Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 65,351 bioRxiv papers from 289,483 authors.

Downloads per author, site-wide

Preprints

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

No bioRxiv download data for this paper yet.

A reference panel of 64,976 haplotypes for genotype imputation

• Downloaded 4,447 times
• Download rankings, all-time:
  • Site-wide: 534 out of 65,351
  • In genetics: 56 out of 3,696
• Year to date:
  • Site-wide: 39,751 out of 65,351
• Since beginning of last month:
  • Site-wide: 40,169 out of 65,351

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

• Downloaded 3,527 times
• Download rankings, all-time:
  • Site-wide: 838 out of 65,351
  • In epidemiology: 5 out of 1,556
• Year to date:
  • Site-wide: 7,393 out of 65,351
• Since beginning of last month:
  • Site-wide: 9,062 out of 65,351

PHESANT: a tool for performing automated phenome scans in UK Biobank

• Downloaded 2,667 times
• Download rankings, all-time:
  • Site-wide: 1,403 out of 65,351
  • In epidemiology: 9 out of 1,556
• Year to date:
  • Site-wide: 3,622 out of 65,351
• Since beginning of last month:
  • Site-wide: 7,213 out of 65,351

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

• Downloaded 2,569 times
• Download rankings, all-time:
  • Site-wide: 1,497 out of 65,351
  • In epidemiology: 11 out of 1,556
• Year to date:
  • Site-wide: 4,927 out of 65,351
• Since beginning of last month:
  • Site-wide: 6,555 out of 65,351

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

• Downloaded 2,366 times
• Download rankings, all-time:
  • Site-wide: 1,741 out of 65,351
  • In genetics: 165 out of 3,696
• Year to date:
  • Site-wide: 40,840 out of 65,351
• Since beginning of last month:
  • Site-wide: 52,858 out of 65,351

Collider Scope: When selection bias can substantially influence observed associations

• Downloaded 2,263 times
• Download rankings, all-time:
  • Site-wide: 1,898 out of 65,351
  • In epidemiology: 17 out of 1,556
• Year to date:
  • Site-wide: 18,392 out of 65,351
• Since beginning of last month:
  • Site-wide: 17,531 out of 65,351

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

• Downloaded 2,214 times
• Download rankings, all-time:
  • Site-wide: 1,971 out of 65,351
  • In genetics: 188 out of 3,696
• Year to date:
  • Site-wide: 25,710 out of 65,351
• Since beginning of last month:
  • Site-wide: 30,773 out of 65,351

Mendelian randomization: a premature burial?

• Downloaded 2,209 times
• Download rankings, all-time:
  • Site-wide: 1,983 out of 65,351
  • In genetics: 189 out of 3,696
• Year to date:
  • Site-wide: 33,785 out of 65,351
• Since beginning of last month:
  • Site-wide: 34,305 out of 65,351

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

• Downloaded 2,185 times
• Download rankings, all-time:
  • Site-wide: 2,023 out of 65,351
  • In epidemiology: 19 out of 1,556
• Year to date:
  • Site-wide: 45,271 out of 65,351
• Since beginning of last month:
  • Site-wide: 37,822 out of 65,351

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

• Downloaded 1,711 times
• Download rankings, all-time:
  • Site-wide: 3,076 out of 65,351
  • In epidemiology: 30 out of 1,556
• Year to date:
  • Site-wide: 7,019 out of 65,351
• Since beginning of last month:
  • Site-wide: 24,720 out of 65,351

Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

• Downloaded 1,677 times
• Download rankings, all-time:
  • Site-wide: 3,175 out of 65,351
  • In genetics: 272 out of 3,696
• Year to date:
  • Site-wide: 21,447 out of 65,351
• Since beginning of last month:
  • Site-wide: 28,571 out of 65,351

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

• Downloaded 1,610 times
• Download rankings, all-time:
  • Site-wide: 3,384 out of 65,351
  • In genetics: 292 out of 3,696
• Year to date:
  • Site-wide: 3,426 out of 65,351
• Since beginning of last month:
  • Site-wide: 20,032 out of 65,351

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

• Downloaded 1,550 times
• Download rankings, all-time:
  • Site-wide: 3,601 out of 65,351
  • In genetics: 311 out of 3,696
• Year to date:
  • Site-wide: 782 out of 65,351
• Since beginning of last month:
  • Site-wide: 1,746 out of 65,351

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

• Downloaded 1,547 times
• Download rankings, all-time:
  • Site-wide: 3,608 out of 65,351
  • In genetics: 312 out of 3,696
• Year to date:
  • Site-wide: 45,392 out of 65,351
• Since beginning of last month:
  • Site-wide: 44,336 out of 65,351

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,494 times
• Download rankings, all-time:
  • Site-wide: 3,847 out of 65,351
  • In genetics: 334 out of 3,696
• Year to date:
  • Site-wide: 13,640 out of 65,351
• Since beginning of last month:
  • Site-wide: 8,350 out of 65,351

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

• Downloaded 1,396 times
• Download rankings, all-time:
  • Site-wide: 4,318 out of 65,351
  • In genetics: 366 out of 3,696
• Year to date:
  • Site-wide: 955 out of 65,351
• Since beginning of last month:
  • Site-wide: 4,038 out of 65,351

Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

• Downloaded 1,362 times
• Download rankings, all-time:
  • Site-wide: 4,506 out of 65,351
  • In epidemiology: 43 out of 1,556
• Year to date:
  • Site-wide: 9,564 out of 65,351
• Since beginning of last month:
  • Site-wide: 10,088 out of 65,351

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

• Downloaded 1,293 times
• Download rankings, all-time:
  • Site-wide: 4,886 out of 65,351
  • In genetics: 396 out of 3,696
• Year to date:
  • Site-wide: 3,409 out of 65,351
• Since beginning of last month:
  • Site-wide: 6,244 out of 65,351

The Causal Effects of Education on Health, Mortality, Cognition, Well-being, and Income in the UK Biobank

• Downloaded 1,231 times
• Download rankings, all-time:
  • Site-wide: 5,298 out of 65,351
  • In epidemiology: 49 out of 1,556
• Year to date:
  • Site-wide: 33,822 out of 65,351
• Since beginning of last month:
  • Site-wide: 21,369 out of 65,351

An examination of multivariable Mendelian randomization in the single sample and two-sample summary data settings.

• Downloaded 1,208 times
• Download rankings, all-time:
  • Site-wide: 5,474 out of 65,351
  • In epidemiology: 53 out of 1,556
• Year to date:
  • Site-wide: 6,932 out of 65,351
• Since beginning of last month:
  • Site-wide: 12,689 out of 65,351

Searching for the causal effects of BMI in over 300 000 individuals, using Mendelian randomization

• Downloaded 1,195 times
• Download rankings, all-time:
  • Site-wide: 5,564 out of 65,351
  • In epidemiology: 56 out of 1,556
• Year to date:
  • Site-wide: 29,708 out of 65,351
• Since beginning of last month:
  • Site-wide: 48,837 out of 65,351

Do early life non-cognitive skills matter? A systematic review and meta-analysis of early life effects on academic achievement, psychosocial, language and cognitive, and health outcomes

• Downloaded 1,172 times
• Download rankings, all-time:
  • Site-wide: 5,754 out of 65,351
  • In epidemiology: 59 out of 1,556
• Year to date:
  • Site-wide: 21,565 out of 65,351
• Since beginning of last month:
  • Site-wide: 18,990 out of 65,351

Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

• Downloaded 1,166 times
• Download rankings, all-time:
  • Site-wide: 5,808 out of 65,351
  • In genetics: 463 out of 3,696
• Year to date:
  • Site-wide: 46,242 out of 65,351
• Since beginning of last month:
  • Site-wide: 52,541 out of 65,351

The genetic architecture of osteoarthritis: insights from UK Biobank

• Downloaded 1,151 times
• Download rankings, all-time:
  • Site-wide: 5,950 out of 65,351
  • In genetics: 477 out of 3,696
• Year to date:
  • Site-wide: 22,336 out of 65,351
• Since beginning of last month:
  • Site-wide: 29,984 out of 65,351

RSGenome-wide association study identifies 49 common genetic variants associated with handedness

• Downloaded 1,126 times
• Download rankings, all-time:
  • Site-wide: 6,153 out of 65,351
  • In genetics: 493 out of 3,696
• Year to date:
  • Site-wide: 1,418 out of 65,351
• Since beginning of last month:
  • Site-wide: 56 out of 65,351

Population phenomena inflate genetic associations of complex social traits

• Downloaded 1,100 times
• Download rankings, all-time:
  • Site-wide: 6,421 out of 65,351
  • In genetics: 513 out of 3,696
• Year to date:
  • Site-wide: 1,489 out of 65,351
• Since beginning of last month:
  • Site-wide: 988 out of 65,351

Meffil: efficient normalisation and analysis of very large DNA methylation samples

• Downloaded 1,087 times
• Download rankings, all-time:
  • Site-wide: 6,545 out of 65,351
  • In bioinformatics: 1,213 out of 6,471
• Year to date:
  • Site-wide: 26,857 out of 65,351
• Since beginning of last month:
  • Site-wide: 30,501 out of 65,351

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,080 times
• Download rankings, all-time:
  • Site-wide: 6,625 out of 65,351
  • In genetics: 530 out of 3,696
• Year to date:
  • Site-wide: 2,577 out of 65,351
• Since beginning of last month:
  • Site-wide: 4,416 out of 65,351

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

• Downloaded 1,068 times
• Download rankings, all-time:
  • Site-wide: 6,740 out of 65,351
  • In epidemiology: 65 out of 1,556
• Year to date:
  • Site-wide: 33,027 out of 65,351
• Since beginning of last month:
  • Site-wide: 26,440 out of 65,351

Cigarette smoking increases coffee consumption: findings from a Mendelian randomisation analysis

• Downloaded 1,041 times
• Download rankings, all-time:
  • Site-wide: 7,020 out of 65,351
  • In genetics: 552 out of 3,696
• Year to date:
  • Site-wide: 21,005 out of 65,351
• Since beginning of last month:
  • Site-wide: 17,931 out of 65,351

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank

• Downloaded 1,010 times
• Download rankings, all-time:
  • Site-wide: 7,350 out of 65,351
  • In genetics: 571 out of 3,696
• Year to date:
  • Site-wide: 2,839 out of 65,351
• Since beginning of last month:
  • Site-wide: 6,513 out of 65,351

Causal effects of lifetime smoking on risk for depression and schizophrenia: Evidence from a Mendelian randomisation study

• Downloaded 970 times
• Download rankings, all-time:
  • Site-wide: 7,832 out of 65,351
  • In epidemiology: 78 out of 1,556
• Year to date:
  • Site-wide: 3,547 out of 65,351
• Since beginning of last month:
  • Site-wide: 2,286 out of 65,351

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

• Downloaded 962 times
• Download rankings, all-time:
  • Site-wide: 7,948 out of 65,351
  • In genetics: 610 out of 3,696
• Year to date:
  • Site-wide: 1,867 out of 65,351
• Since beginning of last month:
  • Site-wide: 4,062 out of 65,351

Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

• Downloaded 937 times
• Download rankings, all-time:
  • Site-wide: 8,313 out of 65,351
  • In pharmacology and toxicology: 36 out of 543
• Year to date:
  • Site-wide: 50,189 out of 65,351
• Since beginning of last month:
  • Site-wide: 57,646 out of 65,351

Body mass index and mortality in UK Biobank: revised estimates using Mendelian randomization

• Downloaded 918 times
• Download rankings, all-time:
  • Site-wide: 8,603 out of 65,351
  • In epidemiology: 91 out of 1,556
• Year to date:
  • Site-wide: 19,526 out of 65,351
• Since beginning of last month:
  • Site-wide: 35,665 out of 65,351

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 903 times
• Download rankings, all-time:
  • Site-wide: 8,806 out of 65,351
  • In genetics: 656 out of 3,696
• Year to date:
  • Site-wide: 16,839 out of 65,351
• Since beginning of last month:
  • Site-wide: 30,629 out of 65,351

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

• Downloaded 866 times
• Download rankings, all-time:
  • Site-wide: 9,389 out of 65,351
  • In genetics: 695 out of 3,696
• Year to date:
  • Site-wide: 3,838 out of 65,351
• Since beginning of last month:
  • Site-wide: 16,267 out of 65,351

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 850 times
• Download rankings, all-time:
  • Site-wide: 9,656 out of 65,351
  • In genetics: 716 out of 3,696
• Year to date:
  • Site-wide: 36,299 out of 65,351
• Since beginning of last month:
  • Site-wide: 32,492 out of 65,351

Selection bias in instrumental variable analyses

• Downloaded 834 times
• Download rankings, all-time:
  • Site-wide: 9,936 out of 65,351
  • In epidemiology: 101 out of 1,556
• Year to date:
  • Site-wide: 8,379 out of 65,351
• Since beginning of last month:
  • Site-wide: 16,070 out of 65,351

The effect of education on adult mortality, health, and income: triangulating across genetic and policy reforms

• Downloaded 829 times
• Download rankings, all-time:
  • Site-wide: 10,021 out of 65,351
  • In epidemiology: 104 out of 1,556
• Year to date:
  • Site-wide: 14,749 out of 65,351
• Since beginning of last month:
  • Site-wide: 40,926 out of 65,351

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?

• Downloaded 828 times
• Download rankings, all-time:
  • Site-wide: 10,036 out of 65,351
  • In epidemiology: 105 out of 1,556
• Year to date:
  • Site-wide: 42,957 out of 65,351
• Since beginning of last month:
  • Site-wide: 56,942 out of 65,351

Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions

• Downloaded 824 times
• Download rankings, all-time:
  • Site-wide: 10,104 out of 65,351
  • In epidemiology: 106 out of 1,556
• Year to date:
  • Site-wide: 16,923 out of 65,351
• Since beginning of last month:
  • Site-wide: 21,658 out of 65,351

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

• Downloaded 821 times
• Download rankings, all-time:
  • Site-wide: 10,179 out of 65,351
  • In genetics: 750 out of 3,696
• Year to date:
  • Site-wide: 10,298 out of 65,351
• Since beginning of last month:
  • Site-wide: 15,451 out of 65,351

Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

• Downloaded 784 times
• Download rankings, all-time:
  • Site-wide: 10,925 out of 65,351
  • In epidemiology: 118 out of 1,556
• Year to date:
  • Site-wide: 38,667 out of 65,351
• Since beginning of last month:
  • Site-wide: 49,604 out of 65,351

Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression

• Downloaded 714 times
• Download rankings, all-time:
  • Site-wide: 12,529 out of 65,351
  • In epidemiology: 135 out of 1,556
• Year to date:
  • Site-wide: 30,456 out of 65,351
• Since beginning of last month:
  • Site-wide: 37,372 out of 65,351

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

• Downloaded 714 times
• Download rankings, all-time:
  • Site-wide: 12,544 out of 65,351
  • In epidemiology: 136 out of 1,556
• Year to date:
  • Site-wide: 17,980 out of 65,351
• Since beginning of last month:
  • Site-wide: 10,928 out of 65,351

Genetic Epidemiology And Mendelian Randomization For Informing Disease Therapeutics: Conceptual And Methodological Challenges

• Downloaded 705 times
• Download rankings, all-time:
  • Site-wide: 12,791 out of 65,351
  • In genetics: 893 out of 3,696
• Year to date:
  • Site-wide: 61,299 out of 65,351
• Since beginning of last month:
  • Site-wide: 51,408 out of 65,351

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

• Downloaded 700 times
• Download rankings, all-time:
  • Site-wide: 12,923 out of 65,351
  • In epidemiology: 142 out of 1,556
• Year to date:
  • Site-wide: 38,077 out of 65,351
• Since beginning of last month:
  • Site-wide: 40,993 out of 65,351

Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

• Downloaded 681 times
• Download rankings, all-time:
  • Site-wide: 13,424 out of 65,351
  • In genomics: 1,816 out of 4,459
• Year to date:
  • Site-wide: 38,803 out of 65,351
• Since beginning of last month:
  • Site-wide: 39,207 out of 65,351

Bayesian network analysis complements Mendelian randomization approaches for exploratory analysis of causal relationships in complex data

• Downloaded 653 times
• Download rankings, all-time:
  • Site-wide: 14,195 out of 65,351
  • In genetics: 989 out of 3,696
• Year to date:
  • Site-wide: 3,705 out of 65,351
• Since beginning of last month:
  • Site-wide: 2,358 out of 65,351

The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

• Downloaded 621 times
• Download rankings, all-time:
  • Site-wide: 15,233 out of 65,351
  • In epidemiology: 168 out of 1,556
• Year to date:
  • Site-wide: 39,757 out of 65,351
• Since beginning of last month:
  • Site-wide: 30,439 out of 65,351

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease

• Downloaded 605 times
• Download rankings, all-time:
  • Site-wide: 15,817 out of 65,351
  • In genetics: 1,089 out of 3,696
• Year to date:
  • Site-wide: 14,977 out of 65,351
• Since beginning of last month:
  • Site-wide: 43,759 out of 65,351

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

• Downloaded 598 times
• Download rankings, all-time:
  • Site-wide: 16,060 out of 65,351
  • In epidemiology: 182 out of 1,556
• Year to date:
  • Site-wide: 30,469 out of 65,351
• Since beginning of last month:
  • Site-wide: 30,940 out of 65,351

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

• Downloaded 596 times
• Download rankings, all-time:
  • Site-wide: 16,140 out of 65,351
  • In genetics: 1,112 out of 3,696
• Year to date:
  • Site-wide: 33,544 out of 65,351
• Since beginning of last month:
  • Site-wide: 58,651 out of 65,351

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

• Downloaded 591 times
• Download rankings, all-time:
  • Site-wide: 16,333 out of 65,351
  • In genetics: 1,121 out of 3,696
• Year to date:
  • Site-wide: 29,001 out of 65,351
• Since beginning of last month:
  • Site-wide: 38,807 out of 65,351

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 588 times
• Download rankings, all-time:
  • Site-wide: 16,414 out of 65,351
  • In genetics: 1,125 out of 3,696
• Year to date:
  • Site-wide: 24,801 out of 65,351
• Since beginning of last month:
  • Site-wide: 39,145 out of 65,351

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

• Downloaded 579 times
• Download rankings, all-time:
  • Site-wide: 16,777 out of 65,351
  • In genetics: 1,144 out of 3,696
• Year to date:
  • Site-wide: 44,874 out of 65,351
• Since beginning of last month:
  • Site-wide: 44,572 out of 65,351

The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children

• Downloaded 565 times
• Download rankings, all-time:
  • Site-wide: 17,373 out of 65,351
  • In genetics: 1,175 out of 3,696
• Year to date:
  • Site-wide: 47,315 out of 65,351
• Since beginning of last month:
  • Site-wide: 49,075 out of 65,351

Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

• Downloaded 559 times
• Download rankings, all-time:
  • Site-wide: 17,629 out of 65,351
  • In systems biology: 540 out of 1,835
• Year to date:
  • Site-wide: 56,925 out of 65,351
• Since beginning of last month:
  • Site-wide: 35,234 out of 65,351

Examining the genetic influences of educational attainment and the validity of value-added measures of progress

• Downloaded 553 times
• Download rankings, all-time:
  • Site-wide: 17,891 out of 65,351
  • In genetics: 1,200 out of 3,696
• Year to date:
  • Site-wide: 33,972 out of 65,351
• Since beginning of last month:
  • Site-wide: 32,452 out of 65,351

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

• Downloaded 551 times
• Download rankings, all-time:
  • Site-wide: 17,978 out of 65,351
  • In epidemiology: 216 out of 1,556
• Year to date:
  • Site-wide: 29,326 out of 65,351
• Since beginning of last month:
  • Site-wide: 63,124 out of 65,351

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

• Downloaded 551 times
• Download rankings, all-time:
  • Site-wide: 17,971 out of 65,351
  • In genetics: 1,209 out of 3,696
• Year to date:
  • Site-wide: 59,708 out of 65,351
• Since beginning of last month:
  • Site-wide: 42,428 out of 65,351

Education and coronary heart disease: a Mendelian randomization study

• Downloaded 550 times
• Download rankings, all-time:
  • Site-wide: 18,010 out of 65,351
  • In epidemiology: 218 out of 1,556
• Year to date:
  • Site-wide: 55,632 out of 65,351
• Since beginning of last month:
  • Site-wide: 44,843 out of 65,351

Distinct Blood DNA Methylation Profiles In Subtypes Of Orofacial Cleft

• Downloaded 535 times
• Download rankings, all-time:
  • Site-wide: 18,655 out of 65,351
  • In epidemiology: 231 out of 1,556
• Year to date:
  • Site-wide: 46,234 out of 65,351
• Since beginning of last month:
  • Site-wide: 46,044 out of 65,351

Can education be personalised using pupils' genetic data?

• Downloaded 533 times
• Download rankings, all-time:
  • Site-wide: 18,729 out of 65,351
  • In genetics: 1,253 out of 3,696
• Year to date:
  • Site-wide: 5,205 out of 65,351
• Since beginning of last month:
  • Site-wide: 4,245 out of 65,351

Using genetics to examine a general liability to childhood psychopathology

• Downloaded 529 times
• Download rankings, all-time:
  • Site-wide: 18,914 out of 65,351
  • In genetics: 1,267 out of 3,696
• Year to date:
  • Site-wide: 14,773 out of 65,351
• Since beginning of last month:
  • Site-wide: 14,042 out of 65,351

Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

• Downloaded 523 times
• Download rankings, all-time:
  • Site-wide: 19,193 out of 65,351
  • In epidemiology: 240 out of 1,556
• Year to date:
  • Site-wide: 56,699 out of 65,351
• Since beginning of last month:
  • Site-wide: 35,615 out of 65,351

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

• Downloaded 510 times
• Download rankings, all-time:
  • Site-wide: 19,862 out of 65,351
  • In bioinformatics: 2,932 out of 6,471
• Year to date:
  • Site-wide: 12,073 out of 65,351
• Since beginning of last month:
  • Site-wide: 15,263 out of 65,351

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

• Downloaded 495 times
• Download rankings, all-time:
  • Site-wide: 20,531 out of 65,351
  • In genomics: 2,356 out of 4,459
• Year to date:
  • Site-wide: 39,967 out of 65,351
• Since beginning of last month:
  • Site-wide: 35,187 out of 65,351

Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population

• Downloaded 494 times
• Download rankings, all-time:
  • Site-wide: 20,582 out of 65,351
  • In genetics: 1,386 out of 3,696
• Year to date:
  • Site-wide: 52,566 out of 65,351
• Since beginning of last month:
  • Site-wide: 47,336 out of 65,351

Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

• Downloaded 489 times
• Download rankings, all-time:
  • Site-wide: 20,829 out of 65,351
  • In epidemiology: 269 out of 1,556
• Year to date:
  • Site-wide: 54,339 out of 65,351
• Since beginning of last month:
  • Site-wide: 46,855 out of 65,351

Investigating causal pathways between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization.

• Downloaded 470 times
• Download rankings, all-time:
  • Site-wide: 21,887 out of 65,351
  • In genetics: 1,463 out of 3,696
• Year to date:
  • Site-wide: 6,411 out of 65,351
• Since beginning of last month:
  • Site-wide: 10,284 out of 65,351

Metabolic signatures of birth weight in 18288 adolescents and adults

• Downloaded 457 times
• Download rankings, all-time:
  • Site-wide: 22,666 out of 65,351
  • In systems biology: 679 out of 1,835
• Year to date:
  • Site-wide: 51,606 out of 65,351
• Since beginning of last month:
  • Site-wide: 47,080 out of 65,351

Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study

• Downloaded 453 times
• Download rankings, all-time:
  • Site-wide: 22,893 out of 65,351
  • In genetics: 1,534 out of 3,696
• Year to date:
  • Site-wide: 49,364 out of 65,351
• Since beginning of last month:
  • Site-wide: 61,934 out of 65,351

Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics

• Downloaded 450 times
• Download rankings, all-time:
  • Site-wide: 23,045 out of 65,351
  • In epidemiology: 306 out of 1,556
• Year to date:
  • Site-wide: 38,722 out of 65,351
• Since beginning of last month:
  • Site-wide: 42,977 out of 65,351

Conditioning on a collider may induce spurious associations: Do the results of Gale et al. (2017) support a protective effect of neuroticism in population sub-groups?

• Downloaded 446 times
• Download rankings, all-time:
  • Site-wide: 23,269 out of 65,351
  • In epidemiology: 310 out of 1,556
• Year to date:
  • Site-wide: 56,979 out of 65,351
• Since beginning of last month:
  • Site-wide: 59,049 out of 65,351

Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study

• Downloaded 428 times
• Download rankings, all-time:
  • Site-wide: 24,374 out of 65,351
  • In epidemiology: 334 out of 1,556
• Year to date:
  • Site-wide: 44,916 out of 65,351
• Since beginning of last month:
  • Site-wide: 50,602 out of 65,351

Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

• Downloaded 422 times
• Download rankings, all-time:
  • Site-wide: 24,825 out of 65,351
  • In epidemiology: 344 out of 1,556
• Year to date:
  • Site-wide: 21,528 out of 65,351
• Since beginning of last month:
  • Site-wide: 23,147 out of 65,351

Cigarette smoking and personality: Investigating causality using Mendelian randomization

• Downloaded 422 times
• Download rankings, all-time:
  • Site-wide: 24,793 out of 65,351
  • In epidemiology: 343 out of 1,556
• Year to date:
  • Site-wide: 31,378 out of 65,351
• Since beginning of last month:
  • Site-wide: 24,080 out of 65,351

Cleft lip/palate and educational attainment: cause, consequence, or correlation? A Mendelian randomization study

• Downloaded 421 times
• Download rankings, all-time:
  • Site-wide: 24,840 out of 65,351
  • In genetics: 1,632 out of 3,696
• Year to date:
  • Site-wide: 11,918 out of 65,351
• Since beginning of last month:
  • Site-wide: 17,731 out of 65,351

Educational attainment causally impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study in ~ 780,000 study participants

• Downloaded 403 times
• Download rankings, all-time:
  • Site-wide: 26,073 out of 65,351
  • In epidemiology: 370 out of 1,556
• Year to date:
  • Site-wide: 8,267 out of 65,351
• Since beginning of last month:
  • Site-wide: 8,712 out of 65,351

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

• Downloaded 366 times
• Download rankings, all-time:
  • Site-wide: 28,913 out of 65,351
  • In genetics: 1,857 out of 3,696
• Year to date:
  • Site-wide: 53,716 out of 65,351
• Since beginning of last month:
  • Site-wide: 48,533 out of 65,351

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

• Downloaded 364 times
• Download rankings, all-time:
  • Site-wide: 29,065 out of 65,351
  • In epidemiology: 419 out of 1,556
• Year to date:
  • Site-wide: 18,269 out of 65,351
• Since beginning of last month:
  • Site-wide: 36,163 out of 65,351

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

• Downloaded 363 times
• Download rankings, all-time:
  • Site-wide: 29,101 out of 65,351
  • In genetics: 1,869 out of 3,696
• Year to date:
  • Site-wide: 30,775 out of 65,351
• Since beginning of last month:
  • Site-wide: 39,290 out of 65,351

Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life

• Downloaded 343 times
• Download rankings, all-time:
  • Site-wide: 30,819 out of 65,351
  • In genetics: 1,968 out of 3,696
• Year to date:
  • Site-wide: 10,821 out of 65,351
• Since beginning of last month:
  • Site-wide: 4,672 out of 65,351

Association Between Genetically Elevated Levels Of Inflammatory Biomarkers And Risk Of Schizophrenia: A Two-Sample Mendelian Randomisation Study

• Downloaded 340 times
• Download rankings, all-time:
  • Site-wide: 31,098 out of 65,351
  • In epidemiology: 465 out of 1,556
• Year to date:
  • Site-wide: 52,048 out of 65,351
• Since beginning of last month:
  • Site-wide: 48,675 out of 65,351

Investigating the longitudinal consistency and genetic architecture of non-cognitive skills, and their relation to educational attainment

• Downloaded 335 times
• Download rankings, all-time:
  • Site-wide: 31,512 out of 65,351
  • In genetics: 2,004 out of 3,696
• Year to date:
  • Site-wide: 22,076 out of 65,351
• Since beginning of last month:
  • Site-wide: 20,569 out of 65,351

Schizophrenia risk and reproductive success: A Mendelian randomization study.

• Downloaded 327 times
• Download rankings, all-time:
  • Site-wide: 32,235 out of 65,351
  • In evolutionary biology: 2,429 out of 4,362
• Year to date:
  • Site-wide: 38,873 out of 65,351
• Since beginning of last month:
  • Site-wide: 61,377 out of 65,351

The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study

• Downloaded 323 times
• Download rankings, all-time:
  • Site-wide: 32,583 out of 65,351
  • In epidemiology: 500 out of 1,556
• Year to date:
  • Site-wide: 40,306 out of 65,351
• Since beginning of last month:
  • Site-wide: 33,442 out of 65,351

Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures

• Downloaded 321 times
• Download rankings, all-time:
  • Site-wide: 32,789 out of 65,351
  • In genetics: 2,072 out of 3,696
• Year to date:
  • Site-wide: 20,086 out of 65,351
• Since beginning of last month:
  • Site-wide: 27,260 out of 65,351

Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

• Downloaded 315 times
• Download rankings, all-time:
  • Site-wide: 33,448 out of 65,351
  • In genetics: 2,113 out of 3,696
• Year to date:
  • Site-wide: 25,497 out of 65,351
• Since beginning of last month:
  • Site-wide: 14,547 out of 65,351

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

• Downloaded 309 times
• Download rankings, all-time:
  • Site-wide: 34,016 out of 65,351
  • In genetics: 2,137 out of 3,696
• Year to date:
  • Site-wide: 12,708 out of 65,351
• Since beginning of last month:
  • Site-wide: 9,461 out of 65,351

MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

• Downloaded 308 times
• Download rankings, all-time:
  • Site-wide: 34,075 out of 65,351
  • In epidemiology: 532 out of 1,556
• Year to date:
  • Site-wide: 26,663 out of 65,351
• Since beginning of last month:
  • Site-wide: 27,458 out of 65,351

Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

• Downloaded 304 times
• Download rankings, all-time:
  • Site-wide: 34,470 out of 65,351
  • In epidemiology: 543 out of 1,556
• Year to date:
  • Site-wide: 56,153 out of 65,351
• Since beginning of last month:
  • Site-wide: 40,159 out of 65,351

The median and the mode as robust meta-analysis methods in the presence of small study effects

• Downloaded 304 times
• Download rankings, all-time:
  • Site-wide: 34,482 out of 65,351
  • In epidemiology: 542 out of 1,556
• Year to date:
  • Site-wide: 27,387 out of 65,351
• Since beginning of last month:
  • Site-wide: 32,192 out of 65,351

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 301 times
• Download rankings, all-time:
  • Site-wide: 34,782 out of 65,351
  • In neuroscience: 6,043 out of 11,706
• Year to date:
  • Site-wide: 13,219 out of 65,351
• Since beginning of last month:
  • Site-wide: 15,667 out of 65,351

PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

• Downloaded 300 times
• Download rankings, all-time:
  • Site-wide: 34,827 out of 65,351
  • In epidemiology: 555 out of 1,556
• Year to date:
  • Site-wide: 37,833 out of 65,351
• Since beginning of last month:
  • Site-wide: 39,956 out of 65,351

Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study

• Downloaded 299 times
• Download rankings, all-time:
  • Site-wide: 34,941 out of 65,351
  • In epidemiology: 557 out of 1,556
• Year to date:
  • Site-wide: 40,823 out of 65,351
• Since beginning of last month:
  • Site-wide: 24,050 out of 65,351

Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 36,132 out of 65,351
  • In epidemiology: 589 out of 1,556
• Year to date:
  • Site-wide: 23,622 out of 65,351
• Since beginning of last month:
  • Site-wide: 43,098 out of 65,351

CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 36,289 out of 65,351
  • In genetics: 2,264 out of 3,696
• Year to date:
  • Site-wide: 38,413 out of 65,351
• Since beginning of last month:
  • Site-wide: 48,655 out of 65,351

The association between adiposity and inpatient hospital costs in the UK Biobank cohort

• Downloaded 279 times
• Download rankings, all-time:
  • Site-wide: 37,057 out of 65,351
  • In epidemiology: 616 out of 1,556
• Year to date:
  • Site-wide: 38,784 out of 65,351
• Since beginning of last month:
  • Site-wide: 38,501 out of 65,351

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 37,442 out of 65,351
  • In genetics: 2,320 out of 3,696
• Year to date:
  • Site-wide: 57,908 out of 65,351
• Since beginning of last month:
  • Site-wide: 60,295 out of 65,351

Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisation

• Downloaded 274 times
• Download rankings, all-time:
  • Site-wide: 37,586 out of 65,351
  • In epidemiology: 626 out of 1,556
• Year to date:
  • Site-wide: 54,230 out of 65,351
• Since beginning of last month:
  • Site-wide: 43,728 out of 65,351

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 274 times
• Download rankings, all-time:
  • Site-wide: 37,559 out of 65,351
  • In epidemiology: 628 out of 1,556
• Year to date:
  • Site-wide: 15,110 out of 65,351
• Since beginning of last month:
  • Site-wide: 29,747 out of 65,351

The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank

• Downloaded 266 times
• Download rankings, all-time:
  • Site-wide: 38,466 out of 65,351
  • In epidemiology: 645 out of 1,556
• Year to date:
  • Site-wide: 15,775 out of 65,351
• Since beginning of last month:
  • Site-wide: 22,195 out of 65,351

Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease

• Downloaded 257 times
• Download rankings, all-time:
  • Site-wide: 39,391 out of 65,351
  • In epidemiology: 668 out of 1,556
• Year to date:
  • Site-wide: 23,988 out of 65,351
• Since beginning of last month:
  • Site-wide: 48,388 out of 65,351

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 39,610 out of 65,351
  • In genetics: 2,429 out of 3,696
• Year to date:
  • Site-wide: 47,501 out of 65,351
• Since beginning of last month:
  • Site-wide: 56,216 out of 65,351

DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

• Downloaded 252 times
• Download rankings, all-time:
  • Site-wide: 39,960 out of 65,351
  • In genetics: 2,444 out of 3,696
• Year to date:
  • Site-wide: 58,539 out of 65,351
• Since beginning of last month:
  • Site-wide: 54,103 out of 65,351

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

• Downloaded 242 times
• Download rankings, all-time:
  • Site-wide: 41,219 out of 65,351
  • In epidemiology: 730 out of 1,556
• Year to date:
  • Site-wide: 27,563 out of 65,351
• Since beginning of last month:
  • Site-wide: 38,590 out of 65,351

Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer

• Downloaded 229 times
• Download rankings, all-time:
  • Site-wide: 42,874 out of 65,351
  • In epidemiology: 777 out of 1,556
• Year to date:
  • Site-wide: 19,426 out of 65,351
• Since beginning of last month:
  • Site-wide: 8,166 out of 65,351

A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank

• Downloaded 225 times
• Download rankings, all-time:
  • Site-wide: 43,302 out of 65,351
  • In epidemiology: 800 out of 1,556
• Year to date:
  • Site-wide: 19,883 out of 65,351
• Since beginning of last month:
  • Site-wide: 15,478 out of 65,351

A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target

• Downloaded 217 times
• Download rankings, all-time:
  • Site-wide: 44,337 out of 65,351
  • In genetics: 2,682 out of 3,696
• Year to date:
  • Site-wide: 20,897 out of 65,351
• Since beginning of last month:
  • Site-wide: 38,342 out of 65,351

Identifying novel subtypes of irritability using a developmental genetic approach

• Downloaded 214 times
• Download rankings, all-time:
  • Site-wide: 44,734 out of 65,351
  • In genetics: 2,701 out of 3,696
• Year to date:
  • Site-wide: 32,360 out of 65,351
• Since beginning of last month:
  • Site-wide: 22,923 out of 65,351

Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

• Downloaded 197 times
• Download rankings, all-time:
  • Site-wide: 46,927 out of 65,351
  • In genomics: 3,816 out of 4,459
• Year to date:
  • Site-wide: 23,527 out of 65,351
• Since beginning of last month:
  • Site-wide: 10,819 out of 65,351

Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals

• Downloaded 190 times
• Download rankings, all-time:
  • Site-wide: 47,917 out of 65,351
  • In genetics: 2,862 out of 3,696
• Year to date:
  • Site-wide: 63,741 out of 65,351
• Since beginning of last month:
  • Site-wide: 59,412 out of 65,351

Mendelian randomization does not support serum calcium in prostate cancer risk

• Downloaded 190 times
• Download rankings, all-time:
  • Site-wide: 47,926 out of 65,351
  • In epidemiology: 942 out of 1,556
• Year to date:
  • Site-wide: 58,205 out of 65,351
• Since beginning of last month:
  • Site-wide: 57,121 out of 65,351

ADHD genetic liability and physical health outcomes - A two-sample Mendelian randomization study

• Downloaded 189 times
• Download rankings, all-time:
  • Site-wide: 48,005 out of 65,351
  • In epidemiology: 951 out of 1,556
• Year to date:
  • Site-wide: 24,748 out of 65,351
• Since beginning of last month:
  • Site-wide: 27,692 out of 65,351

Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype

• Downloaded 170 times
• Download rankings, all-time:
  • Site-wide: 50,582 out of 65,351
  • In epidemiology: 1,050 out of 1,556
• Year to date:
  • Site-wide: 46,507 out of 65,351
• Since beginning of last month:
  • Site-wide: 47,056 out of 65,351

Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health

• Downloaded 170 times
• Download rankings, all-time:
  • Site-wide: 50,675 out of 65,351
  • In epidemiology: 1,042 out of 1,556
• Year to date:
  • Site-wide: 27,916 out of 65,351
• Since beginning of last month:
  • Site-wide: 30,177 out of 65,351

Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis

• Downloaded 162 times
• Download rankings, all-time:
  • Site-wide: 51,751 out of 65,351
  • In genomics: 3,997 out of 4,459
• Year to date:
  • Site-wide: 29,466 out of 65,351
• Since beginning of last month:
  • Site-wide: 15,998 out of 65,351

Polygenic risk score for Alzheimer's disease and trajectories of cardiometabolic risk factors in children

• Downloaded 127 times
• Download rankings, all-time:
  • Site-wide: 56,636 out of 65,351
  • In epidemiology: 1,277 out of 1,556
• Year to date:
  • Site-wide: 37,313 out of 65,351
• Since beginning of last month:
  • Site-wide: 51,537 out of 65,351

Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

• Downloaded 91 times
• Download rankings, all-time:
  • Site-wide: 60,799 out of 65,351
  • In genetics: 3,489 out of 3,696
• Year to date:
  • Site-wide: 48,211 out of 65,351
• Since beginning of last month:
  • Site-wide: 4,693 out of 65,351