Author: Gibran Hemani

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Preprints

Review and further developments in statistical corrections for Winner's Curse in genetic association studies

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Collider bias undermines our understanding of COVID-19 disease risk and severity

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Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

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MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

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Within-sibship GWAS improve estimates of direct genetic effects

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Why are education, socioeconomic position and intelligence genetically correlated?

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Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

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Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases

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  • In genetic and genomic medicine: 58
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The MRC IEU OpenGWAS data infrastructure

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Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

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A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

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Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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High COVID-19 transmission potential associated with re-opening universities can be mitigated with layered interventions

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Meffil: efficient normalisation and analysis of very large DNA methylation samples

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Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

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Bayesian reassessment of the epigenetic architecture of complex traits

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Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

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Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

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  • Site-wide: 25,257
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Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

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  • Site-wide: 25,797
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  • Site-wide: 75,897

COVID-19 transmission in a university setting: a rapid review of modelling studies

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  • Site-wide: 27,622
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  • Site-wide: 76,008
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PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

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  • Site-wide: 27,954
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Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

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  • Site-wide: 31,046
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Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

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  • Site-wide: 31,715
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  • Site-wide: 182,937
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  • Site-wide: 100,388

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes

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University students and staff able to maintain low daily contact numbers during various COVID-19 guideline periods

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  • Site-wide: 9,517
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  • Site-wide: 107,977

Tendency towards being a "Morning person" increases risk of Parkinson's disease: evidence from Mendelian randomisation

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Using genetic instruments to estimate interactions in Mendelian Randomization studies

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The variant call format provides efficient and robust storage of GWAS summary statistics

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  • Site-wide: 38,514
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  • Site-wide: 71,417
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MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

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  • Site-wide: 40,229
  • In bioinformatics: 4,053
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  • Site-wide: 174,193

The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

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  • Site-wide: 40,988
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Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

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  • Site-wide: 73,987

Appraising the causal relevance of DNA methylation for risk of lung cancer

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  • Site-wide: 39,590

Prenatal alcohol exposure and facial morphology in a UK cohort

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  • Site-wide: 61,418
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Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

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  • Site-wide: 73,093
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Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

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  • Site-wide: 73,321
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What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

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  • In epidemiology: 3,550
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  • Site-wide: 101,541

Assortative mating and within-spouse pair comparisons

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  • Site-wide: 81,854
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The Parkinsons Disease Mendelian Randomization Research Portal

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Navigating sample overlap, winner's curse and weak instrument bias in Mendelian randomization studies using the UK Biobank

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The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

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Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

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Does Neuroticism Cause Depression? A Mendelian Randomization Study

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Schizophrenia risk and reproductive success: A Mendelian randomization study.

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  • Site-wide: 98,561
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Impacts of vaccination and asymptomatic testing on SARS-CoV-2 transmission dynamics in a university setting

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The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: A two-step, two-sample Mendelian randomization study

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The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

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Contacts and behaviours of university students during the COVID-19 pandemic at the start of the 2020/21 academic year

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  • Site-wide: 110,708
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  • Site-wide: 166,040

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

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  • Site-wide: 79,509

DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

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Investigating DNA methylation as a potential mediator between pigmentation genes, pigmentary traits and skin cancer

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Modelling pooling strategies for SARS-CoV-2 testing in a university setting

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  • Site-wide: 167,359

The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1

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Limits of lockdown: characterising essential contacts during strict physical distancing

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  • Site-wide: 134,640
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Design and quality control of large-scale two-sample Mendelian randomisation studies

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  • In epidemiology: 5,964
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  • Site-wide: 58,115

EpiGraphDB: a database and data mining platform for health data science

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  • Site-wide: 147,850
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  • Site-wide: 114,781

Evidence of positive and negative selection associated with DNA methylation

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DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

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  • Site-wide: 154,194
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  • Site-wide: 133,651

An efficient and robust tool for colocalisation: Pair-wise Conditional and Colocalisation (PWCoCo)

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  • Site-wide: 173,157

The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers

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Exploring the variance in complex traits captured by DNA methylation assays

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  • Site-wide: 162,607
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Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples

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  • In genetic and genomic medicine: 1,192
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  • Site-wide: 44,274

Evaluating the potential benefits and pitfalls of combining protein and expression quantitative trait loci in evidencing drug targets

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DNA co-methylation has a stable structure and is related to specific aspects of genome regulation

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  • Site-wide: 71,398

Trans-ancestry meta-analysis improves performance of genetic scores for multiple adiposity-related traits in East Asian populations

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  • In genetic and genomic medicine: 1,344
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  • Site-wide: 19,992

Genetic analyses of common infections in the Avon Longitudinal Study of Parents and Children cohort

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Investigating the transparency of reporting in two-sample summary data Mendelian randomization studies

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  • Site-wide: 181,629
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  • Site-wide: 177,446

A comparison of the genes and genesets identified by EWAS and GWAS of fourteen complex traits

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The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: A Mendelian randomization study

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  • In epidemiology: 7,724
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  • Site-wide: 117,048