Author: Ole Rasmus Andreassen

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Preprints

Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father and Child Cohort Study

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Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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  • Site-wide: 1,009
  • In genetics: 19
• Year to date:
  • Site-wide: 5,978
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  • Site-wide: 10,741

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

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  • Site-wide: 1,061
  • In genetics: 21
• Year to date:
  • Site-wide: 5,975
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  • Site-wide: 15,684

Common risk variants identified in autism spectrum disorder

• Downloaded 9,324 times
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  • Site-wide: 1,500
  • In genetics: 31
• Year to date:
  • Site-wide: 7,814
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  • Site-wide: 20,117

The genetic architecture of the human cerebral cortex

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  • Site-wide: 1,681
  • In genetics: 35
• Year to date:
  • Site-wide: 30,356
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  • Site-wide: 26,052

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,920
  • In genetics: 45
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  • Site-wide: 7,831
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  • Site-wide: 26,304

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 2,828
  • In genetics: 79
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  • Site-wide: 5,168
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  • Site-wide: 29,856

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

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  • Site-wide: 3,093
  • In genetics: 86
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  • Site-wide: 40,107
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  • Site-wide: 60,546

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 3,272
  • In genomics: 280
• Year to date:
  • Site-wide: 13,869
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  • Site-wide: 32,839

A global view of pleiotropy and genetic architecture in complex traits

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  • Site-wide: 4,804
  • In genetics: 159
• Year to date:
  • Site-wide: 1,529
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  • Site-wide: 4,391

Greater male than female variability in regional brain structure across the lifespan

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  • Site-wide: 4,827
  • In neuroscience: 359
• Year to date:
  • Site-wide: 81,611
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  • Site-wide: 46,096

Psychiatric Genomics: An Update and an Agenda

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  • Site-wide: 5,440
  • In genetics: 179
• Year to date:
  • Site-wide: 3,083
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  • Site-wide: 90,626

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 5,724
  • In genetics: 185
• Year to date:
  • Site-wide: 70,949
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  • Site-wide: 51,440

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

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  • Site-wide: 5,802
  • In genomics: 540
• Year to date:
  • Site-wide: 94,082
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  • Site-wide: 90,403

Genetics of brain age suggest an overlap with common brain disorders

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  • Site-wide: 6,807
  • In neuroscience: 586
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Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • Site-wide: 7,431
  • In genetics: 268
• Year to date:
  • Site-wide: 60,313
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  • Site-wide: 80,027

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 7,443
  • In genetics: 275
• Year to date:
  • Site-wide: 7,748
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  • Site-wide: 8,715

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

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  • Site-wide: 7,815
  • In genetics: 294
• Year to date:
  • Site-wide: 9,233
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  • Site-wide: 3,539

Estimating inflation in GWAS summary statistics due to variance distortion from cryptic relatedness

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  • Site-wide: 9,080
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  • Site-wide: 4,583
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  • Site-wide: 17,128

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 11,064
  • In genetics: 420
• Year to date:
  • Site-wide: 5,652
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  • Site-wide: 13,039

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 13,665
  • In genetics: 525
• Year to date:
  • Site-wide: 41,150
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  • Site-wide: 198,181

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 14,406
  • In genetics: 565
• Year to date:
  • Site-wide: 132,608
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  • Site-wide: 198,388

The correlation between central and peripheral oxytocin concentrations: a systematic review and meta-analysis

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  • Site-wide: 14,582
  • In physiology: 31
• Year to date:
  • Site-wide: 20,367
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  • Site-wide: 18,227

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

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  • Site-wide: 15,892
  • In genetics: 642
• Year to date:
  • Site-wide: 35,460
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  • Site-wide: 60,493

Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group

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  • Site-wide: 16,311
  • In neuroscience: 1,761
• Year to date:
  • Site-wide: 60,492
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  • Site-wide: 43,074

Oxytocin gene networks in the human brain: A gene expression and large-scale fMRI meta-analysis study

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  • Site-wide: 17,634
  • In neuroscience: 1,954
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  • Site-wide: None
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  • Site-wide: 59,748

Cerebellar grey matter volume is associated with cognitive function and psychopathology in adolescence

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  • Site-wide: 17,657
  • In neuroscience: 1,941
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  • Site-wide: 141,549

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 18,558
  • In genomics: 1,676
• Year to date:
  • Site-wide: 112,578
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  • Site-wide: 51,987

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

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  • Site-wide: 18,816
  • In neuroscience: 2,113
• Year to date:
  • Site-wide: 62,402
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  • Site-wide: 148,935

Linkage Disequilibrium and Heterozygosity Modulate the Genetic Architecture of Human Complex Phenotypes

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  • Site-wide: 22,309
  • In genomics: 1,930
• Year to date:
  • Site-wide: 139,485
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  • Site-wide: 152,761

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

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  • Site-wide: 23,664
  • In genetics: 946
• Year to date:
  • Site-wide: 119,410
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  • Site-wide: 209,693

Partitioning the genetic architecture of amyotrophic lateral sclerosis

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  • Site-wide: 25,277
  • In genetics: 1,022
• Year to date:
  • Site-wide: 25,947
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  • Site-wide: 92,432

Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years

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  • Site-wide: 25,292
  • In neuroscience: 3,056
• Year to date:
  • Site-wide: 37,664
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  • Site-wide: 77,281

Genetic liability for schizophrenia and childhood psychopathology in the general population

• Downloaded 1,328 times
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  • Site-wide: 25,631
  • In psychiatry and clinical psychology: 104
• Year to date:
  • Site-wide: 155,548
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  • Site-wide: 100,773

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

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  • Site-wide: 29,522
  • In genetics: 1,173
• Year to date:
  • Site-wide: 71,047
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  • Site-wide: 198,156

Phenotypically independent mental health symptom profiles are genetically related

• Downloaded 1,196 times
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  • Site-wide: 30,228
  • In psychiatry and clinical psychology: 123
• Year to date:
  • Site-wide: 90,629
• Since beginning of last month:
  • Site-wide: 125,012

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 1,166 times
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  • Site-wide: 31,482
  • In genetics: 1,278
• Year to date:
  • Site-wide: 23,248
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  • Site-wide: 42,659

Vaccination history for diphtheria and tetanus is associated with less severe COVID-19

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  • Site-wide: 32,102
  • In epidemiology: 1,806
• Year to date:
  • Site-wide: 107,471
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  • Site-wide: 41,067

Molecular and connectomic vulnerability shape cross-disorder cortical abnormalities

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  • Site-wide: 33,180
  • In neuroscience: 4,242
• Year to date:
  • Site-wide: 60,160
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  • Site-wide: 23,291

A genome-wide genetic pleiotropy approach identified shared loci between multiple system atrophy and inflammatory bowel disease

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  • Site-wide: 33,426
  • In genetics: 1,329
• Year to date:
  • Site-wide: 72,440
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  • Site-wide: 183,528

Predicting cognitive and mental health traits and their polygenic architecture using large-scale brain connectomics

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  • Site-wide: 33,592
  • In neuroscience: 4,313
• Year to date:
  • Site-wide: 115,706
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  • Site-wide: 21,583

Genome-wide association study identifies new locus associated with OCD

• Downloaded 1,096 times
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  • Site-wide: 34,613
  • In psychiatry and clinical psychology: 149
• Year to date:
  • Site-wide: 12,720
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  • Site-wide: 10,804

Characterization of the genetic architecture of BMI in infancy and early childhood reveals age-specific effects and implicates pathways involved in Mendelian obesity

• Downloaded 1,092 times
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  • Site-wide: 34,799
  • In genetic and genomic medicine: 216
• Year to date:
  • Site-wide: 179,644
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  • Site-wide: 111,149

Personalized genetic assessment of age associated Alzheimers disease risk

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  • Site-wide: 35,158
  • In genetics: 1,390
• Year to date:
  • Site-wide: 132,678
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  • Site-wide: 117,253

A genetic risk score to guide age-specific, personalized prostate cancer screening

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  • Site-wide: 35,528
  • In genetics: 1,403
• Year to date:
  • Site-wide: 166,723
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  • Site-wide: 60,450

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 39,235
  • In neuroscience: 5,184
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  • Site-wide: 93,087

Thinner cortex is associated with psychosis onset in individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group mega-analysis

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  • Site-wide: 39,665
  • In psychiatry and clinical psychology: 171
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  • Site-wide: 19,722
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  • Site-wide: 57,261

The genetic structure of Norway

• Downloaded 990 times
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  • Site-wide: 40,500
  • In genetics: 1,633
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  • Site-wide: 19,608
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  • Site-wide: 79,924

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 41,248
  • In genetics: 1,628
• Year to date:
  • Site-wide: 135,961
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  • Site-wide: 201,487

White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age prediction

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  • Site-wide: 41,721
  • In neuroscience: 5,408
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  • Site-wide: 160,123

Lipid associated polygenic enrichment in Alzheimer's disease

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  • Site-wide: 43,667
  • In genetics: 1,733
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  • Site-wide: 62,953
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  • Site-wide: 51,443

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 44,052
  • In genetic and genomic medicine: 273
• Year to date:
  • Site-wide: 83,879
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  • Site-wide: 112,490

Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

• Downloaded 922 times
• Download rankings, all-time:
  • Site-wide: 45,141
  • In neuroscience: 6,074
• Year to date:
  • Site-wide: None
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  • Site-wide: 81,831

Coordinated Cortical Thickness Alterations across Psychiatric Conditions: A Transdiagnostic ENIGMA Study

• Downloaded 919 times
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  • Site-wide: 45,352
  • In psychiatry and clinical psychology: 199
• Year to date:
  • Site-wide: 31,559
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  • Site-wide: 32,451

The genetic architecture of human cortical folding

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  • Site-wide: 46,139
  • In genomics: 3,473
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  • Site-wide: 88,185
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  • Site-wide: 95,555

Federated Multi-Site Normative Modeling using Hierarchical Bayesian Regression

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  • Site-wide: 47,371
  • In bioinformatics: 4,919
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  • Site-wide: 12,718
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  • Site-wide: 26,786

Functional connectivity directionality between large-scale resting-state networks in children and adolescence from the Healthy Brain Network sample

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  • Site-wide: 47,379
  • In radiology and imaging: 97
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  • Site-wide: 27,896
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  • Site-wide: 37,208

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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  • Site-wide: 47,589
  • In genetics: 1,866
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  • Site-wide: 93,611
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  • Site-wide: 74,916

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy and improves prediction

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  • Site-wide: 48,814
  • In genetics: 1,971
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  • Site-wide: 11,129
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  • Site-wide: 21,439

The genetic architecture of human brainstem structures and their involvement in common brain disorders

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  • Site-wide: 49,059
  • In neuroscience: 6,496
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  • Site-wide: 166,157
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  • Site-wide: 128,361

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

• Downloaded 856 times
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  • Site-wide: 50,657
  • In genetics: 1,961
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  • Site-wide: 167,805
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  • Site-wide: 180,775

FEMA: Fast and efficient mixed-effects algorithm for population-scale whole brain imaging data

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  • Site-wide: 50,911
  • In neuroscience: 7,331
• Year to date:
  • Site-wide: 16,500
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  • Site-wide: 9,136

Identifying intergenerational risk factors for ADHD symptoms using polygenic scores in the Norwegian Mother, Father and Child Cohort

• Downloaded 846 times
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  • Site-wide: 51,645
  • In psychiatry and clinical psychology: 232
• Year to date:
  • Site-wide: 35,096
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  • Site-wide: 33,403

Multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.

• Downloaded 834 times
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  • Site-wide: 52,658
  • In genetics: 2,072
• Year to date:
  • Site-wide: 84,526
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  • Site-wide: 124,274

Probing brain developmental patterns of myelination and associations with psychopathology in youth using gray/white matter contrast

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  • Site-wide: 53,320
  • In neuroscience: 7,139
• Year to date:
  • Site-wide: 191,931
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  • Site-wide: 149,812

Making the MOSTest of imaging genetics

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  • Site-wide: 54,651
  • In neuroscience: 7,413
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  • Site-wide: None
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  • Site-wide: 187,889

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

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  • Site-wide: 55,735
  • In genomics: 3,953
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  • Site-wide: 188,886
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  • Site-wide: 174,783

Genome-wide association analysis of the human thalamus identifies novel genomic loci and reveals genetic overlap with distinct cortical regions and ten brain disorders

• Downloaded 782 times
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  • Site-wide: 58,013
  • In genetic and genomic medicine: 365
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  • Site-wide: 79,519
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  • Site-wide: 158,672

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

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  • Site-wide: 58,068
  • In genomics: 4,097
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  • Site-wide: 120,083
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  • Site-wide: 65,728

Pupillary dilation responses as a midlife indicator of risk for Alzheimer's Disease: Association with Alzheimer's disease polygenic risk

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  • Site-wide: 60,642
  • In genetics: 2,335
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  • Site-wide: 169,504
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  • Site-wide: 182,024

Cortico-genetic mapping links individual brain maturity in youths to cognitive and psychiatric traits

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  • Site-wide: 60,651
  • In neuroscience: 8,336
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  • Site-wide: 116,225
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  • Site-wide: 142,354

Genome-Wide Association Identifies the First Risk Loci for Psychosis in Alzheimer Disease

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  • Site-wide: 61,489
  • In psychiatry and clinical psychology: 276
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  • Site-wide: 125,514
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  • Site-wide: 103,802

Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptoms

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  • Site-wide: 61,913
  • In psychiatry and clinical psychology: 283
• Year to date:
  • Site-wide: 99,384
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  • Site-wide: 33,852

Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

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  • Site-wide: 62,017
  • In neurology: 231
• Year to date:
  • Site-wide: 12,110
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  • Site-wide: 42,506

Recently evolved human-specific methylated regions are enriched in schizophrenia signals

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  • Site-wide: 62,360
  • In genomics: 4,315
• Year to date:
  • Site-wide: 191,184
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  • Site-wide: 174,655

Maturation of cortical microstructure and cognitive development in childhood and adolescence: a T1w/T2w ratio MRI study

• Downloaded 741 times
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  • Site-wide: 62,874
  • In neuroscience: 8,792
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  • Site-wide: None
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  • Site-wide: 92,433

How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa)

• Downloaded 740 times
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  • Site-wide: 62,940
  • In genetic and genomic medicine: 395
• Year to date:
  • Site-wide: 91,093
• Since beginning of last month:
  • Site-wide: 185,631

Deep neural networks learn general and clinically relevant representations of the ageingbrain

• Downloaded 723 times
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  • Site-wide: 65,139
  • In neurology: 240
• Year to date:
  • Site-wide: 43,572
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  • Site-wide: 62,804

Immune-related genetic enrichment in frontotemporal dementia

• Downloaded 715 times
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  • Site-wide: 66,168
  • In genetics: 2,541
• Year to date:
  • Site-wide: 166,833
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  • Site-wide: 198,364

Polygenic hazard scores in preclinical Alzheimer's disease

• Downloaded 703 times
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  • Site-wide: 67,807
  • In genetics: 2,593
• Year to date:
  • Site-wide: 189,092
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  • Site-wide: 198,356

Improved prediction of schizophrenia by leveraging genetic overlap with brain morphology

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  • Site-wide: 68,175
  • In psychiatry and clinical psychology: 312
• Year to date:
  • Site-wide: 83,883
• Since beginning of last month:
  • Site-wide: 160,800

Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment

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  • Site-wide: 69,284
  • In genomics: 4,677
• Year to date:
  • Site-wide: 170,490
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  • Site-wide: 201,131

Sex-dependent polygenic effects on the clinical progressions of Alzheimer's disease

• Downloaded 679 times
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  • Site-wide: 71,128
  • In genetics: 2,735
• Year to date:
  • Site-wide: 168,993
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  • Site-wide: 151,981

All-optical electrophysiology in hiPSC-derived neurons with synthetic voltage sensors

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  • Site-wide: 72,551
  • In neuroscience: 10,068
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  • Site-wide: 184,317
• Since beginning of last month:
  • Site-wide: 171,180

Genetic overlap between multivariate measures of human functional brain connectivity and psychiatric disorders

• Downloaded 669 times
• Download rankings, all-time:
  • Site-wide: 72,552
  • In genetic and genomic medicine: 473
• Year to date:
  • Site-wide: 75,884
• Since beginning of last month:
  • Site-wide: 33,888

Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study

• Downloaded 667 times
• Download rankings, all-time:
  • Site-wide: 72,905
  • In neuroscience: 10,279
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 181,789

Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder

• Downloaded 658 times
• Download rankings, all-time:
  • Site-wide: 74,273
  • In psychiatry and clinical psychology: 340
• Year to date:
  • Site-wide: 155,724
• Since beginning of last month:
  • Site-wide: 128,581

Multilevel neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology

• Downloaded 651 times
• Download rankings, all-time:
  • Site-wide: 75,317
  • In neuroscience: 10,593
• Year to date:
  • Site-wide: 175,740
• Since beginning of last month:
  • Site-wide: 99,615

The dark side of the mean: brain structural heterogeneity in schizophrenia and its polygenic risk.

• Downloaded 644 times
• Download rankings, all-time:
  • Site-wide: 76,357
  • In neuroscience: 10,928
• Year to date:
  • Site-wide: 73,697
• Since beginning of last month:
  • Site-wide: 120,136

Multivariate genome-wide association study on tissue-sensitive diffusion metrics identifies key molecular pathways for axonal growth, synaptogenesis, and astrocyte-mediated neuroinflammation

• Downloaded 643 times
• Download rankings, all-time:
  • Site-wide: 76,563
  • In genetics: 2,959
• Year to date:
  • Site-wide: 77,407
• Since beginning of last month:
  • Site-wide: 73,400

Population-based neuroimaging reveals traces of childbirth in the maternal brain

• Downloaded 633 times
• Download rankings, all-time:
  • Site-wide: 78,203
  • In neuroscience: 11,070
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 147,904

Cardiometabolic risk factors associated with brain age and accelerate brain ageing

• Downloaded 626 times
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  • Site-wide: 79,274
  • In neurology: 315
• Year to date:
  • Site-wide: 102,219
• Since beginning of last month:
  • Site-wide: 134,830

Association between schizophrenia polygenic score and psychotic symptoms in Alzheimer disease: meta-analysis of 11 cohort studies

• Downloaded 616 times
• Download rankings, all-time:
  • Site-wide: 80,894
  • In genomics: 5,214
• Year to date:
  • Site-wide: 188,249
• Since beginning of last month:
  • Site-wide: 154,399

Genetic control of variability in subcortical and intracranial volumes

• Downloaded 606 times
• Download rankings, all-time:
  • Site-wide: 82,624
  • In neuroscience: 11,658
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 142,976

Adipose tissue distribution from body MRI is associated with cross-sectional and longitudinal brain age in adults

• Downloaded 605 times
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  • Site-wide: 82,832
  • In neurology: 333
• Year to date:
  • Site-wide: 178,313
• Since beginning of last month:
  • Site-wide: 40,574

Differences in directed functional brain connectivity related to age, sex and mental health

• Downloaded 602 times
• Download rankings, all-time:
  • Site-wide: 83,278
  • In neuroscience: 11,826
• Year to date:
  • Site-wide: 114,236
• Since beginning of last month:
  • Site-wide: 101,975

Characterization of Age and Polarity at Onset in Bipolar Disorder

• Downloaded 587 times
• Download rankings, all-time:
  • Site-wide: 86,064
  • In psychiatry and clinical psychology: 418
• Year to date:
  • Site-wide: 145,071
• Since beginning of last month:
  • Site-wide: 56,559

Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition

• Downloaded 567 times
• Download rankings, all-time:
  • Site-wide: 89,961
  • In genetics: 3,420
• Year to date:
  • Site-wide: 189,232
• Since beginning of last month:
  • Site-wide: 208,993

Annotation-Informed Causal Mixture Modeling (AI-MiXeR) reveals phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories

• Downloaded 561 times
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  • Site-wide: 91,033
  • In genetics: 3,511
• Year to date:
  • Site-wide: 61,984
• Since beginning of last month:
  • Site-wide: 186,836

Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories

• Downloaded 538 times
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  • Site-wide: 95,807
  • In neuroscience: 13,689
• Year to date:
  • Site-wide: 133,064
• Since beginning of last month:
  • Site-wide: 197,469

Heritable cognitive and psychopathology factors in youth are predicted by brain fronto-temporal white matter pathway

• Downloaded 522 times
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  • Site-wide: 99,267
  • In neuroscience: 14,250
• Year to date:
  • Site-wide: 165,632
• Since beginning of last month:
  • Site-wide: 196,831

Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

• Downloaded 519 times
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  • Site-wide: 99,799
  • In genetics: 4,010
• Year to date:
  • Site-wide: 16,210
• Since beginning of last month:
  • Site-wide: 13,559

Differences in the presentation and progression of Parkinson's disease by sex

• Downloaded 515 times
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  • Site-wide: 100,814
  • In neurology: 436
• Year to date:
  • Site-wide: 157,349
• Since beginning of last month:
  • Site-wide: 129,332

Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry

• Downloaded 510 times
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  • Site-wide: 102,004
  • In neuroscience: 14,704
• Year to date:
  • Site-wide: 192,659
• Since beginning of last month:
  • Site-wide: 175,629

Analysis of differentially methylated regions in primates and non-primates provides support for the evolutionary hypothesis of schizophrenia

• Downloaded 508 times
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  • Site-wide: 102,458
  • In genomics: 6,185
• Year to date:
  • Site-wide: 96,153
• Since beginning of last month:
  • Site-wide: 116,998

Prenatal smoking, alcohol and caffeine exposure and maternal reported ADHD symptoms in childhood: triangulation of evidence using negative control and polygenic risk score analyses

• Downloaded 502 times
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  • Site-wide: 103,703
  • In epidemiology: 4,458
• Year to date:
  • Site-wide: 177,495
• Since beginning of last month:
  • Site-wide: 96,694

The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1

• Downloaded 501 times
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  • Site-wide: 103,946
  • In genetics: 4,350
• Year to date:
  • Site-wide: 2,985
• Since beginning of last month:
  • Site-wide: 12,329

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

• Downloaded 489 times
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  • Site-wide: 106,904
  • In genetics: 4,066
• Year to date:
  • Site-wide: 112,458
• Since beginning of last month:
  • Site-wide: 180,437

Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders

• Downloaded 478 times
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  • Site-wide: 109,414
  • In radiology and imaging: 231
• Year to date:
  • Site-wide: 90,840
• Since beginning of last month:
  • Site-wide: 101,989

Sex differences in the relationship between social difficulties and executive dysfunction in children and adolescents with autism spectrum disorder

• Downloaded 474 times
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  • Site-wide: 110,488
  • In neuroscience: 16,117
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 153,985

Multimodal monitoring of human cortical organoids implanted in mice using transparent graphene microelectrodes reveal functional connection between organoid and mouse visual cortex

• Downloaded 474 times
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  • Site-wide: 110,310
  • In neuroscience: 17,863
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 9,022

Genetic effects on the timing of parturition and links to fetal birth weight

• Downloaded 466 times
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  • Site-wide: 112,499
  • In genetic and genomic medicine: 765
• Year to date:
  • Site-wide: 21,826
• Since beginning of last month:
  • Site-wide: 17,689

A genetic hazard score to personalize prostate cancer screening, applied to population data

• Downloaded 464 times
• Download rankings, all-time:
  • Site-wide: 112,802
  • In genetics: 4,245
• Year to date:
  • Site-wide: 138,458
• Since beginning of last month:
  • Site-wide: 209,969

Genetic architecture of creativity and extensive genetic overlap with psychiatric disorders revealed from genome-wide association analyses of 241,736 individuals

• Downloaded 461 times
• Download rankings, all-time:
  • Site-wide: 113,617
  • In genomics: 7,113
• Year to date:
  • Site-wide: 24,678
• Since beginning of last month:
  • Site-wide: 5,943

Genetic and phenotypic associations between brain imaging, psychopathology and educational attainment in children aged 9-11

• Downloaded 460 times
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  • Site-wide: 113,914
  • In psychiatry and clinical psychology: 621
• Year to date:
  • Site-wide: 33,687
• Since beginning of last month:
  • Site-wide: 48,899

Genome-wide determinants of mortality and clinical progression in Parkinson's disease

• Downloaded 450 times
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  • Site-wide: 116,248
  • In genetic and genomic medicine: 785
• Year to date:
  • Site-wide: 39,563
• Since beginning of last month:
  • Site-wide: 32,075

CXCR4 involvement in neurodegenerative diseases

• Downloaded 447 times
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  • Site-wide: 117,215
  • In genetics: 4,407
• Year to date:
  • Site-wide: 93,645
• Since beginning of last month:
  • Site-wide: 175,181

Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area

• Downloaded 443 times
• Download rankings, all-time:
  • Site-wide: 118,156
  • In neuroscience: 17,144
• Year to date:
  • Site-wide: 111,504
• Since beginning of last month:
  • Site-wide: 215,335

Spatial frequency discrimination in patients with schizophrenia spectrum and bipolar disorders: Evidence of early visual processing deficits and associations with intellectual abilities

• Downloaded 442 times
• Download rankings, all-time:
  • Site-wide: 118,338
  • In psychiatry and clinical psychology: 671
• Year to date:
  • Site-wide: 56,555
• Since beginning of last month:
  • Site-wide: 43,740

Population-based body-brain mapping links brain morphology and body composition

• Downloaded 427 times
• Download rankings, all-time:
  • Site-wide: 122,422
  • In neuroscience: 17,923
• Year to date:
  • Site-wide: 90,416
• Since beginning of last month:
  • Site-wide: 187,974

Genome-wide association analysis reveals extensive genetic overlap between mood instability and psychiatric disorders but divergent patterns of genetic effects

• Downloaded 425 times
• Download rankings, all-time:
  • Site-wide: 123,080
  • In psychiatry and clinical psychology: 704
• Year to date:
  • Site-wide: 75,389
• Since beginning of last month:
  • Site-wide: 29,445

Cross-sectional and longitudinal brain scans reveal accelerated brain aging in multiple sclerosis

• Downloaded 418 times
• Download rankings, all-time:
  • Site-wide: 124,978
  • In neuroscience: 18,087
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 209,532

A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia

• Downloaded 392 times
• Download rankings, all-time:
  • Site-wide: 132,351
  • In neuroscience: 19,292
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 211,064

Birth Order Differences in Education Originate in Post-Natal Environments

• Downloaded 383 times
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  • Site-wide: 135,086
  • In genetics: 5,058
• Year to date:
  • Site-wide: 176,259
• Since beginning of last month:
  • Site-wide: 55,173

The role of liver fat in cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition

• Downloaded 378 times
• Download rankings, all-time:
  • Site-wide: 136,360
  • In genomics: 7,395
• Year to date:
  • Site-wide: 99,999
• Since beginning of last month:
  • Site-wide: 42,371

Maternal and offspring genetic risk score (GRS) analyses of fetal alcohol exposure and ADHD risk in offspring

• Downloaded 377 times
• Download rankings, all-time:
  • Site-wide: 136,908
  • In epidemiology: 5,645
• Year to date:
  • Site-wide: 145,513
• Since beginning of last month:
  • Site-wide: 50,830

Genetic overlap between Alzheimer's disease and depression mapped onto the brain

• Downloaded 374 times
• Download rankings, all-time:
  • Site-wide: 137,759
  • In genetic and genomic medicine: 961
• Year to date:
  • Site-wide: 89,681
• Since beginning of last month:
  • Site-wide: 194,398

Sparse Deep Neural Networks on Imaging Genetics for Schizophrenia Case-Control Classification

• Downloaded 371 times
• Download rankings, all-time:
  • Site-wide: 138,482
  • In psychiatry and clinical psychology: 816
• Year to date:
  • Site-wide: 125,146
• Since beginning of last month:
  • Site-wide: 160,852

Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents

• Downloaded 368 times
• Download rankings, all-time:
  • Site-wide: 139,384
  • In neuroscience: 20,299
• Year to date:
  • Site-wide: 172,921
• Since beginning of last month:
  • Site-wide: 214,635

Impact of second-generation antipsychotics on white matter microstructure in adolescent-onset psychosis

• Downloaded 364 times
• Download rankings, all-time:
  • Site-wide: 140,672
  • In neuroscience: 20,705
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 145,186

Experience-dependent modulation of the visual evoked potential: testing effect sizes, retention over time, and associations with age in 415 healthy individuals

• Downloaded 358 times
• Download rankings, all-time:
  • Site-wide: 142,357
  • In neuroscience: 21,121
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 212,795

Evidence for a moderating effect of drinking severity but not HIV status on brain age in heavy episodic drinkers

• Downloaded 355 times
• Download rankings, all-time:
  • Site-wide: 143,199
  • In hiv aids: 133
• Year to date:
  • Site-wide: 145,438
• Since beginning of last month:
  • Site-wide: 61,730

Generalization of Cortical MOSTest Genome-Wide Associations Within and Across Samples

• Downloaded 353 times
• Download rankings, all-time:
  • Site-wide: 143,974
  • In genomics: 7,644
• Year to date:
  • Site-wide: 104,143
• Since beginning of last month:
  • Site-wide: 113,148

Brain age estimation is a sensitive marker of processing speed in the early course of multiple sclerosis

• Downloaded 346 times
• Download rankings, all-time:
  • Site-wide: 146,099
  • In neuroscience: 21,343
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 196,309

Age dependence of modern clinical risk groups for localized prostate cancer — a population-based study

• Downloaded 314 times
• Download rankings, all-time:
  • Site-wide: 155,572
  • In epidemiology: 6,326
• Year to date:
  • Site-wide: 189,194
• Since beginning of last month:
  • Site-wide: 207,275

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

• Downloaded 312 times
• Download rankings, all-time:
  • Site-wide: 156,178
  • In dermatology: 75
• Year to date:
  • Site-wide: 9,642
• Since beginning of last month:
  • Site-wide: 6,270

In vivo amygdala nuclei volumes in schizophrenia and bipolar disorders

• Downloaded 309 times
• Download rankings, all-time:
  • Site-wide: 157,320
  • In psychiatry and clinical psychology: 965
• Year to date:
  • Site-wide: 150,533
• Since beginning of last month:
  • Site-wide: 110,249

The effect of sample size on polygenic hazard models for prostate cancer

• Downloaded 302 times
• Download rankings, all-time:
  • Site-wide: 159,194
  • In genetics: 5,867
• Year to date:
  • Site-wide: 191,163
• Since beginning of last month:
  • Site-wide: 205,483

Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages

• Downloaded 299 times
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  • Site-wide: 160,296
  • In neuroscience: 24,078
• Year to date:
  • Site-wide: 32,953
• Since beginning of last month:
  • Site-wide: 28,475

White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging

• Downloaded 299 times
• Download rankings, all-time:
  • Site-wide: 160,115
  • In neuroscience: 23,325
• Year to date:
  • Site-wide: 190,780
• Since beginning of last month:
  • Site-wide: 206,242

Gut Microbiota Markers for Antipsychotics Induced Metabolic Disturbance in Drug Naive Patients with First Episode Schizophrenia _ A 24 Weeks Follow-up Study

• Downloaded 293 times
• Download rankings, all-time:
  • Site-wide: 162,235
  • In psychiatry and clinical psychology: 999
• Year to date:
  • Site-wide: 153,595
• Since beginning of last month:
  • Site-wide: 114,802

Prostate cancer risk stratification improved across multiple ancestries with new polygenic hazard score

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 164,069
  • In genetic and genomic medicine: 1,180
• Year to date:
  • Site-wide: 41,446
• Since beginning of last month:
  • Site-wide: 158,189

Distributed genetic architecture across the hippocampal formation implies common neuropathology across major brain disorders

• Downloaded 282 times
• Download rankings, all-time:
  • Site-wide: 165,493
  • In genetic and genomic medicine: 1,182
• Year to date:
  • Site-wide: 110,882
• Since beginning of last month:
  • Site-wide: 98,668

Polygenic resilience scores capture protective genetic effects for Alzheimers disease

• Downloaded 282 times
• Download rankings, all-time:
  • Site-wide: 165,332
  • In genetic and genomic medicine: 1,196
• Year to date:
  • Site-wide: 58,085
• Since beginning of last month:
  • Site-wide: 139,305

Acute COVID-19 severity and 16-month mental morbidity trajectories in patient populations of six nations

• Downloaded 281 times
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  • Site-wide: 165,779
  • In public and global health: 2,416
• Year to date:
  • Site-wide: 105,800
• Since beginning of last month:
  • Site-wide: 110,449

The causal effects of body mass index (BMI) on childhood symptoms of depression, anxiety disorder, and attention-deficit hyperactivity disorder: a within family Mendelian randomization study

• Downloaded 279 times
• Download rankings, all-time:
  • Site-wide: 166,203
  • In epidemiology: 6,870
• Year to date:
  • Site-wide: 13,324
• Since beginning of last month:
  • Site-wide: 19,506

Interplay between the Genetics of Personality Traits, severe Psychiatric Disorders, and COVID-19 Host Genetics in the Susceptibility to SARS-CoV-2 Infection

• Downloaded 278 times
• Download rankings, all-time:
  • Site-wide: 166,775
  • In genetic and genomic medicine: 1,190
• Year to date:
  • Site-wide: 178,015
• Since beginning of last month:
  • Site-wide: 83,505

Additional SNPs improve the performance of a polygenic hazard score for prostate cancer

• Downloaded 271 times
• Download rankings, all-time:
  • Site-wide: 168,533
  • In genetic and genomic medicine: 1,216
• Year to date:
  • Site-wide: 157,137
• Since beginning of last month:
  • Site-wide: 158,677

Childhood temperamental, emotional, and behavioral predictors of clinical mood and anxiety disorders in adolescence

• Downloaded 269 times
• Download rankings, all-time:
  • Site-wide: 169,271
  • In psychiatry and clinical psychology: 1,065
• Year to date:
  • Site-wide: 55,466
• Since beginning of last month:
  • Site-wide: 34,736

Evidence for reduced long-term potentiation-like visual cortical plasticity in schizophrenia and bipolar disorder

• Downloaded 268 times
• Download rankings, all-time:
  • Site-wide: 169,578
  • In neuroscience: 24,628
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 184,429

Cannabis use is associated with increased levels of soluble gp130 in schizophrenia but not in bipolar disorder

• Downloaded 261 times
• Download rankings, all-time:
  • Site-wide: 171,566
  • In pharmacology and toxicology: 1,394
• Year to date:
  • Site-wide: 114,713
• Since beginning of last month:
  • Site-wide: 187,567

The effect of maternal BMI, smoking and alcohol on congenital heart diseases: a Mendelian randomization study

• Downloaded 259 times
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  • Site-wide: 172,313
  • In epidemiology: 6,992
• Year to date:
  • Site-wide: 32,884
• Since beginning of last month:
  • Site-wide: 35,806

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

• Downloaded 257 times
• Download rankings, all-time:
  • Site-wide: 172,837
  • In genetic and genomic medicine: 1,262
• Year to date:
  • Site-wide: 89,611
• Since beginning of last month:
  • Site-wide: 158,594

The Genetic Architecture of Amygdala Nuclei

• Downloaded 251 times
• Download rankings, all-time:
  • Site-wide: 174,447
  • In genetic and genomic medicine: 1,300
• Year to date:
  • Site-wide: 42,362
• Since beginning of last month:
  • Site-wide: 82,708

Functional characterisation of single nucleotide variants of the psychiatric risk gene cacna1c in the zebrafish

• Downloaded 236 times
• Download rankings, all-time:
  • Site-wide: 178,558
  • In neuroscience: 26,534
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 63,945

The relationship of maternal gestational mass spectrometry-derived metabolites with offspring congenital heart disease: results from multivariable and Mendelian randomization analyses

• Downloaded 227 times
• Download rankings, all-time:
  • Site-wide: 180,845
  • In epidemiology: 7,243
• Year to date:
  • Site-wide: 99,288
• Since beginning of last month:
  • Site-wide: 140,237

Challenges at the APOE locus: A robust quality control approach for accurate APOE genotyping

• Downloaded 223 times
• Download rankings, all-time:
  • Site-wide: 181,737
  • In neurology: 1,185
• Year to date:
  • Site-wide: 143,404
• Since beginning of last month:
  • Site-wide: 159,281

Genome-wide association study of placental weight in 179,025 children and parents reveals distinct and shared genetic influences between placental and fetal growth

• Downloaded 219 times
• Download rankings, all-time:
  • Site-wide: 182,855
  • In genetic and genomic medicine: 1,404
• Year to date:
  • Site-wide: 13,240
• Since beginning of last month:
  • Site-wide: 4,554

In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis via the ENIGMA Consortium.

• Downloaded 214 times
• Download rankings, all-time:
  • Site-wide: 184,037
  • In psychiatry and clinical psychology: 1,212
• Year to date:
  • Site-wide: 99,609
• Since beginning of last month:
  • Site-wide: 88,776

Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings

• Downloaded 213 times
• Download rankings, all-time:
  • Site-wide: 184,425
  • In addiction medicine: 132
• Year to date:
  • Site-wide: 57,857
• Since beginning of last month:
  • Site-wide: 66,815

Brain-wide associations between white matter and agehighlight the role of fornix microstructure in brain age

• Downloaded 206 times
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  • Site-wide: 186,131
  • In neuroscience: 28,876
• Year to date:
  • Site-wide: 7,203
• Since beginning of last month:
  • Site-wide: 11,282

Smoking and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study

• Downloaded 194 times
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  • Site-wide: 188,847
  • In sexual and reproductive health: 137
• Year to date:
  • Site-wide: 143,375
• Since beginning of last month:
  • Site-wide: 99,521

Non-Gaussian Normative Modelling With Hierarchical Bayesian Regression

• Downloaded 184 times
• Download rankings, all-time:
  • Site-wide: 191,171
  • In neuroscience: 28,410
• Year to date:
  • Site-wide: 15,106
• Since beginning of last month:
  • Site-wide: 23,349

Quantifying bone marrow adiposity and its genetic architecture from head MRI scans

• Downloaded 167 times
• Download rankings, all-time:
  • Site-wide: 194,695
  • In genetic and genomic medicine: 1,501
• Year to date:
  • Site-wide: 129,236
• Since beginning of last month:
  • Site-wide: 46,374

Identification of a sex-specific genetic signature in dementia with Lewy bodies: a meta-analysis of genome-wide association studies

• Downloaded 165 times
• Download rankings, all-time:
  • Site-wide: 195,193
  • In genetic and genomic medicine: 1,547
• Year to date:
  • Site-wide: 13,585
• Since beginning of last month:
  • Site-wide: 12,735

Clustering schizophrenia genes by their temporal expression patterns aids functional interpretation: genetics-based evidence in favor of the two-hit hypothesis

• Downloaded 150 times
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  • Site-wide: 198,125
  • In psychiatry and clinical psychology: 1,385
• Year to date:
  • Site-wide: 130,300
• Since beginning of last month:
  • Site-wide: 89,096

Efficient meta-analysis of multivariate genome-wide association studies with Meta-MOSTest

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  • Site-wide: 200,496
  • In bioinformatics: 14,711
• Year to date:
  • Site-wide: 130,378
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  • Site-wide: 59,148

Puberty differentially predicts brain maturation in males and females during early adolescence: A longitudinal ABCD Study

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  • Site-wide: 202,558
  • In psychiatry and clinical psychology: 1,651
• Year to date:
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  • Site-wide: 4,927

Shared genetic architecture between mental health and the brain functional connectome in the UK Biobank

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  • Site-wide: 203,087
  • In genetic and genomic medicine: 1,610
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  • Site-wide: 38,486
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  • Site-wide: 48,254

Health behaviours prior to pregnancy and fertility outcomes: Triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)

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  • Site-wide: 204,266
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Brain-Based Gene Expression of Putative Risk Genes for Anorexia Nervosa in the Human Brain

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Genome-wide analyses of neonatal jaundice reveal a marked departure from adult bilirubin metabolism

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  • Site-wide: 5,252

Bounding the average causal effect in Mendelian randomization studies with multiple proposed instruments: An application to prenatal alcohol exposure and attention deficit hyperactivity disorder

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Genetic architecture of brain age and its casual relations with brain and mental disorders

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  • Site-wide: 208,788
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Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression.

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  • Site-wide: 210,232
  • In genetic and genomic medicine: 1,700
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  • Site-wide: 70,250

Finemap-MiXeR: A variational Bayesian approach for genetic finemapping

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  • Site-wide: 3,657

Improved functional mapping with GSA-MiXeR implicates biologically specific gene-sets and estimates enrichment magnitude

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  • Site-wide: 212,625
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  • Site-wide: 6,426

Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

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  • Site-wide: 213,131
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• Year to date:
  • Site-wide: 11,866
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  • Site-wide: 7,038

Bio-psycho-social factors' associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants

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  • Site-wide: 213,483
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  • Site-wide: 21,152
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  • Site-wide: 6,154

Heritability estimation of cognitive phenotypes in the ABCD Study using mixed models

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  • Site-wide: 214,025
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  • Site-wide: 174,298
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  • Site-wide: 35,372