Author: George Davey Smith

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Preprints

Puberty and sex-specific trajectories of systolic blood pressure: a prospective cohort study

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An Informatics Consult approach for generating clinical evidence for treatment decisions

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Selection into shift work is influenced by educational attainment and body mass index: A Mendelian randomization study

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  • Site-wide: 78
  • In epidemiology: 17
• Year to date:
  • Site-wide: 75,499
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  • Site-wide: 66

Collider bias undermines our understanding of COVID-19 disease risk and severity

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  • Site-wide: 569
  • In epidemiology: 84
• Year to date:
  • Site-wide: 1,574
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  • Site-wide: 1,593

A reference panel of 64,976 haplotypes for genotype imputation

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  • Site-wide: 1,971
  • In genetics: 80
• Year to date:
  • Site-wide: 90,285
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  • Site-wide: 59,492

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

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  • Site-wide: 2,453
  • In epidemiology: 247
• Year to date:
  • Site-wide: 26,986
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  • Site-wide: 17,515

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

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  • Site-wide: 2,730
  • In genetics: 111
• Year to date:
  • Site-wide: 9,762
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  • Site-wide: 10,813

PHESANT: a tool for performing automated phenome scans in UK Biobank

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  • Site-wide: 3,114
  • In epidemiology: 294
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  • Site-wide: 26,717
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  • Site-wide: 19,894

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

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  • Site-wide: 3,222
  • In epidemiology: 307
• Year to date:
  • Site-wide: 15,184
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  • Site-wide: 12,256

Collider Scope: When selection bias can substantially influence observed associations

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  • Site-wide: 4,490
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• Year to date:
  • Site-wide: 33,219
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  • Site-wide: 44,689

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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  • Site-wide: 4,735
  • In genetics: 230
• Year to date:
  • Site-wide: 81,474
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  • Site-wide: 94,898

Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • Site-wide: 4,778
  • In genetics: 233
• Year to date:
  • Site-wide: 12,450
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  • Site-wide: 15,667

Mendelian randomization: a premature burial?

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  • Site-wide: 5,010
  • In genetics: 241
• Year to date:
  • Site-wide: 9,970
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  • Site-wide: 45,480

Why are education, socioeconomic position and intelligence genetically correlated?

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  • Site-wide: 5,060
  • In genetics: 245
• Year to date:
  • Site-wide: 47,883
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  • Site-wide: 30,502

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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  • Site-wide: 5,144
  • In genetics: 249
• Year to date:
  • Site-wide: 51,880
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  • Site-wide: 81,855

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

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  • Site-wide: 5,300
  • In epidemiology: 438
• Year to date:
  • Site-wide: 90,725
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  • Site-wide: 102,675

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

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  • Site-wide: 6,223
  • In genetics: 315
• Year to date:
  • Site-wide: 13,911
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  • Site-wide: 23,204

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

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  • Site-wide: 6,991
  • In epidemiology: 533
• Year to date:
  • Site-wide: 105,744
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  • Site-wide: 95,904

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

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  • Site-wide: 7,450
  • In genetics: 370
• Year to date:
  • Site-wide: 95,250
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  • Site-wide: 55,247

Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

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  • Site-wide: 7,498
  • In genetics: 373
• Year to date:
  • Site-wide: 43,713
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  • Site-wide: 77,659

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

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  • Site-wide: 8,186
  • In genetics: 413
• Year to date:
  • Site-wide: 98,402
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  • Site-wide: 72,282

Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

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  • Site-wide: 8,236
  • In epidemiology: 598
• Year to date:
  • Site-wide: 29,721
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  • Site-wide: 46,807

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 8,390
  • In genetics: 425
• Year to date:
  • Site-wide: 88,417
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  • Site-wide: 59,669

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 8,477
  • In genetics: 432
• Year to date:
  • Site-wide: 104,914
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  • Site-wide: 64,040

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

• Downloaded 1,657 times
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  • Site-wide: 8,690
  • In genetics: 444
• Year to date:
  • Site-wide: 100,541
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  • Site-wide: 98,853

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

• Downloaded 1,612 times
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  • Site-wide: 9,070
  • In genetics: 463
• Year to date:
  • Site-wide: 70,137
• Since beginning of last month:
  • Site-wide: 118,682

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

• Downloaded 1,518 times
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  • Site-wide: 9,920
  • In genetics: 503
• Year to date:
  • Site-wide: 5,683
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  • Site-wide: 6,397

An examination of multivariable Mendelian randomization in the single sample and two-sample summary data settings.

• Downloaded 1,498 times
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  • Site-wide: 10,087
  • In epidemiology: 701
• Year to date:
  • Site-wide: 33,187
• Since beginning of last month:
  • Site-wide: 44,833

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,392 times
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  • Site-wide: 11,276
  • In genetics: 573
• Year to date:
  • Site-wide: 76,525
• Since beginning of last month:
  • Site-wide: 62,001

The Causal Effects of Education on Health, Mortality, Cognition, Well-being, and Income in the UK Biobank

• Downloaded 1,376 times
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  • Site-wide: 11,474
  • In epidemiology: 758
• Year to date:
  • Site-wide: 70,271
• Since beginning of last month:
  • Site-wide: 86,059

Cigarette smoking increases coffee consumption: findings from a Mendelian randomisation analysis

• Downloaded 1,367 times
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  • Site-wide: 11,597
  • In genetics: 597
• Year to date:
  • Site-wide: 22,646
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  • Site-wide: 24,427

Do early life non-cognitive skills matter? A systematic review and meta-analysis of early life effects on academic achievement, psychosocial, language and cognitive, and health outcomes

• Downloaded 1,324 times
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  • Site-wide: 12,148
  • In epidemiology: 794
• Year to date:
  • Site-wide: 98,773
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  • Site-wide: 69,444

The genetic architecture of osteoarthritis: insights from UK Biobank

• Downloaded 1,306 times
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  • Site-wide: 12,405
  • In genetics: 638
• Year to date:
  • Site-wide: 116,956
• Since beginning of last month:
  • Site-wide: 59,201

Selection bias in instrumental variable analyses

• Downloaded 1,291 times
• Download rankings, all-time:
  • Site-wide: 12,612
  • In epidemiology: 822
• Year to date:
  • Site-wide: 24,371
• Since beginning of last month:
  • Site-wide: 25,699

Meffil: efficient normalisation and analysis of very large DNA methylation samples

• Downloaded 1,266 times
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  • Site-wide: 13,004
  • In bioinformatics: 1,634
• Year to date:
  • Site-wide: 71,447
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  • Site-wide: 64,265

Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

• Downloaded 1,257 times
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  • Site-wide: 13,139
  • In genetics: 682
• Year to date:
  • Site-wide: 120,644
• Since beginning of last month:
  • Site-wide: 109,127

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

• Downloaded 1,193 times
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  • Site-wide: 14,220
  • In epidemiology: 879
• Year to date:
  • Site-wide: 59,452
• Since beginning of last month:
  • Site-wide: 118,434

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

• Downloaded 1,155 times
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  • Site-wide: 14,907
  • In genetics: 773
• Year to date:
  • Site-wide: 80,064
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  • Site-wide: 48,216

Multi-omics study revealing tissue-dependent putative mechanisms of SARS-CoV-2 drug targets on viral infections and complex diseases

• Downloaded 1,116 times
• Download rankings, all-time:
  • Site-wide: 15,693
  • In genetic and genomic medicine: 43
• Year to date:
  • Site-wide: 46,361
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  • Site-wide: 18,462

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 1,112 times
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  • Site-wide: 15,795
  • In genetics: 818
• Year to date:
  • Site-wide: 60,937
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  • Site-wide: 69,990

Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data

• Downloaded 1,089 times
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  • Site-wide: 16,321
  • In genetics: 844
• Year to date:
  • Site-wide: 62,085
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  • Site-wide: 92,768

Body mass index and mortality in UK Biobank: revised estimates using Mendelian randomization

• Downloaded 1,075 times
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  • Site-wide: 16,651
  • In epidemiology: 981
• Year to date:
  • Site-wide: 97,309
• Since beginning of last month:
  • Site-wide: 88,861

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

• Downloaded 1,050 times
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  • Site-wide: 17,230
  • In epidemiology: 1,014
• Year to date:
  • Site-wide: 23,812
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  • Site-wide: 22,560

Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

• Downloaded 1,045 times
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  • Site-wide: 17,345
  • In pharmacology and toxicology: 97
• Year to date:
  • Site-wide: 102,945
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  • Site-wide: 99,200

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

• Downloaded 1,026 times
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  • Site-wide: 17,817
  • In genetics: 914
• Year to date:
  • Site-wide: 77,724
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  • Site-wide: 87,858

Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions

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  • Site-wide: 18,288
  • In epidemiology: 1,049
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  • Site-wide: 58,601
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  • Site-wide: 60,829

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

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  • Site-wide: 18,589
  • In epidemiology: 1,061
• Year to date:
  • Site-wide: 60,466
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  • Site-wide: 29,876

The effect of education on adult mortality, health, and income: triangulating across genetic and policy reforms

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  • Site-wide: 18,622
  • In epidemiology: 1,063
• Year to date:
  • Site-wide: 85,844
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  • Site-wide: 53,561

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 965 times
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  • Site-wide: 19,527
  • In genetics: 990
• Year to date:
  • Site-wide: 42,760
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  • Site-wide: 117,701

Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

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  • Site-wide: 19,645
  • In epidemiology: 1,106
• Year to date:
  • Site-wide: 87,482
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  • Site-wide: 95,973

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?

• Downloaded 957 times
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  • Site-wide: 19,741
  • In epidemiology: 1,110
• Year to date:
  • Site-wide: 99,103
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  • Site-wide: 118,384

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

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  • Site-wide: 20,445
  • In epidemiology: 1,130
• Year to date:
  • Site-wide: 38,616
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  • Site-wide: 83,129

Can education be personalised using pupils’ genetic data?

• Downloaded 921 times
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  • Site-wide: 20,875
  • In genetics: 1,049
• Year to date:
  • Site-wide: 83,106
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  • Site-wide: 63,923

Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease

• Downloaded 875 times
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  • Site-wide: 22,529
  • In cardiovascular medicine: 31
• Year to date:
  • Site-wide: 112,939
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  • Site-wide: 93,498

Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

• Downloaded 854 times
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  • Site-wide: 23,306
  • In genomics: 2,294
• Year to date:
  • Site-wide: 67,669
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  • Site-wide: 78,493

Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression

• Downloaded 834 times
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  • Site-wide: 24,111
  • In epidemiology: 1,268
• Year to date:
  • Site-wide: 109,870
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  • Site-wide: 116,909

The causes and consequences of Alzheimer's disease: A Mendelian randomization analysis

• Downloaded 790 times
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  • Site-wide: 25,998
  • In genetic and genomic medicine: 66
• Year to date:
  • Site-wide: 7,359
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  • Site-wide: 24,065

Genetic Epidemiology And Mendelian Randomization For Informing Disease Therapeutics: Conceptual And Methodological Challenges

• Downloaded 782 times
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  • Site-wide: 26,353
  • In genetics: 1,333
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  • Site-wide: 107,550
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  • Site-wide: 115,722

Genetic Association Study of Childhood Aggression across raters, instruments and age

• Downloaded 772 times
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  • Site-wide: 26,859
  • In genomics: 2,550
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  • Site-wide: 23,663
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  • Site-wide: 36,306

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

• Downloaded 757 times
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  • Site-wide: 27,567
  • In bioinformatics: 3,257
• Year to date:
  • Site-wide: 60,955
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  • Site-wide: 62,428

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

• Downloaded 757 times
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  • Site-wide: 27,598
  • In genetics: 1,390
• Year to date:
  • Site-wide: 36,655
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  • Site-wide: 76,304

The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

• Downloaded 751 times
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  • Site-wide: 27,920
  • In epidemiology: 1,416
• Year to date:
  • Site-wide: 77,964
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  • Site-wide: 79,927

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease

• Downloaded 728 times
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  • Site-wide: 29,135
  • In genetics: 1,465
• Year to date:
  • Site-wide: 59,487
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  • Site-wide: 99,310

Examining the genetic influences of educational attainment and the validity of value-added measures of progress

• Downloaded 727 times
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  • Site-wide: 29,176
  • In genetics: 1,468
• Year to date:
  • Site-wide: 99,589
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  • Site-wide: 110,787

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

• Downloaded 716 times
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  • Site-wide: 29,782
  • In genetics: 1,502
• Year to date:
  • Site-wide: 39,574
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  • Site-wide: 112,862

Using genetics to examine a general liability to childhood psychopathology

• Downloaded 709 times
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  • Site-wide: 30,196
  • In genetics: 1,528
• Year to date:
  • Site-wide: 54,789
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  • Site-wide: 114,450

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

• Downloaded 704 times
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  • Site-wide: 30,495
  • In epidemiology: 1,509
• Year to date:
  • Site-wide: 53,971
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  • Site-wide: 36,069

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 703 times
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  • Site-wide: 30,528
  • In genetics: 1,545
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  • Site-wide: 97,854
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  • Site-wide: 88,324

Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study

• Downloaded 702 times
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  • Site-wide: 30,586
  • In epidemiology: 1,514
• Year to date:
  • Site-wide: 71,497
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  • Site-wide: 102,492

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

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  • Site-wide: 31,384
  • In genetics: 1,579
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  • Site-wide: 6,634
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  • Site-wide: 4,742

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

• Downloaded 671 times
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  • Site-wide: 32,550
  • In genetics: 1,632
• Year to date:
  • Site-wide: 55,454
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  • Site-wide: 74,616

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

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  • Site-wide: 32,809
  • In genetics: 1,644
• Year to date:
  • Site-wide: 84,154
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  • Site-wide: 105,980

The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children

• Downloaded 658 times
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  • Site-wide: 33,372
  • In genetics: 1,667
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  • Site-wide: 110,092
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  • Site-wide: 108,275

Distinct Blood DNA Methylation Profiles In Subtypes Of Orofacial Cleft

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  • Site-wide: 33,599
  • In epidemiology: 1,605
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  • Site-wide: 97,639
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  • Site-wide: 90,429

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

• Downloaded 652 times
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  • Site-wide: 33,795
  • In genetics: 1,690
• Year to date:
  • Site-wide: 82,261
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  • Site-wide: 102,931

Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

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  • Site-wide: 34,510
  • In systems biology: 806
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  • Site-wide: 86,108
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  • Site-wide: 115,974

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

• Downloaded 639 times
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  • Site-wide: 34,732
  • In epidemiology: 1,641
• Year to date:
  • Site-wide: 119,190
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  • Site-wide: 106,412

Education and coronary heart disease: a Mendelian randomization study

• Downloaded 634 times
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  • Site-wide: 35,071
  • In epidemiology: 1,652
• Year to date:
  • Site-wide: 97,589
• Since beginning of last month:
  • Site-wide: 99,901

Investigating the longitudinal consistency and genetic architecture of non-cognitive skills, and their relation to educational attainment

• Downloaded 625 times
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  • Site-wide: 35,730
  • In genetics: 1,784
• Year to date:
  • Site-wide: 18,952
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  • Site-wide: 45,720

Appraising the causal relevance of DNA methylation for risk of lung cancer

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  • Site-wide: 35,830
  • In epidemiology: 1,690
• Year to date:
  • Site-wide: 75,717
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  • Site-wide: 113,789

Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

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  • Site-wide: 36,079
  • In epidemiology: 1,695
• Year to date:
  • Site-wide: 111,289
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  • Site-wide: 113,497

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

• Downloaded 616 times
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  • Site-wide: 36,413
  • In genomics: 3,150
• Year to date:
  • Site-wide: 43,459
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  • Site-wide: 93,640

Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis

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  • Site-wide: 36,527
  • In genomics: 3,162
• Year to date:
  • Site-wide: 8,332
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  • Site-wide: 40,768

Detecting heterogeneity of intervention effects using analysis and meta-analysis of differences in variance between arms of a trial

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  • Site-wide: 36,543
  • In epidemiology: 1,710
• Year to date:
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  • Site-wide: 31,356

Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population

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  • Site-wide: 36,883
  • In genetics: 1,829
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  • Site-wide: 53,117
• Since beginning of last month:
  • Site-wide: 85,271

Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life

• Downloaded 607 times
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  • Site-wide: 37,076
  • In genetics: 1,838
• Year to date:
  • Site-wide: 54,535
• Since beginning of last month:
  • Site-wide: 107,357

Genetic predictors of participation in optional components of UK Biobank

• Downloaded 593 times
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  • Site-wide: 38,158
  • In genetics: 1,890
• Year to date:
  • Site-wide: 28,120
• Since beginning of last month:
  • Site-wide: 36,639

Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits

• Downloaded 586 times
• Download rankings, all-time:
  • Site-wide: 38,783
  • In genetics: 1,910
• Year to date:
  • Site-wide: 8,248
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  • Site-wide: 43,643

Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

• Downloaded 583 times
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  • Site-wide: 38,988
  • In epidemiology: 1,800
• Year to date:
  • Site-wide: 101,437
• Since beginning of last month:
  • Site-wide: 120,971

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 559 times
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  • Site-wide: 41,126
  • In epidemiology: 1,887
• Year to date:
  • Site-wide: 106,241
• Since beginning of last month:
  • Site-wide: 106,163

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

• Downloaded 558 times
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  • Site-wide: 41,248
  • In genetics: 2,014
• Year to date:
  • Site-wide: 91,591
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  • Site-wide: 108,410

Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

• Downloaded 556 times
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  • Site-wide: 41,379
  • In epidemiology: 1,896
• Year to date:
  • Site-wide: 60,538
• Since beginning of last month:
  • Site-wide: 114,229

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

• Downloaded 544 times
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  • Site-wide: 42,560
  • In genetics: 2,084
• Year to date:
  • Site-wide: 89,125
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  • Site-wide: 75,425

Metabolic signatures of birth weight in 18288 adolescents and adults

• Downloaded 535 times
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  • Site-wide: 43,452
  • In systems biology: 1,032
• Year to date:
  • Site-wide: 103,774
• Since beginning of last month:
  • Site-wide: 102,764

Conditioning on a collider may induce spurious associations: Do the results of Gale et al. (2017) support a protective effect of neuroticism in population sub-groups?

• Downloaded 528 times
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  • Site-wide: 44,048
  • In epidemiology: 1,983
• Year to date:
  • Site-wide: 105,594
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  • Site-wide: 115,744

Cigarette smoking and personality: Investigating causality using Mendelian randomization

• Downloaded 510 times
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  • Site-wide: 45,882
  • In epidemiology: 2,032
• Year to date:
  • Site-wide: 114,461
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  • Site-wide: 113,802

Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study

• Downloaded 509 times
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  • Site-wide: 46,008
  • In epidemiology: 2,037
• Year to date:
  • Site-wide: 116,215
• Since beginning of last month:
  • Site-wide: 120,001

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 507 times
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  • Site-wide: 46,173
  • In genetic and genomic medicine: 114
• Year to date:
  • Site-wide: 6,499
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  • Site-wide: 9,490

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 500 times
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  • Site-wide: 47,043
  • In neuroscience: 7,047
• Year to date:
  • Site-wide: 53,057
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  • Site-wide: 107,822

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

• Downloaded 493 times
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  • Site-wide: 47,766
  • In epidemiology: 2,095
• Year to date:
  • Site-wide: 98,973
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  • Site-wide: 99,355

The median and the mode as robust meta-analysis methods in the presence of small study effects

• Downloaded 478 times
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  • Site-wide: 49,549
  • In epidemiology: 2,140
• Year to date:
  • Site-wide: 48,400
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  • Site-wide: 79,586

Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

• Downloaded 465 times
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  • Site-wide: 51,143
  • In genomics: 4,006
• Year to date:
  • Site-wide: 85,295
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  • Site-wide: 67,749

Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures

• Downloaded 455 times
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  • Site-wide: 52,306
  • In genetics: 2,530
• Year to date:
  • Site-wide: 64,630
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  • Site-wide: 91,567

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

• Downloaded 452 times
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  • Site-wide: 52,694
  • In genetics: 2,543
• Year to date:
  • Site-wide: 69,058
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  • Site-wide: 107,761

A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank

• Downloaded 448 times
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  • Site-wide: 53,234
  • In epidemiology: 2,262
• Year to date:
  • Site-wide: 107,858
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  • Site-wide: 64,760

The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank

• Downloaded 446 times
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  • Site-wide: 53,422
  • In epidemiology: 2,273
• Year to date:
  • Site-wide: 87,953
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  • Site-wide: 115,375

Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

• Downloaded 442 times
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  • Site-wide: 54,008
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• Year to date:
  • Site-wide: 82,385
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  • Site-wide: 106,287

Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease

• Downloaded 432 times
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  • Site-wide: 55,291
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  • Site-wide: 63,398
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  • Site-wide: 110,547

Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood

• Downloaded 427 times
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  • Site-wide: 55,966
  • In epidemiology: 2,359
• Year to date:
  • Site-wide: 98,248
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  • Site-wide: 46,395

Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

• Downloaded 424 times
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  • Site-wide: 56,403
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• Year to date:
  • Site-wide: 109,694
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  • Site-wide: 98,120

PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

• Downloaded 422 times
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  • Site-wide: 56,593
  • In epidemiology: 2,382
• Year to date:
  • Site-wide: 46,899
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  • Site-wide: 67,756

Association Between Genetically Elevated Levels Of Inflammatory Biomarkers And Risk Of Schizophrenia: A Two-Sample Mendelian Randomisation Study

• Downloaded 418 times
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  • Site-wide: 57,154
  • In epidemiology: 2,393
• Year to date:
  • Site-wide: 101,107
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  • Site-wide: 99,686

The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study

• Downloaded 417 times
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  • Site-wide: 57,313
  • In epidemiology: 2,405
• Year to date:
  • Site-wide: 120,315
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  • Site-wide: 121,883

Schizophrenia risk and reproductive success: A Mendelian randomization study.

• Downloaded 414 times
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  • Site-wide: 57,725
  • In evolutionary biology: 3,283
• Year to date:
  • Site-wide: 85,824
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  • Site-wide: 115,355

Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study

• Downloaded 406 times
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  • Site-wide: 58,899
  • In epidemiology: 2,458
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  • Site-wide: 65,989
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  • Site-wide: 93,897

Genetic liability for schizophrenia and childhood psychopathology in the general population

• Downloaded 398 times
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  • Site-wide: 60,124
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• Year to date:
  • Site-wide: 13,666
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  • Site-wide: 9,598

Is genetic liability to ADHD and ASD causally linked to educational attainment?

• Downloaded 396 times
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  • Site-wide: 60,438
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• Year to date:
  • Site-wide: 26,465
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  • Site-wide: 43,593

Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

• Downloaded 394 times
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  • Site-wide: 60,728
  • In epidemiology: 2,535
• Year to date:
  • Site-wide: 91,583
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  • Site-wide: 76,666

CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?

• Downloaded 393 times
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  • Site-wide: 60,803
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  • Site-wide: 115,771
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  • Site-wide: 96,903

MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

• Downloaded 392 times
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  • Site-wide: 60,981
  • In epidemiology: 2,545
• Year to date:
  • Site-wide: 113,883
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  • Site-wide: 121,390

The association between adiposity and inpatient hospital costs in the UK Biobank cohort

• Downloaded 376 times
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  • Site-wide: 63,482
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• Year to date:
  • Site-wide: 121,365
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  • Site-wide: 92,733

Examining the effect of smoking on suicidal ideation and attempts: A Mendelian randomisation study

• Downloaded 376 times
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  • Site-wide: 63,391
  • In epidemiology: 2,631
• Year to date:
  • Site-wide: 115,493
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  • Site-wide: 75,093

The MRC IEU OpenGWAS data infrastructure

• Downloaded 375 times
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  • Site-wide: 63,670
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  • Site-wide: 10,807
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  • Site-wide: 13,132

Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisation

• Downloaded 373 times
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  • Site-wide: 63,991
  • In epidemiology: 2,647
• Year to date:
  • Site-wide: 78,936
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  • Site-wide: 109,735

Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney disease

• Downloaded 371 times
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  • Site-wide: 64,173
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  • Site-wide: 46,565
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  • Site-wide: 24,008

Identifying novel subtypes of irritability using a developmental genetic approach

• Downloaded 361 times
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  • Site-wide: 65,906
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• Year to date:
  • Site-wide: 74,555
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  • Site-wide: 73,143

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

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  • Site-wide: 66,737
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• Year to date:
  • Site-wide: 77,041
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  • Site-wide: 118,033

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

• Downloaded 351 times
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  • Site-wide: 67,548
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• Year to date:
  • Site-wide: 89,277
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  • Site-wide: 115,694

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

• Downloaded 350 times
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  • Site-wide: 67,762
  • In epidemiology: 2,780
• Year to date:
  • Site-wide: 107,696
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  • Site-wide: 102,093

The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

• Downloaded 348 times
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  • Site-wide: 68,157
  • In genetics: 3,234
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  • Site-wide: 46,736
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  • Site-wide: 18,483

A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target

• Downloaded 346 times
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  • Site-wide: 68,472
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  • Site-wide: 82,910
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  • Site-wide: 104,548

DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

• Downloaded 333 times
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  • Site-wide: 70,639
  • In genetics: 3,350
• Year to date:
  • Site-wide: 69,514
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  • Site-wide: 108,064

Assortative mating and within-spouse pair comparisons

• Downloaded 330 times
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  • Site-wide: 71,279
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• Year to date:
  • Site-wide: 89,061
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  • Site-wide: 66,148

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

• Downloaded 327 times
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  • Site-wide: 71,769
  • In epidemiology: 2,936
• Year to date:
  • Site-wide: 29,697
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  • Site-wide: 93,279

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

• Downloaded 326 times
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  • Site-wide: 71,902
  • In epidemiology: 2,940
• Year to date:
  • Site-wide: 48,902
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  • Site-wide: 24,544

The Multivariate Genome-wide Architecture of Interrelated Literacy, Language and Working Memory Skills Reveals Distinct Etiologies

• Downloaded 321 times
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  • Site-wide: 72,843
  • In genetics: 3,445
• Year to date:
  • Site-wide: 29,970
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  • Site-wide: 31,211

Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

• Downloaded 321 times
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  • Site-wide: 72,818
  • In epidemiology: 2,975
• Year to date:
  • Site-wide: 112,331
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  • Site-wide: 56,488

Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer.

• Downloaded 305 times
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  • Site-wide: 75,822
  • In epidemiology: 3,080
• Year to date:
  • Site-wide: 96,329
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  • Site-wide: 47,603

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

• Downloaded 301 times
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  • Site-wide: 76,497
  • In epidemiology: 3,110
• Year to date:
  • Site-wide: 31,583
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  • Site-wide: 20,851

Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study

• Downloaded 299 times
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  • Site-wide: 76,905
  • In neurology: 162
• Year to date:
  • Site-wide: 25,293
• Since beginning of last month:
  • Site-wide: 37,981

Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study

• Downloaded 289 times
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  • Site-wide: 78,769
  • In epidemiology: 3,198
• Year to date:
  • Site-wide: 22,846
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  • Site-wide: 92,729

A robust mean and variance test with application to high-dimensional phenotypes

• Downloaded 289 times
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  • Site-wide: 78,799
  • In bioinformatics: 7,277
• Year to date:
  • Site-wide: 46,777
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  • Site-wide: 67,089

Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health

• Downloaded 283 times
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  • Site-wide: 80,125
  • In epidemiology: 3,241
• Year to date:
  • Site-wide: 104,345
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  • Site-wide: 102,627

Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype

• Downloaded 273 times
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  • Site-wide: 81,985
  • In epidemiology: 3,326
• Year to date:
  • Site-wide: 85,692
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  • Site-wide: 105,973

Estimating the causal effect of genetic liability to prevalent disease on hospital costs using Mendelian Randomization

• Downloaded 271 times
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  • Site-wide: 82,418
  • In health economics: 91
• Year to date:
  • Site-wide: 65,770
• Since beginning of last month:
  • Site-wide: 42,072

Does Smoking Cause Lower Educational Attainment and General Cognitive Ability? Triangulation of causal evidence using multiple study designs

• Downloaded 266 times
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  • Site-wide: 83,519
  • In epidemiology: 3,377
• Year to date:
  • Site-wide: 85,158
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  • Site-wide: 73,896

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 259 times
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  • Site-wide: 85,019
  • In genetics: 3,945
• Year to date:
  • Site-wide: 88,607
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  • Site-wide: 108,039

Mendelian randomization does not support serum calcium in prostate cancer risk

• Downloaded 259 times
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  • Site-wide: 85,005
  • In epidemiology: 3,418
• Year to date:
  • Site-wide: 93,977
• Since beginning of last month:
  • Site-wide: 118,030

The relationship between open angle glaucoma, optic disc morphology and Alzheimer's Disease: a Mendelian randomization study

• Downloaded 247 times
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  • Site-wide: 87,495
  • In ophthalmology: 63
• Year to date:
  • Site-wide: 74,994
• Since beginning of last month:
  • Site-wide: 14,139

Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals

• Downloaded 245 times
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  • Site-wide: 87,878
  • In genetics: 4,075
• Year to date:
  • Site-wide: 97,143
• Since beginning of last month:
  • Site-wide: 118,074

Educational inequalities in statin treatment for preventing cardiovascular disease: cross-sectional analysis of UK Biobank

• Downloaded 241 times
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  • Site-wide: 88,587
  • In epidemiology: 3,564
• Year to date:
  • Site-wide: 47,721
• Since beginning of last month:
  • Site-wide: 28,816

Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions

• Downloaded 238 times
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  • Site-wide: 89,270
  • In epidemiology: 3,578
• Year to date:
  • Site-wide: 84,810
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  • Site-wide: 34,642

Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

• Downloaded 225 times
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  • Site-wide: 92,148
  • In genetics: 4,263
• Year to date:
  • Site-wide: 101,412
• Since beginning of last month:
  • Site-wide: 112,401

Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

• Downloaded 210 times
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  • Site-wide: 95,211
  • In genetics: 4,381
• Year to date:
  • Site-wide: 42,178
• Since beginning of last month:
  • Site-wide: 58,095

Evaluating the direct effects of childhood adiposity on adult systemic metabolism: A multivariable Mendelian randomization analysis

• Downloaded 204 times
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  • Site-wide: 96,622
  • In cardiovascular medicine: 169
• Year to date:
  • Site-wide: 71,811
• Since beginning of last month:
  • Site-wide: 36,510

The effect of smoking on multiple sclerosis: a mendelian randomization study

• Downloaded 202 times
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  • Site-wide: 97,003
  • In genetic and genomic medicine: 333
• Year to date:
  • Site-wide: 47,835
• Since beginning of last month:
  • Site-wide: 60,440

Examining the bidirectional association between emotion recognition and ASD symptoms using observational and genetic analyses

• Downloaded 190 times
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  • Site-wide: 99,493
  • In genetic and genomic medicine: 357
• Year to date:
  • Site-wide: 101,951
• Since beginning of last month:
  • Site-wide: 41,386

Mendelian randomisation with coarsened exposures

• Downloaded 183 times
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  • Site-wide: 101,035
  • In epidemiology: 4,072
• Year to date:
  • Site-wide: 36,847
• Since beginning of last month:
  • Site-wide: 10,059

The role of school enjoyment in the association between externalising and depressive symptoms and academic attainment: findings from a UK prospective cohort study

• Downloaded 182 times
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  • Site-wide: 101,148
  • In epidemiology: 4,082
• Year to date:
  • Site-wide: 117,523
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  • Site-wide: 52,392

Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to SARS-CoV-2 severity

• Downloaded 176 times
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  • Site-wide: 102,206
  • In epidemiology: 4,130
• Year to date:
  • Site-wide: 40,824
• Since beginning of last month:
  • Site-wide: 55,392

The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study

• Downloaded 172 times
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  • Site-wide: 103,121
  • In epidemiology: 4,169
• Year to date:
  • Site-wide: 69,121
• Since beginning of last month:
  • Site-wide: 65,936

Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

• Downloaded 170 times
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  • Site-wide: 103,362
  • In epidemiology: 4,192
• Year to date:
  • Site-wide: 57,823
• Since beginning of last month:
  • Site-wide: 11,648

A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation

• Downloaded 164 times
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  • Site-wide: 104,539
  • In epidemiology: 4,233
• Year to date:
  • Site-wide: 34,228
• Since beginning of last month:
  • Site-wide: 23,387

Association of genetic liability to smoking initiation with e-cigarette use in young adults.

• Downloaded 162 times
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  • Site-wide: 104,980
  • In epidemiology: 4,246
• Year to date:
  • Site-wide: 53,753
• Since beginning of last month:
  • Site-wide: 47,815

Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

• Downloaded 135 times
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  • Site-wide: 110,040
  • In epidemiology: 4,419
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  • Site-wide: None
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  • Site-wide: None

Examining the possible causal relationship between Lung Function, COPD and Alzheimers Disease. A Mendelian Randomization Study

• Downloaded 133 times
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  • Site-wide: 110,436
  • In respiratory medicine: 183
• Year to date:
  • Site-wide: 92,896
• Since beginning of last month:
  • Site-wide: 62,769

Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: prospective cohort study

• Downloaded 129 times
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  • Site-wide: 110,992
  • In epidemiology: 4,458
• Year to date:
  • Site-wide: 78,150
• Since beginning of last month:
  • Site-wide: 57,900

Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study

• Downloaded 126 times
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  • Site-wide: 111,647
  • In epidemiology: 4,477
• Year to date:
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Interpreting Mendelian randomization estimates of the effects of categorical exposures such as disease status and educational attainment

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Epidemiology and Genetics of Preserved Ratio Impaired SpiroMetry (PRISm): An Analysis of UK Biobank

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Causal effects of circulating cytokine concentrations on risk of Alzheimers disease: A bidirectional two-sample Mendelian randomization study

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Cross-sectional association of blood pressure variability and night-time dipping with cardiac structure in adolescents

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Sex-specific associations of adiposity with cardiometabolic traits: multi-life-stage cohort study with repeat metabolomics

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