Author: George Davey Smith

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Preprints

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization

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Selection into shift work is influenced by educational attainment and body mass index: A Mendelian randomization study

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  • Site-wide: 134
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  • Site-wide: 24,033
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Collider bias undermines our understanding of COVID-19 disease risk and severity

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  • Site-wide: 881
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A reference panel of 64,976 haplotypes for genotype imputation

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  • Site-wide: 3,441
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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

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  • Site-wide: 3,826
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MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

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  • Site-wide: 3,858
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Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

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  • Site-wide: 3,923
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PHESANT: a tool for performing automated phenome scans in UK Biobank

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  • Site-wide: 4,460
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  • Site-wide: 35,897
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Within-sibship GWAS improve estimates of direct genetic effects

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  • Site-wide: 5,787
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  • Site-wide: 2,970
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Collider Scope: When selection bias can substantially influence observed associations

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  • Site-wide: 6,589
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Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • Site-wide: 6,859
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  • Site-wide: 46,283
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Why are education, socioeconomic position and intelligence genetically correlated?

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  • Site-wide: 7,597
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  • Site-wide: 47,861
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Mendelian randomization: a premature burial?

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  • Site-wide: 8,030
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  • Site-wide: 104,512
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  • Site-wide: 91,060

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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  • Site-wide: 8,138
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  • Site-wide: 121,678
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  • Site-wide: 132,486

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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  • Site-wide: 8,565
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Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

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  • Site-wide: 8,639
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Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

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  • Site-wide: 8,926
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  • Site-wide: 144,159

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

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  • Site-wide: 10,123
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  • Site-wide: 68,768
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  • Site-wide: 78,214

Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

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  • Site-wide: 10,557
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  • Site-wide: 50,684

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

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  • Site-wide: 11,126
  • In epidemiology: 832
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  • Site-wide: 96,650
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  • Site-wide: 113,919

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

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  • Site-wide: 11,163
  • In genetics: 418
• Year to date:
  • Site-wide: 55,798
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  • Site-wide: 50,280

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

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  • Site-wide: 11,327
  • In neurology: 29
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  • Site-wide: 16,278
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  • Site-wide: 10,035

Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases

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  • Site-wide: 11,357
  • In genetic and genomic medicine: 81
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  • Site-wide: 613
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  • Site-wide: 4,434

Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

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  • Site-wide: 11,971
  • In genetics: 439
• Year to date:
  • Site-wide: 153,619
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  • Site-wide: 146,740

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

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  • Site-wide: 13,115
  • In genetics: 500
• Year to date:
  • Site-wide: 110,848
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  • Site-wide: 86,061

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 13,172
  • In genetics: 498
• Year to date:
  • Site-wide: 124,807
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  • Site-wide: 116,301

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 13,636
  • In genetics: 517
• Year to date:
  • Site-wide: 145,649
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  • Site-wide: 91,115

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

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  • Site-wide: 14,733
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• Year to date:
  • Site-wide: 145,645
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  • Site-wide: 146,301

An examination of multivariable Mendelian randomization in the single sample and two-sample summary data settings.

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  • Site-wide: 14,976
  • In epidemiology: 1,049
• Year to date:
  • Site-wide: 66,277
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  • Site-wide: 130,856

The MRC IEU OpenGWAS data infrastructure

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  • Site-wide: 15,076
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  • Site-wide: 4,399
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  • Site-wide: 3,450

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

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  • Site-wide: 15,226
  • In genetics: 598
• Year to date:
  • Site-wide: 155,593
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  • Site-wide: 129,605

Multi-ancestry omic Mendelian randomization revealing putative drug targets of COVID-19 severity

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  • Site-wide: 15,236
  • In genetic and genomic medicine: 91
• Year to date:
  • Site-wide: 19,019
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  • Site-wide: 22,978

Selection bias in instrumental variable analyses

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  • Site-wide: 15,643
  • In epidemiology: 1,097
• Year to date:
  • Site-wide: 52,088
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  • Site-wide: 40,680

Cigarette smoking increases coffee consumption: findings from a Mendelian randomisation analysis

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  • Site-wide: 16,800
  • In genetics: 685
• Year to date:
  • Site-wide: 94,350
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  • Site-wide: 57,231

The Causal Effects of Education on Health, Mortality, Cognition, Well-being, and Income in the UK Biobank

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  • Site-wide: 17,114
  • In epidemiology: 1,128
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  • Site-wide: 89,377
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  • Site-wide: 116,845

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

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  • Site-wide: 17,422
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  • Site-wide: 19,026
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  • Site-wide: 44,189

Do early life non-cognitive skills matter? A systematic review and meta-analysis of early life effects on academic achievement, psychosocial, language and cognitive, and health outcomes

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  • Site-wide: 18,392
  • In epidemiology: 1,197
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  • Site-wide: 94,335
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  • Site-wide: 105,357

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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  • Site-wide: 18,454
  • In genetics: 739
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  • Site-wide: 113,844

The genetic architecture of osteoarthritis: insights from UK Biobank

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  • Site-wide: 19,056
  • In genetics: 766
• Year to date:
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  • Site-wide: 141,022

Meffil: efficient normalisation and analysis of very large DNA methylation samples

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  • Site-wide: 19,062
  • In bioinformatics: 2,025
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  • Site-wide: 131,715

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

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  • Site-wide: 19,550
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  • Site-wide: 65,866

The causes and consequences of Alzheimer's disease: A Mendelian randomization analysis

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  • Site-wide: 19,733
  • In genetic and genomic medicine: 100
• Year to date:
  • Site-wide: 48,355
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  • Site-wide: 47,834

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

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  • Site-wide: 19,766
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  • Site-wide: 58,624

Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

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  • Site-wide: 22,508
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  • Site-wide: 160,154

Genetic Association Study of Childhood Aggression across raters, instruments and age

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  • Site-wide: 22,995
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  • Site-wide: 15,694

Genetic liability for schizophrenia and childhood psychopathology in the general population

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  • Site-wide: 23,029
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  • Site-wide: 118,682

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

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  • Site-wide: 23,477
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  • Site-wide: 159,759

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

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  • Site-wide: 23,684
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  • Site-wide: 170,837

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

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  • Site-wide: 24,543
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  • Site-wide: 175,860

Body mass index and mortality in UK Biobank: revised estimates using Mendelian randomization

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  • Site-wide: 24,729
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  • Site-wide: 121,728
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  • Site-wide: 115,800

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

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Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data

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  • Site-wide: 24,984
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  • Site-wide: 129,254

The effect of education on adult mortality, health, and income: triangulating across genetic and policy reforms

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  • Site-wide: 27,364
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  • Site-wide: 124,955
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  • Site-wide: 130,576

Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits

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  • Site-wide: 27,987
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  • Site-wide: 27,062
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  • Site-wide: 29,798

Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

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  • Site-wide: 28,773
  • In pharmacology and toxicology: 147
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  • Site-wide: 162,049

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

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  • Site-wide: 28,976
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  • Site-wide: 144,141

Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions

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  • Site-wide: 112,725

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

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  • Site-wide: 29,389
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  • Site-wide: 172,123

Can education be personalised using pupils’ genetic data?

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  • Site-wide: 29,762
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  • Site-wide: 79,770
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An epigenome-wide association study of educational attainment (n = 10,767)

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  • Site-wide: 30,738
  • In genetics: 1,216
• Year to date:
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  • Site-wide: 132,744

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?

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  • Site-wide: 30,868
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  • Site-wide: 71,781

Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

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  • Site-wide: 31,450
  • In genomics: 2,529
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Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

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  • Site-wide: 31,627
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  • Site-wide: 188,217

Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease

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  • Site-wide: 32,377
  • In cardiovascular medicine: 52
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Detecting heterogeneity of intervention effects using analysis and meta-analysis of differences in variance between arms of a trial

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  • Site-wide: 33,683
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  • Site-wide: 73,431

Consistency of non-cognitive skills and their relation to educational outcomes in a UK cohort

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Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression

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  • Site-wide: 36,613
  • In epidemiology: 1,864
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MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

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  • Site-wide: 37,489
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The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

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  • Site-wide: 38,404
  • In epidemiology: 1,960
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  • Site-wide: 54,218

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

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  • In epidemiology: 1,990
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  • Site-wide: 152,627
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  • Site-wide: 173,205

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

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  • Site-wide: 132,862

Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis

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  • Site-wide: 41,811
  • In genomics: 3,124
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  • Site-wide: 174,212

Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney disease

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Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study

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  • Site-wide: 43,166
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  • Site-wide: 123,963
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Genetic Epidemiology And Mendelian Randomization For Informing Disease Therapeutics: Conceptual And Methodological Challenges

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Using genetics to examine a general liability to childhood psychopathology

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  • Site-wide: 45,627
  • In genetics: 1,825
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  • Site-wide: 104,577

Examining the genetic influences of educational attainment and the validity of value-added measures of progress

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  • Site-wide: 45,692
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  • Site-wide: 142,794
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Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease

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  • In genetics: 1,786
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Distinct Blood DNA Methylation Profiles In Subtypes Of Orofacial Cleft

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Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

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  • In genetics: 1,855
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Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population

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Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

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  • In genetics: 1,932
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Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

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  • In genetics: 1,963
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Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

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• Download rankings, all-time:
  • Site-wide: 49,419
  • In genetics: 1,919
• Year to date:
  • Site-wide: 176,440
• Since beginning of last month:
  • Site-wide: 159,666

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

• Downloaded 773 times
• Download rankings, all-time:
  • Site-wide: 49,689
  • In genetics: 1,953
• Year to date:
  • Site-wide: 125,028
• Since beginning of last month:
  • Site-wide: 142,335

An atlas of associations between polygenic risk scores from across the human phenome and circulating metabolic biomarkers

• Downloaded 754 times
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  • Site-wide: 51,493
  • In genetic and genomic medicine: 324
• Year to date:
  • Site-wide: 18,714
• Since beginning of last month:
  • Site-wide: 26,073

The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children

• Downloaded 745 times
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  • Site-wide: 52,378
  • In genetics: 2,039
• Year to date:
  • Site-wide: 134,011
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  • Site-wide: 175,085

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

• Downloaded 743 times
• Download rankings, all-time:
  • Site-wide: 52,630
  • In genomics: 3,733
• Year to date:
  • Site-wide: 99,370
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  • Site-wide: 169,897

Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

• Downloaded 739 times
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  • Site-wide: 52,955
  • In systems biology: 1,021
• Year to date:
  • Site-wide: 118,044
• Since beginning of last month:
  • Site-wide: 146,111

Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life

• Downloaded 732 times
• Download rankings, all-time:
  • Site-wide: 53,725
  • In genetics: 2,058
• Year to date:
  • Site-wide: 151,319
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  • Site-wide: 186,086

Mendelian randomisation with coarsened exposures

• Downloaded 731 times
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  • Site-wide: 53,758
  • In epidemiology: 2,611
• Year to date:
  • Site-wide: 69,517
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  • Site-wide: 59,672

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

• Downloaded 730 times
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  • Site-wide: 53,842
  • In epidemiology: 2,488
• Year to date:
  • Site-wide: 173,561
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  • Site-wide: 184,972

Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

• Downloaded 727 times
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  • Site-wide: 54,203
  • In epidemiology: 2,547
• Year to date:
  • Site-wide: 121,550
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  • Site-wide: 144,108

Appraising the causal relevance of DNA methylation for risk of lung cancer

• Downloaded 724 times
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  • Site-wide: 54,526
  • In epidemiology: 2,574
• Year to date:
  • Site-wide: 110,628
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  • Site-wide: 94,234

Genetic predictors of participation in optional components of UK Biobank

• Downloaded 700 times
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  • Site-wide: 57,113
  • In genetics: 2,198
• Year to date:
  • Site-wide: 168,243
• Since beginning of last month:
  • Site-wide: 135,121

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

• Downloaded 686 times
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  • Site-wide: 58,741
  • In genetics: 2,270
• Year to date:
  • Site-wide: 142,763
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  • Site-wide: 175,843

Education and coronary heart disease: a Mendelian randomization study

• Downloaded 684 times
• Download rankings, all-time:
  • Site-wide: 59,099
  • In epidemiology: 2,652
• Year to date:
  • Site-wide: 186,064
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  • Site-wide: 172,766

Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

• Downloaded 684 times
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  • Site-wide: 59,131
  • In epidemiology: 2,706
• Year to date:
  • Site-wide: 124,862
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  • Site-wide: 172,763

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

• Downloaded 672 times
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  • Site-wide: 60,622
  • In genetics: 2,403
• Year to date:
  • Site-wide: 93,877
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  • Site-wide: 115,242

Association of COVID-19 with arterial and venous vascular diseases: a population-wide cohort study of 48 million adults in England and Wales

• Downloaded 668 times
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  • Site-wide: 61,103
  • In infectious diseases: 4,719
• Year to date:
  • Site-wide: 7,849
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  • Site-wide: 8,517

Cigarette smoking and personality: Investigating causality using Mendelian randomization

• Downloaded 644 times
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  • Site-wide: 64,015
  • In epidemiology: 2,899
• Year to date:
  • Site-wide: 108,107
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  • Site-wide: 115,240

Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

• Downloaded 644 times
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  • Site-wide: 64,009
  • In epidemiology: 2,845
• Year to date:
  • Site-wide: 139,733
• Since beginning of last month:
  • Site-wide: 130,818

Conditioning on a collider may induce spurious associations: Do the results of Gale et al. (2017) support a protective effect of neuroticism in population sub-groups?

• Downloaded 629 times
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  • Site-wide: 66,017
  • In epidemiology: 2,926
• Year to date:
  • Site-wide: 105,369
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  • Site-wide: 144,194

Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood

• Downloaded 627 times
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  • Site-wide: 66,293
  • In epidemiology: 2,957
• Year to date:
  • Site-wide: 100,918
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  • Site-wide: 106,647

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 624 times
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  • Site-wide: 66,780
  • In epidemiology: 2,897
• Year to date:
  • Site-wide: 188,026
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  • Site-wide: 189,641

Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions

• Downloaded 623 times
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  • Site-wide: 66,850
  • In epidemiology: 3,132
• Year to date:
  • Site-wide: 48,500
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  • Site-wide: 47,697

The median and the mode as robust meta-analysis methods in the presence of small study effects

• Downloaded 617 times
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  • Site-wide: 67,668
  • In epidemiology: 2,948
• Year to date:
  • Site-wide: 154,674
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  • Site-wide: 115,804

Metabolic signatures of birth weight in 18288 adolescents and adults

• Downloaded 612 times
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  • Site-wide: 68,428
  • In systems biology: 1,340
• Year to date:
  • Site-wide: 182,434
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  • Site-wide: 177,343

Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease

• Downloaded 606 times
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  • Site-wide: 69,299
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  • Site-wide: 101,980
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  • Site-wide: 164,349

Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

• Downloaded 605 times
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  • Site-wide: 69,375
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• Year to date:
  • Site-wide: 150,179
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  • Site-wide: 93,578

Identifying intergenerational risk factors for ADHD symptoms using polygenic scores in the Norwegian Mother, Father and Child Cohort

• Downloaded 579 times
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  • Site-wide: 73,328
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• Year to date:
  • Site-wide: 31,843
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  • Site-wide: 22,092

Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study

• Downloaded 575 times
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  • Site-wide: 73,999
  • In epidemiology: 3,170
• Year to date:
  • Site-wide: 149,551
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  • Site-wide: 144,158

Risk of death among teachers in England and Wales during the Covid19 pandemic

• Downloaded 571 times
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  • Site-wide: 74,690
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• Year to date:
  • Site-wide: 30,440
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  • Site-wide: 8,052

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

• Downloaded 569 times
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  • Site-wide: 74,881
  • In epidemiology: 3,187
• Year to date:
  • Site-wide: 165,170
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  • Site-wide: 176,315

Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

• Downloaded 567 times
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  • Site-wide: 75,270
  • In genomics: 4,835
• Year to date:
  • Site-wide: 162,497
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  • Site-wide: 150,235

PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

• Downloaded 566 times
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  • Site-wide: 75,391
  • In epidemiology: 3,197
• Year to date:
  • Site-wide: 164,735
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  • Site-wide: 162,683

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 566 times
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  • Site-wide: 75,453
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  • Site-wide: 144,849
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  • Site-wide: 160,863

Examining the effect of smoking on suicidal ideation and attempts: A Mendelian randomisation study

• Downloaded 558 times
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  • Site-wide: 76,769
  • In epidemiology: 3,265
• Year to date:
  • Site-wide: 129,476
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  • Site-wide: 157,515

Assortative mating and within-spouse pair comparisons

• Downloaded 552 times
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  • Site-wide: 77,752
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• Year to date:
  • Site-wide: 119,393
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  • Site-wide: 134,990

Is genetic liability to ADHD and ASD causally linked to educational attainment?

• Downloaded 550 times
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  • Site-wide: 78,076
  • In genetics: 3,042
• Year to date:
  • Site-wide: 137,176
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  • Site-wide: 182,704

The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank

• Downloaded 550 times
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  • Site-wide: 78,087
  • In epidemiology: 3,354
• Year to date:
  • Site-wide: 144,452
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  • Site-wide: 131,637

A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank

• Downloaded 545 times
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  • Site-wide: 78,985
  • In epidemiology: 3,347
• Year to date:
  • Site-wide: 145,217
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  • Site-wide: 174,861

CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?

• Downloaded 537 times
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  • Site-wide: 80,478
  • In genetics: 3,090
• Year to date:
  • Site-wide: 171,037
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  • Site-wide: 130,206

Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

• Downloaded 533 times
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  • Site-wide: 81,085
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• Year to date:
  • Site-wide: 144,986
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  • Site-wide: 140,208

Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures

• Downloaded 532 times
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  • Site-wide: 81,357
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  • Site-wide: 189,558

The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

• Downloaded 532 times
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  • Site-wide: 81,278
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• Year to date:
  • Site-wide: 103,640
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  • Site-wide: 70,404

Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer.

• Downloaded 530 times
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  • Site-wide: 81,703
  • In epidemiology: 3,508
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  • Site-wide: 106,496
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  • Site-wide: 88,554

Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK Biobank

• Downloaded 525 times
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  • Site-wide: 82,539
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  • Site-wide: 33,565
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  • Site-wide: 8,732

Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study

• Downloaded 522 times
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  • Site-wide: 83,214
  • In epidemiology: 3,499
• Year to date:
  • Site-wide: 134,543
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  • Site-wide: 170,787

Association Between Genetically Elevated Levels Of Inflammatory Biomarkers And Risk Of Schizophrenia: A Two-Sample Mendelian Randomisation Study

• Downloaded 518 times
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  • Site-wide: 83,960
  • In epidemiology: 3,491
• Year to date:
  • Site-wide: 153,141
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  • Site-wide: 165,085

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

• Downloaded 509 times
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  • Site-wide: 85,832
  • In epidemiology: 3,534
• Year to date:
  • Site-wide: 150,541
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  • Site-wide: 168,820

Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study

• Downloaded 508 times
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  • Site-wide: 85,867
  • In neurology: 276
• Year to date:
  • Site-wide: 138,105
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  • Site-wide: 136,299

The relationship between open angle glaucoma, optic disc morphology and Alzheimer's Disease: a Mendelian randomization study

• Downloaded 506 times
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  • Site-wide: 86,399
  • In ophthalmology: 60
• Year to date:
  • Site-wide: 85,959
• Since beginning of last month:
  • Site-wide: 138,868

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

• Downloaded 501 times
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  • Site-wide: 87,386
  • In genetics: 3,340
• Year to date:
  • Site-wide: 175,819
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  • Site-wide: 170,066

Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisation

• Downloaded 500 times
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  • Site-wide: 87,487
  • In epidemiology: 3,669
• Year to date:
  • Site-wide: 139,735
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  • Site-wide: 175,952

The Multivariate Genome-wide Architecture of Interrelated Literacy, Language and Working Memory Skills Reveals Distinct Etiologies

• Downloaded 494 times
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  • Site-wide: 88,810
  • In genetics: 3,416
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  • Site-wide: 151,985
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  • Site-wide: 134,570

A robust mean and variance test with application to high-dimensional phenotypes

• Downloaded 490 times
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  • Site-wide: 89,469
  • In bioinformatics: 7,509
• Year to date:
  • Site-wide: 168,022
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  • Site-wide: 179,236

A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target

• Downloaded 489 times
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  • Site-wide: 89,740
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• Year to date:
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  • Site-wide: 140,407

Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

• Downloaded 487 times
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  • Site-wide: 90,081
  • In epidemiology: 3,747
• Year to date:
  • Site-wide: 123,590
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  • Site-wide: 127,675

Estimating the causal effect of genetic liability to prevalent disease on hospital costs using Mendelian Randomization

• Downloaded 482 times
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  • Site-wide: 91,180
  • In health economics: 131
• Year to date:
  • Site-wide: 96,058
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  • Site-wide: 95,549

Schizophrenia risk and reproductive success: A Mendelian randomization study.

• Downloaded 481 times
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  • Site-wide: 91,420
  • In evolutionary biology: 4,126
• Year to date:
  • Site-wide: 174,426
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  • Site-wide: 184,381

The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study

• Downloaded 476 times
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  • Site-wide: 92,382
  • In epidemiology: 3,806
• Year to date:
  • Site-wide: 171,315
• Since beginning of last month:
  • Site-wide: 162,818

Dominant role of abdominal adiposity in circulating lipoprotein, lipid, and metabolite levels in UK Biobank: Mendelian randomization study

• Downloaded 473 times
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  • Site-wide: 93,188
  • In epidemiology: 4,369
• Year to date:
  • Site-wide: 39,426
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  • Site-wide: 69,618

Educational inequalities in statin treatment for preventing cardiovascular disease: cross-sectional analysis of UK Biobank

• Downloaded 471 times
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  • Site-wide: 93,501
  • In epidemiology: 3,909
• Year to date:
  • Site-wide: 119,430
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  • Site-wide: 108,696

Estimation of causal effects of a time-varying exposure at multiple time points through Multivariable Mendelian randomization

• Downloaded 467 times
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  • Site-wide: 94,563
  • In epidemiology: 5,204
• Year to date:
  • Site-wide: 5,491
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  • Site-wide: 14,742

Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study

• Downloaded 464 times
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  • Site-wide: 95,103
  • In epidemiology: 3,934
• Year to date:
  • Site-wide: 136,238
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  • Site-wide: 126,756

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

• Downloaded 463 times
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  • Site-wide: 95,268
  • In epidemiology: 3,878
• Year to date:
  • Site-wide: 152,333
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  • Site-wide: 136,247

Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

• Downloaded 462 times
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  • Site-wide: 95,618
  • In epidemiology: 3,869
• Year to date:
  • Site-wide: 181,291
• Since beginning of last month:
  • Site-wide: 187,283

Interrogating structural inequalities in COVID-19 Mortality in England and Wales

• Downloaded 458 times
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  • Site-wide: 96,536
  • In epidemiology: 4,254
• Year to date:
  • Site-wide: 70,714
• Since beginning of last month:
  • Site-wide: 28,890

A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation

• Downloaded 455 times
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  • Site-wide: 97,251
  • In epidemiology: 4,152
• Year to date:
  • Site-wide: 85,935
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  • Site-wide: 90,896

MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

• Downloaded 453 times
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  • Site-wide: 97,673
  • In epidemiology: 3,953
• Year to date:
  • Site-wide: 179,093
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  • Site-wide: 186,694

Identifying novel subtypes of irritability using a developmental genetic approach

• Downloaded 453 times
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  • Site-wide: 97,687
  • In genetics: 3,710
• Year to date:
  • Site-wide: 155,251
• Since beginning of last month:
  • Site-wide: 129,591

Osteophyte size and location on hip DXA scans are associated with hip pain: findings from a cross sectional study in UK Biobank

• Downloaded 452 times
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  • Site-wide: 97,884
  • In rheumatology: 108
• Year to date:
  • Site-wide: 42,434
• Since beginning of last month:
  • Site-wide: 19,620

Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

• Downloaded 447 times
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  • Site-wide: 98,949
  • In epidemiology: 4,204
• Year to date:
  • Site-wide: 86,163
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  • Site-wide: 75,379

The association between adiposity and inpatient hospital costs in the UK Biobank cohort

• Downloaded 443 times
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  • Site-wide: 99,822
  • In epidemiology: 4,061
• Year to date:
  • Site-wide: 169,950
• Since beginning of last month:
  • Site-wide: 172,105

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

• Downloaded 441 times
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  • Site-wide: 100,442
  • In epidemiology: 4,093
• Year to date:
  • Site-wide: 153,952
• Since beginning of last month:
  • Site-wide: 143,717

Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

• Downloaded 437 times
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  • Site-wide: 101,309
  • In epidemiology: 4,178
• Year to date:
  • Site-wide: 113,352
• Since beginning of last month:
  • Site-wide: 103,591

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

• Downloaded 436 times
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  • Site-wide: 101,458
  • In epidemiology: 4,121
• Year to date:
  • Site-wide: 152,310
• Since beginning of last month:
  • Site-wide: 136,268

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

• Downloaded 429 times
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  • Site-wide: 103,242
  • In genetics: 3,841
• Year to date:
  • Site-wide: 185,968
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  • Site-wide: 160,273

Causal effects of circulating cytokine concentrations on risk of Alzheimers disease: A bidirectional two-sample Mendelian randomization study

• Downloaded 428 times
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  • Site-wide: 103,339
  • In genetic and genomic medicine: 609
• Year to date:
  • Site-wide: 53,753
• Since beginning of last month:
  • Site-wide: 55,170

DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

• Downloaded 420 times
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  • Site-wide: 105,342
  • In genetics: 3,962
• Year to date:
  • Site-wide: 160,148
• Since beginning of last month:
  • Site-wide: 159,987

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

• Downloaded 418 times
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  • Site-wide: 105,759
  • In genetics: 4,006
• Year to date:
  • Site-wide: 164,521
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  • Site-wide: 115,952

Mendelian randomization analyses show that higher acetyl-carnitine and carnitine levels in blood protect against severe Covid19

• Downloaded 411 times
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  • Site-wide: 107,413
  • In epidemiology: 4,643
• Year to date:
  • Site-wide: 54,447
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  • Site-wide: 68,796

Epidemiology and Genetics of Preserved Ratio Impaired SpiroMetry (PRISm): An Analysis of UK Biobank

• Downloaded 410 times
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  • Site-wide: 107,780
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• Year to date:
  • Site-wide: 53,271
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  • Site-wide: 69,962

The role of school enjoyment in the association between externalising and depressive symptoms and academic attainment: findings from a UK prospective cohort study

• Downloaded 402 times
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  • Site-wide: 109,638
  • In epidemiology: 4,548
• Year to date:
  • Site-wide: 104,081
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  • Site-wide: 85,042

Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

• Downloaded 402 times
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  • Site-wide: 109,636
  • In genetics: 4,428
• Year to date:
  • Site-wide: 83,281
• Since beginning of last month:
  • Site-wide: 79,206

Disentangling the direct and indirect effects of childhood adiposity on type 1 diabetes and immune-associated diseases: a multivariable Mendelian randomization study

• Downloaded 402 times
• Download rankings, all-time:
  • Site-wide: 109,558
  • In epidemiology: 5,076
• Year to date:
  • Site-wide: 45,800
• Since beginning of last month:
  • Site-wide: 18,868

Examining the bidirectional association between emotion recognition and ASD symptoms using observational and genetic analyses

• Downloaded 397 times
• Download rankings, all-time:
  • Site-wide: 110,810
  • In genetic and genomic medicine: 613
• Year to date:
  • Site-wide: 104,050
• Since beginning of last month:
  • Site-wide: 103,552

Navigating sample overlap, winner's curse and weak instrument bias in Mendelian randomization studies using the UK Biobank

• Downloaded 396 times
• Download rankings, all-time:
  • Site-wide: 111,119
  • In epidemiology: 5,846
• Year to date:
  • Site-wide: 16,160
• Since beginning of last month:
  • Site-wide: 22,337

Does Smoking Cause Lower Educational Attainment and General Cognitive Ability? Triangulation of causal evidence using multiple study designs

• Downloaded 387 times
• Download rankings, all-time:
  • Site-wide: 113,522
  • In epidemiology: 4,632
• Year to date:
  • Site-wide: 136,864
• Since beginning of last month:
  • Site-wide: 103,284

Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype

• Downloaded 385 times
• Download rankings, all-time:
  • Site-wide: 113,993
  • In epidemiology: 4,585
• Year to date:
  • Site-wide: 145,449
• Since beginning of last month:
  • Site-wide: 113,756

Metabolomic signatures of lipid-modifying therapies using drug target Mendelian randomization

• Downloaded 383 times
• Download rankings, all-time:
  • Site-wide: 114,661
  • In genetic and genomic medicine: 672
• Year to date:
  • Site-wide: 50,803
• Since beginning of last month:
  • Site-wide: 89,724

Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers

• Downloaded 381 times
• Download rankings, all-time:
  • Site-wide: 115,010
  • In epidemiology: 4,925
• Year to date:
  • Site-wide: 70,604
• Since beginning of last month:
  • Site-wide: 49,389

Interpreting Mendelian randomization estimates of the effects of categorical exposures such as disease status and educational attainment

• Downloaded 371 times
• Download rankings, all-time:
  • Site-wide: 117,892
  • In epidemiology: 4,832
• Year to date:
  • Site-wide: 102,738
• Since beginning of last month:
  • Site-wide: 123,760

Association of genetic liability to smoking initiation with e-cigarette use in young adults.

• Downloaded 370 times
• Download rankings, all-time:
  • Site-wide: 117,962
  • In epidemiology: 4,889
• Year to date:
  • Site-wide: 106,173
• Since beginning of last month:
  • Site-wide: 78,033

Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study

• Downloaded 367 times
• Download rankings, all-time:
  • Site-wide: 118,995
  • In epidemiology: 4,917
• Year to date:
  • Site-wide: 92,378
• Since beginning of last month:
  • Site-wide: 56,459

Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to SARS-CoV-2 severity

• Downloaded 364 times
• Download rankings, all-time:
  • Site-wide: 119,794
  • In epidemiology: 4,847
• Year to date:
  • Site-wide: 131,661
• Since beginning of last month:
  • Site-wide: 123,164

Evaluating the direct effects of childhood adiposity on adult systemic metabolism: A multivariable Mendelian randomization analysis

• Downloaded 360 times
• Download rankings, all-time:
  • Site-wide: 120,695
  • In cardiovascular medicine: 272
• Year to date:
  • Site-wide: 161,205
• Since beginning of last month:
  • Site-wide: 155,682

Strategies to investigate and mitigate collider bias in genetic and Mendelian randomization studies of disease progression

• Downloaded 348 times
• Download rankings, all-time:
  • Site-wide: 124,181
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 8,548
• Since beginning of last month:
  • Site-wide: 3,625

Hypothesis-free detection of gene-interaction effects on biomarker concentration in UK Biobank using variance prioritisation

• Downloaded 346 times
• Download rankings, all-time:
  • Site-wide: 124,551
  • In genetic and genomic medicine: 814
• Year to date:
  • Site-wide: 8,635
• Since beginning of last month:
  • Site-wide: 20,932

Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health

• Downloaded 346 times
• Download rankings, all-time:
  • Site-wide: 124,699
  • In epidemiology: 4,954
• Year to date:
  • Site-wide: 174,525
• Since beginning of last month:
  • Site-wide: 184,110

The effect of smoking on multiple sclerosis: a mendelian randomization study

• Downloaded 345 times
• Download rankings, all-time:
  • Site-wide: 124,929
  • In genetic and genomic medicine: 723
• Year to date:
  • Site-wide: 151,466
• Since beginning of last month:
  • Site-wide: 125,644

Cross-sectional association of blood pressure variability and night-time dipping with cardiac structure in adolescents

• Downloaded 337 times
• Download rankings, all-time:
  • Site-wide: 127,133
  • In epidemiology: 5,520
• Year to date:
  • Site-wide: 53,481
• Since beginning of last month:
  • Site-wide: 39,708

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 336 times
• Download rankings, all-time:
  • Site-wide: 127,628
  • In genetics: 4,758
• Year to date:
  • Site-wide: 155,297
• Since beginning of last month:
  • Site-wide: 174,873

Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization

• Downloaded 330 times
• Download rankings, all-time:
  • Site-wide: 129,067
  • In epidemiology: 5,425
• Year to date:
  • Site-wide: 64,236
• Since beginning of last month:
  • Site-wide: 137,824

An Informatics Consult approach for generating clinical evidence for treatment decisions

• Downloaded 329 times
• Download rankings, all-time:
  • Site-wide: 129,562
  • In health informatics: 522
• Year to date:
  • Site-wide: 145,701
• Since beginning of last month:
  • Site-wide: 156,046

The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study

• Downloaded 324 times
• Download rankings, all-time:
  • Site-wide: 130,947
  • In epidemiology: 5,291
• Year to date:
  • Site-wide: 121,187
• Since beginning of last month:
  • Site-wide: 136,241

Mendelian randomization does not support serum calcium in prostate cancer risk

• Downloaded 307 times
• Download rankings, all-time:
  • Site-wide: 136,034
  • In epidemiology: 5,434
• Year to date:
  • Site-wide: 176,404
• Since beginning of last month:
  • Site-wide: 112,727

Exploring selection bias in COVID-19 research: Simulations and prospective analyses of two UK cohort studies

• Downloaded 298 times
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  • Site-wide: 138,828
  • In epidemiology: 6,114
• Year to date:
  • Site-wide: 27,252
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  • Site-wide: 47,017

Examining the possible causal relationship between Lung Function, COPD and Alzheimers Disease. A Mendelian Randomization Study

• Downloaded 296 times
• Download rankings, all-time:
  • Site-wide: 139,467
  • In respiratory medicine: 288
• Year to date:
  • Site-wide: 171,599
• Since beginning of last month:
  • Site-wide: 138,903

Parental inflammatory bowel disease and autism in the offspring: Triangulating the evidence using four complementary study designs.

• Downloaded 292 times
• Download rankings, all-time:
  • Site-wide: 140,638
  • In epidemiology: 5,853
• Year to date:
  • Site-wide: 75,325
• Since beginning of last month:
  • Site-wide: 81,850

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

• Downloaded 292 times
• Download rankings, all-time:
  • Site-wide: 140,649
  • In epidemiology: 6,214
• Year to date:
  • Site-wide: 29,314
• Since beginning of last month:
  • Site-wide: 42,308

Educational attainment as a modifier of the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank

• Downloaded 290 times
• Download rankings, all-time:
  • Site-wide: 141,208
  • In genetic and genomic medicine: 934
• Year to date:
  • Site-wide: 61,543
• Since beginning of last month:
  • Site-wide: 31,351

Design and quality control of large-scale two-sample Mendelian randomisation studies

• Downloaded 289 times
• Download rankings, all-time:
  • Site-wide: 141,498
  • In epidemiology: 5,953
• Year to date:
  • Site-wide: 39,929
• Since beginning of last month:
  • Site-wide: 46,688

Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals

• Downloaded 284 times
• Download rankings, all-time:
  • Site-wide: 142,750
  • In genetics: 5,209
• Year to date:
  • Site-wide: 185,984
• Since beginning of last month:
  • Site-wide: 146,589

Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: prospective cohort study

• Downloaded 283 times
• Download rankings, all-time:
  • Site-wide: 143,062
  • In epidemiology: 5,731
• Year to date:
  • Site-wide: 137,570
• Since beginning of last month:
  • Site-wide: 133,921

Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 145,511
  • In genetics: 5,306
• Year to date:
  • Site-wide: 178,742
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  • Site-wide: 136,723

Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independent of body mass index

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 145,571
  • In genetic and genomic medicine: 977
• Year to date:
  • Site-wide: 58,202
• Since beginning of last month:
  • Site-wide: 23,231

Interpretation of mendelian randomization using one measure of an exposure that varies over time.

• Downloaded 264 times
• Download rankings, all-time:
  • Site-wide: 148,835
  • In epidemiology: 6,737
• Year to date:
  • Site-wide: 24,201
• Since beginning of last month:
  • Site-wide: 36,055

Immunological pathways underlying autism: Findings from Mendelian randomization and genetic colocalisation analyses.

• Downloaded 261 times
• Download rankings, all-time:
  • Site-wide: 149,922
  • In epidemiology: None
• Year to date:
  • Site-wide: 13,212
• Since beginning of last month:
  • Site-wide: 19,239

Tools for the assessment of quality and risk of bias in Mendelian randomization studies: a systematic review

• Downloaded 256 times
• Download rankings, all-time:
  • Site-wide: 151,255
  • In epidemiology: 6,488
• Year to date:
  • Site-wide: 54,460
• Since beginning of last month:
  • Site-wide: 33,970

Puberty and sex-specific trajectories of systolic blood pressure: a prospective cohort study

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 151,420
  • In epidemiology: 6,005
• Year to date:
  • Site-wide: 94,714
• Since beginning of last month:
  • Site-wide: 110,379

Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 151,619
  • In epidemiology: 6,879
• Year to date:
  • Site-wide: 13,658
• Since beginning of last month:
  • Site-wide: 12,082

Germline TYK2 mutation and cancer risk

• Downloaded 252 times
• Download rankings, all-time:
  • Site-wide: 152,485
  • In genetic and genomic medicine: 1,219
• Year to date:
  • Site-wide: 13,850
• Since beginning of last month:
  • Site-wide: 28,145

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

• Downloaded 248 times
• Download rankings, all-time:
  • Site-wide: 153,582
  • In genetic and genomic medicine: 937
• Year to date:
  • Site-wide: 109,187
• Since beginning of last month:
  • Site-wide: 153,655

Sex-specific associations of adiposity with cardiometabolic traits: multi-life-stage cohort study with repeat metabolomics

• Downloaded 246 times
• Download rankings, all-time:
  • Site-wide: 154,019
  • In epidemiology: 6,102
• Year to date:
  • Site-wide: 119,013
• Since beginning of last month:
  • Site-wide: 98,270

Correlations in sleeping patterns and circadian preference between spouses

• Downloaded 220 times
• Download rankings, all-time:
  • Site-wide: 161,288
  • In epidemiology: 6,700
• Year to date:
  • Site-wide: 16,947
• Since beginning of last month:
  • Site-wide: 72,616

Genetic effect modification of cis-acting C-reactive protein variants in cardiometabolic disease status

• Downloaded 219 times
• Download rankings, all-time:
  • Site-wide: 161,608
  • In genetics: 6,121
• Year to date:
  • Site-wide: 44,601
• Since beginning of last month:
  • Site-wide: 70,151

Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis

• Downloaded 215 times
• Download rankings, all-time:
  • Site-wide: 162,820
  • In epidemiology: 6,629
• Year to date:
  • Site-wide: 41,614
• Since beginning of last month:
  • Site-wide: 90,580

Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimers disease risk in the general population: a Mendelian randomization study

• Downloaded 214 times
• Download rankings, all-time:
  • Site-wide: 162,896
  • In epidemiology: None
• Year to date:
  • Site-wide: 17,687
• Since beginning of last month:
  • Site-wide: 13,400

Systematic comparison of Mendelian randomization studies and randomized controlled trials using electronic databases

• Downloaded 210 times
• Download rankings, all-time:
  • Site-wide: 164,189
  • In epidemiology: None
• Year to date:
  • Site-wide: 18,144
• Since beginning of last month:
  • Site-wide: 7,962

Taller height and risk of coronary heart disease and cancer: a within-sibship Mendelian randomization study

• Downloaded 192 times
• Download rankings, all-time:
  • Site-wide: 168,584
  • In genetic and genomic medicine: 1,143
• Year to date:
  • Site-wide: 68,112
• Since beginning of last month:
  • Site-wide: 70,203

The impact of low input DNA on the reliability of DNA methylation as measured by the Illumina Infinium MethylationEPIC BeadChip

• Downloaded 191 times
• Download rankings, all-time:
  • Site-wide: 168,999
  • In bioinformatics: 12,214
• Year to date:
  • Site-wide: 39,610
• Since beginning of last month:
  • Site-wide: 96,846

Genetic analyses of common infections in the Avon Longitudinal Study of Parents and Children cohort

• Downloaded 190 times
• Download rankings, all-time:
  • Site-wide: 169,228
  • In epidemiology: 6,647
• Year to date:
  • Site-wide: 126,854
• Since beginning of last month:
  • Site-wide: 122,908

Continuing inequalities in COVID-19 mortality in England and Wales, and the changing importance of regional, over local, deprivation

• Downloaded 186 times
• Download rankings, all-time:
  • Site-wide: 170,212
  • In epidemiology: 6,832
• Year to date:
  • Site-wide: 21,562
• Since beginning of last month:
  • Site-wide: 96,836

Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples

• Downloaded 184 times
• Download rankings, all-time:
  • Site-wide: 170,649
  • In genetic and genomic medicine: 1,213
• Year to date:
  • Site-wide: 38,059
• Since beginning of last month:
  • Site-wide: 46,410

Investigating the transparency of reporting in two-sample summary data Mendelian randomization studies

• Downloaded 175 times
• Download rankings, all-time:
  • Site-wide: 172,699
  • In epidemiology: 6,835
• Year to date:
  • Site-wide: 84,663
• Since beginning of last month:
  • Site-wide: 89,167

Characterisation of ethnic differences in DNA methylation between UK resident South Asians and Europeans

• Downloaded 171 times
• Download rankings, all-time:
  • Site-wide: 173,634
  • In epidemiology: None
• Year to date:
  • Site-wide: 24,121
• Since beginning of last month:
  • Site-wide: 20,022

The relationship between BMI and COVID-19: exploring misclassification and selection bias in a two-sample Mendelian randomisation study

• Downloaded 153 times
• Download rankings, all-time:
  • Site-wide: 177,363
  • In epidemiology: None
• Year to date:
  • Site-wide: 27,809
• Since beginning of last month:
  • Site-wide: 54,594

Age-specific effects of body size on fracture risk in later life: A lifecourse Mendelian randomization study

• Downloaded 151 times
• Download rankings, all-time:
  • Site-wide: 177,864
  • In epidemiology: 7,018
• Year to date:
  • Site-wide: 65,127
• Since beginning of last month:
  • Site-wide: 60,328

Estimating the genetically predicted effects of lifestyle risk factors, educational attainment and Alzheimer's disease liability on weight change during midlife

• Downloaded 148 times
• Download rankings, all-time:
  • Site-wide: 178,313
  • In epidemiology: 6,931
• Year to date:
  • Site-wide: 109,270
• Since beginning of last month:
  • Site-wide: 110,508

Sex-specific trajectories of molecular cardiometabolic trait concentrations through childhood, adolescence and young adulthood: a cohort study

• Downloaded 144 times
• Download rankings, all-time:
  • Site-wide: 179,026
  • In epidemiology: 6,968
• Year to date:
  • Site-wide: 105,513
• Since beginning of last month:
  • Site-wide: 97,944

Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study

• Downloaded 143 times
• Download rankings, all-time:
  • Site-wide: 179,245
  • In epidemiology: None
• Year to date:
  • Site-wide: 30,339
• Since beginning of last month:
  • Site-wide: 32,319

Separating the direct effects of risk factors for atherosclerotic cardiovascular disease from those mediated by type 2 diabetes

• Downloaded 142 times
• Download rankings, all-time:
  • Site-wide: 179,408
  • In epidemiology: 6,937
• Year to date:
  • Site-wide: 122,579
• Since beginning of last month:
  • Site-wide: 110,395

Life stage-specific effects of genetic susceptibility to higher body size on body fat and lean mass: prospective cohort study

• Downloaded 139 times
• Download rankings, all-time:
  • Site-wide: 179,918
  • In epidemiology: None
• Year to date:
  • Site-wide: 31,555
• Since beginning of last month:
  • Site-wide: 10,950

Association of lipid-regulating drugs with dementia and related conditions: an observational study of data from the Clinical Practice Research Datalink

• Downloaded 123 times
• Download rankings, all-time:
  • Site-wide: 182,598
  • In epidemiology: 7,089
• Year to date:
  • Site-wide: 71,224
• Since beginning of last month:
  • Site-wide: 82,134

Mental-health before and during the COVID-19 pandemic in adults with neurodevelopmental disorders.

• Downloaded 121 times
• Download rankings, all-time:
  • Site-wide: 182,819
  • In psychiatry and clinical psychology: None
• Year to date:
  • Site-wide: 37,340
• Since beginning of last month:
  • Site-wide: 5,806

Socioeconomic inequality in SARS-CoV-2 testing and COVID-19 outcomes in UK Biobank over the first year of the pandemic: can inequalities be explained byselection bias?

• Downloaded 107 times
• Download rankings, all-time:
  • Site-wide: 184,803
  • In epidemiology: None
• Year to date:
  • Site-wide: 42,669
• Since beginning of last month:
  • Site-wide: 7,174

Genetically proxied PCSK9 inhibition provides indication of lower prostate cancer risk: a Mendelian randomization study

• Downloaded 99 times
• Download rankings, all-time:
  • Site-wide: 185,815
  • In oncology: None
• Year to date:
  • Site-wide: 46,501
• Since beginning of last month:
  • Site-wide: 32,559

The global randomization test: A Mendelian randomization falsification test for the exclusion restriction assumption

• Downloaded 97 times
• Download rankings, all-time:
  • Site-wide: 186,002
  • In epidemiology: None
• Year to date:
  • Site-wide: 47,728
• Since beginning of last month:
  • Site-wide: 8,405

The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: A Mendelian randomization study

• Downloaded 78 times
• Download rankings, all-time:
  • Site-wide: 187,989
  • In epidemiology: None
• Year to date:
  • Site-wide: 59,218
• Since beginning of last month:
  • Site-wide: 39,251

Examining the association between genetic risk for depression, wellbeing and schizophrenia, and proximity to greenspace

• Downloaded 76 times
• Download rankings, all-time:
  • Site-wide: 188,177
  • In epidemiology: None
• Year to date:
  • Site-wide: 60,997
• Since beginning of last month:
  • Site-wide: 43,249

Health behaviours prior to pregnancy and fertility outcomes: Triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)

• Downloaded 65 times
• Download rankings, all-time:
  • Site-wide: 188,987
  • In epidemiology: None
• Year to date:
  • Site-wide: 70,170
• Since beginning of last month:
  • Site-wide: 67,267

Associations between vitamin D and disease risk may be attributed to the confounding influence of adiposity during childhood and adulthood: a lifecourse Mendelian randomization study

• Downloaded 45 times
• Download rankings, all-time:
  • Site-wide: 190,095
  • In epidemiology: None
• Year to date:
  • Site-wide: 94,668
• Since beginning of last month:
  • Site-wide: 28,088

Sex-specific associations of childhood socioeconomic position and trajectories of metabolic traits across early life: prospective cohort study

• Downloaded 36 times
• Download rankings, all-time:
  • Site-wide: 190,396
  • In epidemiology: None
• Year to date:
  • Site-wide: 111,725
• Since beginning of last month:
  • Site-wide: 37,161