Author: Stephan Ripke

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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Partitioning heritability by functional category using GWAS summary statistics

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Common risk variants identified in autism spectrum disorder

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Genomewide association study identifies 30 loci associated with bipolar disorder

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LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

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  • In genomics: 114
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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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Regulatory variants explain much more heritability than coding variants across 11 common diseases

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Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

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  • In bioinformatics: 355
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Haplotypes of common SNPs can explain missing heritability of complex diseases

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Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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Comparative genetic architectures of schizophrenia in East Asian and European populations

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Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • In psychiatry and clinical psychology: 23
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Largest GWAS (N=1,126,563) of Alzheimer's Disease Implicates Microglia and Immune Cells

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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 9,350
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• Year to date:
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Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

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  • Site-wide: 104,560

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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Subtle stratification confounds estimates of heritability from rare variants

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Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 26,768
  • In genetics: 1,293
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Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

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Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

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RICOPILI: Rapid Imputation for COnsortias PIpeLIne

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Genomewide Analyses of Psychological Resilience in US Army Soldiers

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Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 52,478
  • In genetic and genomic medicine: 167
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  • Site-wide: 9,958

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

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  • Site-wide: 74,300
  • In psychiatry and clinical psychology: 235
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  • Site-wide: 25,889

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

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