Author: Gibran Hemani

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Preprints

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

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Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

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Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

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Why are education, socioeconomic position and intelligence genetically correlated?

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Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

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An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

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Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

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A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

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Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

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Meffil: efficient normalisation and analysis of very large DNA methylation samples

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Causal effects of lifetime smoking on risk for depression and schizophrenia: Evidence from a Mendelian randomisation study

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Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

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Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

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PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

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Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

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Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

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Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes

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The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

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Tendency towards being a "Morning person" increases risk of Parkinson's disease: evidence from Mendelian randomisation

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MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

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Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

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Appraising the causal relevance of DNA methylation for risk of lung cancer

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Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

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Using genetic instruments to estimate interactions in Mendelian Randomization studies

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Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

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The Parkinsons Disease Mendelian Randomization Research Portal

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Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

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Schizophrenia risk and reproductive success: A Mendelian randomization study.

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Does Neuroticism Cause Depression? A Mendelian Randomization Study

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The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: A two-step, two-sample Mendelian randomization study

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Prenatal alcohol exposure and facial morphology in a UK cohort

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Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

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The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

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DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

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Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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Assortative mating and within-spouse pair comparisons

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The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers

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