Author: George Davey Smith
- ORCiD: http://orcid.org/0000-0002-1407-8314
- Most recently observed institution: MRC Integrative Epidemiology Unit, University of Bristol
Rankings
- All-time downloads: 270,530 (rank: 311 )
- Categories:
- bioinformatics: 2,970 (rank: 5,964 (tie) )
- cardiovascular medicine: 1,362 (rank: 520 (tie) )
- epidemiology: 150,794 (rank: 115 )
- evolutionary biology: 470 (rank: 18,249 (tie) )
- genetic and genomic medicine: 9,246 (rank: 146 )
- genetics: 79,381 (rank: 44 )
- genomics: 4,367 (rank: 6,842 )
- health economics: 456 (rank: 583 (tie) )
- health informatics: 312 (rank: 3,512 (tie) )
- infectious diseases: 451 (rank: 47,571 (tie) )
- neurology: 2,399 (rank: 648 )
- neuroscience: 545 (rank: 55,487 (tie) )
- ophthalmology: 479 (rank: 418 (tie) )
- pharmacology and toxicology: 1,106 (rank: 1,535 (tie) )
- psychiatry and clinical psychology: 2,172 (rank: 720 )
- respiratory medicine: 645 (rank: 1,666 )
- rheumatology: 365 (rank: 1,135 (tie) )
- systems biology: 1,331 (rank: 4,102 (tie) )
Downloads per author, site-wide
Preprints
Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization
genetic and genomic medicine more details view paperNo download data for this paper yet.
Selection into shift work is influenced by educational attainment and body mass index: A Mendelian randomization study
epidemiology more details view paper- Downloaded 62,187 times
- Download rankings, all-time:
- Site-wide: 134
- In epidemiology: 31
- Year to date:
- Site-wide: 24,033
- Since beginning of last month:
- Site-wide: 95,998
Collider bias undermines our understanding of COVID-19 disease risk and severity
epidemiology more details view paper- Downloaded 13,375 times
- Download rankings, all-time:
- Site-wide: 881
- In epidemiology: 129
- Year to date:
- Site-wide: 7,196
- Since beginning of last month:
- Site-wide: 9,437
A reference panel of 64,976 haplotypes for genotype imputation
genetics more details view paper- Downloaded 4,695 times
- Download rankings, all-time:
- Site-wide: 3,441
- In genetics: 92
- Year to date:
- Site-wide: 126,419
- Since beginning of last month:
- Site-wide: 91,196
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
genetics more details view paper- Downloaded 4,333 times
- Download rankings, all-time:
- Site-wide: 3,826
- In genetics: 109
- Year to date:
- Site-wide: 24,619
- Since beginning of last month:
- Site-wide: 18,413
MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations
epidemiology more details view paper- Downloaded 4,304 times
- Download rankings, all-time:
- Site-wide: 3,858
- In epidemiology: 394
- Year to date:
- Site-wide: 55,799
- Since beginning of last month:
- Site-wide: 50,573
Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome
epidemiology more details view paper- Downloaded 4,258 times
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- Site-wide: 3,923
- In epidemiology: 416
- Year to date:
- Site-wide: 9,198
- Since beginning of last month:
- Site-wide: 9,277
PHESANT: a tool for performing automated phenome scans in UK Biobank
epidemiology more details view paper- Downloaded 3,891 times
- Download rankings, all-time:
- Site-wide: 4,460
- In epidemiology: 432
- Year to date:
- Site-wide: 35,897
- Since beginning of last month:
- Site-wide: 40,448
Within-sibship GWAS improve estimates of direct genetic effects
genetics more details view paper- Downloaded 3,257 times
- Download rankings, all-time:
- Site-wide: 5,787
- In genetics: 242
- Year to date:
- Site-wide: 2,970
- Since beginning of last month:
- Site-wide: 4,788
Collider Scope: When selection bias can substantially influence observed associations
epidemiology more details view paper- Downloaded 2,976 times
- Download rankings, all-time:
- Site-wide: 6,589
- In epidemiology: 573
- Year to date:
- Site-wide: 53,855
- Since beginning of last month:
- Site-wide: 61,580
Genome-wide association study identifies 48 common genetic variants associated with handedness
genetics more details view paper- Downloaded 2,893 times
- Download rankings, all-time:
- Site-wide: 6,859
- In genetics: 250
- Year to date:
- Site-wide: 46,283
- Since beginning of last month:
- Site-wide: 61,447
Why are education, socioeconomic position and intelligence genetically correlated?
genetics more details view paper- Downloaded 2,696 times
- Download rankings, all-time:
- Site-wide: 7,597
- In genetics: 290
- Year to date:
- Site-wide: 47,861
- Since beginning of last month:
- Site-wide: 38,897
Mendelian randomization: a premature burial?
genetics more details view paper- Downloaded 2,604 times
- Download rankings, all-time:
- Site-wide: 8,030
- In genetics: 301
- Year to date:
- Site-wide: 104,512
- Since beginning of last month:
- Site-wide: 91,060
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
genetics more details view paper- Downloaded 2,582 times
- Download rankings, all-time:
- Site-wide: 8,138
- In genetics: 303
- Year to date:
- Site-wide: 121,678
- Since beginning of last month:
- Site-wide: 132,486
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
genetics more details view paper- Downloaded 2,489 times
- Download rankings, all-time:
- Site-wide: 8,565
- In genetics: 324
- Year to date:
- Site-wide: 99,416
- Since beginning of last month:
- Site-wide: 132,666
Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases
genetics more details view paper- Downloaded 2,471 times
- Download rankings, all-time:
- Site-wide: 8,639
- In genetics: 340
- Year to date:
- Site-wide: 47,958
- Since beginning of last month:
- Site-wide: 57,130
Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis
epidemiology more details view paper- Downloaded 2,416 times
- Download rankings, all-time:
- Site-wide: 8,926
- In epidemiology: 694
- Year to date:
- Site-wide: 163,110
- Since beginning of last month:
- Site-wide: 144,159
Mendelian randomisation for mediation analysis: current methods and challenges for implementation
genetics more details view paper- Downloaded 2,215 times
- Download rankings, all-time:
- Site-wide: 10,123
- In genetics: 378
- Year to date:
- Site-wide: 68,768
- Since beginning of last month:
- Site-wide: 78,214
Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption
epidemiology more details view paper- Downloaded 2,156 times
- Download rankings, all-time:
- Site-wide: 10,557
- In epidemiology: 818
- Year to date:
- Site-wide: 42,143
- Since beginning of last month:
- Site-wide: 50,684
Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study
epidemiology more details view paper- Downloaded 2,089 times
- Download rankings, all-time:
- Site-wide: 11,126
- In epidemiology: 832
- Year to date:
- Site-wide: 96,650
- Since beginning of last month:
- Site-wide: 113,919
An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome
genetics more details view paper- Downloaded 2,085 times
- Download rankings, all-time:
- Site-wide: 11,163
- In genetics: 418
- Year to date:
- Site-wide: 55,798
- Since beginning of last month:
- Site-wide: 50,280
Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
neurology more details view paper- Downloaded 2,063 times
- Download rankings, all-time:
- Site-wide: 11,327
- In neurology: 29
- Year to date:
- Site-wide: 16,278
- Since beginning of last month:
- Site-wide: 10,035
Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases
genetic and genomic medicine more details view paper- Downloaded 2,060 times
- Download rankings, all-time:
- Site-wide: 11,357
- In genetic and genomic medicine: 81
- Year to date:
- Site-wide: 613
- Since beginning of last month:
- Site-wide: 4,434
Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.
genetics more details view paper- Downloaded 1,987 times
- Download rankings, all-time:
- Site-wide: 11,971
- In genetics: 439
- Year to date:
- Site-wide: 153,619
- Since beginning of last month:
- Site-wide: 146,740
Genomic analysis of diet composition finds novel loci and associations with health and lifestyle
genetics more details view paper- Downloaded 1,867 times
- Download rankings, all-time:
- Site-wide: 13,115
- In genetics: 500
- Year to date:
- Site-wide: 110,848
- Since beginning of last month:
- Site-wide: 86,061
Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide
genetics more details view paper- Downloaded 1,861 times
- Download rankings, all-time:
- Site-wide: 13,172
- In genetics: 498
- Year to date:
- Site-wide: 124,807
- Since beginning of last month:
- Site-wide: 116,301
Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism
genetics more details view paper- Downloaded 1,817 times
- Download rankings, all-time:
- Site-wide: 13,636
- In genetics: 517
- Year to date:
- Site-wide: 145,649
- Since beginning of last month:
- Site-wide: 91,115
Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population
genetics more details view paper- Downloaded 1,726 times
- Download rankings, all-time:
- Site-wide: 14,733
- In genetics: 576
- Year to date:
- Site-wide: 145,645
- Since beginning of last month:
- Site-wide: 146,301
An examination of multivariable Mendelian randomization in the single sample and two-sample summary data settings.
epidemiology more details view paper- Downloaded 1,707 times
- Download rankings, all-time:
- Site-wide: 14,976
- In epidemiology: 1,049
- Year to date:
- Site-wide: 66,277
- Since beginning of last month:
- Site-wide: 130,856
The MRC IEU OpenGWAS data infrastructure
genetics more details view paper- Downloaded 1,699 times
- Download rankings, all-time:
- Site-wide: 15,076
- In genetics: 887
- Year to date:
- Site-wide: 4,399
- Since beginning of last month:
- Site-wide: 3,450
A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome
genetics more details view paper- Downloaded 1,687 times
- Download rankings, all-time:
- Site-wide: 15,226
- In genetics: 598
- Year to date:
- Site-wide: 155,593
- Since beginning of last month:
- Site-wide: 129,605
Multi-ancestry omic Mendelian randomization revealing putative drug targets of COVID-19 severity
genetic and genomic medicine more details view paper- Downloaded 1,687 times
- Download rankings, all-time:
- Site-wide: 15,236
- In genetic and genomic medicine: 91
- Year to date:
- Site-wide: 19,019
- Since beginning of last month:
- Site-wide: 22,978
Selection bias in instrumental variable analyses
epidemiology more details view paper- Downloaded 1,657 times
- Download rankings, all-time:
- Site-wide: 15,643
- In epidemiology: 1,097
- Year to date:
- Site-wide: 52,088
- Since beginning of last month:
- Site-wide: 40,680
Cigarette smoking increases coffee consumption: findings from a Mendelian randomisation analysis
genetics more details view paper- Downloaded 1,583 times
- Download rankings, all-time:
- Site-wide: 16,800
- In genetics: 685
- Year to date:
- Site-wide: 94,350
- Since beginning of last month:
- Site-wide: 57,231
The Causal Effects of Education on Health, Mortality, Cognition, Well-being, and Income in the UK Biobank
epidemiology more details view paper- Downloaded 1,566 times
- Download rankings, all-time:
- Site-wide: 17,114
- In epidemiology: 1,128
- Year to date:
- Site-wide: 89,377
- Since beginning of last month:
- Site-wide: 116,845
Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments
genetics more details view paper- Downloaded 1,547 times
- Download rankings, all-time:
- Site-wide: 17,422
- In genetics: 768
- Year to date:
- Site-wide: 19,026
- Since beginning of last month:
- Site-wide: 44,189
Do early life non-cognitive skills matter? A systematic review and meta-analysis of early life effects on academic achievement, psychosocial, language and cognitive, and health outcomes
epidemiology more details view paper- Downloaded 1,491 times
- Download rankings, all-time:
- Site-wide: 18,392
- In epidemiology: 1,197
- Year to date:
- Site-wide: 94,335
- Since beginning of last month:
- Site-wide: 105,357
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
genetics more details view paper- Downloaded 1,488 times
- Download rankings, all-time:
- Site-wide: 18,454
- In genetics: 739
- Year to date:
- Site-wide: 155,290
- Since beginning of last month:
- Site-wide: 113,844
The genetic architecture of osteoarthritis: insights from UK Biobank
genetics more details view paper- Downloaded 1,458 times
- Download rankings, all-time:
- Site-wide: 19,056
- In genetics: 766
- Year to date:
- Site-wide: 142,807
- Since beginning of last month:
- Site-wide: 141,022
Meffil: efficient normalisation and analysis of very large DNA methylation samples
bioinformatics more details view paper- Downloaded 1,457 times
- Download rankings, all-time:
- Site-wide: 19,062
- In bioinformatics: 2,025
- Year to date:
- Site-wide: 78,055
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- Site-wide: 131,715
Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood
epidemiology more details view paper- Downloaded 1,436 times
- Download rankings, all-time:
- Site-wide: 19,550
- In epidemiology: 1,268
- Year to date:
- Site-wide: 59,071
- Since beginning of last month:
- Site-wide: 65,866
The causes and consequences of Alzheimer's disease: A Mendelian randomization analysis
genetic and genomic medicine more details view paper- Downloaded 1,426 times
- Download rankings, all-time:
- Site-wide: 19,733
- In genetic and genomic medicine: 100
- Year to date:
- Site-wide: 48,355
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- Site-wide: 47,834
Genomic and phenomic insights from an atlas of genetic effects on DNA methylation
genetic and genomic medicine more details view paper- Downloaded 1,424 times
- Download rankings, all-time:
- Site-wide: 19,766
- In genetic and genomic medicine: 98
- Year to date:
- Site-wide: 31,747
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- Site-wide: 58,624
Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels
genetics more details view paper- Downloaded 1,311 times
- Download rankings, all-time:
- Site-wide: 22,508
- In genetics: 894
- Year to date:
- Site-wide: 176,009
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- Site-wide: 160,154
Genetic Association Study of Childhood Aggression across raters, instruments and age
genomics more details view paper- Downloaded 1,292 times
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- Site-wide: 22,995
- In genomics: 2,082
- Year to date:
- Site-wide: 48,465
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- Site-wide: 15,694
Genetic liability for schizophrenia and childhood psychopathology in the general population
psychiatry and clinical psychology more details view paper- Downloaded 1,291 times
- Download rankings, all-time:
- Site-wide: 23,029
- In psychiatry and clinical psychology: 86
- Year to date:
- Site-wide: 71,643
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- Site-wide: 118,682
Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates
genetics more details view paper- Downloaded 1,276 times
- Download rankings, all-time:
- Site-wide: 23,477
- In genetics: 932
- Year to date:
- Site-wide: 143,824
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- Site-wide: 159,759
Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk
epidemiology more details view paper- Downloaded 1,268 times
- Download rankings, all-time:
- Site-wide: 23,684
- In epidemiology: 1,384
- Year to date:
- Site-wide: 159,729
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- Site-wide: 170,837
Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.
epidemiology more details view paper- Downloaded 1,241 times
- Download rankings, all-time:
- Site-wide: 24,543
- In epidemiology: 1,414
- Year to date:
- Site-wide: 165,051
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- Site-wide: 175,860
Body mass index and mortality in UK Biobank: revised estimates using Mendelian randomization
epidemiology more details view paper- Downloaded 1,234 times
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- Site-wide: 24,729
- In epidemiology: 1,439
- Year to date:
- Site-wide: 121,728
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- Site-wide: 115,800
Narrow-sense heritability estimation of complex traits using identity-by-descent information.
genetics more details view paper- Downloaded 1,233 times
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- Site-wide: 24,771
- In genetics: 974
- Year to date:
- Site-wide: 148,750
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- Site-wide: 160,202
Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data
genetics more details view paper- Downloaded 1,226 times
- Download rankings, all-time:
- Site-wide: 24,984
- In genetics: 984
- Year to date:
- Site-wide: 143,051
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- Site-wide: 129,254
The effect of education on adult mortality, health, and income: triangulating across genetic and policy reforms
epidemiology more details view paper- Downloaded 1,155 times
- Download rankings, all-time:
- Site-wide: 27,364
- In epidemiology: 1,540
- Year to date:
- Site-wide: 124,955
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- Site-wide: 130,576
Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits
genetics more details view paper- Downloaded 1,138 times
- Download rankings, all-time:
- Site-wide: 27,987
- In genetics: 1,204
- Year to date:
- Site-wide: 27,062
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- Site-wide: 29,798
Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities
pharmacology and toxicology more details view paper- Downloaded 1,117 times
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- Site-wide: 28,773
- In pharmacology and toxicology: 147
- Year to date:
- Site-wide: 179,453
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- Site-wide: 162,049
Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study
epidemiology more details view paper- Downloaded 1,112 times
- Download rankings, all-time:
- Site-wide: 28,976
- In epidemiology: 1,628
- Year to date:
- Site-wide: 114,120
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- Site-wide: 144,141
Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions
epidemiology more details view paper- Downloaded 1,106 times
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- Site-wide: 29,202
- In epidemiology: 1,622
- Year to date:
- Site-wide: 139,737
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- Site-wide: 112,725
Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study
genetics more details view paper- Downloaded 1,102 times
- Download rankings, all-time:
- Site-wide: 29,389
- In genetics: 1,153
- Year to date:
- Site-wide: 185,024
- Since beginning of last month:
- Site-wide: 172,123
Can education be personalised using pupils’ genetic data?
genetics more details view paper- Downloaded 1,093 times
- Download rankings, all-time:
- Site-wide: 29,762
- In genetics: 1,229
- Year to date:
- Site-wide: 79,770
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- Site-wide: 147,452
An epigenome-wide association study of educational attainment (n = 10,767)
genetics more details view paper- Downloaded 1,070 times
- Download rankings, all-time:
- Site-wide: 30,738
- In genetics: 1,216
- Year to date:
- Site-wide: 165,158
- Since beginning of last month:
- Site-wide: 132,744
Causal inference in cancer epidemiology: what is the role of Mendelian randomization?
epidemiology more details view paper- Downloaded 1,066 times
- Download rankings, all-time:
- Site-wide: 30,868
- In epidemiology: 1,687
- Year to date:
- Site-wide: 124,948
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- Site-wide: 71,781
Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals
genomics more details view paper- Downloaded 1,053 times
- Download rankings, all-time:
- Site-wide: 31,450
- In genomics: 2,529
- Year to date:
- Site-wide: 142,714
- Since beginning of last month:
- Site-wide: 129,818
Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption
epidemiology more details view paper- Downloaded 1,048 times
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- Site-wide: 31,627
- In epidemiology: 1,693
- Year to date:
- Site-wide: 185,937
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- Site-wide: 188,217
Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease
cardiovascular medicine more details view paper- Downloaded 1,033 times
- Download rankings, all-time:
- Site-wide: 32,377
- In cardiovascular medicine: 52
- Year to date:
- Site-wide: 132,312
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- Site-wide: 136,019
Detecting heterogeneity of intervention effects using analysis and meta-analysis of differences in variance between arms of a trial
epidemiology more details view paper- Downloaded 1,006 times
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- Site-wide: 33,683
- In epidemiology: 1,803
- Year to date:
- Site-wide: 81,086
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- Site-wide: 73,431
Consistency of non-cognitive skills and their relation to educational outcomes in a UK cohort
genetics more details view paper- Downloaded 966 times
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- Site-wide: 35,711
- In genetics: 1,507
- Year to date:
- Site-wide: 57,931
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- Site-wide: 36,549
Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression
epidemiology more details view paper- Downloaded 951 times
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- Site-wide: 36,613
- In epidemiology: 1,864
- Year to date:
- Site-wide: 107,572
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- Site-wide: 170,818
MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways
bioinformatics more details view paper- Downloaded 937 times
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- Site-wide: 37,489
- In bioinformatics: 3,773
- Year to date:
- Site-wide: 130,305
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- Site-wide: 164,226
The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study
epidemiology more details view paper- Downloaded 921 times
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- Site-wide: 38,404
- In epidemiology: 1,960
- Year to date:
- Site-wide: 96,913
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Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants
epidemiology more details view paper- Downloaded 894 times
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- Site-wide: 40,063
- In epidemiology: 1,990
- Year to date:
- Site-wide: 152,627
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- Site-wide: 173,205
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
genetics more details view paper- Downloaded 883 times
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- Site-wide: 40,845
- In genetics: 1,613
- Year to date:
- Site-wide: 154,448
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- Site-wide: 132,862
Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis
genomics more details view paper- Downloaded 869 times
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- Site-wide: 41,811
- In genomics: 3,124
- Year to date:
- Site-wide: 126,046
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- Site-wide: 174,212
Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney disease
epidemiology more details view paper- Downloaded 852 times
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- Site-wide: 43,030
- In epidemiology: 2,197
- Year to date:
- Site-wide: 56,385
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- Site-wide: 52,028
Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study
epidemiology more details view paper- Downloaded 851 times
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- Site-wide: 43,166
- In epidemiology: 2,134
- Year to date:
- Site-wide: 123,963
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- Site-wide: 167,020
Genetic Epidemiology And Mendelian Randomization For Informing Disease Therapeutics: Conceptual And Methodological Challenges
genetics more details view paper- Downloaded 845 times
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- Site-wide: 43,616
- In genetics: 1,699
- Year to date:
- Site-wide: 176,137
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- Site-wide: 170,118
Using genetics to examine a general liability to childhood psychopathology
genetics more details view paper- Downloaded 819 times
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- Site-wide: 45,627
- In genetics: 1,825
- Year to date:
- Site-wide: 107,989
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- Site-wide: 104,577
Examining the genetic influences of educational attainment and the validity of value-added measures of progress
genetics more details view paper- Downloaded 818 times
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- Site-wide: 45,692
- In genetics: 1,796
- Year to date:
- Site-wide: 142,794
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- Site-wide: 133,008
Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease
genetics more details view paper- Downloaded 811 times
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- Site-wide: 46,277
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Distinct Blood DNA Methylation Profiles In Subtypes Of Orofacial Cleft
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Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language
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Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population
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Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization
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Evidence that low socioeconomic position accentuates genetic susceptibility to obesity
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Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies
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Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization
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An atlas of associations between polygenic risk scores from across the human phenome and circulating metabolic biomarkers
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The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children
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Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity
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Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments
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Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life
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Mendelian randomisation with coarsened exposures
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Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment
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Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses
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Appraising the causal relevance of DNA methylation for risk of lung cancer
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Genetic predictors of participation in optional components of UK Biobank
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Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
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Education and coronary heart disease: a Mendelian randomization study
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Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts
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Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility
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Association of COVID-19 with arterial and venous vascular diseases: a population-wide cohort study of 48 million adults in England and Wales
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Cigarette smoking and personality: Investigating causality using Mendelian randomization
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Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour
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Conditioning on a collider may induce spurious associations: Do the results of Gale et al. (2017) support a protective effect of neuroticism in population sub-groups?
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Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood
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Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis
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Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions
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The median and the mode as robust meta-analysis methods in the presence of small study effects
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Metabolic signatures of birth weight in 18288 adolescents and adults
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Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease
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Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein
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Identifying intergenerational risk factors for ADHD symptoms using polygenic scores in the Norwegian Mother, Father and Child Cohort
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Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study
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Risk of death among teachers in England and Wales during the Covid19 pandemic
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What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality
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Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization
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PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study
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The Parkinsons Disease Mendelian Randomization Research Portal
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Examining the effect of smoking on suicidal ideation and attempts: A Mendelian randomisation study
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Assortative mating and within-spouse pair comparisons
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Is genetic liability to ADHD and ASD causally linked to educational attainment?
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The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank
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A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank
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CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?
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Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis
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Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures
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The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.
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Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer.
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Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK Biobank
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Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study
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Association Between Genetically Elevated Levels Of Inflammatory Biomarkers And Risk Of Schizophrenia: A Two-Sample Mendelian Randomisation Study
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Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives
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Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study
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The relationship between open angle glaucoma, optic disc morphology and Alzheimer's Disease: a Mendelian randomization study
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Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology
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Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisation
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The Multivariate Genome-wide Architecture of Interrelated Literacy, Language and Working Memory Skills Reveals Distinct Etiologies
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A robust mean and variance test with application to high-dimensional phenotypes
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A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target
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Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics
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Estimating the causal effect of genetic liability to prevalent disease on hospital costs using Mendelian Randomization
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Schizophrenia risk and reproductive success: A Mendelian randomization study.
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The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study
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Dominant role of abdominal adiposity in circulating lipoprotein, lipid, and metabolite levels in UK Biobank: Mendelian randomization study
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Educational inequalities in statin treatment for preventing cardiovascular disease: cross-sectional analysis of UK Biobank
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Estimation of causal effects of a time-varying exposure at multiple time points through Multivariable Mendelian randomization
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Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study
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Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
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Circulating selenium and prostate cancer risk: a Mendelian randomization analysis
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Interrogating structural inequalities in COVID-19 Mortality in England and Wales
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A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation
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MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging
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Identifying novel subtypes of irritability using a developmental genetic approach
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Osteophyte size and location on hip DXA scans are associated with hip pain: findings from a cross sectional study in UK Biobank
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Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population
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The association between adiposity and inpatient hospital costs in the UK Biobank cohort
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The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study
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Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates
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Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study
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Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices
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Causal effects of circulating cytokine concentrations on risk of Alzheimers disease: A bidirectional two-sample Mendelian randomization study
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DNA methylation mediates genetic liability to non-syndromic cleft lip/palate
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Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition
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Mendelian randomization analyses show that higher acetyl-carnitine and carnitine levels in blood protect against severe Covid19
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Epidemiology and Genetics of Preserved Ratio Impaired SpiroMetry (PRISm): An Analysis of UK Biobank
respiratory medicine more details view paper- Downloaded 410 times
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The role of school enjoyment in the association between externalising and depressive symptoms and academic attainment: findings from a UK prospective cohort study
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Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease
genetics more details view paper- Downloaded 402 times
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Disentangling the direct and indirect effects of childhood adiposity on type 1 diabetes and immune-associated diseases: a multivariable Mendelian randomization study
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Examining the bidirectional association between emotion recognition and ASD symptoms using observational and genetic analyses
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Navigating sample overlap, winner's curse and weak instrument bias in Mendelian randomization studies using the UK Biobank
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Does Smoking Cause Lower Educational Attainment and General Cognitive Ability? Triangulation of causal evidence using multiple study designs
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Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype
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Metabolomic signatures of lipid-modifying therapies using drug target Mendelian randomization
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Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers
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Interpreting Mendelian randomization estimates of the effects of categorical exposures such as disease status and educational attainment
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Association of genetic liability to smoking initiation with e-cigarette use in young adults.
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Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study
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Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to SARS-CoV-2 severity
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Evaluating the direct effects of childhood adiposity on adult systemic metabolism: A multivariable Mendelian randomization analysis
cardiovascular medicine more details view paper- Downloaded 360 times
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Strategies to investigate and mitigate collider bias in genetic and Mendelian randomization studies of disease progression
genetic and genomic medicine more details view paper- Downloaded 348 times
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Hypothesis-free detection of gene-interaction effects on biomarker concentration in UK Biobank using variance prioritisation
genetic and genomic medicine more details view paper- Downloaded 346 times
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Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health
epidemiology more details view paper- Downloaded 346 times
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The effect of smoking on multiple sclerosis: a mendelian randomization study
genetic and genomic medicine more details view paper- Downloaded 345 times
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Cross-sectional association of blood pressure variability and night-time dipping with cardiac structure in adolescents
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Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization
genetics more details view paper- Downloaded 336 times
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Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization
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An Informatics Consult approach for generating clinical evidence for treatment decisions
health informatics more details view paper- Downloaded 329 times
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The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study
epidemiology more details view paper- Downloaded 324 times
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- Site-wide: 130,947
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Mendelian randomization does not support serum calcium in prostate cancer risk
epidemiology more details view paper- Downloaded 307 times
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Exploring selection bias in COVID-19 research: Simulations and prospective analyses of two UK cohort studies
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Examining the possible causal relationship between Lung Function, COPD and Alzheimers Disease. A Mendelian Randomization Study
respiratory medicine more details view paper- Downloaded 296 times
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- Site-wide: 139,467
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Parental inflammatory bowel disease and autism in the offspring: Triangulating the evidence using four complementary study designs.
epidemiology more details view paper- Downloaded 292 times
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Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study
epidemiology more details view paper- Downloaded 292 times
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- Site-wide: 140,649
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Educational attainment as a modifier of the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank
genetic and genomic medicine more details view paper- Downloaded 290 times
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Design and quality control of large-scale two-sample Mendelian randomisation studies
epidemiology more details view paper- Downloaded 289 times
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Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals
genetics more details view paper- Downloaded 284 times
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- Site-wide: 142,750
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Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: prospective cohort study
epidemiology more details view paper- Downloaded 283 times
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- Site-wide: 143,062
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Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)
genetics more details view paper- Downloaded 275 times
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Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independent of body mass index
genetic and genomic medicine more details view paper- Downloaded 275 times
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Interpretation of mendelian randomization using one measure of an exposure that varies over time.
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Immunological pathways underlying autism: Findings from Mendelian randomization and genetic colocalisation analyses.
epidemiology more details view paper- Downloaded 261 times
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- Site-wide: 149,922
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Tools for the assessment of quality and risk of bias in Mendelian randomization studies: a systematic review
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Puberty and sex-specific trajectories of systolic blood pressure: a prospective cohort study
epidemiology more details view paper- Downloaded 255 times
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Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study
epidemiology more details view paper- Downloaded 255 times
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Germline TYK2 mutation and cancer risk
genetic and genomic medicine more details view paper- Downloaded 252 times
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Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization
genetic and genomic medicine more details view paper- Downloaded 248 times
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Sex-specific associations of adiposity with cardiometabolic traits: multi-life-stage cohort study with repeat metabolomics
epidemiology more details view paper- Downloaded 246 times
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- Site-wide: 154,019
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Correlations in sleeping patterns and circadian preference between spouses
epidemiology more details view paper- Downloaded 220 times
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Genetic effect modification of cis-acting C-reactive protein variants in cardiometabolic disease status
genetics more details view paper- Downloaded 219 times
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Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis
epidemiology more details view paper- Downloaded 215 times
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Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimers disease risk in the general population: a Mendelian randomization study
epidemiology more details view paper- Downloaded 214 times
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- Site-wide: 162,896
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Systematic comparison of Mendelian randomization studies and randomized controlled trials using electronic databases
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Taller height and risk of coronary heart disease and cancer: a within-sibship Mendelian randomization study
genetic and genomic medicine more details view paper- Downloaded 192 times
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The impact of low input DNA on the reliability of DNA methylation as measured by the Illumina Infinium MethylationEPIC BeadChip
bioinformatics more details view paper- Downloaded 191 times
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Genetic analyses of common infections in the Avon Longitudinal Study of Parents and Children cohort
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Continuing inequalities in COVID-19 mortality in England and Wales, and the changing importance of regional, over local, deprivation
epidemiology more details view paper- Downloaded 186 times
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Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples
genetic and genomic medicine more details view paper- Downloaded 184 times
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Investigating the transparency of reporting in two-sample summary data Mendelian randomization studies
epidemiology more details view paper- Downloaded 175 times
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Characterisation of ethnic differences in DNA methylation between UK resident South Asians and Europeans
epidemiology more details view paper- Downloaded 171 times
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- Site-wide: 173,634
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The relationship between BMI and COVID-19: exploring misclassification and selection bias in a two-sample Mendelian randomisation study
epidemiology more details view paper- Downloaded 153 times
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Age-specific effects of body size on fracture risk in later life: A lifecourse Mendelian randomization study
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- Site-wide: 177,864
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Estimating the genetically predicted effects of lifestyle risk factors, educational attainment and Alzheimer's disease liability on weight change during midlife
epidemiology more details view paper- Downloaded 148 times
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- Site-wide: 178,313
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Sex-specific trajectories of molecular cardiometabolic trait concentrations through childhood, adolescence and young adulthood: a cohort study
epidemiology more details view paper- Downloaded 144 times
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- Site-wide: 179,026
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Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study
epidemiology more details view paper- Downloaded 143 times
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- Site-wide: 179,245
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Separating the direct effects of risk factors for atherosclerotic cardiovascular disease from those mediated by type 2 diabetes
epidemiology more details view paper- Downloaded 142 times
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- Site-wide: 179,408
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Life stage-specific effects of genetic susceptibility to higher body size on body fat and lean mass: prospective cohort study
epidemiology more details view paper- Downloaded 139 times
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- Site-wide: 179,918
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Association of lipid-regulating drugs with dementia and related conditions: an observational study of data from the Clinical Practice Research Datalink
epidemiology more details view paper- Downloaded 123 times
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- Site-wide: 182,598
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Mental-health before and during the COVID-19 pandemic in adults with neurodevelopmental disorders.
psychiatry and clinical psychology more details view paper- Downloaded 121 times
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- Site-wide: 182,819
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Socioeconomic inequality in SARS-CoV-2 testing and COVID-19 outcomes in UK Biobank over the first year of the pandemic: can inequalities be explained byselection bias?
epidemiology more details view paper- Downloaded 107 times
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- Site-wide: 184,803
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- Site-wide: 42,669
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Genetically proxied PCSK9 inhibition provides indication of lower prostate cancer risk: a Mendelian randomization study
oncology more details view paper- Downloaded 99 times
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- Site-wide: 185,815
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The global randomization test: A Mendelian randomization falsification test for the exclusion restriction assumption
epidemiology more details view paper- Downloaded 97 times
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- Site-wide: 186,002
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The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: A Mendelian randomization study
epidemiology more details view paper- Downloaded 78 times
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- Site-wide: 187,989
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Examining the association between genetic risk for depression, wellbeing and schizophrenia, and proximity to greenspace
epidemiology more details view paper- Downloaded 76 times
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- Site-wide: 188,177
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Health behaviours prior to pregnancy and fertility outcomes: Triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)
epidemiology more details view paper- Downloaded 65 times
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- Site-wide: 188,987
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- Site-wide: 70,170
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Associations between vitamin D and disease risk may be attributed to the confounding influence of adiposity during childhood and adulthood: a lifecourse Mendelian randomization study
epidemiology more details view paper- Downloaded 45 times
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- Site-wide: 190,095
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- Site-wide: 94,668
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- Site-wide: 28,088
Sex-specific associations of childhood socioeconomic position and trajectories of metabolic traits across early life: prospective cohort study
epidemiology more details view paper- Downloaded 36 times
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- Site-wide: 190,396
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- Site-wide: 111,725
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- Site-wide: 37,161
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News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
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