Author: Stephan Ripke

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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  • Site-wide: 794
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• Year to date:
  • Site-wide: 3,994
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  • Site-wide: 61,112

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 1,029
  • In genetics: 26
• Year to date:
  • Site-wide: 50,606
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  • Site-wide: 114,776

Common risk variants identified in autism spectrum disorder

• Downloaded 8,485 times
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  • Site-wide: 1,195
  • In genetics: 30
• Year to date:
  • Site-wide: 2,866
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  • Site-wide: 35,669

Partitioning heritability by functional category using GWAS summary statistics

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  • Site-wide: 1,259
  • In genetics: 33
• Year to date:
  • Site-wide: 13,039
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  • Site-wide: 96,827

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,397
  • In genetics: 40
• Year to date:
  • Site-wide: 20,165
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  • Site-wide: 6,651

LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

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  • Site-wide: 1,461
  • In genomics: 119
• Year to date:
  • Site-wide: 88,716
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  • Site-wide: 96,682

Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

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  • Site-wide: 1,739
  • In genetic and genomic medicine: 8
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  • Site-wide: 674
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  • Site-wide: 930

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 2,483
  • In genomics: 241
• Year to date:
  • Site-wide: 20,167
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  • Site-wide: 99,325

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,611 times
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  • Site-wide: 2,680
  • In genetics: 87
• Year to date:
  • Site-wide: 42,332
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  • Site-wide: 106,280

Regulatory variants explain much more heritability than coding variants across 11 common diseases

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  • Site-wide: 2,780
  • In genetics: 91
• Year to date:
  • Site-wide: 111,981
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  • Site-wide: 114,503

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

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  • Site-wide: 4,086
  • In bioinformatics: 390
• Year to date:
  • Site-wide: 91,492
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  • Site-wide: None

Haplotypes of common SNPs can explain missing heritability of complex diseases

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  • Site-wide: 4,597
  • In genetics: 180
• Year to date:
  • Site-wide: 63,996
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  • Site-wide: 22,833

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 5,014
  • In psychiatry and clinical psychology: 18
• Year to date:
  • Site-wide: 1,623
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  • Site-wide: 2,817

Largest GWAS (N=1,126,563) of Alzheimer's Disease Implicates Microglia and Immune Cells

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  • Site-wide: 5,971
  • In genetic and genomic medicine: 24
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  • Site-wide: 2,387
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Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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  • Site-wide: 6,256
  • In genomics: 660
• Year to date:
  • Site-wide: 100,440
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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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  • Site-wide: 6,688
  • In genetics: 295
• Year to date:
  • Site-wide: 87,227
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Comparative genetic architectures of schizophrenia in East Asian and European populations

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  • Site-wide: 6,994
  • In genetics: 306
• Year to date:
  • Site-wide: 46,305
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  • Site-wide: 98,785

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 9,962
  • In genetics: 439
• Year to date:
  • Site-wide: 22,968
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  • Site-wide: 75,721

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 10,118
  • In genetics: 448
• Year to date:
  • Site-wide: 72,229
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  • Site-wide: 84,892

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

• Downloaded 1,681 times
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  • Site-wide: 11,459
  • In genetics: 510
• Year to date:
  • Site-wide: 145,193
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  • Site-wide: None

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 13,717
  • In genomics: 1,402
• Year to date:
  • Site-wide: 100,877
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  • Site-wide: 45,436

Subtle stratification confounds estimates of heritability from rare variants

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  • Site-wide: 18,692
  • In genetics: 861
• Year to date:
  • Site-wide: 78,809
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  • Site-wide: 29,018

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

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  • Site-wide: 19,777
  • In neurology: 41
• Year to date:
  • Site-wide: 2,666
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  • Site-wide: 55,060

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

• Downloaded 866 times
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  • Site-wide: 30,486
  • In genetics: 1,400
• Year to date:
  • Site-wide: 109,416
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  • Site-wide: None

Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

• Downloaded 862 times
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  • Site-wide: 30,728
  • In genetics: 1,413
• Year to date:
  • Site-wide: 104,582
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  • Site-wide: None

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 796 times
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  • Site-wide: 34,310
  • In genetics: 1,573
• Year to date:
  • Site-wide: 24,880
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  • Site-wide: 20,555

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

• Downloaded 727 times
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  • Site-wide: 38,910
  • In genetics: 1,751
• Year to date:
  • Site-wide: 119,791
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  • Site-wide: None

RICOPILI: Rapid Imputation for COnsortias PIpeLIne

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  • Site-wide: 44,183
  • In genetics: 1,979
• Year to date:
  • Site-wide: 140,447
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  • Site-wide: None

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

• Downloaded 658 times
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  • Site-wide: 44,365
  • In genetic and genomic medicine: 180
• Year to date:
  • Site-wide: 15,176
• Since beginning of last month:
  • Site-wide: 50,378

New susceptibility loci for severe COVID-19 by detailed GWAS analysis in European populations

• Downloaded 614 times
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  • Site-wide: 48,532
  • In genetic and genomic medicine: 193
• Year to date:
  • Site-wide: 6,726
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  • Site-wide: 23,080

Genomewide Analyses of Psychological Resilience in US Army Soldiers

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  • Site-wide: 55,314
  • In genetics: 2,438
• Year to date:
  • Site-wide: 142,742
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  • Site-wide: 104,422

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

• Downloaded 478 times
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  • Site-wide: 65,239
  • In psychiatry and clinical psychology: 233
• Year to date:
  • Site-wide: 15,754
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  • Site-wide: 81,923

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

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  • Site-wide: 93,485
  • In genetic and genomic medicine: 427
• Year to date:
  • Site-wide: 45,154
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  • Site-wide: 56,333

Characterization of Age and Polarity at Onset in Bipolar Disorder

• Downloaded 229 times
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  • Site-wide: 116,582
  • In psychiatry and clinical psychology: 525
• Year to date:
  • Site-wide: 27,534
• Since beginning of last month:
  • Site-wide: 131,536

Increasing Sample Diversity in Psychiatric Genetics - Introducing a new Cohort of Patients with Schizophrenia and Controls from Vietnam - Results from a Pilot Study

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  • Site-wide: 146,244
  • In genetic and genomic medicine: 851
• Year to date:
  • Site-wide: 69,910
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  • Site-wide: 130,744