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Author: George Davey Smith

Rankings

  • All-time downloads: 235,061 (rank: 212 )
  • Categories:
    • bioinformatics: 2,619 (rank: 5,889 (tie) )
    • cardiovascular medicine: 1,257 (rank: 361 (tie) )
    • epidemiology: 140,477 (rank: 92 )
    • evolutionary biology: 441 (rank: 16,244 (tie) )
    • genetic and genomic medicine: 4,820 (rank: 280 )
    • genetics: 73,660 (rank: 44 )
    • genomics: 4,038 (rank: 6,575 (tie) )
    • health economics: 364 (rank: 452 (tie) )
    • health informatics: 244 (rank: 2,891 (tie) )
    • neurology: 1,785 (rank: 645 )
    • neuroscience: 523 (rank: 47,159 (tie) )
    • ophthalmology: 368 (rank: 405 (tie) )
    • pharmacology and toxicology: 1,083 (rank: 1,221 (tie) )
    • psychiatry and clinical psychology: 1,562 (rank: 779 )
    • respiratory medicine: 394 (rank: 1,874 )
    • rheumatology: 182 (rank: 1,092 (tie) )
    • systems biology: 1,244 (rank: 3,841 (tie) )

Downloads per author, site-wide

Preprints

Genetic effect modification of cis-acting C-reactive protein variants in cardiometabolic disease status

genetics more details view paper

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Selection into shift work is influenced by educational attainment and body mass index: A Mendelian randomization study

epidemiology more details view paper
  • Downloaded 61,507 times
  • Download rankings, all-time:
    • Site-wide: 104
    • In epidemiology: 24
  • Year to date:
    • Site-wide: 73,678
  • Since beginning of last month:
    • Site-wide: 82,275

Collider bias undermines our understanding of COVID-19 disease risk and severity

epidemiology more details view paper
  • Downloaded 12,488 times
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    • Site-wide: 725
    • In epidemiology: 106
  • Year to date:
    • Site-wide: 2,996
  • Since beginning of last month:
    • Site-wide: 25,741

A reference panel of 64,976 haplotypes for genotype imputation

genetics more details view paper
  • Downloaded 4,602 times
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    • Site-wide: 2,698
    • In genetics: 90
  • Year to date:
    • Site-wide: 123,215
  • Since beginning of last month:
    • Site-wide: 105,688

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

epidemiology more details view paper
  • Downloaded 4,137 times
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    • Site-wide: 3,137
    • In epidemiology: 333
  • Year to date:
    • Site-wide: 27,578
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    • Site-wide: 11,536

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

genetics more details view paper
  • Downloaded 4,078 times
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    • Site-wide: 3,196
    • In genetics: 107
  • Year to date:
    • Site-wide: 10,130
  • Since beginning of last month:
    • Site-wide: 7,983

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

epidemiology more details view paper
  • Downloaded 3,763 times
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    • Site-wide: 3,582
    • In epidemiology: 366
  • Year to date:
    • Site-wide: 8,717
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    • Site-wide: 3,726

PHESANT: a tool for performing automated phenome scans in UK Biobank

epidemiology more details view paper
  • Downloaded 3,699 times
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    • Site-wide: 3,670
    • In epidemiology: 371
  • Year to date:
    • Site-wide: 13,821
  • Since beginning of last month:
    • Site-wide: 6,974

Collider Scope: When selection bias can substantially influence observed associations

epidemiology more details view paper
  • Downloaded 2,781 times
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    • Site-wide: 5,475
    • In epidemiology: 496
  • Year to date:
    • Site-wide: 30,755
  • Since beginning of last month:
    • Site-wide: 31,852

Genome-wide association study identifies 48 common genetic variants associated with handedness

genetics more details view paper
  • Downloaded 2,711 times
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    • Site-wide: 5,663
    • In genetics: 238
  • Year to date:
    • Site-wide: 23,648
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    • Site-wide: 10,533

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

genetics more details view paper
  • Downloaded 2,530 times
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    • Site-wide: 6,323
    • In genetics: 268
  • Year to date:
    • Site-wide: 120,567
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    • Site-wide: 105,609

Mendelian randomization: a premature burial?

genetics more details view paper
  • Downloaded 2,510 times
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    • Site-wide: 6,394
    • In genetics: 273
  • Year to date:
    • Site-wide: 52,384
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    • Site-wide: None

Why are education, socioeconomic position and intelligence genetically correlated?

genetics more details view paper
  • Downloaded 2,497 times
  • Download rankings, all-time:
    • Site-wide: 6,439
    • In genetics: 276
  • Year to date:
    • Site-wide: 58,262
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    • Site-wide: 101,428

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

genetics more details view paper
  • Downloaded 2,427 times
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    • Site-wide: 6,703
    • In genetics: 295
  • Year to date:
    • Site-wide: 88,352
  • Since beginning of last month:
    • Site-wide: 29,730

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

epidemiology more details view paper
  • Downloaded 2,381 times
  • Download rankings, all-time:
    • Site-wide: 6,897
    • In epidemiology: 578
  • Year to date:
    • Site-wide: 95,409
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    • Site-wide: 50,506

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

genetics more details view paper
  • Downloaded 2,264 times
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    • Site-wide: 7,429
    • In genetics: 327
  • Year to date:
    • Site-wide: 29,952
  • Since beginning of last month:
    • Site-wide: 112,020

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

genetics more details view paper
  • Downloaded 2,093 times
  • Download rankings, all-time:
    • Site-wide: 8,307
    • In genetics: 363
  • Year to date:
    • Site-wide: 6,762
  • Since beginning of last month:
    • Site-wide: 15,009

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

epidemiology more details view paper
  • Downloaded 1,997 times
  • Download rankings, all-time:
    • Site-wide: 8,932
    • In epidemiology: 709
  • Year to date:
    • Site-wide: 78,190
  • Since beginning of last month:
    • Site-wide: 23,082

Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

epidemiology more details view paper
  • Downloaded 1,989 times
  • Download rankings, all-time:
    • Site-wide: 8,987
    • In epidemiology: 712
  • Year to date:
    • Site-wide: 20,346
  • Since beginning of last month:
    • Site-wide: 11,017

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

genetics more details view paper
  • Downloaded 1,925 times
  • Download rankings, all-time:
    • Site-wide: 9,417
    • In genetics: 401
  • Year to date:
    • Site-wide: 69,045
  • Since beginning of last month:
    • Site-wide: 100,728

Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

genetics more details view paper
  • Downloaded 1,901 times
  • Download rankings, all-time:
    • Site-wide: 9,590
    • In genetics: 414
  • Year to date:
    • Site-wide: 75,863
  • Since beginning of last month:
    • Site-wide: 106,046

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

genetics more details view paper
  • Downloaded 1,790 times
  • Download rankings, all-time:
    • Site-wide: 10,481
    • In genetics: 460
  • Year to date:
    • Site-wide: 89,097
  • Since beginning of last month:
    • Site-wide: 109,443

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

genetics more details view paper
  • Downloaded 1,779 times
  • Download rankings, all-time:
    • Site-wide: 10,576
    • In genetics: 465
  • Year to date:
    • Site-wide: 75,884
  • Since beginning of last month:
    • Site-wide: 45,865

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

genetics more details view paper
  • Downloaded 1,755 times
  • Download rankings, all-time:
    • Site-wide: 10,794
    • In genetics: 477
  • Year to date:
    • Site-wide: 89,166
  • Since beginning of last month:
    • Site-wide: 40,395

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

genetics more details view paper
  • Downloaded 1,681 times
  • Download rankings, all-time:
    • Site-wide: 11,484
    • In genetics: 511
  • Year to date:
    • Site-wide: 146,120
  • Since beginning of last month:
    • Site-wide: None

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

genetics more details view paper
  • Downloaded 1,647 times
  • Download rankings, all-time:
    • Site-wide: 11,861
    • In genetics: 536
  • Year to date:
    • Site-wide: 127,087
  • Since beginning of last month:
    • Site-wide: 65,796

An examination of multivariable Mendelian randomization in the single sample and two-sample summary data settings.

epidemiology more details view paper
  • Downloaded 1,612 times
  • Download rankings, all-time:
    • Site-wide: 12,229
    • In epidemiology: 880
  • Year to date:
    • Site-wide: 55,976
  • Since beginning of last month:
    • Site-wide: 38,907

Selection bias in instrumental variable analyses

epidemiology more details view paper
  • Downloaded 1,522 times
  • Download rankings, all-time:
    • Site-wide: 13,219
    • In epidemiology: 939
  • Year to date:
    • Site-wide: 25,329
  • Since beginning of last month:
    • Site-wide: 8,009

Cigarette smoking increases coffee consumption: findings from a Mendelian randomisation analysis

genetics more details view paper
  • Downloaded 1,484 times
  • Download rankings, all-time:
    • Site-wide: 13,794
    • In genetics: 633
  • Year to date:
    • Site-wide: 52,935
  • Since beginning of last month:
    • Site-wide: 18,522

The Causal Effects of Education on Health, Mortality, Cognition, Well-being, and Income in the UK Biobank

epidemiology more details view paper
  • Downloaded 1,466 times
  • Download rankings, all-time:
    • Site-wide: 14,068
    • In epidemiology: 975
  • Year to date:
    • Site-wide: 71,730
  • Since beginning of last month:
    • Site-wide: 17,245

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

genetics more details view paper
  • Downloaded 1,440 times
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    • Site-wide: 14,469
    • In genetics: 661
  • Year to date:
    • Site-wide: 111,956
  • Since beginning of last month:
    • Site-wide: 103,516

Within-sibship GWAS improve estimates of direct genetic effects

genetics more details view paper
  • Downloaded 1,414 times
  • Download rankings, all-time:
    • Site-wide: 14,881
    • In genetics: 687
  • Year to date:
    • Site-wide: 2,070
  • Since beginning of last month:
    • Site-wide: 59,427

Do early life non-cognitive skills matter? A systematic review and meta-analysis of early life effects on academic achievement, psychosocial, language and cognitive, and health outcomes

epidemiology more details view paper
  • Downloaded 1,400 times
  • Download rankings, all-time:
    • Site-wide: 15,106
    • In epidemiology: 1,032
  • Year to date:
    • Site-wide: 84,279
  • Since beginning of last month:
    • Site-wide: 21,119

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

neurology more details view paper
  • Downloaded 1,397 times
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    • Site-wide: 15,145
    • In neurology: 32
  • Year to date:
    • Site-wide: 2,117
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    • Site-wide: 960

The genetic architecture of osteoarthritis: insights from UK Biobank

genetics more details view paper
  • Downloaded 1,388 times
  • Download rankings, all-time:
    • Site-wide: 15,307
    • In genetics: 703
  • Year to date:
    • Site-wide: 80,584
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    • Site-wide: 26,535

Multi-omics study revealing putative drug targets of COVID-19 severity and other viral infection diseases

genetic and genomic medicine more details view paper
  • Downloaded 1,384 times
  • Download rankings, all-time:
    • Site-wide: 15,389
    • In genetic and genomic medicine: 66
  • Year to date:
    • Site-wide: 21,632
  • Since beginning of last month:
    • Site-wide: 7,174

Meffil: efficient normalisation and analysis of very large DNA methylation samples

bioinformatics more details view paper
  • Downloaded 1,378 times
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    • Site-wide: 15,475
    • In bioinformatics: 1,784
  • Year to date:
    • Site-wide: 59,087
  • Since beginning of last month:
    • Site-wide: 15,202

Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

genetics more details view paper
  • Downloaded 1,287 times
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    • Site-wide: 17,154
    • In genetics: 797
  • Year to date:
    • Site-wide: 140,831
  • Since beginning of last month:
    • Site-wide: 61,288

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

epidemiology more details view paper
  • Downloaded 1,285 times
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    • Site-wide: 17,195
    • In epidemiology: 1,133
  • Year to date:
    • Site-wide: 24,729
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    • Site-wide: 9,991

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

epidemiology more details view paper
  • Downloaded 1,239 times
  • Download rankings, all-time:
    • Site-wide: 18,136
    • In epidemiology: 1,176
  • Year to date:
    • Site-wide: 111,754
  • Since beginning of last month:
    • Site-wide: 39,078

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

genetics more details view paper
  • Downloaded 1,231 times
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    • Site-wide: 18,325
    • In genetics: 844
  • Year to date:
    • Site-wide: 83,015
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    • Site-wide: 27,723

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

epidemiology more details view paper
  • Downloaded 1,187 times
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    • Site-wide: 19,333
    • In epidemiology: 1,229
  • Year to date:
    • Site-wide: 33,997
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    • Site-wide: 25,286

Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data

genetics more details view paper
  • Downloaded 1,175 times
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    • Site-wide: 19,615
    • In genetics: 906
  • Year to date:
    • Site-wide: 73,835
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    • Site-wide: 22,712

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

genetics more details view paper
  • Downloaded 1,164 times
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    • Site-wide: 19,876
    • In genetics: 912
  • Year to date:
    • Site-wide: 104,635
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    • Site-wide: 103,652

Body mass index and mortality in UK Biobank: revised estimates using Mendelian randomization

epidemiology more details view paper
  • Downloaded 1,160 times
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    • Site-wide: 19,994
    • In epidemiology: 1,249
  • Year to date:
    • Site-wide: 76,755
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    • Site-wide: 22,739

The causes and consequences of Alzheimer's disease: A Mendelian randomization analysis

genetic and genomic medicine more details view paper
  • Downloaded 1,148 times
  • Download rankings, all-time:
    • Site-wide: 20,295
    • In genetic and genomic medicine: 84
  • Year to date:
    • Site-wide: 13,213
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    • Site-wide: 34,725

Genetic Association Study of Childhood Aggression across raters, instruments and age

genomics more details view paper
  • Downloaded 1,146 times
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    • Site-wide: 20,338
    • In genomics: 1,955
  • Year to date:
    • Site-wide: 13,358
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    • Site-wide: 11,041

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

genetics more details view paper
  • Downloaded 1,135 times
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    • Site-wide: 20,649
    • In genetics: 946
  • Year to date:
    • Site-wide: 9,758
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    • Site-wide: 94,773

Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

pharmacology and toxicology more details view paper
  • Downloaded 1,083 times
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    • Site-wide: 22,100
    • In pharmacology and toxicology: 122
  • Year to date:
    • Site-wide: 127,892
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    • Site-wide: 74,127

The effect of education on adult mortality, health, and income: triangulating across genetic and policy reforms

epidemiology more details view paper
  • Downloaded 1,079 times
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    • Site-wide: 22,241
    • In epidemiology: 1,344
  • Year to date:
    • Site-wide: 79,442
  • Since beginning of last month:
    • Site-wide: 27,436

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

genetics more details view paper
  • Downloaded 1,069 times
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    • Site-wide: 22,547
    • In genetics: 1,029
  • Year to date:
    • Site-wide: 117,872
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    • Site-wide: None

Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions

epidemiology more details view paper
  • Downloaded 1,067 times
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    • Site-wide: 22,627
    • In epidemiology: 1,363
  • Year to date:
    • Site-wide: 98,734
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    • Site-wide: 38,910

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

genetic and genomic medicine more details view paper
  • Downloaded 1,033 times
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    • Site-wide: 23,698
    • In genetic and genomic medicine: 97
  • Year to date:
    • Site-wide: 7,723
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    • Site-wide: 5,935

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

epidemiology more details view paper
  • Downloaded 1,021 times
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    • Site-wide: 24,083
    • In epidemiology: 1,417
  • Year to date:
    • Site-wide: 71,813
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    • Site-wide: 36,576

Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

epidemiology more details view paper
  • Downloaded 1,018 times
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    • Site-wide: 24,171
    • In epidemiology: 1,421
  • Year to date:
    • Site-wide: 101,947
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    • Site-wide: 45,169

An epigenome-wide association study of educational attainment (n = 10,767)

genetics more details view paper
  • Downloaded 1,012 times
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    • Site-wide: 24,365
    • In genetics: 1,114
  • Year to date:
    • Site-wide: 107,977
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    • Site-wide: 103,552

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?

epidemiology more details view paper
  • Downloaded 1,011 times
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    • Site-wide: 24,405
    • In epidemiology: 1,428
  • Year to date:
    • Site-wide: 106,815
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    • Site-wide: None

Can education be personalised using pupils’ genetic data?

genetics more details view paper
  • Downloaded 993 times
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    • Site-wide: 25,088
    • In genetics: 1,139
  • Year to date:
    • Site-wide: 86,683
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    • Site-wide: 32,670

Genetic liability for schizophrenia and childhood psychopathology in the general population

psychiatry and clinical psychology more details view paper
  • Downloaded 981 times
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    • Site-wide: 25,553
    • In psychiatry and clinical psychology: 93
  • Year to date:
    • Site-wide: 6,975
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    • Site-wide: 25,751

Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease

cardiovascular medicine more details view paper
  • Downloaded 956 times
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    • Site-wide: 26,560
    • In cardiovascular medicine: 39
  • Year to date:
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    • Site-wide: 67,959

Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

genomics more details view paper
  • Downloaded 953 times
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    • Site-wide: 26,664
    • In genomics: 2,437
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    • Site-wide: 66,237
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    • Site-wide: 78,923

The MRC IEU OpenGWAS data infrastructure

genetics more details view paper
  • Downloaded 909 times
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    • Site-wide: 28,520
    • In genetics: 1,305
  • Year to date:
    • Site-wide: 7,823
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    • Site-wide: 2,587

Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression

epidemiology more details view paper
  • Downloaded 873 times
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    • Site-wide: 30,178
    • In epidemiology: 1,626
  • Year to date:
    • Site-wide: 127,797
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    • Site-wide: None

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

epidemiology more details view paper
  • Downloaded 842 times
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    • Site-wide: 31,735
    • In epidemiology: 1,686
  • Year to date:
    • Site-wide: 47,732
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    • Site-wide: 15,101

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

genetics more details view paper
  • Downloaded 836 times
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    • Site-wide: 32,076
    • In genetics: 1,478
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    • Site-wide: 75,946
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    • Site-wide: 19,816

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

bioinformatics more details view paper
  • Downloaded 830 times
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    • Site-wide: 32,350
    • In bioinformatics: 3,569
  • Year to date:
    • Site-wide: 83,870
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    • Site-wide: 79,641

The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

epidemiology more details view paper
  • Downloaded 819 times
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    • Site-wide: 32,938
    • In epidemiology: 1,722
  • Year to date:
    • Site-wide: 89,602
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    • Site-wide: 36,748

Genetic Epidemiology And Mendelian Randomization For Informing Disease Therapeutics: Conceptual And Methodological Challenges

genetics more details view paper
  • Downloaded 813 times
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    • Site-wide: 33,304
    • In genetics: 1,536
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    • Site-wide: 137,090
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    • Site-wide: None

Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits

genetics more details view paper
  • Downloaded 803 times
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    • Site-wide: 33,911
    • In genetics: 1,560
  • Year to date:
    • Site-wide: 24,865
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    • Site-wide: 109,548

Detecting heterogeneity of intervention effects using analysis and meta-analysis of differences in variance between arms of a trial

epidemiology more details view paper
  • Downloaded 802 times
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    • Site-wide: 33,960
    • In epidemiology: 1,765
  • Year to date:
    • Site-wide: 32,679
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    • Site-wide: 84,609

Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis

genomics more details view paper
  • Downloaded 777 times
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    • Site-wide: 35,537
    • In genomics: 2,993
  • Year to date:
    • Site-wide: 34,296
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    • Site-wide: 78,706

Consistency of non-cognitive skills and their relation to educational outcomes in a UK cohort

genetics more details view paper
  • Downloaded 770 times
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Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study

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Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease

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Using genetics to examine a general liability to childhood psychopathology

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Examining the genetic influences of educational attainment and the validity of value-added measures of progress

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Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

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Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

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Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

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Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population

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Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

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Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

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Distinct Blood DNA Methylation Profiles In Subtypes Of Orofacial Cleft

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Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

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Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life

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The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children

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Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

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Appraising the causal relevance of DNA methylation for risk of lung cancer

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Education and coronary heart disease: a Mendelian randomization study

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Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

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Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

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Genetic predictors of participation in optional components of UK Biobank

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Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

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Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

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Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney disease

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Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

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Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

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Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

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Cigarette smoking and personality: Investigating causality using Mendelian randomization

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Metabolic signatures of birth weight in 18288 adolescents and adults

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Mendelian randomisation with coarsened exposures

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Conditioning on a collider may induce spurious associations: Do the results of Gale et al. (2017) support a protective effect of neuroticism in population sub-groups?

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The median and the mode as robust meta-analysis methods in the presence of small study effects

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Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

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Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study

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What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

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The Parkinsons Disease Mendelian Randomization Research Portal

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Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood

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Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease

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PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

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Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

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Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures

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The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank

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Is genetic liability to ADHD and ASD causally linked to educational attainment?

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A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank

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CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?

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Examining the effect of smoking on suicidal ideation and attempts: A Mendelian randomisation study

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Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

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Assortative mating and within-spouse pair comparisons

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Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

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Association Between Genetically Elevated Levels Of Inflammatory Biomarkers And Risk Of Schizophrenia: A Two-Sample Mendelian Randomisation Study

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Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study

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The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study

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Schizophrenia risk and reproductive success: A Mendelian randomization study.

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Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

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The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

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Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisation

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A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target

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MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

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The association between adiposity and inpatient hospital costs in the UK Biobank cohort

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A robust mean and variance test with application to high-dimensional phenotypes

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Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

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Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

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Identifying novel subtypes of irritability using a developmental genetic approach

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Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer.

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Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions

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The Multivariate Genome-wide Architecture of Interrelated Literacy, Language and Working Memory Skills Reveals Distinct Etiologies

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Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

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The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

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Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

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Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study

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Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

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Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

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The relationship between open angle glaucoma, optic disc morphology and Alzheimer's Disease: a Mendelian randomization study

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Estimating the causal effect of genetic liability to prevalent disease on hospital costs using Mendelian Randomization

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DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

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Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study

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Educational inequalities in statin treatment for preventing cardiovascular disease: cross-sectional analysis of UK Biobank

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Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype

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Risk of death among teachers in England and Wales during the Covid19 pandemic

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Does Smoking Cause Lower Educational Attainment and General Cognitive Ability? Triangulation of causal evidence using multiple study designs

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A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation

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Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

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Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK Biobank

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Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health

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The role of school enjoyment in the association between externalising and depressive symptoms and academic attainment: findings from a UK prospective cohort study

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Evaluating the direct effects of childhood adiposity on adult systemic metabolism: A multivariable Mendelian randomization analysis

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Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

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Mendelian randomization does not support serum calcium in prostate cancer risk

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Examining the bidirectional association between emotion recognition and ASD symptoms using observational and genetic analyses

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Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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Association of genetic liability to smoking initiation with e-cigarette use in young adults.

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Dominant role of abdominal adiposity in circulating lipoprotein, lipid, and metabolite levels in UK Biobank: Mendelian randomization study

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Interrogating structural inequalities in COVID-19 Mortality in England and Wales

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Identifying intergenerational risk factors for ADHD symptoms using polygenic scores in the Norwegian Mother, Father and Child Cohort

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Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

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Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to SARS-CoV-2 severity

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The effect of smoking on multiple sclerosis: a mendelian randomization study

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Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals

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Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study

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Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

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An Informatics Consult approach for generating clinical evidence for treatment decisions

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Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers

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Causal effects of circulating cytokine concentrations on risk of Alzheimers disease: A bidirectional two-sample Mendelian randomization study

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Interpreting Mendelian randomization estimates of the effects of categorical exposures such as disease status and educational attainment

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Examining the possible causal relationship between Lung Function, COPD and Alzheimers Disease. A Mendelian Randomization Study

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The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study

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Disentangling the direct and indirect effects of childhood adiposity on type 1 diabetes and immune-associated diseases: a multivariable Mendelian randomization study

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Cross-sectional association of blood pressure variability and night-time dipping with cardiac structure in adolescents

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Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: prospective cohort study

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Osteophyte size and location on hip DXA scans are associated with hip pain: findings from a cross sectional study in UK Biobank

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Epidemiology and Genetics of Preserved Ratio Impaired SpiroMetry (PRISm): An Analysis of UK Biobank

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Mendelian randomization analyses show that higher acetyl-carnitine and carnitine levels in blood protect against severe Covid19

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Puberty and sex-specific trajectories of systolic blood pressure: a prospective cohort study

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Sex-specific associations of adiposity with cardiometabolic traits: multi-life-stage cohort study with repeat metabolomics

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Educational attainment as a modifier of the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank

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Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization

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Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independent of body mass index

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Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

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Parental inflammatory bowel disease and autism in the offspring: Triangulating the evidence using four complementary study designs.

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Design and quality control of large-scale two-sample Mendelian randomisation studies

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Taller height and risk of coronary heart disease and cancer: a within-sibship Mendelian randomization study

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Navigating sample overlap, winner's curse and weak instrument bias in Mendelian randomization studies using the UK Biobank

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Estimating the genetically predicted effects of lifestyle risk factors, educational attainment and Alzheimer's disease liability on weight change during midlife

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Genetic analyses of common infections in the Avon Longitudinal Study of Parents and Children cohort

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Sex-specific trajectories of molecular cardiometabolic trait concentrations through childhood, adolescence and young adulthood: a cohort study

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Metabolomic signatures of lipid-modifying therapies using drug target Mendelian randomization

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Separating the direct effects of risk factors for atherosclerotic cardiovascular disease from those mediated by type 2 diabetes

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