Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,521 bioRxiv papers from 264,855 authors.

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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Genomewide association study identifies 30 loci associated with bipolar disorder

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Common risk variants identified in autism spectrum disorder

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  • In genetics: 34 out of 3,296
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  • Site-wide: 3,209 out of 57,521

The genetic architecture of the human cerebral cortex

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  • Site-wide: 299 out of 57,521
  • In genetics: 37 out of 3,296
• Year to date:
  • Site-wide: 239 out of 57,521
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  • Site-wide: 74 out of 57,521

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • In genetics: 51 out of 3,296
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  • Site-wide: 8,406 out of 57,521

Psychiatric Genomics: An Update and an Agenda

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  • In genetics: 92 out of 3,296
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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • In genetics: 103 out of 3,296
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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • In genomics: 299 out of 4,029
• Year to date:
  • Site-wide: 166 out of 57,521
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  • Site-wide: 1,096 out of 57,521

Genetics of brain age suggest an overlap with common brain disorders

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  • In neuroscience: 284 out of 10,110
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A global view of pleiotropy and genetic architecture in complex traits

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  • In genetics: 230 out of 3,296
• Year to date:
  • Site-wide: 817 out of 57,521
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  • Site-wide: 1,446 out of 57,521

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

• Downloaded 1,778 times
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  • Site-wide: 2,504 out of 57,521
  • In genomics: 513 out of 4,029
• Year to date:
  • Site-wide: 2,991 out of 57,521
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  • Site-wide: 2,708 out of 57,521

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • In genetics: 275 out of 3,296
• Year to date:
  • Site-wide: 41,957 out of 57,521
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  • Site-wide: 37,129 out of 57,521

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,399 times
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  • In genetics: 336 out of 3,296
• Year to date:
  • Site-wide: 15,047 out of 57,521
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  • Site-wide: 10,449 out of 57,521

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

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  • In neuroscience: 679 out of 10,110
• Year to date:
  • Site-wide: 40,397 out of 57,521
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  • Site-wide: 35,307 out of 57,521

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • In genomics: 795 out of 4,029
• Year to date:
  • Site-wide: 16,217 out of 57,521
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  • Site-wide: 31,934 out of 57,521

Oxytocin gene networks in the human brain: A gene expression and large-scale fMRI meta-analysis study

• Downloaded 1,134 times
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  • Site-wide: 5,243 out of 57,521
  • In neuroscience: 815 out of 10,110
• Year to date:
  • Site-wide: 12,733 out of 57,521
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  • Site-wide: 13,835 out of 57,521

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

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  • In genetics: 511 out of 3,296
• Year to date:
  • Site-wide: 10,477 out of 57,521
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  • Site-wide: 24,167 out of 57,521

Estimating inflation in GWAS summary statistics due to variance distortion from cryptic relatedness

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  • In genomics: 1,107 out of 4,029
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  • Site-wide: 11,434 out of 57,521

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 7,173 out of 57,521
  • In genetics: 568 out of 3,296
• Year to date:
  • Site-wide: 2,098 out of 57,521
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  • Site-wide: 2,862 out of 57,521

The correlation between central and peripheral oxytocin concentrations: a systematic review and meta-analysis

• Downloaded 878 times
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  • Site-wide: 7,972 out of 57,521
  • In physiology: 22 out of 675
• Year to date:
  • Site-wide: 19,741 out of 57,521
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  • Site-wide: 23,346 out of 57,521

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

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  • In genetics: 625 out of 3,296
• Year to date:
  • Site-wide: 34,033 out of 57,521
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  • Site-wide: 36,301 out of 57,521

Personalized genetic assessment of age associated Alzheimers disease risk

• Downloaded 820 times
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  • Site-wide: 8,855 out of 57,521
  • In genetics: 672 out of 3,296
• Year to date:
  • Site-wide: 45,273 out of 57,521
• Since beginning of last month:
  • Site-wide: 50,650 out of 57,521

A genetic risk score to guide age-specific, personalized prostate cancer screening

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  • Site-wide: 9,191 out of 57,521
  • In genetics: 689 out of 3,296
• Year to date:
  • Site-wide: 44,318 out of 57,521
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  • Site-wide: 54,657 out of 57,521

Cerebellar grey matter volume is associated with cognitive function and psychopathology in adolescence

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  • Site-wide: 11,566 out of 57,521
  • In neuroscience: 1,839 out of 10,110
• Year to date:
  • Site-wide: 4,375 out of 57,521
• Since beginning of last month:
  • Site-wide: 7,910 out of 57,521

Partitioning the genetic architecture of amyotrophic lateral sclerosis

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  • Site-wide: 13,971 out of 57,521
  • In genetics: 992 out of 3,296
• Year to date:
  • Site-wide: 3,647 out of 57,521
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  • Site-wide: 10,888 out of 57,521

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

• Downloaded 550 times
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  • In genomics: 1,984 out of 4,029
• Year to date:
  • Site-wide: 48,790 out of 57,521
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  • Site-wide: 29,205 out of 57,521

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

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  • In genetics: 1,149 out of 3,296
• Year to date:
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  • Site-wide: 5,360 out of 57,521

Recently evolved human-specific methylated regions are enriched in schizophrenia signals

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  • In genomics: 2,086 out of 4,029
• Year to date:
  • Site-wide: 46,397 out of 57,521
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  • Site-wide: 36,953 out of 57,521

Polygenic hazard scores in preclinical Alzheimer's disease

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  • In genetics: 1,166 out of 3,296
• Year to date:
  • Site-wide: 52,729 out of 57,521
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  • Site-wide: 49,804 out of 57,521

Immune-related genetic enrichment in frontotemporal dementia

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  • In genetics: 1,376 out of 3,296
• Year to date:
  • Site-wide: 30,553 out of 57,521
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  • Site-wide: 30,456 out of 57,521

Cortico-genetic mapping links individual brain maturity in youths to cognitive and psychiatric traits

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  • In neuroscience: 3,468 out of 10,110
• Year to date:
  • Site-wide: 13,585 out of 57,521
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  • Site-wide: 23,386 out of 57,521

Probing brain developmental patterns of myelination and associations with psychopathology in youth using gray/white matter contrast

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  • In neuroscience: 3,782 out of 10,110
• Year to date:
  • Site-wide: 17,318 out of 57,521
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  • Site-wide: 16,904 out of 57,521

The dark side of the mean: brain structural heterogeneity in schizophrenia and its polygenic risk.

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  • In neuroscience: 3,938 out of 10,110
• Year to date:
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  • Site-wide: 30,626 out of 57,521

Genetic control of variability in subcortical and intracranial volumes

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  • In neuroscience: 4,770 out of 10,110
• Year to date:
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  • Site-wide: 45,151 out of 57,521

Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories

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  • In neuroscience: 4,791 out of 10,110
• Year to date:
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  • Site-wide: 28,484 out of 57,521

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

• Downloaded 310 times
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  • Site-wide: 29,034 out of 57,521
  • In genetics: 1,869 out of 3,296
• Year to date:
  • Site-wide: 16,270 out of 57,521
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  • Site-wide: 53,523 out of 57,521

Heritable cognitive and psychopathology factors in youth are predicted by brain fronto-temporal white matter pathway

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  • In neuroscience: 5,181 out of 10,110
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  • Site-wide: 52,191 out of 57,521

Association between schizophrenia polygenic score and psychotic symptoms in Alzheimer disease: meta-analysis of 11 cohort studies

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  • In genomics: 2,984 out of 4,029
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  • Site-wide: 28,913 out of 57,521

Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition

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  • In genetics: 2,012 out of 3,296
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  • Site-wide: 49,085 out of 57,521
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  • Site-wide: 50,754 out of 57,521

Predicting cognitive and mental health traits and their polygenic architecture using large-scale brain connectomics

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  • In neuroscience: 5,427 out of 10,110
• Year to date:
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  • Site-wide: 14,276 out of 57,521

Sex-dependent polygenic effects on the clinical progressions of Alzheimer's disease

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  • In genetics: 2,028 out of 3,296
• Year to date:
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  • Site-wide: 13,729 out of 57,521

Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment

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  • Site-wide: 26,106 out of 57,521

Analysis of differentially methylated regions in primates and non-primates provides support for the evolutionary hypothesis of schizophrenia

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  • In genomics: 3,116 out of 4,029
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  • Site-wide: 49,286 out of 57,521

A genetic hazard score to personalize prostate cancer screening, applied to population data

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  • Site-wide: 36,724 out of 57,521
  • In genetics: 2,286 out of 3,296
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  • Site-wide: 12,437 out of 57,521
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  • Site-wide: 30,157 out of 57,521

Cross-sectional and longitudinal brain scans reveal accelerated brain aging in multiple sclerosis

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  • Site-wide: 38,629 out of 57,521
  • In neuroscience: 6,697 out of 10,110
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  • Site-wide: 25,028 out of 57,521
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  • Site-wide: 44,555 out of 57,521

Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study

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  • Site-wide: 39,919 out of 57,521
  • In neuroscience: 6,921 out of 10,110
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  • Site-wide: 14,876 out of 57,521
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  • Site-wide: 31,308 out of 57,521

Sex differences in the relationship between social difficulties and executive dysfunction in children and adolescents with autism spectrum disorder

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  • Site-wide: 42,495 out of 57,521
  • In neuroscience: 7,404 out of 10,110
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  • Site-wide: 21,025 out of 57,521
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  • Site-wide: 39,941 out of 57,521

Linkage Disequilibrium and Heterozygosity Modulate the Genetic Architecture of Human Complex Phenotypes: Evidence of Natural Selection from GWAS Summary Statistics

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  • In genomics: 3,532 out of 4,029
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  • Site-wide: 17,770 out of 57,521
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  • Site-wide: 1,534 out of 57,521

Maturation of cortical microstructure and cognitive development in childhood and adolescence: a T1w/T2w ratio MRI study

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  • Site-wide: 43,491 out of 57,521
  • In neuroscience: 7,613 out of 10,110
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  • Site-wide: 18,211 out of 57,521
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  • Site-wide: 13,435 out of 57,521

White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging

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  • In neuroscience: 8,202 out of 10,110
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  • Site-wide: 49,790 out of 57,521

Brain age estimation is a sensitive marker of processing speed in the early course of multiple sclerosis

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  • In neuroscience: 8,824 out of 10,110
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  • Site-wide: 16,969 out of 57,521

The effect of sample size on polygenic hazard models for prostate cancer

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  • Site-wide: 34,217 out of 57,521
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  • Site-wide: 34,246 out of 57,521

Pupillary dilation responses as a midlife indicator of risk for Alzheimer's Disease: Association with Alzheimer's disease polygenic risk

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  • In genetics: 3,114 out of 3,296
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  • Site-wide: 31,672 out of 57,521

Age dependence of modern clinical risk groups for localized prostate cancer — a population-based study

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  • Site-wide: 55,633 out of 57,521
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  • Site-wide: 38,671 out of 57,521

Impact of second-generation antipsychotics on white matter microstructure in adolescent-onset psychosis.

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  • Site-wide: 19,889 out of 57,521