Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 70,177 bioRxiv papers from 306,444 authors.

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

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  • In genetics: 22 out of 3,895
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  • Site-wide: 213 out of 70,177
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  • Site-wide: 569 out of 70,177

The genetic architecture of the human cerebral cortex

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  • In genetics: 31 out of 3,895
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  • Site-wide: 1,883 out of 70,177

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • In genetics: 33 out of 3,895
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  • Site-wide: 2,116 out of 70,177

Common risk variants identified in autism spectrum disorder

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  • Site-wide: 2,193 out of 70,177
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Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

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GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • In genetics: 52 out of 3,895
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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 382 out of 70,177
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  • Site-wide: 243 out of 70,177

Psychiatric Genomics: An Update and an Agenda

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  • In genetics: 99 out of 3,895
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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • In genetics: 117 out of 3,895
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  • Site-wide: 23,079 out of 70,177

Genetics of brain age suggest an overlap with common brain disorders

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  • In neuroscience: 287 out of 12,620
• Year to date:
  • Site-wide: 9,187 out of 70,177
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  • Site-wide: 5,213 out of 70,177

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

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  • Site-wide: 2,042 out of 70,177
  • In genomics: 442 out of 4,698
• Year to date:
  • Site-wide: 1,260 out of 70,177
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  • Site-wide: 1,169 out of 70,177

A global view of pleiotropy and genetic architecture in complex traits

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  • In genetics: 218 out of 3,895
• Year to date:
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  • Site-wide: 3,806 out of 70,177

Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • In genetics: 274 out of 3,895
• Year to date:
  • Site-wide: 1,139 out of 70,177
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  • Site-wide: 2,224 out of 70,177

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • In genetics: 308 out of 3,895
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Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • In genetics: 340 out of 3,895
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  • Site-wide: 23,435 out of 70,177

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • In genomics: 895 out of 4,698
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  • Site-wide: 36,155 out of 70,177
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  • Site-wide: 22,882 out of 70,177

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

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  • In neuroscience: 835 out of 12,620
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  • Site-wide: 12,101 out of 70,177
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  • Site-wide: 46,943 out of 70,177

Oxytocin gene networks in the human brain: A gene expression and large-scale fMRI meta-analysis study

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  • Site-wide: 5,962 out of 70,177
  • In neuroscience: 934 out of 12,620
• Year to date:
  • Site-wide: 56,498 out of 70,177
• Since beginning of last month:
  • Site-wide: 23,909 out of 70,177

Estimating inflation in GWAS summary statistics due to variance distortion from cryptic relatedness

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  • In genomics: 1,028 out of 4,698
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  • Site-wide: 7,943 out of 70,177

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 6,292 out of 70,177
  • In genetics: 493 out of 3,895
• Year to date:
  • Site-wide: 12,049 out of 70,177
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  • Site-wide: 15,279 out of 70,177

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

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  • In genetics: 560 out of 3,895
• Year to date:
  • Site-wide: 9,388 out of 70,177
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  • Site-wide: 44,157 out of 70,177

Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group

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  • In neuroscience: 1,211 out of 12,620
• Year to date:
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  • Site-wide: 3,413 out of 70,177

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

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  • Site-wide: 8,333 out of 70,177
  • In genetics: 631 out of 3,895
• Year to date:
  • Site-wide: 9,672 out of 70,177
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  • Site-wide: 8,856 out of 70,177

The correlation between central and peripheral oxytocin concentrations: a systematic review and meta-analysis

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  • Site-wide: 8,693 out of 70,177
  • In physiology: 27 out of 897
• Year to date:
  • Site-wide: 13,594 out of 70,177
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  • Site-wide: 33,272 out of 70,177

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

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  • In genetics: 706 out of 3,895
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  • Site-wide: 45,183 out of 70,177
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  • Site-wide: 50,420 out of 70,177

Cerebellar grey matter volume is associated with cognitive function and psychopathology in adolescence

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  • In neuroscience: 1,588 out of 12,620
• Year to date:
  • Site-wide: 3,145 out of 70,177
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  • Site-wide: 6,561 out of 70,177

Personalized genetic assessment of age associated Alzheimers disease risk

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  • In genetics: 755 out of 3,895
• Year to date:
  • Site-wide: 28,900 out of 70,177
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  • Site-wide: 34,295 out of 70,177

A genetic risk score to guide age-specific, personalized prostate cancer screening

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  • Site-wide: 10,769 out of 70,177
  • In genetics: 784 out of 3,895
• Year to date:
  • Site-wide: 28,166 out of 70,177
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  • Site-wide: 53,638 out of 70,177

Partitioning the genetic architecture of amyotrophic lateral sclerosis

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  • In genetics: 941 out of 3,895
• Year to date:
  • Site-wide: 44,104 out of 70,177
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  • Site-wide: 19,168 out of 70,177

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • In genetics: 981 out of 3,895
• Year to date:
  • Site-wide: 19,164 out of 70,177
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  • Site-wide: 42,811 out of 70,177

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

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  • In genetics: 1,119 out of 3,895
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  • Site-wide: 39,584 out of 70,177

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

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  • In genomics: 2,212 out of 4,698
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  • Site-wide: 41,214 out of 70,177

A genome-wide genetic pleiotropy approach identified shared loci between multiple system atrophy and inflammatory bowel disease

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  • In genetics: 1,262 out of 3,895
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  • Site-wide: 13,127 out of 70,177

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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  • In genetics: 1,271 out of 3,895
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  • Site-wide: 41,902 out of 70,177

Recently evolved human-specific methylated regions are enriched in schizophrenia signals

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  • In genomics: 2,366 out of 4,698
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  • Site-wide: 63,613 out of 70,177

Polygenic hazard scores in preclinical Alzheimer's disease

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  • In genetics: 1,343 out of 3,895
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  • Site-wide: 66,380 out of 70,177

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 41,147 out of 70,177

Cortico-genetic mapping links individual brain maturity in youths to cognitive and psychiatric traits

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  • In neuroscience: 3,721 out of 12,620
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  • Site-wide: 15,263 out of 70,177

Lipid associated polygenic enrichment in Alzheimer's disease

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  • In genetics: 1,483 out of 3,895
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  • Site-wide: 53,679 out of 70,177

Immune-related genetic enrichment in frontotemporal dementia

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  • Site-wide: 44,158 out of 70,177

Probing brain developmental patterns of myelination and associations with psychopathology in youth using gray/white matter contrast

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  • Site-wide: 53,132 out of 70,177

The dark side of the mean: brain structural heterogeneity in schizophrenia and its polygenic risk.

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  • Site-wide: 66,477 out of 70,177

Population-based neuroimaging reveals traces of childbirth in the maternal brain

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  • In neuroscience: 4,758 out of 12,620
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  • Site-wide: 9,047 out of 70,177

Predicting cognitive and mental health traits and their polygenic architecture using large-scale brain connectomics

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  • In neuroscience: 5,195 out of 12,620
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  • Site-wide: 28,206 out of 70,177

Genetic control of variability in subcortical and intracranial volumes

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  • Site-wide: 32,584 out of 70,177

Association between schizophrenia polygenic score and psychotic symptoms in Alzheimer disease: meta-analysis of 11 cohort studies

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The genetic architecture of human brainstem structures and their involvement in common brain disorders

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Linkage Disequilibrium and Heterozygosity Modulate the Genetic Architecture of Human Complex Phenotypes: Evidence of Natural Selection from GWAS Summary Statistics

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  • Site-wide: 4,794 out of 70,177

Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories

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  • Site-wide: 17,614 out of 70,177

Sex-dependent polygenic effects on the clinical progressions of Alzheimer's disease

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Making the MOSTest of imaging genetics

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Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

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  • In genetics: 2,130 out of 3,895
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  • Site-wide: 67,269 out of 70,177

Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment

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  • Site-wide: 26,583 out of 70,177

Heritable cognitive and psychopathology factors in youth are predicted by brain fronto-temporal white matter pathway

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Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition

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Pupillary dilation responses as a midlife indicator of risk for Alzheimer's Disease: Association with Alzheimer's disease polygenic risk

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CXCR4 involvement in neurodegenerative diseases

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Analysis of differentially methylated regions in primates and non-primates provides support for the evolutionary hypothesis of schizophrenia

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Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry

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Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study

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A genetic hazard score to personalize prostate cancer screening, applied to population data

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Cross-sectional and longitudinal brain scans reveal accelerated brain aging in multiple sclerosis

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Maturation of cortical microstructure and cognitive development in childhood and adolescence: a T1w/T2w ratio MRI study

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Annotation-Informed Causal Mixture Modeling (AI-MiXeR) reveals phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories

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Sex differences in the relationship between social difficulties and executive dysfunction in children and adolescents with autism spectrum disorder

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White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging

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Brain age estimation is a sensitive marker of processing speed in the early course of multiple sclerosis

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The effect of sample size on polygenic hazard models for prostate cancer

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Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area

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Differences in directed functional brain connectivity related to age and sex

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Age dependence of modern clinical risk groups for localized prostate cancer — a population-based study

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Cannabis use is associated with increased levels of soluble gp130 in schizophrenia but not in bipolar disorder

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Impact of second-generation antipsychotics on white matter microstructure in adolescent-onset psychosis

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Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents

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