Author: Ole Andreassen

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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  • Site-wide: 854
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  • Site-wide: 3,768
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  • Site-wide: 10,753

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

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  • Site-wide: 899
  • In genetics: 20
• Year to date:
  • Site-wide: 3,897
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  • Site-wide: 6,869

Common risk variants identified in autism spectrum disorder

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  • Site-wide: 1,238
  • In genetics: 27
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  • Site-wide: 2,918
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  • Site-wide: 4,381

The genetic architecture of the human cerebral cortex

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  • Site-wide: 1,381
  • In genetics: 35
• Year to date:
  • Site-wide: 23,144
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  • Site-wide: 46,537

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,547
  • In genetics: 41
• Year to date:
  • Site-wide: 31,035
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  • Site-wide: 117,382

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 2,353
  • In genetics: 70
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  • Site-wide: 22,725
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  • Site-wide: 30,949

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

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  • Site-wide: 2,431
  • In genetics: 73
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  • Site-wide: 60,598
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  • Site-wide: 78,009

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 2,686
  • In genomics: 249
• Year to date:
  • Site-wide: 23,430
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  • Site-wide: 56,905

Greater male than female variability in regional brain structure across the lifespan

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  • Site-wide: 3,920
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  • Site-wide: 32,565
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  • Site-wide: 71,800

Psychiatric Genomics: An Update and an Agenda

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  • Site-wide: 4,432
  • In genetics: 155
• Year to date:
  • Site-wide: 80,649
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  • Site-wide: 125,775

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 4,638
  • In genetics: 168
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  • Site-wide: 67,369
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  • Site-wide: 135,473

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

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  • Site-wide: 4,838
  • In genomics: 476
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  • Site-wide: 44,913
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  • Site-wide: 81,632

A global view of pleiotropy and genetic architecture in complex traits

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  • Site-wide: 5,029
  • In genetics: 194
• Year to date:
  • Site-wide: 10,884
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  • Site-wide: 12,115

Genetics of brain age suggest an overlap with common brain disorders

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  • Site-wide: 5,662
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  • Site-wide: 42,855
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  • Site-wide: 49,223

Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • Site-wide: 6,177
  • In genetics: 251
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  • Site-wide: 32,852
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  • Site-wide: 67,388

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

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  • Site-wide: 8,492
  • In genetics: 355
• Year to date:
  • Site-wide: 11,256
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  • Site-wide: 4,163

Estimating inflation in GWAS summary statistics due to variance distortion from cryptic relatedness

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  • Site-wide: 8,514
  • In genomics: 851
• Year to date:
  • Site-wide: 15,685
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  • Site-wide: 57,599

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 10,267
  • In genetics: 424
• Year to date:
  • Site-wide: 24,828
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  • Site-wide: 35,257

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 10,758
  • In genetics: 457
• Year to date:
  • Site-wide: 72,812
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  • Site-wide: 57,317

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 11,450
  • In genetics: 482
• Year to date:
  • Site-wide: 90,249
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  • Site-wide: 81,814

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 11,643
  • In genetics: 493
• Year to date:
  • Site-wide: 4,312
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  • Site-wide: 4,025

The correlation between central and peripheral oxytocin concentrations: a systematic review and meta-analysis

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  • Site-wide: 13,309
  • In physiology: 29
• Year to date:
  • Site-wide: 28,849
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  • Site-wide: 25,563

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

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  • Site-wide: 13,992
  • In genetics: 611
• Year to date:
  • Site-wide: 47,912
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  • Site-wide: 57,095

Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group

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  • Site-wide: 14,068
  • In neuroscience: 1,526
• Year to date:
  • Site-wide: 87,355
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  • Site-wide: 133,575

Oxytocin gene networks in the human brain: A gene expression and large-scale fMRI meta-analysis study

• Downloaded 1,541 times
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  • Site-wide: 14,742
  • In neuroscience: 1,622
• Year to date:
  • Site-wide: 81,359
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  • Site-wide: 106,810

Cerebellar grey matter volume is associated with cognitive function and psychopathology in adolescence

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  • Site-wide: 14,924
  • In neuroscience: 1,645
• Year to date:
  • Site-wide: 56,465
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  • Site-wide: 52,126

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

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  • Site-wide: 15,111
  • In neuroscience: 1,673
• Year to date:
  • Site-wide: 134,928
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  • Site-wide: 146,012

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 15,268
  • In genomics: 1,494
• Year to date:
  • Site-wide: 129,015
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  • Site-wide: 139,943

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

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  • Site-wide: 18,929
  • In genetics: 845
• Year to date:
  • Site-wide: 124,823
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  • Site-wide: 137,026

Linkage Disequilibrium and Heterozygosity Modulate the Genetic Architecture of Human Complex Phenotypes

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  • Site-wide: 19,066
  • In genomics: 1,788
• Year to date:
  • Site-wide: 37,115
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  • Site-wide: 63,710

Partitioning the genetic architecture of amyotrophic lateral sclerosis

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  • Site-wide: 21,021
  • In genetics: 927
• Year to date:
  • Site-wide: 69,978
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  • Site-wide: 73,870

Genetic liability for schizophrenia and childhood psychopathology in the general population

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  • Site-wide: 21,233
  • In psychiatry and clinical psychology: 83
• Year to date:
  • Site-wide: 7,046
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  • Site-wide: 11,698

Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years

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  • Site-wide: 21,749
  • In neuroscience: 2,647
• Year to date:
  • Site-wide: 34,830
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  • Site-wide: 55,688

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

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  • Site-wide: 22,890
  • In genetics: 1,001
• Year to date:
  • Site-wide: 110,878
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  • Site-wide: 153,689

Personalized genetic assessment of age associated Alzheimers disease risk

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  • Site-wide: 27,446
  • In genetics: 1,208
• Year to date:
  • Site-wide: 131,832
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  • Site-wide: 158,026

A genetic risk score to guide age-specific, personalized prostate cancer screening

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  • Site-wide: 27,864
  • In genetics: 1,228
• Year to date:
  • Site-wide: 131,744
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  • Site-wide: 102,177

A genome-wide genetic pleiotropy approach identified shared loci between multiple system atrophy and inflammatory bowel disease

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  • Site-wide: 28,076
  • In genetics: 1,239
• Year to date:
  • Site-wide: 95,704
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  • Site-wide: 98,164

Phenotypically independent mental health symptom profiles are genetically related

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  • Site-wide: 30,395
  • In psychiatry and clinical psychology: 117
• Year to date:
  • Site-wide: 28,292
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  • Site-wide: 76,031

Vaccination history for diphtheria and tetanus is associated with less severe COVID-19

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  • Site-wide: 31,073
  • In epidemiology: 1,695
• Year to date:
  • Site-wide: 5,855
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  • Site-wide: 21,674

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 32,065
  • In genetics: 1,408
• Year to date:
  • Site-wide: 106,093
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  • Site-wide: 96,172

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 34,292
  • In neuroscience: 4,487
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  • Site-wide: 78,021
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  • Site-wide: 90,980

White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age prediction

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  • Site-wide: 35,073
  • In neuroscience: 4,612
• Year to date:
  • Site-wide: 53,761
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  • Site-wide: 75,705

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • Site-wide: 35,177
  • In genetics: 1,543
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  • Site-wide: 31,868
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  • Site-wide: 38,690

The genetic structure of Norway

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  • Site-wide: 35,470
  • In genetics: 1,551
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  • Site-wide: 59,702
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  • Site-wide: 88,596

Lipid associated polygenic enrichment in Alzheimer's disease

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  • Site-wide: 36,411
  • In genetics: 1,590
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  • Site-wide: 93,134
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  • Site-wide: 117,187

Predicting cognitive and mental health traits and their polygenic architecture using large-scale brain connectomics

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  • Site-wide: 36,661
  • In neuroscience: 4,867
• Year to date:
  • Site-wide: 31,626
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  • Site-wide: 15,250

Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

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  • Site-wide: 36,990
  • In neuroscience: 4,917
• Year to date:
  • Site-wide: 60,808
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  • Site-wide: 61,873

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 38,112
  • In genetic and genomic medicine: 179
• Year to date:
  • Site-wide: 15,103
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  • Site-wide: 22,832

The genetic architecture of human brainstem structures and their involvement in common brain disorders

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  • Site-wide: 39,211
  • In neuroscience: 5,243
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  • Site-wide: 112,525
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  • Site-wide: 146,690

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

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  • Site-wide: 39,584
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  • Site-wide: 150,936
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Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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  • Site-wide: 40,593
  • In genetics: 1,751
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  • Site-wide: 111,987
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Thinner cortex is associated with psychosis onset in individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group mega-analysis

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  • Site-wide: 42,036
  • In psychiatry and clinical psychology: 157
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  • Site-wide: 8,104
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  • Site-wide: 20,605

Making the MOSTest of imaging genetics

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  • Site-wide: 43,206
  • In neuroscience: 5,891
• Year to date:
  • Site-wide: 117,793
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  • Site-wide: 136,319

Probing brain developmental patterns of myelination and associations with psychopathology in youth using gray/white matter contrast

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  • Site-wide: 44,284
  • In neuroscience: 6,066
• Year to date:
  • Site-wide: 101,917
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  • Site-wide: 87,504

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

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  • Site-wide: 44,373
  • In genomics: 3,489
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  • Site-wide: 158,519
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  • Site-wide: 148,297

Cortico-genetic mapping links individual brain maturity in youths to cognitive and psychiatric traits

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  • Site-wide: 47,083
  • In neuroscience: 6,509
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  • Site-wide: 132,254
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  • Site-wide: 106,988

Recently evolved human-specific methylated regions are enriched in schizophrenia signals

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  • Site-wide: 48,048
  • In genomics: 3,689
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  • Site-wide: 147,088
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  • Site-wide: 149,841

How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa)

• Downloaded 686 times
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  • Site-wide: 48,956
  • In genetic and genomic medicine: 230
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  • Site-wide: 102,145
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  • Site-wide: 140,677

Genome-wide association analysis of the human thalamus identifies novel genomic loci and reveals genetic overlap with distinct cortical regions and ten brain disorders

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  • Site-wide: 49,127
  • In genetic and genomic medicine: 231
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  • Site-wide: 59,430
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  • Site-wide: 79,981

Pupillary dilation responses as a midlife indicator of risk for Alzheimer's Disease: Association with Alzheimer's disease polygenic risk

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  • Site-wide: 49,162
  • In genetics: 2,106
• Year to date:
  • Site-wide: 83,921
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  • Site-wide: 41,996

Polygenic hazard scores in preclinical Alzheimer's disease

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  • Site-wide: 50,887
  • In genetics: 2,173
• Year to date:
  • Site-wide: 149,414
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  • Site-wide: 120,858

Immune-related genetic enrichment in frontotemporal dementia

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  • Site-wide: 51,165
  • In genetics: 2,184
• Year to date:
  • Site-wide: 132,319
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  • Site-wide: 129,814

Maturation of cortical microstructure and cognitive development in childhood and adolescence: a T1w/T2w ratio MRI study

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  • Site-wide: 51,630
  • In neuroscience: 7,273
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  • Site-wide: 95,120
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  • Site-wide: 137,079

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

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  • Site-wide: 52,279
  • In genomics: 3,931
• Year to date:
  • Site-wide: 67,071
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  • Site-wide: 83,268

Sex-dependent polygenic effects on the clinical progressions of Alzheimer's disease

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  • Site-wide: 54,610
  • In genetics: 2,323
• Year to date:
  • Site-wide: 127,845
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  • Site-wide: 127,203

Multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.

• Downloaded 627 times
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  • Site-wide: 55,410
  • In genetics: 2,349
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  • Site-wide: 29,636
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  • Site-wide: 55,874

Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment

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  • Site-wide: 57,149
  • In genomics: 4,193
• Year to date:
  • Site-wide: 95,251
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  • Site-wide: 44,301

Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study

• Downloaded 597 times
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  • Site-wide: 58,935
  • In neuroscience: 8,400
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  • Site-wide: 111,035
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  • Site-wide: 124,730

The genetic architecture of human cortical folding

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  • Site-wide: 60,428
  • In genomics: 4,365
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  • Site-wide: 12,397
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  • Site-wide: 23,686

The dark side of the mean: brain structural heterogeneity in schizophrenia and its polygenic risk.

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  • Site-wide: 60,644
  • In neuroscience: 8,698
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  • Site-wide: 134,767
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  • Site-wide: 101,718

Population-based neuroimaging reveals traces of childbirth in the maternal brain

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  • Site-wide: 61,483
  • In neuroscience: 8,832
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  • Site-wide: 152,093
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  • Site-wide: 145,457

Genetic control of variability in subcortical and intracranial volumes

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  • Site-wide: 63,231
  • In neuroscience: 9,121
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  • Site-wide: 143,736
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  • Site-wide: 152,481

Association between schizophrenia polygenic score and psychotic symptoms in Alzheimer disease: meta-analysis of 11 cohort studies

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  • Site-wide: 64,662
  • In genomics: 4,586
• Year to date:
  • Site-wide: 141,267
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  • Site-wide: 137,973

Characterization of the genetic architecture of BMI in infancy and early childhood reveals age-specific effects and implicates pathways involved in Mendelian obesity

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  • Site-wide: 64,852
  • In genetic and genomic medicine: 304
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  • Site-wide: 13,572
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  • Site-wide: 19,378

All-optical electrophysiology in hiPSC-derived neurons with synthetic voltage sensors

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  • Site-wide: 65,763
  • In neuroscience: 9,532
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  • Site-wide: 13,801
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  • Site-wide: 105,464

Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder

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  • Site-wide: 65,914
  • In psychiatry and clinical psychology: 253
• Year to date:
  • Site-wide: 50,863
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  • Site-wide: 93,353

Genome-Wide Association Identifies the First Risk Loci for Psychosis in Alzheimer Disease

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  • Site-wide: 67,521
  • In psychiatry and clinical psychology: 260
• Year to date:
  • Site-wide: 31,739
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  • Site-wide: 120,351

Improved prediction of schizophrenia by leveraging genetic overlap with brain morphology

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  • Site-wide: 68,113
  • In psychiatry and clinical psychology: 263
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  • Site-wide: 40,096
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  • Site-wide: 32,509

Differences in directed functional brain connectivity related to age, sex and mental health

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  • Site-wide: 68,582
  • In neuroscience: 9,951
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  • Site-wide: 120,305
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  • Site-wide: 138,521

Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition

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  • Site-wide: 70,623
  • In genetics: 3,004
• Year to date:
  • Site-wide: 132,313
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  • Site-wide: 150,177

Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories

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  • Site-wide: 75,106
  • In neuroscience: 10,979
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  • Site-wide: 159,093
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  • Site-wide: 150,335

Annotation-Informed Causal Mixture Modeling (AI-MiXeR) reveals phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories

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  • Site-wide: 78,039
  • In genetics: 3,309
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  • Site-wide: 105,714
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  • Site-wide: 74,406

Heritable cognitive and psychopathology factors in youth are predicted by brain fronto-temporal white matter pathway

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  • Site-wide: 78,234
  • In neuroscience: 11,518
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  • Site-wide: 86,043

Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry

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Analysis of differentially methylated regions in primates and non-primates provides support for the evolutionary hypothesis of schizophrenia

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Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

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Functional connectivity directionality between large-scale resting-state networks in children and adolescence from the Healthy Brain Network sample

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A genetic hazard score to personalize prostate cancer screening, applied to population data

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Differences in the presentation and progression of Parkinson's disease by sex

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Sex differences in the relationship between social difficulties and executive dysfunction in children and adolescents with autism spectrum disorder

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Identifying intergenerational risk factors for ADHD symptoms using polygenic scores in the Norwegian Mother, Father and Child Cohort

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Federated Multi-Site Normative Modeling using Hierarchical Bayesian Regression

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Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders

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CXCR4 involvement in neurodegenerative diseases

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Cardiometabolic risk factors associated with brain age and accelerate brain ageing

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Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area

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Genetic overlap between multivariate measures of human functional brain connectivity and psychiatric disorders

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Cross-sectional and longitudinal brain scans reveal accelerated brain aging in multiple sclerosis

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Population-based body-brain mapping links brain morphology and body composition

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Adipose tissue distribution from body MRI is associated with cross-sectional and longitudinal brain age in adults

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Characterization of Age and Polarity at Onset in Bipolar Disorder

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A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia

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Genome-wide association study identifies new locus associated with OCD

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Multivariate genome-wide association study on tissue-sensitive diffusion metrics identifies key molecular pathways for axonal growth, synaptogenesis, and astrocyte-mediated neuroinflammation

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Sparse Deep Neural Networks on Imaging Genetics for Schizophrenia Case-Control Classification

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Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents

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Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptoms

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Experience-dependent modulation of the visual evoked potential: testing effect sizes, retention over time, and associations with age in 415 healthy individuals

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Genetic overlap between Alzheimer's disease and depression mapped onto the brain

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Impact of second-generation antipsychotics on white matter microstructure in adolescent-onset psychosis

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Brain age estimation is a sensitive marker of processing speed in the early course of multiple sclerosis

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The effect of sample size on polygenic hazard models for prostate cancer

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Age dependence of modern clinical risk groups for localized prostate cancer — a population-based study

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White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging

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Multilevel neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology

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Prenatal smoking, alcohol and caffeine exposure and maternal reported ADHD symptoms in childhood: triangulation of evidence using negative control and polygenic risk score analyses

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In vivo amygdala nuclei volumes in schizophrenia and bipolar disorders

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Evidence for reduced long-term potentiation-like visual cortical plasticity in schizophrenia and bipolar disorder

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Additional SNPs improve the performance of a polygenic hazard score for prostate cancer

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Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

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Cannabis use is associated with increased levels of soluble gp130 in schizophrenia but not in bipolar disorder

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Generalization of Cortical MOSTest Genome-Wide Associations Within and Across Samples

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Birth Order Differences in Education Are Environmental in Origin

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Gut Microbiota Markers for Antipsychotics Induced Metabolic Disturbance in Drug Naive Patients with First Episode Schizophrenia _ A 24 Weeks Follow-up Study

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Deep neural networks learn general and clinically relevant representations of the ageingbrain

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Interplay between the Genetics of Personality Traits, severe Psychiatric Disorders, and COVID-19 Host Genetics in the Susceptibility to SARS-CoV-2 Infection

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Spatial frequency discrimination in patients with schizophrenia spectrum and bipolar disorders: Evidence of early visual processing deficits and associations with intellectual abilities

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Prostate cancer risk stratification improved across multiple ancestries with new polygenic hazard score

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Distributed genetic architecture across the hippocampal formation implies common neuropathology across major brain disorders

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Maternal and offspring genetic risk score (GRS) analyses of fetal alcohol exposure and ADHD risk in offspring

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Genome-wide association analysis reveals extensive genetic overlap between mood instability and psychiatric disorders but divergent patterns of genetic effects

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Evidence for a moderating effect of drinking severity but not HIV status on brain age in heavy episodic drinkers

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The Genetic Architecture of Amygdala Nuclei

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Challenges at the APOE locus: A robust quality control approach for accurate APOE genotyping

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Functional characterisation of single nucleotide variants of the psychiatric risk gene cacna1c in the zebrafish

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Smoking and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study

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