Author: Stephan Ripke

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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  • Site-wide: 7,783
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Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

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  • Site-wide: 1,115
  • In genetic and genomic medicine: 5
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 1,376
  • In genetics: 27
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  • Site-wide: 39,559
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Common risk variants identified in autism spectrum disorder

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  • Site-wide: 1,483
  • In genetics: 31
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  • Site-wide: 28,137
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Partitioning heritability by functional category using GWAS summary statistics

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Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,902
  • In genetics: 42
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  • Site-wide: 60,791
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LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

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  • In genomics: 140
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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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Regulatory variants explain much more heritability than coding variants across 11 common diseases

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  • Site-wide: 3,781
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  • Site-wide: 104,312
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Largest GWAS (N=1,126,563) of Alzheimer's Disease Implicates Microglia and Immune Cells

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  • In genetic and genomic medicine: 25
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  • Site-wide: 8,282
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Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 5,318
  • In psychiatry and clinical psychology: 20
• Year to date:
  • Site-wide: 11,693
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  • Site-wide: 16,884

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

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  • Site-wide: 5,713
  • In bioinformatics: 486
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Haplotypes of common SNPs can explain missing heritability of complex diseases

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  • Site-wide: 6,277
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Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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Comparative genetic architectures of schizophrenia in East Asian and European populations

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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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  • Site-wide: 9,111
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• Year to date:
  • Site-wide: 114,227
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Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

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  • Site-wide: 11,150
  • In neurology: 33
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  • Site-wide: 16,957
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Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 11,215
  • In genetics: 427
• Year to date:
  • Site-wide: 35,275
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  • Site-wide: 27,921

New susceptibility loci for severe COVID-19 by detailed GWAS analysis in European populations

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  • Site-wide: 11,661
  • In genetic and genomic medicine: 68
• Year to date:
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  • Site-wide: 11,474

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 13,451
  • In genetics: 504
• Year to date:
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Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

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  • Site-wide: 16,003
  • In genetics: 622
• Year to date:
  • Site-wide: 181,300
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 18,203
  • In genomics: 1,618
• Year to date:
  • Site-wide: 109,237
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  • Site-wide: 91,987

Subtle stratification confounds estimates of heritability from rare variants

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  • Site-wide: 24,981
  • In genetics: 982
• Year to date:
  • Site-wide: 136,175
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  • Site-wide: 151,021

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • Site-wide: 32,009
  • In genetics: 1,345
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  • Site-wide: 31,989
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  • Site-wide: 27,807

Genome-wide association study identifies new locus associated with OCD

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  • Site-wide: 36,733
  • In psychiatry and clinical psychology: 188
• Year to date:
  • Site-wide: 8,891
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  • Site-wide: 7,690

Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

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  • Site-wide: 39,013
  • In genetics: 1,547
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  • Site-wide: 126,864
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  • Site-wide: 66,953

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 39,959
  • In genetics: 1,579
• Year to date:
  • Site-wide: 172,680
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  • Site-wide: 126,200

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 43,269
  • In genetic and genomic medicine: 249
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  • Site-wide: 107,004
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  • Site-wide: 113,669

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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  • Site-wide: 46,773
  • In genetics: 1,866
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  • Site-wide: 104,032
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  • Site-wide: 48,668

Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference

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  • Site-wide: 49,058
  • In genetics: 4,378
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  • Site-wide: 3,081

RICOPILI: Rapid Imputation for COnsortias PIpeLIne

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  • Site-wide: 57,716
  • In genetics: 2,266
• Year to date:
  • Site-wide: 150,269
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  • Site-wide: 94,588

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

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  • Site-wide: 65,781
  • In psychiatry and clinical psychology: 300
• Year to date:
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  • Site-wide: 56,093

Genomewide Analyses of Psychological Resilience in US Army Soldiers

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  • Site-wide: 74,701
  • In genetics: 2,825
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  • Site-wide: 129,114

Characterization of Age and Polarity at Onset in Bipolar Disorder

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  • Site-wide: 85,458
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  • Site-wide: 152,698

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

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  • Site-wide: 90,680
  • In genetic and genomic medicine: 557
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  • Site-wide: 80,306
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Increasing Sample Diversity in Psychiatric Genetics - Introducing a new Cohort of Patients with Schizophrenia and Controls from Vietnam - Results from a Pilot Study

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  • Site-wide: 150,394
  • In genetic and genomic medicine: 1,029
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DNAJC13 influences responses of the extended reward system to conditioned stimuli: a genome-wide association study

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  • In genomics: 8,998
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  • Site-wide: 184,879