Author: George Davey Smith

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Preprints

Selection into shift work is influenced by educational attainment and body mass index: A Mendelian randomization study

• Downloaded 61,469 times
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  • Site-wide: 87
  • In epidemiology: 20
• Year to date:
  • Site-wide: 50,036
• Since beginning of last month:
  • Site-wide: 37,738

Collider bias undermines our understanding of COVID-19 disease risk and severity

• Downloaded 11,992 times
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  • Site-wide: 629
  • In epidemiology: 93
• Year to date:
  • Site-wide: 2,490
• Since beginning of last month:
  • Site-wide: 2,615

A reference panel of 64,976 haplotypes for genotype imputation

• Downloaded 4,588 times
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  • Site-wide: 2,262
  • In genetics: 82
• Year to date:
  • Site-wide: 81,054
• Since beginning of last month:
  • Site-wide: 101,752

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

• Downloaded 4,025 times
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  • Site-wide: 2,720
  • In epidemiology: 287
• Year to date:
  • Site-wide: 22,851
• Since beginning of last month:
  • Site-wide: 28,310

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

• Downloaded 3,834 times
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  • Site-wide: 2,931
  • In genetics: 113
• Year to date:
  • Site-wide: 9,813
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  • Site-wide: 10,609

PHESANT: a tool for performing automated phenome scans in UK Biobank

• Downloaded 3,473 times
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  • Site-wide: 3,384
  • In epidemiology: 332
• Year to date:
  • Site-wide: 16,470
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  • Site-wide: 14,985

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

• Downloaded 3,426 times
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  • Site-wide: 3,449
  • In epidemiology: 335
• Year to date:
  • Site-wide: 13,101
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  • Site-wide: 18,110

Collider Scope: When selection bias can substantially influence observed associations

• Downloaded 2,653 times
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  • Site-wide: 4,961
  • In epidemiology: 444
• Year to date:
  • Site-wide: 33,839
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  • Site-wide: 33,068

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,567 times
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  • Site-wide: 5,193
  • In genetics: 237
• Year to date:
  • Site-wide: 23,664
• Since beginning of last month:
  • Site-wide: 29,943

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

• Downloaded 2,509 times
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  • Site-wide: 5,385
  • In genetics: 246
• Year to date:
  • Site-wide: 91,718
• Since beginning of last month:
  • Site-wide: 94,288

Mendelian randomization: a premature burial?

• Downloaded 2,463 times
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  • Site-wide: 5,548
  • In genetics: 256
• Year to date:
  • Site-wide: 32,656
• Since beginning of last month:
  • Site-wide: 39,280

Why are education, socioeconomic position and intelligence genetically correlated?

• Downloaded 2,442 times
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  • Site-wide: 5,624
  • In genetics: 262
• Year to date:
  • Site-wide: 42,876
• Since beginning of last month:
  • Site-wide: 43,860

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

• Downloaded 2,377 times
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  • Site-wide: 5,834
  • In genetics: 270
• Year to date:
  • Site-wide: 91,839
• Since beginning of last month:
  • Site-wide: 109,194

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

• Downloaded 2,341 times
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  • Site-wide: 5,971
  • In epidemiology: 495
• Year to date:
  • Site-wide: 87,448
• Since beginning of last month:
  • Site-wide: 128,078

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

• Downloaded 2,168 times
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  • Site-wide: 6,669
  • In genetics: 322
• Year to date:
  • Site-wide: 22,523
• Since beginning of last month:
  • Site-wide: 21,593

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

• Downloaded 1,930 times
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  • Site-wide: 7,926
  • In epidemiology: 617
• Year to date:
  • Site-wide: 106,018
• Since beginning of last month:
  • Site-wide: 78,400

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

• Downloaded 1,877 times
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  • Site-wide: 8,287
  • In genetics: 386
• Year to date:
  • Site-wide: 51,977
• Since beginning of last month:
  • Site-wide: 37,135

Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

• Downloaded 1,856 times
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  • Site-wide: 8,416
  • In genetics: 394
• Year to date:
  • Site-wide: 58,935
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  • Site-wide: 58,123

Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

• Downloaded 1,825 times
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  • Site-wide: 8,634
  • In epidemiology: 659
• Year to date:
  • Site-wide: 21,313
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  • Site-wide: 18,145

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

• Downloaded 1,790 times
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  • Site-wide: 8,877
  • In genetics: 418
• Year to date:
  • Site-wide: 6,277
• Since beginning of last month:
  • Site-wide: 6,694

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

• Downloaded 1,751 times
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  • Site-wide: 9,181
  • In genetics: 437
• Year to date:
  • Site-wide: 72,777
• Since beginning of last month:
  • Site-wide: 64,080

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,717 times
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  • Site-wide: 9,478
  • In genetics: 450
• Year to date:
  • Site-wide: 85,161
• Since beginning of last month:
  • Site-wide: 94,471

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,713 times
• Download rankings, all-time:
  • Site-wide: 9,507
  • In genetics: 453
• Year to date:
  • Site-wide: 78,666
• Since beginning of last month:
  • Site-wide: 85,472

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

• Downloaded 1,676 times
• Download rankings, all-time:
  • Site-wide: 9,807
  • In genetics: 468
• Year to date:
  • Site-wide: 100,126
• Since beginning of last month:
  • Site-wide: 109,395

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

• Downloaded 1,622 times
• Download rankings, all-time:
  • Site-wide: 10,273
  • In genetics: 493
• Year to date:
  • Site-wide: 115,940
• Since beginning of last month:
  • Site-wide: 131,839

An examination of multivariable Mendelian randomization in the single sample and two-sample summary data settings.

• Downloaded 1,547 times
• Download rankings, all-time:
  • Site-wide: 11,036
  • In epidemiology: 788
• Year to date:
  • Site-wide: 45,885
• Since beginning of last month:
  • Site-wide: 38,961

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,418 times
• Download rankings, all-time:
  • Site-wide: 12,530
  • In genetics: 615
• Year to date:
  • Site-wide: 79,280
• Since beginning of last month:
  • Site-wide: 55,150

Cigarette smoking increases coffee consumption: findings from a Mendelian randomisation analysis

• Downloaded 1,417 times
• Download rankings, all-time:
  • Site-wide: 12,557
  • In genetics: 616
• Year to date:
  • Site-wide: 43,046
• Since beginning of last month:
  • Site-wide: 48,839

The Causal Effects of Education on Health, Mortality, Cognition, Well-being, and Income in the UK Biobank

• Downloaded 1,406 times
• Download rankings, all-time:
  • Site-wide: 12,689
  • In epidemiology: 858
• Year to date:
  • Site-wide: 70,452
• Since beginning of last month:
  • Site-wide: 85,453

Selection bias in instrumental variable analyses

• Downloaded 1,377 times
• Download rankings, all-time:
  • Site-wide: 13,100
  • In epidemiology: 881
• Year to date:
  • Site-wide: 27,503
• Since beginning of last month:
  • Site-wide: 31,500

Do early life non-cognitive skills matter? A systematic review and meta-analysis of early life effects on academic achievement, psychosocial, language and cognitive, and health outcomes

• Downloaded 1,341 times
• Download rankings, all-time:
  • Site-wide: 13,640
  • In epidemiology: 903
• Year to date:
  • Site-wide: 106,596
• Since beginning of last month:
  • Site-wide: 103,850

The genetic architecture of osteoarthritis: insights from UK Biobank

• Downloaded 1,338 times
• Download rankings, all-time:
  • Site-wide: 13,685
  • In genetics: 662
• Year to date:
  • Site-wide: 74,090
• Since beginning of last month:
  • Site-wide: 101,697

Meffil: efficient normalisation and analysis of very large DNA methylation samples

• Downloaded 1,294 times
• Download rankings, all-time:
  • Site-wide: 14,426
  • In bioinformatics: 1,749
• Year to date:
  • Site-wide: 74,017
• Since beginning of last month:
  • Site-wide: 79,720

Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

• Downloaded 1,267 times
• Download rankings, all-time:
  • Site-wide: 14,891
  • In genetics: 735
• Year to date:
  • Site-wide: 130,627
• Since beginning of last month:
  • Site-wide: 132,788

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

• Downloaded 1,215 times
• Download rankings, all-time:
  • Site-wide: 15,856
  • In epidemiology: 1,010
• Year to date:
  • Site-wide: 83,866
• Since beginning of last month:
  • Site-wide: 102,275

Multi-omics study revealing tissue-dependent putative mechanisms of SARS-CoV-2 drug targets on viral infections and complex diseases

• Downloaded 1,198 times
• Download rankings, all-time:
  • Site-wide: 16,165
  • In genetic and genomic medicine: 54
• Year to date:
  • Site-wide: 30,713
• Since beginning of last month:
  • Site-wide: 28,393

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

• Downloaded 1,179 times
• Download rankings, all-time:
  • Site-wide: 16,580
  • In genetics: 808
• Year to date:
  • Site-wide: 84,791
• Since beginning of last month:
  • Site-wide: 87,812

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

• Downloaded 1,144 times
• Download rankings, all-time:
  • Site-wide: 17,320
  • In epidemiology: 1,078
• Year to date:
  • Site-wide: 25,129
• Since beginning of last month:
  • Site-wide: 28,095

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 1,138 times
• Download rankings, all-time:
  • Site-wide: 17,445
  • In genetics: 849
• Year to date:
  • Site-wide: 75,697
• Since beginning of last month:
  • Site-wide: 72,095

Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data

• Downloaded 1,126 times
• Download rankings, all-time:
  • Site-wide: 17,739
  • In genetics: 865
• Year to date:
  • Site-wide: 60,847
• Since beginning of last month:
  • Site-wide: 63,072

Body mass index and mortality in UK Biobank: revised estimates using Mendelian randomization

• Downloaded 1,103 times
• Download rankings, all-time:
  • Site-wide: 18,292
  • In epidemiology: 1,116
• Year to date:
  • Site-wide: 78,494
• Since beginning of last month:
  • Site-wide: 72,475

Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

• Downloaded 1,064 times
• Download rankings, all-time:
  • Site-wide: 19,290
  • In pharmacology and toxicology: 104
• Year to date:
  • Site-wide: 99,816
• Since beginning of last month:
  • Site-wide: 78,499

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

• Downloaded 1,049 times
• Download rankings, all-time:
  • Site-wide: 19,680
  • In epidemiology: 1,171
• Year to date:
  • Site-wide: 48,133
• Since beginning of last month:
  • Site-wide: 36,011

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

• Downloaded 1,046 times
• Download rankings, all-time:
  • Site-wide: 19,760
  • In genetics: 951
• Year to date:
  • Site-wide: 92,070
• Since beginning of last month:
  • Site-wide: 87,452

Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions

• Downloaded 1,035 times
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  • Site-wide: 20,073
  • In epidemiology: 1,192
• Year to date:
  • Site-wide: 78,450
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  • Site-wide: 93,034

The effect of education on adult mortality, health, and income: triangulating across genetic and policy reforms

• Downloaded 1,028 times
• Download rankings, all-time:
  • Site-wide: 20,262
  • In epidemiology: 1,203
• Year to date:
  • Site-wide: 74,229
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  • Site-wide: 88,257

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 996 times
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  • Site-wide: 21,219
  • In genetics: 1,018
• Year to date:
  • Site-wide: 64,906
• Since beginning of last month:
  • Site-wide: 67,173

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?

• Downloaded 990 times
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  • Site-wide: 21,376
  • In epidemiology: 1,241
• Year to date:
  • Site-wide: 70,469
• Since beginning of last month:
  • Site-wide: 74,473

Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

• Downloaded 985 times
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  • Site-wide: 21,521
  • In epidemiology: 1,247
• Year to date:
  • Site-wide: 85,669
• Since beginning of last month:
  • Site-wide: 79,041

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

• Downloaded 968 times
• Download rankings, all-time:
  • Site-wide: 22,075
  • In epidemiology: 1,268
• Year to date:
  • Site-wide: 61,133
• Since beginning of last month:
  • Site-wide: 58,244

The causes and consequences of Alzheimer's disease: A Mendelian randomization analysis

• Downloaded 964 times
• Download rankings, all-time:
  • Site-wide: 22,221
  • In genetic and genomic medicine: 76
• Year to date:
  • Site-wide: 11,173
• Since beginning of last month:
  • Site-wide: 13,590

Can education be personalised using pupils’ genetic data?

• Downloaded 941 times
• Download rankings, all-time:
  • Site-wide: 23,035
  • In genetics: 1,109
• Year to date:
  • Site-wide: 91,922
• Since beginning of last month:
  • Site-wide: 104,616

Genetic Association Study of Childhood Aggression across raters, instruments and age

• Downloaded 916 times
• Download rankings, all-time:
  • Site-wide: 23,973
  • In genomics: 2,306
• Year to date:
  • Site-wide: 15,864
• Since beginning of last month:
  • Site-wide: 10,042

Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease

• Downloaded 912 times
• Download rankings, all-time:
  • Site-wide: 24,134
  • In cardiovascular medicine: 35
• Year to date:
  • Site-wide: 66,719
• Since beginning of last month:
  • Site-wide: 53,667

Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

• Downloaded 898 times
• Download rankings, all-time:
  • Site-wide: 24,678
  • In genomics: 2,351
• Year to date:
  • Site-wide: 54,349
• Since beginning of last month:
  • Site-wide: 50,893

Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression

• Downloaded 847 times
• Download rankings, all-time:
  • Site-wide: 26,762
  • In epidemiology: 1,448
• Year to date:
  • Site-wide: 119,860
• Since beginning of last month:
  • Site-wide: 123,756

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

• Downloaded 821 times
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  • Site-wide: 27,961
  • In genetics: 1,357
• Year to date:
  • Site-wide: 14,620
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  • Site-wide: 12,715

Within-sibship GWAS improve estimates of direct genetic effects

• Downloaded 801 times
• Download rankings, all-time:
  • Site-wide: 28,953
  • In genetics: 1,398
• Year to date:
  • Site-wide: 1,612
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  • Site-wide: 525

Genetic Epidemiology And Mendelian Randomization For Informing Disease Therapeutics: Conceptual And Methodological Challenges

• Downloaded 792 times
• Download rankings, all-time:
  • Site-wide: 29,392
  • In genetics: 1,429
• Year to date:
  • Site-wide: 125,237
• Since beginning of last month:
  • Site-wide: 109,091

The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

• Downloaded 785 times
• Download rankings, all-time:
  • Site-wide: 29,769
  • In epidemiology: 1,548
• Year to date:
  • Site-wide: 66,302
• Since beginning of last month:
  • Site-wide: 67,273

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

• Downloaded 782 times
• Download rankings, all-time:
  • Site-wide: 29,944
  • In bioinformatics: 3,416
• Year to date:
  • Site-wide: 78,252
• Since beginning of last month:
  • Site-wide: 103,743

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

• Downloaded 781 times
• Download rankings, all-time:
  • Site-wide: 29,975
  • In genetics: 1,455
• Year to date:
  • Site-wide: 73,160
• Since beginning of last month:
  • Site-wide: 89,129

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

• Downloaded 758 times
• Download rankings, all-time:
  • Site-wide: 31,293
  • In epidemiology: 1,600
• Year to date:
  • Site-wide: 44,910
• Since beginning of last month:
  • Site-wide: 39,176

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease

• Downloaded 747 times
• Download rankings, all-time:
  • Site-wide: 31,901
  • In genetics: 1,545
• Year to date:
  • Site-wide: 91,149
• Since beginning of last month:
  • Site-wide: 86,638

Examining the genetic influences of educational attainment and the validity of value-added measures of progress

• Downloaded 739 times
• Download rankings, all-time:
  • Site-wide: 32,410
  • In genetics: 1,566
• Year to date:
  • Site-wide: 119,311
• Since beginning of last month:
  • Site-wide: 113,493

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

• Downloaded 734 times
• Download rankings, all-time:
  • Site-wide: 32,780
  • In genetics: 1,581
• Year to date:
  • Site-wide: 85,435
• Since beginning of last month:
  • Site-wide: 78,150

Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study

• Downloaded 732 times
• Download rankings, all-time:
  • Site-wide: 32,909
  • In epidemiology: 1,653
• Year to date:
  • Site-wide: 71,227
• Since beginning of last month:
  • Site-wide: 61,301

Using genetics to examine a general liability to childhood psychopathology

• Downloaded 732 times
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  • Site-wide: 32,894
  • In genetics: 1,588
• Year to date:
  • Site-wide: 81,731
• Since beginning of last month:
  • Site-wide: 107,480

Genetic liability for schizophrenia and childhood psychopathology in the general population

• Downloaded 723 times
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  • Site-wide: 33,384
  • In psychiatry and clinical psychology: 108
• Year to date:
  • Site-wide: 5,403
• Since beginning of last month:
  • Site-wide: 7,259

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 713 times
• Download rankings, all-time:
  • Site-wide: 33,951
  • In genetics: 1,639
• Year to date:
  • Site-wide: 123,834
• Since beginning of last month:
  • Site-wide: 116,109

Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis

• Downloaded 711 times
• Download rankings, all-time:
  • Site-wide: 34,100
  • In genomics: 2,983
• Year to date:
  • Site-wide: 20,982
• Since beginning of last month:
  • Site-wide: 20,887

Consistency of non-cognitive skills and their relation to educational outcomes in a UK cohort

• Downloaded 698 times
• Download rankings, all-time:
  • Site-wide: 35,040
  • In genetics: 1,675
• Year to date:
  • Site-wide: 30,987
• Since beginning of last month:
  • Site-wide: 30,223

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

• Downloaded 689 times
• Download rankings, all-time:
  • Site-wide: 35,632
  • In genetics: 1,700
• Year to date:
  • Site-wide: 92,395
• Since beginning of last month:
  • Site-wide: 84,990

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 689 times
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  • Site-wide: 35,606
  • In genetic and genomic medicine: 112
• Year to date:
  • Site-wide: 10,387
• Since beginning of last month:
  • Site-wide: 12,296

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

• Downloaded 685 times
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  • Site-wide: 35,931
  • In neurology: 66
• Year to date:
  • Site-wide: 2,038
• Since beginning of last month:
  • Site-wide: 651

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

• Downloaded 675 times
• Download rankings, all-time:
  • Site-wide: 36,624
  • In genetics: 1,746
• Year to date:
  • Site-wide: 125,555
• Since beginning of last month:
  • Site-wide: 129,371

Detecting heterogeneity of intervention effects using analysis and meta-analysis of differences in variance between arms of a trial

• Downloaded 674 times
• Download rankings, all-time:
  • Site-wide: 36,711
  • In epidemiology: 1,791
• Year to date:
  • Site-wide: 38,260
• Since beginning of last month:
  • Site-wide: 42,154

The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children

• Downloaded 670 times
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  • Site-wide: 36,949
  • In genetics: 1,766
• Year to date:
  • Site-wide: 123,043
• Since beginning of last month:
  • Site-wide: 101,684

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

• Downloaded 669 times
• Download rankings, all-time:
  • Site-wide: 37,056
  • In genetics: 1,767
• Year to date:
  • Site-wide: 99,981
• Since beginning of last month:
  • Site-wide: 94,361

Distinct Blood DNA Methylation Profiles In Subtypes Of Orofacial Cleft

• Downloaded 668 times
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  • Site-wide: 37,107
  • In epidemiology: 1,805
• Year to date:
  • Site-wide: 114,046
• Since beginning of last month:
  • Site-wide: 121,369

Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits

• Downloaded 667 times
• Download rankings, all-time:
  • Site-wide: 37,228
  • In genetics: 1,773
• Year to date:
  • Site-wide: 24,191
• Since beginning of last month:
  • Site-wide: 36,368

Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

• Downloaded 653 times
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  • Site-wide: 38,254
  • In systems biology: 869
• Year to date:
  • Site-wide: 119,578
• Since beginning of last month:
  • Site-wide: 106,578

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

• Downloaded 652 times
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  • Site-wide: 38,308
  • In epidemiology: 1,846
• Year to date:
  • Site-wide: 123,067
• Since beginning of last month:
  • Site-wide: 127,981

Education and coronary heart disease: a Mendelian randomization study

• Downloaded 644 times
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  • Site-wide: 38,929
  • In epidemiology: 1,867
• Year to date:
  • Site-wide: 123,577
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  • Site-wide: 121,376

Appraising the causal relevance of DNA methylation for risk of lung cancer

• Downloaded 643 times
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  • Site-wide: 38,991
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  • Site-wide: 92,738
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  • Site-wide: 74,551

Genetic predictors of participation in optional components of UK Biobank

• Downloaded 640 times
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  • Site-wide: 39,320
  • In genetics: 1,864
• Year to date:
  • Site-wide: 46,253
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  • Site-wide: 97,906

Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population

• Downloaded 639 times
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  • Site-wide: 39,396
  • In genetics: 1,865
• Year to date:
  • Site-wide: 68,778
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  • Site-wide: 88,985

Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

• Downloaded 637 times
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  • Site-wide: 39,515
  • In epidemiology: 1,890
• Year to date:
  • Site-wide: 108,743
• Since beginning of last month:
  • Site-wide: 128,126

Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life

• Downloaded 634 times
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  • Site-wide: 39,780
  • In genetics: 1,886
• Year to date:
  • Site-wide: 74,408
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  • Site-wide: 83,967

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

• Downloaded 630 times
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  • Site-wide: 40,062
  • In genomics: 3,333
• Year to date:
  • Site-wide: 98,126
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  • Site-wide: 94,866

Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

• Downloaded 611 times
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  • Site-wide: 41,626
  • In epidemiology: 1,978
• Year to date:
  • Site-wide: 78,961
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  • Site-wide: 113,522

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 579 times
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  • Site-wide: 44,513
  • In epidemiology: 2,086
• Year to date:
  • Site-wide: 98,504
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  • Site-wide: 79,532

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

• Downloaded 576 times
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  • Site-wide: 44,804
  • In genetics: 2,099
• Year to date:
  • Site-wide: 70,808
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  • Site-wide: 89,325

Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

• Downloaded 572 times
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  • Site-wide: 45,170
  • In epidemiology: 2,099
• Year to date:
  • Site-wide: 98,449
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  • Site-wide: 113,726

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

• Downloaded 572 times
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  • Site-wide: 45,179
  • In genetics: 2,120
• Year to date:
  • Site-wide: 111,222
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  • Site-wide: 114,451

The MRC IEU OpenGWAS data infrastructure

• Downloaded 567 times
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  • Site-wide: 45,653
  • In genetics: 2,154
• Year to date:
  • Site-wide: 10,480
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  • Site-wide: 11,628

Metabolic signatures of birth weight in 18288 adolescents and adults

• Downloaded 553 times
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  • Site-wide: 47,094
  • In systems biology: 1,089
• Year to date:
  • Site-wide: 103,111
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  • Site-wide: 103,225

Cigarette smoking and personality: Investigating causality using Mendelian randomization

• Downloaded 538 times
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  • Site-wide: 48,692
  • In epidemiology: 2,212
• Year to date:
  • Site-wide: 81,450
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  • Site-wide: 66,777

Conditioning on a collider may induce spurious associations: Do the results of Gale et al. (2017) support a protective effect of neuroticism in population sub-groups?

• Downloaded 535 times
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  • Site-wide: 49,026
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• Year to date:
  • Site-wide: 131,439
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  • Site-wide: 128,014

Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study

• Downloaded 518 times
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  • Site-wide: 50,908
  • In epidemiology: 2,277
• Year to date:
  • Site-wide: 129,501
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  • Site-wide: 113,506

The median and the mode as robust meta-analysis methods in the presence of small study effects

• Downloaded 509 times
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  • Site-wide: 51,994
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  • Site-wide: 66,573
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  • Site-wide: 51,107

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 508 times
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  • Site-wide: 52,073
  • In neuroscience: 7,693
• Year to date:
  • Site-wide: 116,630
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  • Site-wide: 132,180

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

• Downloaded 505 times
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  • Site-wide: 52,523
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• Year to date:
  • Site-wide: 119,075
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  • Site-wide: 108,381

Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood

• Downloaded 489 times
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  • Site-wide: 54,417
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• Year to date:
  • Site-wide: 42,606
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  • Site-wide: 33,346

Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

• Downloaded 486 times
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  • Site-wide: 54,909
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  • Site-wide: 54,575
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  • Site-wide: 32,619

Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

• Downloaded 477 times
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  • Site-wide: 55,975
  • In genomics: 4,228
• Year to date:
  • Site-wide: 118,238
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  • Site-wide: 118,052

Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures

• Downloaded 473 times
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  • Site-wide: 56,495
  • In genetics: 2,638
• Year to date:
  • Site-wide: 95,110
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  • Site-wide: 103,633

Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney disease

• Downloaded 465 times
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  • Site-wide: 57,539
  • In epidemiology: 2,491
• Year to date:
  • Site-wide: 26,919
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  • Site-wide: 24,400

The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank

• Downloaded 463 times
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  • Site-wide: 57,809
  • In epidemiology: 2,504
• Year to date:
  • Site-wide: 102,652
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  • Site-wide: 116,613

A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank

• Downloaded 463 times
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  • Site-wide: 57,837
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• Year to date:
  • Site-wide: 111,215
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  • Site-wide: 106,041

Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease

• Downloaded 461 times
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  • Site-wide: 58,042
  • In epidemiology: 2,513
• Year to date:
  • Site-wide: 73,277
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  • Site-wide: 87,779

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

• Downloaded 457 times
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  • Site-wide: 58,629
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• Year to date:
  • Site-wide: 130,419
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  • Site-wide: 132,947

PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

• Downloaded 450 times
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  • Site-wide: 59,641
  • In epidemiology: 2,580
• Year to date:
  • Site-wide: 69,008
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  • Site-wide: 63,628

Is genetic liability to ADHD and ASD causally linked to educational attainment?

• Downloaded 442 times
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  • Site-wide: 60,755
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• Year to date:
  • Site-wide: 46,237
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  • Site-wide: 53,359

Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

• Downloaded 440 times
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  • Site-wide: 60,982
  • In epidemiology: 2,627
• Year to date:
  • Site-wide: 110,447
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  • Site-wide: 125,838

Association Between Genetically Elevated Levels Of Inflammatory Biomarkers And Risk Of Schizophrenia: A Two-Sample Mendelian Randomisation Study

• Downloaded 429 times
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  • Site-wide: 62,623
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• Year to date:
  • Site-wide: 122,907
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  • Site-wide: 105,593

The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study

• Downloaded 429 times
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  • Site-wide: 62,608
  • In epidemiology: 2,691
• Year to date:
  • Site-wide: 124,989
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  • Site-wide: 102,245

CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?

• Downloaded 428 times
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  • Site-wide: 62,742
  • In genetics: 2,898
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  • Site-wide: 69,058
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  • Site-wide: 49,012

Schizophrenia risk and reproductive success: A Mendelian randomization study.

• Downloaded 427 times
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  • Site-wide: 62,904
  • In evolutionary biology: 3,452
• Year to date:
  • Site-wide: 114,508
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  • Site-wide: 115,340

Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study

• Downloaded 421 times
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  • Site-wide: 63,786
  • In epidemiology: 2,737
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  • Site-wide: 101,579
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  • Site-wide: 123,805

Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

• Downloaded 414 times
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  • Site-wide: 64,921
  • In epidemiology: 2,771
• Year to date:
  • Site-wide: 94,499
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  • Site-wide: 93,001

MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

• Downloaded 405 times
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  • Site-wide: 66,412
  • In epidemiology: 2,835
• Year to date:
  • Site-wide: 118,981
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  • Site-wide: 125,967

Examining the effect of smoking on suicidal ideation and attempts: A Mendelian randomisation study

• Downloaded 405 times
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  • Site-wide: 66,288
  • In epidemiology: 2,832
• Year to date:
  • Site-wide: 80,480
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  • Site-wide: 81,705

Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisation

• Downloaded 401 times
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  • Site-wide: 66,990
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• Year to date:
  • Site-wide: 75,671
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  • Site-wide: 85,887

The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

• Downloaded 391 times
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  • Site-wide: 68,654
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  • Site-wide: 52,532
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  • Site-wide: 41,492

The association between adiposity and inpatient hospital costs in the UK Biobank cohort

• Downloaded 384 times
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  • Site-wide: 69,822
  • In epidemiology: 2,947
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  • Site-wide: 132,913
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  • Site-wide: 121,718

Identifying novel subtypes of irritability using a developmental genetic approach

• Downloaded 372 times
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  • Site-wide: 71,812
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  • Site-wide: 117,417
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  • Site-wide: 103,498

Assortative mating and within-spouse pair comparisons

• Downloaded 367 times
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  • Site-wide: 72,766
  • In genetics: 3,313
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  • Site-wide: 63,954
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  • Site-wide: 41,194

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

• Downloaded 367 times
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  • Site-wide: 72,668
  • In genetics: 3,316
• Year to date:
  • Site-wide: 105,667
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  • Site-wide: 94,590

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

• Downloaded 367 times
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  • Site-wide: 72,681
  • In epidemiology: 3,054
• Year to date:
  • Site-wide: 105,680
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  • Site-wide: 103,807

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

• Downloaded 366 times
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  • Site-wide: 72,814
  • In epidemiology: 3,065
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  • Site-wide: 52,466
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  • Site-wide: 56,390

A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target

• Downloaded 365 times
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  • Site-wide: 72,968
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• Year to date:
  • Site-wide: 94,036
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  • Site-wide: 104,191

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

• Downloaded 363 times
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  • Site-wide: 73,409
  • In genetics: 3,343
• Year to date:
  • Site-wide: 127,131
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  • Site-wide: 124,884

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

• Downloaded 357 times
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  • Site-wide: 74,485
  • In epidemiology: 3,122
• Year to date:
  • Site-wide: 40,998
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  • Site-wide: 36,766

The Multivariate Genome-wide Architecture of Interrelated Literacy, Language and Working Memory Skills Reveals Distinct Etiologies

• Downloaded 350 times
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  • Site-wide: 75,810
  • In genetics: 3,454
• Year to date:
  • Site-wide: 63,411
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  • Site-wide: 76,805

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

• Downloaded 349 times
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  • Site-wide: 76,029
  • In epidemiology: 3,172
• Year to date:
  • Site-wide: 80,604
• Since beginning of last month:
  • Site-wide: 70,067

Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

• Downloaded 346 times
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  • Site-wide: 76,605
  • In epidemiology: 3,189
• Year to date:
  • Site-wide: 88,734
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  • Site-wide: 53,175

Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study

• Downloaded 345 times
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  • Site-wide: 76,683
  • In neurology: 180
• Year to date:
  • Site-wide: 46,424
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  • Site-wide: 42,676

DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

• Downloaded 341 times
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  • Site-wide: 77,423
  • In genetics: 3,524
• Year to date:
  • Site-wide: 123,136
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  • Site-wide: 129,221

Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer.

• Downloaded 338 times
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  • Site-wide: 78,126
  • In epidemiology: 3,255
• Year to date:
  • Site-wide: 69,942
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  • Site-wide: 65,390

A robust mean and variance test with application to high-dimensional phenotypes

• Downloaded 335 times
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  • Site-wide: 78,663
  • In bioinformatics: 7,224
• Year to date:
  • Site-wide: 49,729
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  • Site-wide: 46,705

Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions

• Downloaded 328 times
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  • Site-wide: 80,036
  • In epidemiology: 3,320
• Year to date:
  • Site-wide: 29,168
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  • Site-wide: 26,542

Estimating the causal effect of genetic liability to prevalent disease on hospital costs using Mendelian Randomization

• Downloaded 325 times
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  • Site-wide: 80,660
  • In health economics: 102
• Year to date:
  • Site-wide: 46,396
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  • Site-wide: 46,267

Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study

• Downloaded 320 times
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  • Site-wide: 81,621
  • In epidemiology: 3,376
• Year to date:
  • Site-wide: 58,015
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  • Site-wide: 52,745

Mendelian randomisation with coarsened exposures

• Downloaded 307 times
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  • Site-wide: 84,066
  • In epidemiology: 3,465
• Year to date:
  • Site-wide: 19,480
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  • Site-wide: 28,649

The relationship between open angle glaucoma, optic disc morphology and Alzheimer's Disease: a Mendelian randomization study

• Downloaded 302 times
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  • Site-wide: 85,350
  • In ophthalmology: 54
• Year to date:
  • Site-wide: 45,831
• Since beginning of last month:
  • Site-wide: 32,572

Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health

• Downloaded 289 times
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  • Site-wide: 88,014
  • In epidemiology: 3,622
• Year to date:
  • Site-wide: 133,215
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  • Site-wide: 123,458

Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype

• Downloaded 289 times
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  • Site-wide: 88,017
  • In epidemiology: 3,626
• Year to date:
  • Site-wide: 105,202
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  • Site-wide: 121,306

Does Smoking Cause Lower Educational Attainment and General Cognitive Ability? Triangulation of causal evidence using multiple study designs

• Downloaded 281 times
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  • Site-wide: 89,723
  • In epidemiology: 3,691
• Year to date:
  • Site-wide: 104,793
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  • Site-wide: 92,082

Educational inequalities in statin treatment for preventing cardiovascular disease: cross-sectional analysis of UK Biobank

• Downloaded 274 times
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  • Site-wide: 91,205
  • In epidemiology: 3,745
• Year to date:
  • Site-wide: 64,006
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  • Site-wide: 59,619

Mendelian randomization does not support serum calcium in prostate cancer risk

• Downloaded 270 times
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  • Site-wide: 92,248
  • In epidemiology: 3,780
• Year to date:
  • Site-wide: 118,825
• Since beginning of last month:
  • Site-wide: 93,028

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 269 times
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  • Site-wide: 92,293
  • In genetics: 4,142
• Year to date:
  • Site-wide: 123,207
• Since beginning of last month:
  • Site-wide: 106,960

Evaluating the direct effects of childhood adiposity on adult systemic metabolism: A multivariable Mendelian randomization analysis

• Downloaded 255 times
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  • Site-wide: 95,441
  • In cardiovascular medicine: 178
• Year to date:
  • Site-wide: 47,895
• Since beginning of last month:
  • Site-wide: 30,941

Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals

• Downloaded 253 times
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  • Site-wide: 95,814
  • In genetics: 4,282
• Year to date:
  • Site-wide: 127,148
• Since beginning of last month:
  • Site-wide: 129,086

Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

• Downloaded 251 times
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  • Site-wide: 96,346
  • In epidemiology: 3,945
• Year to date:
  • Site-wide: 32,304
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  • Site-wide: 41,613

The role of school enjoyment in the association between externalising and depressive symptoms and academic attainment: findings from a UK prospective cohort study

• Downloaded 237 times
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  • Site-wide: 99,343
  • In epidemiology: 4,077
• Year to date:
  • Site-wide: 48,281
• Since beginning of last month:
  • Site-wide: 42,609

Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

• Downloaded 236 times
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  • Site-wide: 99,600
  • In genetics: 4,430
• Year to date:
  • Site-wide: 121,775
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  • Site-wide: 130,174

The effect of smoking on multiple sclerosis: a mendelian randomization study

• Downloaded 235 times
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  • Site-wide: 99,944
  • In genetic and genomic medicine: 408
• Year to date:
  • Site-wide: 63,940
• Since beginning of last month:
  • Site-wide: 64,380

A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation

• Downloaded 234 times
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  • Site-wide: 100,102
  • In epidemiology: 4,100
• Year to date:
  • Site-wide: 34,447
• Since beginning of last month:
  • Site-wide: 33,717

Association of genetic liability to smoking initiation with e-cigarette use in young adults.

• Downloaded 228 times
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  • Site-wide: 101,316
  • In epidemiology: 4,147
• Year to date:
  • Site-wide: 37,547
• Since beginning of last month:
  • Site-wide: 27,471

Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

• Downloaded 226 times
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  • Site-wide: 101,819
  • In genetics: 4,517
• Year to date:
  • Site-wide: 92,912
• Since beginning of last month:
  • Site-wide: 111,908

Examining the bidirectional association between emotion recognition and ASD symptoms using observational and genetic analyses

• Downloaded 225 times
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  • Site-wide: 102,021
  • In genetic and genomic medicine: 422
• Year to date:
  • Site-wide: 67,851
• Since beginning of last month:
  • Site-wide: 61,092

Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to SARS-CoV-2 severity

• Downloaded 219 times
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  • Site-wide: 103,456
  • In epidemiology: 4,259
• Year to date:
  • Site-wide: 51,488
• Since beginning of last month:
  • Site-wide: 36,727

Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

• Downloaded 219 times
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  • Site-wide: 103,471
  • In epidemiology: 4,258
• Year to date:
  • Site-wide: 49,040
• Since beginning of last month:
  • Site-wide: 44,845

Risk of death among teachers in England and Wales during the Covid19 pandemic

• Downloaded 216 times
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  • Site-wide: 104,167
  • In epidemiology: 4,301
• Year to date:
  • Site-wide: 10,596
• Since beginning of last month:
  • Site-wide: 6,206

Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK Biobank

• Downloaded 202 times
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  • Site-wide: 107,205
  • In psychiatry and clinical psychology: 435
• Year to date:
  • Site-wide: 11,540
• Since beginning of last month:
  • Site-wide: 17,503

The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study

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Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study

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Interrogating structural inequalities in COVID-19 Mortality in England and Wales

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Causal effects of circulating cytokine concentrations on risk of Alzheimers disease: A bidirectional two-sample Mendelian randomization study

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Examining the possible causal relationship between Lung Function, COPD and Alzheimers Disease. A Mendelian Randomization Study

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Identifying intergenerational risk factors for ADHD symptoms using polygenic scores in the Norwegian Mother, Father and Child Cohort

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Interpreting Mendelian randomization estimates of the effects of categorical exposures such as disease status and educational attainment

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An Informatics Consult approach for generating clinical evidence for treatment decisions

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Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: prospective cohort study

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Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers

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Epidemiology and Genetics of Preserved Ratio Impaired SpiroMetry (PRISm): An Analysis of UK Biobank

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Cross-sectional association of blood pressure variability and night-time dipping with cardiac structure in adolescents

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Sex-specific associations of adiposity with cardiometabolic traits: multi-life-stage cohort study with repeat metabolomics

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Puberty and sex-specific trajectories of systolic blood pressure: a prospective cohort study

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Educational attainment as a modifier of the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank

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Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independent of body mass index

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