:
  • Site-wide: None

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

• Downloaded 375 times
• Download rankings, all-time:
  • Site-wide: 81,639
  • In genetics: 3,561
• Year to date:
  • Site-wide: 144,409
• Since beginning of last month:
  • Site-wide: None

University students and staff able to maintain low daily contact numbers during various COVID-19 guideline periods

• Downloaded 359 times
• Download rankings, all-time:
  • Site-wide: 84,721
  • In epidemiology: 3,582
• Year to date:
  • Site-wide: 13,733
• Since beginning of last month:
  • Site-wide: 19,293

DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

• Downloaded 358 times
• Download rankings, all-time:
  • Site-wide: 84,976
  • In genetics: 3,714
• Year to date:
  • Site-wide: 134,605
• Since beginning of last month:
  • Site-wide: 73,110

Investigating DNA methylation as a potential mediator between pigmentation genes, pigmentary traits and skin cancer

• Downloaded 329 times
• Download rankings, all-time:
  • Site-wide: 91,124
  • In genetics: 3,950
• Year to date:
  • Site-wide: 60,516
• Since beginning of last month:
  • Site-wide: 34,315

Contacts and behaviours of university students during the COVID-19 pandemic at the start of the 2020/21 academic year

• Downloaded 324 times
• Download rankings, all-time:
  • Site-wide: 92,339
  • In public and global health: 1,165
• Year to date:
  • Site-wide: 25,495
• Since beginning of last month:
  • Site-wide: 107,928

Modelling pooling strategies for SARS-CoV-2 testing in a university setting

• Downloaded 299 times
• Download rankings, all-time:
  • Site-wide: 97,732
  • In infectious diseases: 4,258
• Year to date:
  • Site-wide: 17,825
• Since beginning of last month:
  • Site-wide: None

EpiGraphDB: a database and data mining platform for health data science

• Downloaded 254 times
• Download rankings, all-time:
  • Site-wide: 108,497
  • In bioinformatics: 9,160
• Year to date:
  • Site-wide: 122,586
• Since beginning of last month:
  • Site-wide: 100,610

The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers

• Downloaded 201 times
• Download rankings, all-time:
  • Site-wide: 121,623
  • In genetics: 5,051
• Year to date:
  • Site-wide: 147,126
• Since beginning of last month:
  • Site-wide: 93,627

Limits of lockdown: characterising essential contacts during strict physical distancing

• Downloaded 151 times
• Download rankings, all-time:
  • Site-wide: 133,310
  • In epidemiology: 5,532
• Year to date:
  • Site-wide: 41,987
• Since beginning of last month:
  • Site-wide: 111,176

Exploring the variance in complex traits captured by DNA methylation assays

• Downloaded 138 times
• Download rankings, all-time:
  • Site-wide: 136,330
  • In genetics: 5,496
• Year to date:
  • Site-wide: 109,586
• Since beginning of last month:
  • Site-wide: 50,175

Genetic analyses of common infections in the Avon Longitudinal Study of Parents and Children cohort

• Downloaded 73 times
• Download rankings, all-time:
  • Site-wide: 147,789
  • In epidemiology: 6,083
• Year to date:
  • Site-wide: 82,542
• Since beginning of last month:
  • Site-wide: 42,954

DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

• Downloaded 71 times
• Download rankings, all-time:
  • Site-wide: 148,028
  • In psychiatry and clinical psychology: 901
• Year to date:
  • Site-wide: 83,990
• Since beginning of last month:
  • Site-wide: 115,258

Navigating sample overlap, winner's curse and weak instrument bias in Mendelian randomization studies using the UK Biobank

• Downloaded 48 times
• Download rankings, all-time:
  • Site-wide: 150,307
  • In epidemiology: 6,186
• Year to date:
  • Site-wide: 108,628
• Since beginning of last month:
  • Site-wide: 17,844

Design and quality control of large-scale two-sample Mendelian randomisation studies

• Downloaded 2 times
• Download rankings, all-time:
  • Site-wide: 154,106
  • In epidemiology: 6,355
• Year to date:
  • Site-wide: 154,252
• Since beginning of last month:
  • Site-wide: 42,489