Author: George Davey Smith

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Preprints

Genetic effect modification of cis-acting C-reactive protein variants in cardiometabolic disease status

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Selection into shift work is influenced by educational attainment and body mass index: A Mendelian randomization study

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  • Site-wide: 104
  • In epidemiology: 24
• Year to date:
  • Site-wide: 73,678
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  • Site-wide: 82,275

Collider bias undermines our understanding of COVID-19 disease risk and severity

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  • Site-wide: 725
  • In epidemiology: 106
• Year to date:
  • Site-wide: 2,996
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  • Site-wide: 25,741

A reference panel of 64,976 haplotypes for genotype imputation

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  • Site-wide: 2,698
  • In genetics: 90
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  • Site-wide: 123,215
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  • Site-wide: 105,688

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

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  • Site-wide: 3,137
  • In epidemiology: 333
• Year to date:
  • Site-wide: 27,578
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  • Site-wide: 11,536

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

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  • Site-wide: 3,196
  • In genetics: 107
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  • Site-wide: 10,130
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  • Site-wide: 7,983

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

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  • Site-wide: 3,582
  • In epidemiology: 366
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  • Site-wide: 8,717
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  • Site-wide: 3,726

PHESANT: a tool for performing automated phenome scans in UK Biobank

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  • Site-wide: 3,670
  • In epidemiology: 371
• Year to date:
  • Site-wide: 13,821
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  • Site-wide: 6,974

Collider Scope: When selection bias can substantially influence observed associations

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  • Site-wide: 5,475
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  • Site-wide: 30,755
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  • Site-wide: 31,852

Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • Site-wide: 5,663
  • In genetics: 238
• Year to date:
  • Site-wide: 23,648
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  • Site-wide: 10,533

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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  • Site-wide: 6,323
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  • Site-wide: 120,567
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  • Site-wide: 105,609

Mendelian randomization: a premature burial?

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  • Site-wide: 6,394
  • In genetics: 273
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  • Site-wide: 52,384
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  • Site-wide: None

Why are education, socioeconomic position and intelligence genetically correlated?

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  • Site-wide: 6,439
  • In genetics: 276
• Year to date:
  • Site-wide: 58,262
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  • Site-wide: 101,428

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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  • Site-wide: 6,703
  • In genetics: 295
• Year to date:
  • Site-wide: 88,352
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  • Site-wide: 29,730

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

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  • Site-wide: 6,897
  • In epidemiology: 578
• Year to date:
  • Site-wide: 95,409
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  • Site-wide: 50,506

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

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  • Site-wide: 7,429
  • In genetics: 327
• Year to date:
  • Site-wide: 29,952
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  • Site-wide: 112,020

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

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  • Site-wide: 8,307
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• Year to date:
  • Site-wide: 6,762
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  • Site-wide: 15,009

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

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  • Site-wide: 8,932
  • In epidemiology: 709
• Year to date:
  • Site-wide: 78,190
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  • Site-wide: 23,082

Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

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  • Site-wide: 8,987
  • In epidemiology: 712
• Year to date:
  • Site-wide: 20,346
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  • Site-wide: 11,017

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

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  • Site-wide: 9,417
  • In genetics: 401
• Year to date:
  • Site-wide: 69,045
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  • Site-wide: 100,728

Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

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  • Site-wide: 9,590
  • In genetics: 414
• Year to date:
  • Site-wide: 75,863
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  • Site-wide: 106,046

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

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  • Site-wide: 10,481
  • In genetics: 460
• Year to date:
  • Site-wide: 89,097
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  • Site-wide: 109,443

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 10,576
  • In genetics: 465
• Year to date:
  • Site-wide: 75,884
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  • Site-wide: 45,865

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 10,794
  • In genetics: 477
• Year to date:
  • Site-wide: 89,166
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  • Site-wide: 40,395

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

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  • Site-wide: 11,484
  • In genetics: 511
• Year to date:
  • Site-wide: 146,120
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  • Site-wide: None

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

• Downloaded 1,647 times
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  • Site-wide: 11,861
  • In genetics: 536
• Year to date:
  • Site-wide: 127,087
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  • Site-wide: 65,796

An examination of multivariable Mendelian randomization in the single sample and two-sample summary data settings.

• Downloaded 1,612 times
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  • Site-wide: 12,229
  • In epidemiology: 880
• Year to date:
  • Site-wide: 55,976
• Since beginning of last month:
  • Site-wide: 38,907

Selection bias in instrumental variable analyses

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  • Site-wide: 13,219
  • In epidemiology: 939
• Year to date:
  • Site-wide: 25,329
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  • Site-wide: 8,009

Cigarette smoking increases coffee consumption: findings from a Mendelian randomisation analysis

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  • Site-wide: 13,794
  • In genetics: 633
• Year to date:
  • Site-wide: 52,935
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  • Site-wide: 18,522

The Causal Effects of Education on Health, Mortality, Cognition, Well-being, and Income in the UK Biobank

• Downloaded 1,466 times
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  • Site-wide: 14,068
  • In epidemiology: 975
• Year to date:
  • Site-wide: 71,730
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  • Site-wide: 17,245

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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  • Site-wide: 14,469
  • In genetics: 661
• Year to date:
  • Site-wide: 111,956
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  • Site-wide: 103,516

Within-sibship GWAS improve estimates of direct genetic effects

• Downloaded 1,414 times
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  • Site-wide: 14,881
  • In genetics: 687
• Year to date:
  • Site-wide: 2,070
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  • Site-wide: 59,427

Do early life non-cognitive skills matter? A systematic review and meta-analysis of early life effects on academic achievement, psychosocial, language and cognitive, and health outcomes

• Downloaded 1,400 times
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  • Site-wide: 15,106
  • In epidemiology: 1,032
• Year to date:
  • Site-wide: 84,279
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  • Site-wide: 21,119

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

• Downloaded 1,397 times
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  • Site-wide: 15,145
  • In neurology: 32
• Year to date:
  • Site-wide: 2,117
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  • Site-wide: 960

The genetic architecture of osteoarthritis: insights from UK Biobank

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  • Site-wide: 15,307
  • In genetics: 703
• Year to date:
  • Site-wide: 80,584
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  • Site-wide: 26,535

Multi-omics study revealing putative drug targets of COVID-19 severity and other viral infection diseases

• Downloaded 1,384 times
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  • Site-wide: 15,389
  • In genetic and genomic medicine: 66
• Year to date:
  • Site-wide: 21,632
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  • Site-wide: 7,174

Meffil: efficient normalisation and analysis of very large DNA methylation samples

• Downloaded 1,378 times
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  • Site-wide: 15,475
  • In bioinformatics: 1,784
• Year to date:
  • Site-wide: 59,087
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  • Site-wide: 15,202

Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

• Downloaded 1,287 times
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  • Site-wide: 17,154
  • In genetics: 797
• Year to date:
  • Site-wide: 140,831
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  • Site-wide: 61,288

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

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  • Site-wide: 17,195
  • In epidemiology: 1,133
• Year to date:
  • Site-wide: 24,729
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  • Site-wide: 9,991

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

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  • Site-wide: 18,136
  • In epidemiology: 1,176
• Year to date:
  • Site-wide: 111,754
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  • Site-wide: 39,078

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

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  • Site-wide: 18,325
  • In genetics: 844
• Year to date:
  • Site-wide: 83,015
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  • Site-wide: 27,723

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

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  • Site-wide: 19,333
  • In epidemiology: 1,229
• Year to date:
  • Site-wide: 33,997
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  • Site-wide: 25,286

Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data

• Downloaded 1,175 times
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  • Site-wide: 19,615
  • In genetics: 906
• Year to date:
  • Site-wide: 73,835
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  • Site-wide: 22,712

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

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  • Site-wide: 19,876
  • In genetics: 912
• Year to date:
  • Site-wide: 104,635
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  • Site-wide: 103,652

Body mass index and mortality in UK Biobank: revised estimates using Mendelian randomization

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  • Site-wide: 19,994
  • In epidemiology: 1,249
• Year to date:
  • Site-wide: 76,755
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  • Site-wide: 22,739

The causes and consequences of Alzheimer's disease: A Mendelian randomization analysis

• Downloaded 1,148 times
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  • Site-wide: 20,295
  • In genetic and genomic medicine: 84
• Year to date:
  • Site-wide: 13,213
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  • Site-wide: 34,725

Genetic Association Study of Childhood Aggression across raters, instruments and age

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  • Site-wide: 20,338
  • In genomics: 1,955
• Year to date:
  • Site-wide: 13,358
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  • Site-wide: 11,041

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

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  • Site-wide: 20,649
  • In genetics: 946
• Year to date:
  • Site-wide: 9,758
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  • Site-wide: 94,773

Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

• Downloaded 1,083 times
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  • Site-wide: 22,100
  • In pharmacology and toxicology: 122
• Year to date:
  • Site-wide: 127,892
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  • Site-wide: 74,127

The effect of education on adult mortality, health, and income: triangulating across genetic and policy reforms

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  • Site-wide: 22,241
  • In epidemiology: 1,344
• Year to date:
  • Site-wide: 79,442
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  • Site-wide: 27,436

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

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  • Site-wide: 22,547
  • In genetics: 1,029
• Year to date:
  • Site-wide: 117,872
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  • Site-wide: None

Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions

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  • Site-wide: 22,627
  • In epidemiology: 1,363
• Year to date:
  • Site-wide: 98,734
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  • Site-wide: 38,910

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

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  • Site-wide: 23,698
  • In genetic and genomic medicine: 97
• Year to date:
  • Site-wide: 7,723
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  • Site-wide: 5,935

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

• Downloaded 1,021 times
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  • Site-wide: 24,083
  • In epidemiology: 1,417
• Year to date:
  • Site-wide: 71,813
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  • Site-wide: 36,576

Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

• Downloaded 1,018 times
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  • Site-wide: 24,171
  • In epidemiology: 1,421
• Year to date:
  • Site-wide: 101,947
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  • Site-wide: 45,169

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 1,012 times
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  • Site-wide: 24,365
  • In genetics: 1,114
• Year to date:
  • Site-wide: 107,977
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  • Site-wide: 103,552

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?

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  • Site-wide: 24,405
  • In epidemiology: 1,428
• Year to date:
  • Site-wide: 106,815
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  • Site-wide: None

Can education be personalised using pupils’ genetic data?

• Downloaded 993 times
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  • Site-wide: 25,088
  • In genetics: 1,139
• Year to date:
  • Site-wide: 86,683
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  • Site-wide: 32,670

Genetic liability for schizophrenia and childhood psychopathology in the general population

• Downloaded 981 times
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  • Site-wide: 25,553
  • In psychiatry and clinical psychology: 93
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  • Site-wide: 6,975
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  • Site-wide: 25,751

Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease

• Downloaded 956 times
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  • Site-wide: 26,560
  • In cardiovascular medicine: 39
• Year to date:
  • Site-wide: 81,003
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  • Site-wide: 67,959

Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

• Downloaded 953 times
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  • Site-wide: 26,664
  • In genomics: 2,437
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  • Site-wide: 66,237
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  • Site-wide: 78,923

The MRC IEU OpenGWAS data infrastructure

• Downloaded 909 times
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  • Site-wide: 28,520
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  • Site-wide: 7,823
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  • Site-wide: 2,587

Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression

• Downloaded 873 times
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  • Site-wide: 30,178
  • In epidemiology: 1,626
• Year to date:
  • Site-wide: 127,797
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  • Site-wide: None

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

• Downloaded 842 times
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  • Site-wide: 31,735
  • In epidemiology: 1,686
• Year to date:
  • Site-wide: 47,732
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  • Site-wide: 15,101

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

• Downloaded 836 times
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  • Site-wide: 32,076
  • In genetics: 1,478
• Year to date:
  • Site-wide: 75,946
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  • Site-wide: 19,816

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

• Downloaded 830 times
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  • Site-wide: 32,350
  • In bioinformatics: 3,569
• Year to date:
  • Site-wide: 83,870
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  • Site-wide: 79,641

The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

• Downloaded 819 times
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  • Site-wide: 32,938
  • In epidemiology: 1,722
• Year to date:
  • Site-wide: 89,602
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  • Site-wide: 36,748

Genetic Epidemiology And Mendelian Randomization For Informing Disease Therapeutics: Conceptual And Methodological Challenges

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  • Site-wide: 33,304
  • In genetics: 1,536
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  • Site-wide: 137,090
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  • Site-wide: None

Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits

• Downloaded 803 times
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  • Site-wide: 33,911
  • In genetics: 1,560
• Year to date:
  • Site-wide: 24,865
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  • Site-wide: 109,548

Detecting heterogeneity of intervention effects using analysis and meta-analysis of differences in variance between arms of a trial

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  • Site-wide: 33,960
  • In epidemiology: 1,765
• Year to date:
  • Site-wide: 32,679
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  • Site-wide: 84,609

Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis

• Downloaded 777 times
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  • Site-wide: 35,537
  • In genomics: 2,993
• Year to date:
  • Site-wide: 34,296
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  • Site-wide: 78,706

Consistency of non-cognitive skills and their relation to educational outcomes in a UK cohort

• Downloaded 770 times
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  • Site-wide: 35,996
  • In genetics: 1,632
• Year to date:
  • Site-wide: 42,314
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  • Site-wide: 78,537

Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study

• Downloaded 769 times
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  • Site-wide: 36,025
  • In epidemiology: 1,843
• Year to date:
  • Site-wide: 90,194
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  • Site-wide: None

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease

• Downloaded 761 times
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  • Site-wide: 36,613
  • In genetics: 1,657
• Year to date:
  • Site-wide: 128,111
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  • Site-wide: 106,213

Using genetics to examine a general liability to childhood psychopathology

• Downloaded 760 times
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  • Site-wide: 36,674
  • In genetics: 1,658
• Year to date:
  • Site-wide: 105,463
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  • Site-wide: 62,858

Examining the genetic influences of educational attainment and the validity of value-added measures of progress

• Downloaded 757 times
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  • Site-wide: 36,887
  • In genetics: 1,671
• Year to date:
  • Site-wide: 137,956
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  • Site-wide: None

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

• Downloaded 743 times
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  • Site-wide: 37,849
  • In genetics: 1,708
• Year to date:
  • Site-wide: 132,062
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  • Site-wide: None

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 724 times
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  • Site-wide: 39,214
  • In genetics: 1,765
• Year to date:
  • Site-wide: 147,731
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  • Site-wide: 113,203

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

• Downloaded 716 times
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  • Site-wide: 39,797
  • In genetics: 1,792
• Year to date:
  • Site-wide: 112,331
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  • Site-wide: 110,731

Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population

• Downloaded 701 times
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  • Site-wide: 40,945
  • In genetics: 1,842
• Year to date:
  • Site-wide: 69,049
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  • Site-wide: 17,169

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

• Downloaded 697 times
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  • Site-wide: 41,227
  • In genetics: 1,850
• Year to date:
  • Site-wide: 115,366
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  • Site-wide: 36,078

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

• Downloaded 695 times
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  • Site-wide: 41,402
  • In genetics: 1,855
• Year to date:
  • Site-wide: 138,005
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  • Site-wide: 63,095

Distinct Blood DNA Methylation Profiles In Subtypes Of Orofacial Cleft

• Downloaded 694 times
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  • Site-wide: 41,474
  • In epidemiology: 2,054
• Year to date:
  • Site-wide: 124,436
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  • Site-wide: None

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

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  • Site-wide: 42,444
  • In epidemiology: 2,099
• Year to date:
  • Site-wide: 123,317
• Since beginning of last month:
  • Site-wide: 49,845

Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life

• Downloaded 682 times
• Download rankings, all-time:
  • Site-wide: 42,414
  • In genetics: 1,902
• Year to date:
  • Site-wide: 82,304
• Since beginning of last month:
  • Site-wide: 39,971

The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children

• Downloaded 677 times
• Download rankings, all-time:
  • Site-wide: 42,838
  • In genetics: 1,919
• Year to date:
  • Site-wide: 150,798
• Since beginning of last month:
  • Site-wide: 87,313

Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

• Downloaded 675 times
• Download rankings, all-time:
  • Site-wide: 42,997
  • In systems biology: 935
• Year to date:
  • Site-wide: 132,884
• Since beginning of last month:
  • Site-wide: 73,497

Appraising the causal relevance of DNA methylation for risk of lung cancer

• Downloaded 671 times
• Download rankings, all-time:
  • Site-wide: 43,330
  • In epidemiology: 2,133
• Year to date:
  • Site-wide: 111,705
• Since beginning of last month:
  • Site-wide: 55,851

Education and coronary heart disease: a Mendelian randomization study

• Downloaded 667 times
• Download rankings, all-time:
  • Site-wide: 43,704
  • In epidemiology: 2,145
• Year to date:
  • Site-wide: 132,264
• Since beginning of last month:
  • Site-wide: 57,687

Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

• Downloaded 665 times
• Download rankings, all-time:
  • Site-wide: 43,859
  • In epidemiology: 2,148
• Year to date:
  • Site-wide: 119,651
• Since beginning of last month:
  • Site-wide: 30,125

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

• Downloaded 661 times
• Download rankings, all-time:
  • Site-wide: 44,242
  • In genomics: 3,518
• Year to date:
  • Site-wide: 110,769
• Since beginning of last month:
  • Site-wide: 36,167

Genetic predictors of participation in optional components of UK Biobank

• Downloaded 657 times
• Download rankings, all-time:
  • Site-wide: 44,606
  • In genetics: 1,993
• Year to date:
  • Site-wide: 86,178
• Since beginning of last month:
  • Site-wide: 72,758

Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

• Downloaded 635 times
• Download rankings, all-time:
  • Site-wide: 46,538
  • In epidemiology: 2,247
• Year to date:
  • Site-wide: 109,082
• Since beginning of last month:
  • Site-wide: 41,505

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

• Downloaded 620 times
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  • Site-wide: 48,047
  • In genetics: 2,135
• Year to date:
  • Site-wide: 83,780
• Since beginning of last month:
  • Site-wide: 104,186

Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney disease

• Downloaded 603 times
• Download rankings, all-time:
  • Site-wide: 49,705
  • In epidemiology: 2,343
• Year to date:
  • Site-wide: 26,052
• Since beginning of last month:
  • Site-wide: 53,032

Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

• Downloaded 600 times
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  • Site-wide: 49,960
  • In epidemiology: 2,355
• Year to date:
  • Site-wide: 113,942
• Since beginning of last month:
  • Site-wide: 49,886

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 594 times
• Download rankings, all-time:
  • Site-wide: 50,624
  • In epidemiology: 2,377
• Year to date:
  • Site-wide: 131,466
• Since beginning of last month:
  • Site-wide: 61,771

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

• Downloaded 592 times
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  • Site-wide: 50,872
  • In genetics: 2,246
• Year to date:
  • Site-wide: 131,489
• Since beginning of last month:
  • Site-wide: None

Cigarette smoking and personality: Investigating causality using Mendelian randomization

• Downloaded 578 times
• Download rankings, all-time:
  • Site-wide: 52,488
  • In epidemiology: 2,448
• Year to date:
  • Site-wide: 92,632
• Since beginning of last month:
  • Site-wide: 33,363

Metabolic signatures of birth weight in 18288 adolescents and adults

• Downloaded 569 times
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  • Site-wide: 53,528
  • In systems biology: 1,186
• Year to date:
  • Site-wide: 132,014
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  • Site-wide: 73,459

Mendelian randomisation with coarsened exposures

• Downloaded 551 times
• Download rankings, all-time:
  • Site-wide: 55,635
  • In epidemiology: 2,547
• Year to date:
  • Site-wide: 13,833
• Since beginning of last month:
  • Site-wide: 6,523

Conditioning on a collider may induce spurious associations: Do the results of Gale et al. (2017) support a protective effect of neuroticism in population sub-groups?

• Downloaded 549 times
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  • Site-wide: 55,804
  • In epidemiology: 2,556
• Year to date:
  • Site-wide: 148,987
• Since beginning of last month:
  • Site-wide: 61,760

The median and the mode as robust meta-analysis methods in the presence of small study effects

• Downloaded 547 times
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  • Site-wide: 56,065
  • In epidemiology: 2,568
• Year to date:
  • Site-wide: 86,440
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  • Site-wide: 36,784

Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

• Downloaded 539 times
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  • Site-wide: 57,057
  • In genetics: 2,534
• Year to date:
  • Site-wide: 68,078
• Since beginning of last month:
  • Site-wide: 19,578

Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study

• Downloaded 537 times
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  • Site-wide: 57,297
  • In epidemiology: 2,602
• Year to date:
  • Site-wide: 142,650
• Since beginning of last month:
  • Site-wide: 57,250

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

• Downloaded 525 times
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  • Site-wide: 58,917
  • In epidemiology: 2,657
• Year to date:
  • Site-wide: 135,756
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  • Site-wide: 41,496

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 523 times
• Download rankings, all-time:
  • Site-wide: 59,260
  • In neuroscience: 8,549
• Year to date:
  • Site-wide: 140,538
• Since beginning of last month:
  • Site-wide: 112,035

Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood

• Downloaded 522 times
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  • Site-wide: 59,373
  • In epidemiology: 2,683
• Year to date:
  • Site-wide: 70,473
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  • Site-wide: 98,454

Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease

• Downloaded 517 times
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  • Site-wide: 59,986
  • In epidemiology: 2,702
• Year to date:
  • Site-wide: 74,942
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  • Site-wide: 26,765

PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 62,110
  • In epidemiology: 2,783
• Year to date:
  • Site-wide: 76,955
• Since beginning of last month:
  • Site-wide: 45,686

Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

• Downloaded 501 times
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  • Site-wide: 62,184
  • In genomics: 4,475
• Year to date:
  • Site-wide: 128,963
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  • Site-wide: 118,194

Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures

• Downloaded 497 times
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  • Site-wide: 62,661
  • In genetics: 2,766
• Year to date:
  • Site-wide: 118,293
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  • Site-wide: 41,394

The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank

• Downloaded 495 times
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  • Site-wide: 62,908
  • In epidemiology: 2,821
• Year to date:
  • Site-wide: 112,169
• Since beginning of last month:
  • Site-wide: 36,422

Is genetic liability to ADHD and ASD causally linked to educational attainment?

• Downloaded 492 times
• Download rankings, all-time:
  • Site-wide: 63,450
  • In genetics: 2,797
• Year to date:
  • Site-wide: 63,330
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  • Site-wide: 99,342

A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank

• Downloaded 491 times
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  • Site-wide: 63,588
  • In epidemiology: 2,837
• Year to date:
  • Site-wide: 120,019
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  • Site-wide: 41,282

CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?

• Downloaded 483 times
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  • Site-wide: 64,689
  • In genetics: 2,853
• Year to date:
  • Site-wide: 74,613
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  • Site-wide: 40,340

Examining the effect of smoking on suicidal ideation and attempts: A Mendelian randomisation study

• Downloaded 477 times
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  • Site-wide: 65,604
  • In epidemiology: 2,901
• Year to date:
  • Site-wide: 67,614
• Since beginning of last month:
  • Site-wide: 14,658

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

• Downloaded 468 times
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  • Site-wide: 66,931
  • In genetics: 2,950
• Year to date:
  • Site-wide: 150,425
• Since beginning of last month:
  • Site-wide: 105,944

Assortative mating and within-spouse pair comparisons

• Downloaded 464 times
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  • Site-wide: 67,613
  • In genetics: 2,986
• Year to date:
  • Site-wide: 50,397
• Since beginning of last month:
  • Site-wide: 11,814

Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

• Downloaded 462 times
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  • Site-wide: 67,902
  • In epidemiology: 3,003
• Year to date:
  • Site-wide: 128,420
• Since beginning of last month:
  • Site-wide: 48,796

Association Between Genetically Elevated Levels Of Inflammatory Biomarkers And Risk Of Schizophrenia: A Two-Sample Mendelian Randomisation Study

• Downloaded 460 times
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  • Site-wide: 68,296
  • In epidemiology: 3,016
• Year to date:
  • Site-wide: 121,929
• Since beginning of last month:
  • Site-wide: 45,139

Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study

• Downloaded 449 times
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  • Site-wide: 70,002
  • In epidemiology: 3,080
• Year to date:
  • Site-wide: 116,700
• Since beginning of last month:
  • Site-wide: 78,354

The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study

• Downloaded 448 times
• Download rankings, all-time:
  • Site-wide: 70,196
  • In epidemiology: 3,093
• Year to date:
  • Site-wide: 140,072
• Since beginning of last month:
  • Site-wide: 49,884

Schizophrenia risk and reproductive success: A Mendelian randomization study.

• Downloaded 441 times
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  • Site-wide: 71,297
  • In evolutionary biology: 3,705
• Year to date:
  • Site-wide: 140,441
• Since beginning of last month:
  • Site-wide: None

Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

• Downloaded 438 times
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  • Site-wide: 71,812
  • In epidemiology: 3,151
• Year to date:
  • Site-wide: 118,221
• Since beginning of last month:
  • Site-wide: 61,785

The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

• Downloaded 433 times
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  • Site-wide: 72,616
  • In genetics: 3,187
• Year to date:
  • Site-wide: 73,231
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  • Site-wide: 77,278

Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisation

• Downloaded 430 times
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  • Site-wide: 73,197
  • In epidemiology: 3,189
• Year to date:
  • Site-wide: 101,061
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  • Site-wide: 38,913

A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target

• Downloaded 423 times
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  • Site-wide: 74,364
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• Year to date:
  • Site-wide: 81,663
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  • Site-wide: 12,083

MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

• Downloaded 417 times
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  • Site-wide: 75,378
  • In epidemiology: 3,266
• Year to date:
  • Site-wide: 145,646
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  • Site-wide: 61,645

The association between adiposity and inpatient hospital costs in the UK Biobank cohort

• Downloaded 416 times
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  • Site-wide: 75,573
  • In epidemiology: 3,274
• Year to date:
  • Site-wide: 127,555
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  • Site-wide: 36,062

A robust mean and variance test with application to high-dimensional phenotypes

• Downloaded 411 times
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  • Site-wide: 76,566
  • In bioinformatics: 7,095
• Year to date:
  • Site-wide: 53,359
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  • Site-wide: 22,943

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

• Downloaded 408 times
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  • Site-wide: 77,055
  • In epidemiology: 3,322
• Year to date:
  • Site-wide: 58,606
• Since beginning of last month:
  • Site-wide: 122,949

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

• Downloaded 404 times
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  • Site-wide: 77,684
  • In epidemiology: 3,344
• Year to date:
  • Site-wide: 75,616
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  • Site-wide: 120,828

Identifying novel subtypes of irritability using a developmental genetic approach

• Downloaded 401 times
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  • Site-wide: 78,322
  • In genetics: 3,401
• Year to date:
  • Site-wide: 122,404
• Since beginning of last month:
  • Site-wide: 44,430

Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer.

• Downloaded 401 times
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  • Site-wide: 78,206
  • In epidemiology: 3,368
• Year to date:
  • Site-wide: 69,446
• Since beginning of last month:
  • Site-wide: 97,836

Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions

• Downloaded 399 times
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  • Site-wide: 78,703
  • In epidemiology: 3,377
• Year to date:
  • Site-wide: 41,246
• Since beginning of last month:
  • Site-wide: 44,155

The Multivariate Genome-wide Architecture of Interrelated Literacy, Language and Working Memory Skills Reveals Distinct Etiologies

• Downloaded 395 times
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  • Site-wide: 79,306
  • In genetics: 3,458
• Year to date:
  • Site-wide: 78,858
• Since beginning of last month:
  • Site-wide: 123,579

Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

• Downloaded 392 times
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  • Site-wide: 79,924
  • In epidemiology: 3,426
• Year to date:
  • Site-wide: 90,354
• Since beginning of last month:
  • Site-wide: None

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

• Downloaded 391 times
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  • Site-wide: 80,247
  • In epidemiology: 3,431
• Year to date:
  • Site-wide: 123,630
• Since beginning of last month:
  • Site-wide: 36,993

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

• Downloaded 389 times
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  • Site-wide: 80,555
  • In genetics: 3,504
• Year to date:
  • Site-wide: 126,066
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  • Site-wide: 51,847

Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study

• Downloaded 388 times
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  • Site-wide: 80,680
  • In neurology: 230
• Year to date:
  • Site-wide: 67,520
• Since beginning of last month:
  • Site-wide: 71,988

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

• Downloaded 382 times
• Download rankings, all-time:
  • Site-wide: 81,873
  • In epidemiology: 3,497
• Year to date:
  • Site-wide: 99,007
• Since beginning of last month:
  • Site-wide: 120,803

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

• Downloaded 375 times
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  • Site-wide: 83,149
  • In genetics: 3,621
• Year to date:
  • Site-wide: 148,875
• Since beginning of last month:
  • Site-wide: None

The relationship between open angle glaucoma, optic disc morphology and Alzheimer's Disease: a Mendelian randomization study

• Downloaded 368 times
• Download rankings, all-time:
  • Site-wide: 84,744
  • In ophthalmology: 60
• Year to date:
  • Site-wide: 55,529
• Since beginning of last month:
  • Site-wide: 70,871

Estimating the causal effect of genetic liability to prevalent disease on hospital costs using Mendelian Randomization

• Downloaded 364 times
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  • Site-wide: 85,445
  • In health economics: 112
• Year to date:
  • Site-wide: 69,628
• Since beginning of last month:
  • Site-wide: 58,841

DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

• Downloaded 358 times
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  • Site-wide: 86,765
  • In genetics: 3,772
• Year to date:
  • Site-wide: 140,844
• Since beginning of last month:
  • Site-wide: 105,950

Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study

• Downloaded 353 times
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  • Site-wide: 87,659
  • In epidemiology: 3,723
• Year to date:
  • Site-wide: 84,714
• Since beginning of last month:
  • Site-wide: 85,700

Educational inequalities in statin treatment for preventing cardiovascular disease: cross-sectional analysis of UK Biobank

• Downloaded 352 times
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  • Site-wide: 87,941
  • In epidemiology: 3,729
• Year to date:
  • Site-wide: 58,820
• Since beginning of last month:
  • Site-wide: 34,887

Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype

• Downloaded 324 times
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  • Site-wide: 93,938
  • In epidemiology: 3,976
• Year to date:
  • Site-wide: 109,039
• Since beginning of last month:
  • Site-wide: 44,414

Risk of death among teachers in England and Wales during the Covid19 pandemic

• Downloaded 323 times
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  • Site-wide: 94,309
  • In epidemiology: 3,982
• Year to date:
  • Site-wide: 17,398
• Since beginning of last month:
  • Site-wide: 96,773

Does Smoking Cause Lower Educational Attainment and General Cognitive Ability? Triangulation of causal evidence using multiple study designs

• Downloaded 318 times
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  • Site-wide: 95,430
  • In epidemiology: 4,029
• Year to date:
  • Site-wide: 106,604
• Since beginning of last month:
  • Site-wide: None

A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation

• Downloaded 316 times
• Download rankings, all-time:
  • Site-wide: 95,750
  • In epidemiology: 4,043
• Year to date:
  • Site-wide: 42,040
• Since beginning of last month:
  • Site-wide: 77,835

Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

• Downloaded 315 times
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  • Site-wide: 96,121
  • In epidemiology: 4,050
• Year to date:
  • Site-wide: 45,914
• Since beginning of last month:
  • Site-wide: 55,741

Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK Biobank

• Downloaded 310 times
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  • Site-wide: 97,124
  • In psychiatry and clinical psychology: 392
• Year to date:
  • Site-wide: 18,427
• Since beginning of last month:
  • Site-wide: 84,892

Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health

• Downloaded 309 times
• Download rankings, all-time:
  • Site-wide: 97,337
  • In epidemiology: 4,115
• Year to date:
  • Site-wide: 143,208
• Since beginning of last month:
  • Site-wide: 65,201

The role of school enjoyment in the association between externalising and depressive symptoms and academic attainment: findings from a UK prospective cohort study

• Downloaded 301 times
• Download rankings, all-time:
  • Site-wide: 99,232
  • In epidemiology: 4,193
• Year to date:
  • Site-wide: 57,975
• Since beginning of last month:
  • Site-wide: 67,540

Evaluating the direct effects of childhood adiposity on adult systemic metabolism: A multivariable Mendelian randomization analysis

• Downloaded 301 times
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  • Site-wide: 99,192
  • In cardiovascular medicine: 204
• Year to date:
  • Site-wide: 67,378
• Since beginning of last month:
  • Site-wide: 60,819

Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

• Downloaded 294 times
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  • Site-wide: 100,909
  • In epidemiology: 4,264
• Year to date:
  • Site-wide: 53,154
• Since beginning of last month:
  • Site-wide: 53,033

Mendelian randomization does not support serum calcium in prostate cancer risk

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 102,589
  • In epidemiology: 4,331
• Year to date:
  • Site-wide: 139,427
• Since beginning of last month:
  • Site-wide: 50,572

Examining the bidirectional association between emotion recognition and ASD symptoms using observational and genetic analyses

• Downloaded 286 times
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  • Site-wide: 102,749
  • In genetic and genomic medicine: 493
• Year to date:
  • Site-wide: 69,559
• Since beginning of last month:
  • Site-wide: 24,090

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 105,487
  • In genetics: 4,475
• Year to date:
  • Site-wide: 151,606
• Since beginning of last month:
  • Site-wide: None

Association of genetic liability to smoking initiation with e-cigarette use in young adults.

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 105,349
  • In epidemiology: 4,434
• Year to date:
  • Site-wide: 57,981
• Since beginning of last month:
  • Site-wide: 60,251

Dominant role of abdominal adiposity in circulating lipoprotein, lipid, and metabolite levels in UK Biobank: Mendelian randomization study

• Downloaded 274 times
• Download rankings, all-time:
  • Site-wide: 105,553
  • In epidemiology: 4,444
• Year to date:
  • Site-wide: 21,798
• Since beginning of last month:
  • Site-wide: 5,449

Interrogating structural inequalities in COVID-19 Mortality in England and Wales

• Downloaded 272 times
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  • Site-wide: 106,247
  • In epidemiology: 4,472
• Year to date:
  • Site-wide: 22,032
• Since beginning of last month:
  • Site-wide: 95,963

Identifying intergenerational risk factors for ADHD symptoms using polygenic scores in the Norwegian Mother, Father and Child Cohort

• Downloaded 271 times
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  • Site-wide: 106,296
  • In psychiatry and clinical psychology: 456
• Year to date:
  • Site-wide: 22,099
• Since beginning of last month:
  • Site-wide: 128,594

Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

• Downloaded 266 times
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  • Site-wide: 107,515
  • In genetics: 4,558
• Year to date:
  • Site-wide: 97,704
• Since beginning of last month:
  • Site-wide: 83,368

Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to SARS-CoV-2 severity

• Downloaded 264 times
• Download rankings, all-time:
  • Site-wide: 108,107
  • In epidemiology: 4,550
• Year to date:
  • Site-wide: 70,218
• Since beginning of last month:
  • Site-wide: None

The effect of smoking on multiple sclerosis: a mendelian randomization study

• Downloaded 263 times
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  • Site-wide: 108,301
  • In genetic and genomic medicine: 536
• Year to date:
  • Site-wide: 93,527
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  • Site-wide: 59,967

Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals

• Downloaded 258 times
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  • Site-wide: 109,463
  • In genetics: 4,632
• Year to date:
  • Site-wide: 152,885
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  • Site-wide: None

Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study

• Downloaded 252 times
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  • Site-wide: 110,994
  • In epidemiology: 4,671
• Year to date:
  • Site-wide: 51,279
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  • Site-wide: 93,353

Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

• Downloaded 249 times
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  • Site-wide: 111,878
  • In genetics: 4,699
• Year to date:
  • Site-wide: 145,112
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  • Site-wide: 119,757

An Informatics Consult approach for generating clinical evidence for treatment decisions

• Downloaded 244 times
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  • Site-wide: 112,963
  • In health informatics: 440
• Year to date:
  • Site-wide: 25,419
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  • Site-wide: 20,349

Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers

• Downloaded 242 times
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  • Site-wide: 113,641
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• Year to date:
  • Site-wide: 25,784
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  • Site-wide: 28,493

Causal effects of circulating cytokine concentrations on risk of Alzheimers disease: A bidirectional two-sample Mendelian randomization study

• Downloaded 240 times
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  • Site-wide: 114,098
  • In genetic and genomic medicine: 591
• Year to date:
  • Site-wide: 46,651
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  • Site-wide: 52,944

Interpreting Mendelian randomization estimates of the effects of categorical exposures such as disease status and educational attainment

• Downloaded 218 times
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  • Site-wide: 119,739
  • In epidemiology: 5,022
• Year to date:
  • Site-wide: 55,023
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  • Site-wide: 124,137

Examining the possible causal relationship between Lung Function, COPD and Alzheimers Disease. A Mendelian Randomization Study

• Downloaded 216 times
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  • Site-wide: 120,073
  • In respiratory medicine: 241
• Year to date:
  • Site-wide: 78,336
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  • Site-wide: 52,726

The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study

• Downloaded 211 times
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  • Site-wide: 121,353
  • In epidemiology: 5,103
• Year to date:
  • Site-wide: 121,480
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  • Site-wide: None

Disentangling the direct and indirect effects of childhood adiposity on type 1 diabetes and immune-associated diseases: a multivariable Mendelian randomization study

• Downloaded 198 times
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  • Site-wide: 124,519
  • In epidemiology: 5,242
• Year to date:
  • Site-wide: 33,136
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  • Site-wide: 18,691

Cross-sectional association of blood pressure variability and night-time dipping with cardiac structure in adolescents

• Downloaded 195 times
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  • Site-wide: 125,350
  • In epidemiology: 5,276
• Year to date:
  • Site-wide: 52,580
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  • Site-wide: 9,986

Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: prospective cohort study

• Downloaded 182 times
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  • Site-wide: 128,392
  • In epidemiology: 5,387
• Year to date:
  • Site-wide: 105,868
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  • Site-wide: 42,317

Osteophyte size and location on hip DXA scans are associated with hip pain: findings from a cross sectional study in UK Biobank

• Downloaded 182 times
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  • Site-wide: 128,501
  • In rheumatology: 109
• Year to date:
  • Site-wide: 36,673
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  • Site-wide: 90,051

Epidemiology and Genetics of Preserved Ratio Impaired SpiroMetry (PRISm): An Analysis of UK Biobank

• Downloaded 178 times
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  • Site-wide: 129,412
  • In respiratory medicine: 265
• Year to date:
  • Site-wide: 80,848
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  • Site-wide: 43,022

Mendelian randomization analyses show that higher acetyl-carnitine and carnitine levels in blood protect against severe Covid19

• Downloaded 167 times
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  • Site-wide: 132,076
  • In epidemiology: 5,505
• Year to date:
  • Site-wide: 40,651
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  • Site-wide: 25,446

Puberty and sex-specific trajectories of systolic blood pressure: a prospective cohort study

• Downloaded 152 times
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  • Site-wide: 135,440
  • In epidemiology: 5,625
• Year to date:
  • Site-wide: 45,198
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  • Site-wide: 15,628

Sex-specific associations of adiposity with cardiometabolic traits: multi-life-stage cohort study with repeat metabolomics

• Downloaded 136 times
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  • Site-wide: 139,042
  • In epidemiology: 5,750
• Year to date:
  • Site-wide: 76,152
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  • Site-wide: 42,866

Educational attainment as a modifier of the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank

• Downloaded 131 times
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  • Site-wide: 140,059
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  • Site-wide: 53,058
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  • Site-wide: 47,881

Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization

• Downloaded 124 times
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  • Site-wide: 141,428
  • In epidemiology: 5,831
• Year to date:
  • Site-wide: 55,730
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  • Site-wide: 131,815

Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independent of body mass index

• Downloaded 122 times
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  • Site-wide: 141,800
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  • Site-wide: 56,942
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  • Site-wide: 24,692

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

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  • Site-wide: 142,451
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  • Site-wide: 58,431
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  • Site-wide: 131,224

Parental inflammatory bowel disease and autism in the offspring: Triangulating the evidence using four complementary study designs.

• Downloaded 117 times
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  • Site-wide: 142,787
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  • Site-wide: 59,165
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  • Site-wide: 80,610

Design and quality control of large-scale two-sample Mendelian randomisation studies

• Downloaded 94 times
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  • Site-wide: 146,945
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• Year to date:
  • Site-wide: 72,203
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  • Site-wide: 3,698

Taller height and risk of coronary heart disease and cancer: a within-sibship Mendelian randomization study

• Downloaded 93 times
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  • Site-wide: 147,143
  • In genetic and genomic medicine: 863
• Year to date:
  • Site-wide: 73,004
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  • Site-wide: 11,103

Navigating sample overlap, winner's curse and weak instrument bias in Mendelian randomization studies using the UK Biobank

• Downloaded 82 times
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  • Site-wide: 148,742
  • In epidemiology: 6,140
• Year to date:
  • Site-wide: 80,865
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  • Site-wide: 11,605

Estimating the genetically predicted effects of lifestyle risk factors, educational attainment and Alzheimer's disease liability on weight change during midlife

• Downloaded 79 times
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  • Site-wide: 149,132
  • In epidemiology: 6,155
• Year to date:
  • Site-wide: 83,255
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  • Site-wide: 6,638

Genetic analyses of common infections in the Avon Longitudinal Study of Parents and Children cohort

• Downloaded 73 times
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  • Site-wide: 149,910
  • In epidemiology: 6,181
• Year to date:
  • Site-wide: 88,587
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  • Site-wide: 89,783

Sex-specific trajectories of molecular cardiometabolic trait concentrations through childhood, adolescence and young adulthood: a cohort study

• Downloaded 66 times
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  • Site-wide: 150,751
  • In epidemiology: 6,214
• Year to date:
  • Site-wide: 95,693
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  • Site-wide: 8,999

Metabolomic signatures of lipid-modifying therapies using drug target Mendelian randomization

• Downloaded 1 times
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  • Site-wide: 155,416
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  • Site-wide: 155,403
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  • Site-wide: 91,971

Separating the direct effects of risk factors for atherosclerotic cardiovascular disease from those mediated by type 2 diabetes

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  • Site-wide: 155,615
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• Year to date:
  • Site-wide: 155,631
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  • Site-wide: 132,650