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Author: George Davey Smith

Rankings

  • All-time downloads: 270,530 (rank: 311 )
  • Categories:
    • bioinformatics: 2,970 (rank: 5,964 (tie) )
    • cardiovascular medicine: 1,362 (rank: 520 (tie) )
    • epidemiology: 150,794 (rank: 115 )
    • evolutionary biology: 470 (rank: 18,249 (tie) )
    • genetic and genomic medicine: 9,246 (rank: 146 )
    • genetics: 79,381 (rank: 44 )
    • genomics: 4,367 (rank: 6,842 )
    • health economics: 456 (rank: 583 (tie) )
    • health informatics: 312 (rank: 3,512 (tie) )
    • infectious diseases: 451 (rank: 47,571 (tie) )
    • neurology: 2,399 (rank: 648 )
    • neuroscience: 545 (rank: 55,487 (tie) )
    • ophthalmology: 479 (rank: 418 (tie) )
    • pharmacology and toxicology: 1,106 (rank: 1,535 (tie) )
    • psychiatry and clinical psychology: 2,172 (rank: 720 )
    • respiratory medicine: 645 (rank: 1,666 )
    • rheumatology: 365 (rank: 1,135 (tie) )
    • systems biology: 1,331 (rank: 4,102 (tie) )

Downloads per author, site-wide

Preprints

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization

genetic and genomic medicine more details view paper

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Selection into shift work is influenced by educational attainment and body mass index: A Mendelian randomization study

epidemiology more details view paper
  • Downloaded 62,187 times
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    • Site-wide: 134
    • In epidemiology: 31
  • Year to date:
    • Site-wide: 24,033
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    • Site-wide: 95,998

Collider bias undermines our understanding of COVID-19 disease risk and severity

epidemiology more details view paper
  • Downloaded 13,375 times
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    • Site-wide: 881
    • In epidemiology: 129
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A reference panel of 64,976 haplotypes for genotype imputation

genetics more details view paper
  • Downloaded 4,695 times
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    • Site-wide: 3,441
    • In genetics: 92
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    • Site-wide: 126,419
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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

genetics more details view paper
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    • Site-wide: 3,826
    • In genetics: 109
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MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

epidemiology more details view paper
  • Downloaded 4,304 times
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    • Site-wide: 3,858
    • In epidemiology: 394
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    • Site-wide: 55,799
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Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

epidemiology more details view paper
  • Downloaded 4,258 times
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    • Site-wide: 3,923
    • In epidemiology: 416
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PHESANT: a tool for performing automated phenome scans in UK Biobank

epidemiology more details view paper
  • Downloaded 3,891 times
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    • Site-wide: 4,460
    • In epidemiology: 432
  • Year to date:
    • Site-wide: 35,897
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Within-sibship GWAS improve estimates of direct genetic effects

genetics more details view paper
  • Downloaded 3,257 times
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    • Site-wide: 5,787
    • In genetics: 242
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    • Site-wide: 2,970
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Collider Scope: When selection bias can substantially influence observed associations

epidemiology more details view paper
  • Downloaded 2,976 times
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    • Site-wide: 6,589
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Genome-wide association study identifies 48 common genetic variants associated with handedness

genetics more details view paper
  • Downloaded 2,893 times
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    • Site-wide: 6,859
    • In genetics: 250
  • Year to date:
    • Site-wide: 46,283
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    • Site-wide: 61,447

Why are education, socioeconomic position and intelligence genetically correlated?

genetics more details view paper
  • Downloaded 2,696 times
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    • Site-wide: 7,597
    • In genetics: 290
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Mendelian randomization: a premature burial?

genetics more details view paper
  • Downloaded 2,604 times
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    • Site-wide: 8,030
    • In genetics: 301
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    • Site-wide: 104,512
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    • Site-wide: 91,060

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

genetics more details view paper
  • Downloaded 2,582 times
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    • Site-wide: 8,138
    • In genetics: 303
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    • Site-wide: 121,678
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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

genetics more details view paper
  • Downloaded 2,489 times
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    • Site-wide: 8,565
    • In genetics: 324
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    • Site-wide: 99,416
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Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

genetics more details view paper
  • Downloaded 2,471 times
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    • Site-wide: 8,639
    • In genetics: 340
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    • Site-wide: 47,958
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    • Site-wide: 57,130

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

epidemiology more details view paper
  • Downloaded 2,416 times
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    • Site-wide: 8,926
    • In epidemiology: 694
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    • Site-wide: 163,110
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    • Site-wide: 144,159

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

genetics more details view paper
  • Downloaded 2,215 times
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    • Site-wide: 10,123
    • In genetics: 378
  • Year to date:
    • Site-wide: 68,768
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    • Site-wide: 78,214

Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

epidemiology more details view paper
  • Downloaded 2,156 times
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    • Site-wide: 10,557
    • In epidemiology: 818
  • Year to date:
    • Site-wide: 42,143
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Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

epidemiology more details view paper
  • Downloaded 2,089 times
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    • Site-wide: 11,126
    • In epidemiology: 832
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    • Site-wide: 96,650
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    • Site-wide: 113,919

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

genetics more details view paper
  • Downloaded 2,085 times
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    • Site-wide: 11,163
    • In genetics: 418
  • Year to date:
    • Site-wide: 55,798
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Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

neurology more details view paper
  • Downloaded 2,063 times
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    • Site-wide: 11,327
    • In neurology: 29
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Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases

genetic and genomic medicine more details view paper
  • Downloaded 2,060 times
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    • Site-wide: 11,357
    • In genetic and genomic medicine: 81
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    • Site-wide: 613
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    • Site-wide: 4,434

Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

genetics more details view paper
  • Downloaded 1,987 times
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    • Site-wide: 11,971
    • In genetics: 439
  • Year to date:
    • Site-wide: 153,619
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    • Site-wide: 146,740

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

genetics more details view paper
  • Downloaded 1,867 times
  • Download rankings, all-time:
    • Site-wide: 13,115
    • In genetics: 500
  • Year to date:
    • Site-wide: 110,848
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    • Site-wide: 86,061

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

genetics more details view paper
  • Downloaded 1,861 times
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    • Site-wide: 13,172
    • In genetics: 498
  • Year to date:
    • Site-wide: 124,807
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    • Site-wide: 116,301

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

genetics more details view paper
  • Downloaded 1,817 times
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    • Site-wide: 13,636
    • In genetics: 517
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    • Site-wide: 145,649
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    • Site-wide: 91,115

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

genetics more details view paper
  • Downloaded 1,726 times
  • Download rankings, all-time:
    • Site-wide: 14,733
    • In genetics: 576
  • Year to date:
    • Site-wide: 145,645
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    • Site-wide: 146,301

An examination of multivariable Mendelian randomization in the single sample and two-sample summary data settings.

epidemiology more details view paper
  • Downloaded 1,707 times
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    • Site-wide: 14,976
    • In epidemiology: 1,049
  • Year to date:
    • Site-wide: 66,277
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    • Site-wide: 130,856

The MRC IEU OpenGWAS data infrastructure

genetics more details view paper
  • Downloaded 1,699 times
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    • Site-wide: 15,076
    • In genetics: 887
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    • Site-wide: 4,399
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    • Site-wide: 3,450

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

genetics more details view paper
  • Downloaded 1,687 times
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    • Site-wide: 15,226
    • In genetics: 598
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    • Site-wide: 155,593
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    • Site-wide: 129,605

Multi-ancestry omic Mendelian randomization revealing putative drug targets of COVID-19 severity

genetic and genomic medicine more details view paper
  • Downloaded 1,687 times
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    • Site-wide: 15,236
    • In genetic and genomic medicine: 91
  • Year to date:
    • Site-wide: 19,019
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    • Site-wide: 22,978

Selection bias in instrumental variable analyses

epidemiology more details view paper
  • Downloaded 1,657 times
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    • Site-wide: 15,643
    • In epidemiology: 1,097
  • Year to date:
    • Site-wide: 52,088
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    • Site-wide: 40,680

Cigarette smoking increases coffee consumption: findings from a Mendelian randomisation analysis

genetics more details view paper
  • Downloaded 1,583 times
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    • Site-wide: 16,800
    • In genetics: 685
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    • Site-wide: 94,350
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The Causal Effects of Education on Health, Mortality, Cognition, Well-being, and Income in the UK Biobank

epidemiology more details view paper
  • Downloaded 1,566 times
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    • Site-wide: 17,114
    • In epidemiology: 1,128
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    • Site-wide: 89,377
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    • Site-wide: 116,845

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

genetics more details view paper
  • Downloaded 1,547 times
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    • Site-wide: 17,422
    • In genetics: 768
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    • Site-wide: 19,026
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    • Site-wide: 44,189

Do early life non-cognitive skills matter? A systematic review and meta-analysis of early life effects on academic achievement, psychosocial, language and cognitive, and health outcomes

epidemiology more details view paper
  • Downloaded 1,491 times
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    • Site-wide: 18,392
    • In epidemiology: 1,197
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    • Site-wide: 94,335
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    • Site-wide: 105,357

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

genetics more details view paper
  • Downloaded 1,488 times
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    • Site-wide: 18,454
    • In genetics: 739
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    • Site-wide: 155,290
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    • Site-wide: 113,844

The genetic architecture of osteoarthritis: insights from UK Biobank

genetics more details view paper
  • Downloaded 1,458 times
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    • Site-wide: 19,056
    • In genetics: 766
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    • Site-wide: 141,022

Meffil: efficient normalisation and analysis of very large DNA methylation samples

bioinformatics more details view paper
  • Downloaded 1,457 times
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    • Site-wide: 19,062
    • In bioinformatics: 2,025
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Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

epidemiology more details view paper
  • Downloaded 1,436 times
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    • Site-wide: 19,550
    • In epidemiology: 1,268
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    • Site-wide: 65,866

The causes and consequences of Alzheimer's disease: A Mendelian randomization analysis

genetic and genomic medicine more details view paper
  • Downloaded 1,426 times
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    • Site-wide: 19,733
    • In genetic and genomic medicine: 100
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Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

genetic and genomic medicine more details view paper
  • Downloaded 1,424 times
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    • Site-wide: 19,766
    • In genetic and genomic medicine: 98
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Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

genetics more details view paper
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    • Site-wide: 22,508
    • In genetics: 894
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    • Site-wide: 160,154

Genetic Association Study of Childhood Aggression across raters, instruments and age

genomics more details view paper
  • Downloaded 1,292 times
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    • Site-wide: 22,995
    • In genomics: 2,082
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    • Site-wide: 48,465
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    • Site-wide: 15,694

Genetic liability for schizophrenia and childhood psychopathology in the general population

psychiatry and clinical psychology more details view paper
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    • Site-wide: 23,029
    • In psychiatry and clinical psychology: 86
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    • Site-wide: 118,682

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

genetics more details view paper
  • Downloaded 1,276 times
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    • Site-wide: 23,477
    • In genetics: 932
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    • Site-wide: 143,824
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    • Site-wide: 159,759

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

epidemiology more details view paper
  • Downloaded 1,268 times
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    • Site-wide: 23,684
    • In epidemiology: 1,384
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    • Site-wide: 159,729
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    • Site-wide: 170,837

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

epidemiology more details view paper
  • Downloaded 1,241 times
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    • Site-wide: 24,543
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    • Site-wide: 175,860

Body mass index and mortality in UK Biobank: revised estimates using Mendelian randomization

epidemiology more details view paper
  • Downloaded 1,234 times
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    • Site-wide: 24,729
    • In epidemiology: 1,439
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    • Site-wide: 121,728
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    • Site-wide: 115,800

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

genetics more details view paper
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    • Site-wide: 24,771
    • In genetics: 974
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    • Site-wide: 148,750
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Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data

genetics more details view paper
  • Downloaded 1,226 times
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    • Site-wide: 24,984
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    • Site-wide: 129,254

The effect of education on adult mortality, health, and income: triangulating across genetic and policy reforms

epidemiology more details view paper
  • Downloaded 1,155 times
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    • Site-wide: 27,364
    • In epidemiology: 1,540
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    • Site-wide: 124,955
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    • Site-wide: 130,576

Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits

genetics more details view paper
  • Downloaded 1,138 times
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    • Site-wide: 27,987
    • In genetics: 1,204
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Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

pharmacology and toxicology more details view paper
  • Downloaded 1,117 times
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    • Site-wide: 28,773
    • In pharmacology and toxicology: 147
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    • Site-wide: 179,453
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    • Site-wide: 162,049

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

epidemiology more details view paper
  • Downloaded 1,112 times
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    • Site-wide: 28,976
    • In epidemiology: 1,628
  • Year to date:
    • Site-wide: 114,120
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    • Site-wide: 144,141

Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions

epidemiology more details view paper
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    • Site-wide: 29,202
    • In epidemiology: 1,622
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    • Site-wide: 139,737
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    • Site-wide: 112,725

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

genetics more details view paper
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    • Site-wide: 29,389
    • In genetics: 1,153
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    • Site-wide: 185,024
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    • Site-wide: 172,123

Can education be personalised using pupils’ genetic data?

genetics more details view paper
  • Downloaded 1,093 times
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    • Site-wide: 29,762
    • In genetics: 1,229
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    • Site-wide: 79,770
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    • Site-wide: 147,452

An epigenome-wide association study of educational attainment (n = 10,767)

genetics more details view paper
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    • Site-wide: 30,738
    • In genetics: 1,216
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    • Site-wide: 132,744

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?

epidemiology more details view paper
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    • Site-wide: 30,868
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Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

genomics more details view paper
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    • Site-wide: 31,450
    • In genomics: 2,529
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    • Site-wide: 142,714
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    • Site-wide: 129,818

Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

epidemiology more details view paper
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    • Site-wide: 31,627
    • In epidemiology: 1,693
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    • Site-wide: 185,937
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    • Site-wide: 188,217

Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease

cardiovascular medicine more details view paper
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    • Site-wide: 32,377
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Detecting heterogeneity of intervention effects using analysis and meta-analysis of differences in variance between arms of a trial

epidemiology more details view paper
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    • Site-wide: 33,683
    • In epidemiology: 1,803
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    • Site-wide: 81,086
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    • Site-wide: 73,431

Consistency of non-cognitive skills and their relation to educational outcomes in a UK cohort

genetics more details view paper
  • Downloaded 966 times
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    • Site-wide: 35,711
    • In genetics: 1,507
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Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression

epidemiology more details view paper
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    • Site-wide: 36,613
    • In epidemiology: 1,864
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    • Site-wide: 107,572
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    • Site-wide: 170,818

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

bioinformatics more details view paper
  • Downloaded 937 times
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    • Site-wide: 37,489
    • In bioinformatics: 3,773
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    • Site-wide: 130,305
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    • Site-wide: 164,226

The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

epidemiology more details view paper
  • Downloaded 921 times
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    • Site-wide: 38,404
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    • Site-wide: 96,913
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    • Site-wide: 54,218

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

epidemiology more details view paper
  • Downloaded 894 times
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    • Site-wide: 40,063
    • In epidemiology: 1,990
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    • Site-wide: 152,627
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    • Site-wide: 173,205

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

genetics more details view paper
  • Downloaded 883 times
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    • Site-wide: 40,845
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Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis

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Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney disease

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Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study

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Genetic Epidemiology And Mendelian Randomization For Informing Disease Therapeutics: Conceptual And Methodological Challenges

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Using genetics to examine a general liability to childhood psychopathology

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Examining the genetic influences of educational attainment and the validity of value-added measures of progress

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Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease

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Distinct Blood DNA Methylation Profiles In Subtypes Of Orofacial Cleft

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Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

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Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population

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Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

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Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

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Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

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Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

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An atlas of associations between polygenic risk scores from across the human phenome and circulating metabolic biomarkers

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The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children

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Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

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Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

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Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life

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Mendelian randomisation with coarsened exposures

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Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

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Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

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Appraising the causal relevance of DNA methylation for risk of lung cancer

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Genetic predictors of participation in optional components of UK Biobank

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Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

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Education and coronary heart disease: a Mendelian randomization study

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Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

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Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

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Association of COVID-19 with arterial and venous vascular diseases: a population-wide cohort study of 48 million adults in England and Wales

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Cigarette smoking and personality: Investigating causality using Mendelian randomization

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Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

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Conditioning on a collider may induce spurious associations: Do the results of Gale et al. (2017) support a protective effect of neuroticism in population sub-groups?

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Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood

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Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

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Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions

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The median and the mode as robust meta-analysis methods in the presence of small study effects

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Metabolic signatures of birth weight in 18288 adolescents and adults

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Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease

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Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

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Identifying intergenerational risk factors for ADHD symptoms using polygenic scores in the Norwegian Mother, Father and Child Cohort

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Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study

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Risk of death among teachers in England and Wales during the Covid19 pandemic

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What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

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Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

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PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

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The Parkinsons Disease Mendelian Randomization Research Portal

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Examining the effect of smoking on suicidal ideation and attempts: A Mendelian randomisation study

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Assortative mating and within-spouse pair comparisons

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Is genetic liability to ADHD and ASD causally linked to educational attainment?

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The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank

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A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank

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CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?

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Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

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Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures

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The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

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Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer.

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Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK Biobank

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Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study

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Association Between Genetically Elevated Levels Of Inflammatory Biomarkers And Risk Of Schizophrenia: A Two-Sample Mendelian Randomisation Study

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Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

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Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study

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The relationship between open angle glaucoma, optic disc morphology and Alzheimer's Disease: a Mendelian randomization study

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Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

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Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisation

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The Multivariate Genome-wide Architecture of Interrelated Literacy, Language and Working Memory Skills Reveals Distinct Etiologies

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A robust mean and variance test with application to high-dimensional phenotypes

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A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target

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Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

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Estimating the causal effect of genetic liability to prevalent disease on hospital costs using Mendelian Randomization

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Schizophrenia risk and reproductive success: A Mendelian randomization study.

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The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study

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Dominant role of abdominal adiposity in circulating lipoprotein, lipid, and metabolite levels in UK Biobank: Mendelian randomization study

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Educational inequalities in statin treatment for preventing cardiovascular disease: cross-sectional analysis of UK Biobank

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Estimation of causal effects of a time-varying exposure at multiple time points through Multivariable Mendelian randomization

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Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study

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Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

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Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

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Interrogating structural inequalities in COVID-19 Mortality in England and Wales

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A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation

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MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

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Identifying novel subtypes of irritability using a developmental genetic approach

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Osteophyte size and location on hip DXA scans are associated with hip pain: findings from a cross sectional study in UK Biobank

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Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

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The association between adiposity and inpatient hospital costs in the UK Biobank cohort

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The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

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Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

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Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

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Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

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Causal effects of circulating cytokine concentrations on risk of Alzheimers disease: A bidirectional two-sample Mendelian randomization study

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DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

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Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

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Mendelian randomization analyses show that higher acetyl-carnitine and carnitine levels in blood protect against severe Covid19

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Epidemiology and Genetics of Preserved Ratio Impaired SpiroMetry (PRISm): An Analysis of UK Biobank

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The role of school enjoyment in the association between externalising and depressive symptoms and academic attainment: findings from a UK prospective cohort study

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Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

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Disentangling the direct and indirect effects of childhood adiposity on type 1 diabetes and immune-associated diseases: a multivariable Mendelian randomization study

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Examining the bidirectional association between emotion recognition and ASD symptoms using observational and genetic analyses

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Navigating sample overlap, winner's curse and weak instrument bias in Mendelian randomization studies using the UK Biobank

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Does Smoking Cause Lower Educational Attainment and General Cognitive Ability? Triangulation of causal evidence using multiple study designs

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Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype

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Metabolomic signatures of lipid-modifying therapies using drug target Mendelian randomization

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Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers

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Interpreting Mendelian randomization estimates of the effects of categorical exposures such as disease status and educational attainment

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Association of genetic liability to smoking initiation with e-cigarette use in young adults.

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Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study

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Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to SARS-CoV-2 severity

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Evaluating the direct effects of childhood adiposity on adult systemic metabolism: A multivariable Mendelian randomization analysis

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Strategies to investigate and mitigate collider bias in genetic and Mendelian randomization studies of disease progression

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Hypothesis-free detection of gene-interaction effects on biomarker concentration in UK Biobank using variance prioritisation

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Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health

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The effect of smoking on multiple sclerosis: a mendelian randomization study

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Cross-sectional association of blood pressure variability and night-time dipping with cardiac structure in adolescents

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Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization

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An Informatics Consult approach for generating clinical evidence for treatment decisions

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The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study

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Mendelian randomization does not support serum calcium in prostate cancer risk

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Exploring selection bias in COVID-19 research: Simulations and prospective analyses of two UK cohort studies

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Examining the possible causal relationship between Lung Function, COPD and Alzheimers Disease. A Mendelian Randomization Study

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Parental inflammatory bowel disease and autism in the offspring: Triangulating the evidence using four complementary study designs.

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Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

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Educational attainment as a modifier of the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank

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Design and quality control of large-scale two-sample Mendelian randomisation studies

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Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals

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Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: prospective cohort study

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Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

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Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independent of body mass index

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Interpretation of mendelian randomization using one measure of an exposure that varies over time.

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Immunological pathways underlying autism: Findings from Mendelian randomization and genetic colocalisation analyses.

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Tools for the assessment of quality and risk of bias in Mendelian randomization studies: a systematic review

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Puberty and sex-specific trajectories of systolic blood pressure: a prospective cohort study

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Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study

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Germline TYK2 mutation and cancer risk

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Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

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Sex-specific associations of adiposity with cardiometabolic traits: multi-life-stage cohort study with repeat metabolomics

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Correlations in sleeping patterns and circadian preference between spouses

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Genetic effect modification of cis-acting C-reactive protein variants in cardiometabolic disease status

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Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis

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Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimers disease risk in the general population: a Mendelian randomization study

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Systematic comparison of Mendelian randomization studies and randomized controlled trials using electronic databases

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Taller height and risk of coronary heart disease and cancer: a within-sibship Mendelian randomization study

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The impact of low input DNA on the reliability of DNA methylation as measured by the Illumina Infinium MethylationEPIC BeadChip

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Genetic analyses of common infections in the Avon Longitudinal Study of Parents and Children cohort

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Continuing inequalities in COVID-19 mortality in England and Wales, and the changing importance of regional, over local, deprivation

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Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples

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Investigating the transparency of reporting in two-sample summary data Mendelian randomization studies

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Characterisation of ethnic differences in DNA methylation between UK resident South Asians and Europeans

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The relationship between BMI and COVID-19: exploring misclassification and selection bias in a two-sample Mendelian randomisation study

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Age-specific effects of body size on fracture risk in later life: A lifecourse Mendelian randomization study

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Estimating the genetically predicted effects of lifestyle risk factors, educational attainment and Alzheimer's disease liability on weight change during midlife

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Sex-specific trajectories of molecular cardiometabolic trait concentrations through childhood, adolescence and young adulthood: a cohort study

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Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study

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Separating the direct effects of risk factors for atherosclerotic cardiovascular disease from those mediated by type 2 diabetes

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Life stage-specific effects of genetic susceptibility to higher body size on body fat and lean mass: prospective cohort study

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Association of lipid-regulating drugs with dementia and related conditions: an observational study of data from the Clinical Practice Research Datalink

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Mental-health before and during the COVID-19 pandemic in adults with neurodevelopmental disorders.

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Socioeconomic inequality in SARS-CoV-2 testing and COVID-19 outcomes in UK Biobank over the first year of the pandemic: can inequalities be explained byselection bias?

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Genetically proxied PCSK9 inhibition provides indication of lower prostate cancer risk: a Mendelian randomization study

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The global randomization test: A Mendelian randomization falsification test for the exclusion restriction assumption

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The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: A Mendelian randomization study

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Examining the association between genetic risk for depression, wellbeing and schizophrenia, and proximity to greenspace

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Health behaviours prior to pregnancy and fertility outcomes: Triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)

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Associations between vitamin D and disease risk may be attributed to the confounding influence of adiposity during childhood and adulthood: a lifecourse Mendelian randomization study

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Sex-specific associations of childhood socioeconomic position and trajectories of metabolic traits across early life: prospective cohort study

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