Author: Peter M Visscher

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Preprints

Recovery of trait heritability from whole genome sequence data

• Downloaded 12,829 times
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  • Site-wide: 696
  • In genetics: 15
• Year to date:
  • Site-wide: 1,534
• Since beginning of last month:
  • Site-wide: 31,783

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

• Downloaded 11,234 times
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  • Site-wide: 831
  • In genetics: 21
• Year to date:
  • Site-wide: 4,056
• Since beginning of last month:
  • Site-wide: 72,216

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

• Downloaded 11,087 times
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  • Site-wide: 853
  • In genomics: 61
• Year to date:
  • Site-wide: 1,347
• Since beginning of last month:
  • Site-wide: 17,127

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,444 times
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  • Site-wide: 1,032
  • In genetics: 26
• Year to date:
  • Site-wide: 51,070
• Since beginning of last month:
  • Site-wide: 105,850

Genetic Consequences of Social Stratification in Great Britain

• Downloaded 7,979 times
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  • Site-wide: 1,294
  • In genetics: 34
• Year to date:
  • Site-wide: 10,692
• Since beginning of last month:
  • Site-wide: 86,769

New mutations, old statistical challenges

• Downloaded 7,183 times
• Download rankings, all-time:
  • Site-wide: 1,472
  • In genetics: 44
• Year to date:
  • Site-wide: 77,121
• Since beginning of last month:
  • Site-wide: 105,833

MTAG: Multi-Trait Analysis of GWAS

• Downloaded 6,829 times
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  • Site-wide: 1,558
  • In genomics: 128
• Year to date:
  • Site-wide: 22,182
• Since beginning of last month:
  • Site-wide: 78,929

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

• Downloaded 6,761 times
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  • Site-wide: 1,584
  • In genetics: 46
• Year to date:
  • Site-wide: 21,567
• Since beginning of last month:
  • Site-wide: 103,997

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

• Downloaded 3,061 times
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  • Site-wide: 4,782
  • In genetics: 189
• Year to date:
  • Site-wide: 30,189
• Since beginning of last month:
  • Site-wide: 17,249

A resource-efficient tool for mixed model association analysis of large-scale data

• Downloaded 2,979 times
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  • Site-wide: 4,969
  • In genetics: 206
• Year to date:
  • Site-wide: 12,893
• Since beginning of last month:
  • Site-wide: 62,783

Improved polygenic prediction by Bayesian multiple regression on summary statistics

• Downloaded 2,839 times
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  • Site-wide: 5,334
  • In genetics: 221
• Year to date:
  • Site-wide: 66,984
• Since beginning of last month:
  • Site-wide: 65,762

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.

• Downloaded 2,674 times
• Download rankings, all-time:
  • Site-wide: 5,782
  • In genetics: 244
• Year to date:
  • Site-wide: 92,176
• Since beginning of last month:
  • Site-wide: 105,788

Widespread signatures of negative selection in the genetic architecture of human complex traits

• Downloaded 2,328 times
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  • Site-wide: 7,127
  • In genetics: 314
• Year to date:
  • Site-wide: 50,001
• Since beginning of last month:
  • Site-wide: 87,278

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

• Downloaded 2,188 times
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  • Site-wide: 7,802
  • In genetic and genomic medicine: 34
• Year to date:
  • Site-wide: 1,995
• Since beginning of last month:
  • Site-wide: 15,919

GWAS on family history of Alzheimer's disease

• Downloaded 2,011 times
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  • Site-wide: 8,832
  • In genetics: 381
• Year to date:
  • Site-wide: 101,701
• Since beginning of last month:
  • Site-wide: None

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

• Downloaded 1,830 times
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  • Site-wide: 10,132
  • In genetics: 448
• Year to date:
  • Site-wide: 72,766
• Since beginning of last month:
  • Site-wide: 87,202

Causal associations between risk factors and common diseases inferred from GWAS summary data

• Downloaded 1,823 times
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  • Site-wide: 10,194
  • In genetics: 449
• Year to date:
  • Site-wide: 90,907
• Since beginning of last month:
  • Site-wide: 39,840

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

• Downloaded 1,667 times
• Download rankings, all-time:
  • Site-wide: 11,646
  • In genetics: 523
• Year to date:
  • Site-wide: 18,491
• Since beginning of last month:
  • Site-wide: 8,586

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

• Downloaded 1,662 times
• Download rankings, all-time:
  • Site-wide: 11,693
  • In genetics: 526
• Year to date:
  • Site-wide: 70,808
• Since beginning of last month:
  • Site-wide: 99,179

Equivalence of LD-Score Regression and Individual-Level-Data Methods

• Downloaded 1,619 times
• Download rankings, all-time:
  • Site-wide: 12,160
  • In genetics: 554
• Year to date:
  • Site-wide: 29,944
• Since beginning of last month:
  • Site-wide: 8,609

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

• Downloaded 1,581 times
• Download rankings, all-time:
  • Site-wide: 12,550
  • In genetics: 569
• Year to date:
  • Site-wide: 48,327
• Since beginning of last month:
  • Site-wide: 48,189

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,496 times
• Download rankings, all-time:
  • Site-wide: 13,614
  • In genetics: 620
• Year to date:
  • Site-wide: 114,206
• Since beginning of last month:
  • Site-wide: 100,383

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,487 times
• Download rankings, all-time:
  • Site-wide: 13,743
  • In genomics: 1,403
• Year to date:
  • Site-wide: 101,120
• Since beginning of last month:
  • Site-wide: 48,416

Expectation of the intercept from bivariate LD score regression in the presence of population stratification

• Downloaded 1,483 times
• Download rankings, all-time:
  • Site-wide: 13,814
  • In genetics: 634
• Year to date:
  • Site-wide: 20,920
• Since beginning of last month:
  • Site-wide: 106,080

Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms

• Downloaded 1,469 times
• Download rankings, all-time:
  • Site-wide: 14,005
  • In genetics: 642
• Year to date:
  • Site-wide: 46,826
• Since beginning of last month:
  • Site-wide: 18,507

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

• Downloaded 1,454 times
• Download rankings, all-time:
  • Site-wide: 14,245
  • In genetics: 651
• Year to date:
  • Site-wide: 72,414
• Since beginning of last month:
  • Site-wide: 108,669

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

• Downloaded 1,432 times
• Download rankings, all-time:
  • Site-wide: 14,581
  • In genetics: 667
• Year to date:
  • Site-wide: 138,730
• Since beginning of last month:
  • Site-wide: None

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

• Downloaded 1,392 times
• Download rankings, all-time:
  • Site-wide: 15,241
  • In genetics: 701
• Year to date:
  • Site-wide: 37,352
• Since beginning of last month:
  • Site-wide: 88,126

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

• Downloaded 1,372 times
• Download rankings, all-time:
  • Site-wide: 15,594
  • In bioinformatics: 1,808
• Year to date:
  • Site-wide: 65,344
• Since beginning of last month:
  • Site-wide: 102,693

Bayesian reassessment of the epigenetic architecture of complex traits

• Downloaded 1,352 times
• Download rankings, all-time:
  • Site-wide: 15,918
  • In genomics: 1,572
• Year to date:
  • Site-wide: 127,152
• Since beginning of last month:
  • Site-wide: 39,507

Imprint of Assortative Mating on the Human Genome

• Downloaded 1,300 times
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  • Site-wide: 16,919
  • In genetics: 785
• Year to date:
  • Site-wide: 134,217
• Since beginning of last month:
  • Site-wide: 72,325

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 1,164 times
• Download rankings, all-time:
  • Site-wide: 19,876
  • In genetics: 912
• Year to date:
  • Site-wide: 104,635
• Since beginning of last month:
  • Site-wide: 103,652

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 1,130 times
• Download rankings, all-time:
  • Site-wide: 20,754
  • In bioinformatics: 2,379
• Year to date:
  • Site-wide: 136,214
• Since beginning of last month:
  • Site-wide: None

Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors

• Downloaded 1,124 times
• Download rankings, all-time:
  • Site-wide: 20,932
  • In genetics: 962
• Year to date:
  • Site-wide: 8,447
• Since beginning of last month:
  • Site-wide: 2,647

Identification of 55,000 Replicated DNA Methylation QTL

• Downloaded 1,079 times
• Download rankings, all-time:
  • Site-wide: 22,223
  • In genomics: 2,110
• Year to date:
  • Site-wide: 104,644
• Since beginning of last month:
  • Site-wide: 36,118

Probabilistic inference of the genetic architecture of functional enrichment of complex traits

• Downloaded 1,079 times
• Download rankings, all-time:
  • Site-wide: 22,220
  • In genetic and genomic medicine: 92
• Year to date:
  • Site-wide: 5,978
• Since beginning of last month:
  • Site-wide: 47,278

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 1,033 times
• Download rankings, all-time:
  • Site-wide: 23,698
  • In genetic and genomic medicine: 97
• Year to date:
  • Site-wide: 7,723
• Since beginning of last month:
  • Site-wide: 5,935

Epigenetic prediction of complex traits and death

• Downloaded 1,028 times
• Download rankings, all-time:
  • Site-wide: 23,859
  • In genomics: 2,237
• Year to date:
  • Site-wide: 101,474
• Since beginning of last month:
  • Site-wide: None

Polygenic risk for Alzheimer's disease predicts sleep slow-waves and daytime sleepiness in youth

• Downloaded 904 times
• Download rankings, all-time:
  • Site-wide: 28,727
  • In neurology: 67
• Year to date:
  • Site-wide: 37,297
• Since beginning of last month:
  • Site-wide: 42,297

Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

• Downloaded 903 times
• Download rankings, all-time:
  • Site-wide: 28,763
  • In genetics: 1,321
• Year to date:
  • Site-wide: 108,742
• Since beginning of last month:
  • Site-wide: None

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

• Downloaded 841 times
• Download rankings, all-time:
  • Site-wide: 31,819
  • In genetics: 1,461
• Year to date:
  • Site-wide: 134,256
• Since beginning of last month:
  • Site-wide: 51,733

Widespread associations between grey matter structure and the human phenome

• Downloaded 834 times
• Download rankings, all-time:
  • Site-wide: 32,143
  • In neuroscience: 4,202
• Year to date:
  • Site-wide: 101,275
• Since beginning of last month:
  • Site-wide: 45,843

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 816 times
• Download rankings, all-time:
  • Site-wide: 33,113
  • In genetics: 1,525
• Year to date:
  • Site-wide: 126,052
• Since beginning of last month:
  • Site-wide: None

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

• Downloaded 782 times
• Download rankings, all-time:
  • Site-wide: 35,218
  • In genetics: 1,602
• Year to date:
  • Site-wide: 117,402
• Since beginning of last month:
  • Site-wide: None

Quantifying genetic heterogeneity between continental populations for human height and body mass index

• Downloaded 769 times
• Download rankings, all-time:
  • Site-wide: 36,036
  • In genetics: 1,636
• Year to date:
  • Site-wide: 91,672
• Since beginning of last month:
  • Site-wide: 87,371

Genome-wide association study of gastrointestinal disorders reinforces the link between the digestive tract and the nervous system

• Downloaded 756 times
• Download rankings, all-time:
  • Site-wide: 36,965
  • In genomics: 3,086
• Year to date:
  • Site-wide: 32,344
• Since beginning of last month:
  • Site-wide: 99,727

Genome-wide analyses of behavioural traits biased by misreports and longitudinal changes

• Downloaded 754 times
• Download rankings, all-time:
  • Site-wide: 37,060
  • In genetic and genomic medicine: 146
• Year to date:
  • Site-wide: 62,379
• Since beginning of last month:
  • Site-wide: 43,948

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 701 times
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  • Site-wide: 40,925
  • In genetics: 1,841
• Year to date:
  • Site-wide: 115,742
• Since beginning of last month:
  • Site-wide: 31,663

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

• Downloaded 686 times
• Download rankings, all-time:
  • Site-wide: 42,086
  • In genetics: 1,893
• Year to date:
  • Site-wide: 20,423
• Since beginning of last month:
  • Site-wide: 84,105

Epigenetic scores for the circulating proteome as tools for disease prediction

• Downloaded 663 times
• Download rankings, all-time:
  • Site-wide: 44,054
  • In genomics: 3,507
• Year to date:
  • Site-wide: 8,165
• Since beginning of last month:
  • Site-wide: 5,630

Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

• Downloaded 663 times
• Download rankings, all-time:
  • Site-wide: 44,012
  • In genetics: 1,969
• Year to date:
  • Site-wide: 147,237
• Since beginning of last month:
  • Site-wide: None

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

• Downloaded 602 times
• Download rankings, all-time:
  • Site-wide: 49,834
  • In genetics: 2,202
• Year to date:
  • Site-wide: 122,319
• Since beginning of last month:
  • Site-wide: 48,923

No evidence for social genetic effects or genetic similarity among friends beyond that due to population stratification: a reappraisal of Domingue et al (2018)

• Downloaded 596 times
• Download rankings, all-time:
  • Site-wide: 50,464
  • In genetics: 2,232
• Year to date:
  • Site-wide: 128,549
• Since beginning of last month:
  • Site-wide: 49,038

Genetic analyses of medication-use and implications for precision medicine

• Downloaded 580 times
• Download rankings, all-time:
  • Site-wide: 52,224
  • In genetics: 2,310
• Year to date:
  • Site-wide: 83,856
• Since beginning of last month:
  • Site-wide: 73,596

The effect of X-linked dosage compensation on complex trait variation

• Downloaded 550 times
• Download rankings, all-time:
  • Site-wide: 55,745
  • In genetics: 2,452
• Year to date:
  • Site-wide: 138,524
• Since beginning of last month:
  • Site-wide: 112,736

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 62,151
  • In genomics: 4,477
• Year to date:
  • Site-wide: 96,449
• Since beginning of last month:
  • Site-wide: 35,114

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

• Downloaded 404 times
• Download rankings, all-time:
  • Site-wide: 77,737
  • In neuroscience: 11,540
• Year to date:
  • Site-wide: 143,050
• Since beginning of last month:
  • Site-wide: 88,909

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

• Downloaded 378 times
• Download rankings, all-time:
  • Site-wide: 82,659
  • In genetics: 3,599
• Year to date:
  • Site-wide: 102,693
• Since beginning of last month:
  • Site-wide: 123,456

Assortative Mating Biases Marker-based Heritability Estimators

• Downloaded 337 times
• Download rankings, all-time:
  • Site-wide: 91,052
  • In genetics: 3,936
• Year to date:
  • Site-wide: 16,364
• Since beginning of last month:
  • Site-wide: 81,887

An epigenome-wide association study of sex-specific chronological ageing

• Downloaded 336 times
• Download rankings, all-time:
  • Site-wide: 91,310
  • In genomics: 5,729
• Year to date:
  • Site-wide: 152,375
• Since beginning of last month:
  • Site-wide: None

Creating and validating a DNA methylation-based proxy for Interleukin-6

• Downloaded 304 times
• Download rankings, all-time:
  • Site-wide: 98,555
  • In genetic and genomic medicine: 465
• Year to date:
  • Site-wide: 60,769
• Since beginning of last month:
  • Site-wide: 47,531

Epigenetic signatures of starting and stopping smoking

• Downloaded 301 times
• Download rankings, all-time:
  • Site-wide: 99,329
  • In genomics: 6,024
• Year to date:
  • Site-wide: 149,527
• Since beginning of last month:
  • Site-wide: 73,013

A parsimonious model for mass-univariate vertex-wise analysis

• Downloaded 296 times
• Download rankings, all-time:
  • Site-wide: 100,555
  • In neuroscience: 15,130
• Year to date:
  • Site-wide: 19,695
• Since beginning of last month:
  • Site-wide: 28,085

Using prior information from humans to prioritize genes and gene-associated variants for complex traits in livestock

• Downloaded 248 times
• Download rankings, all-time:
  • Site-wide: 112,010
  • In genetics: 4,707
• Year to date:
  • Site-wide: 145,149
• Since beginning of last month:
  • Site-wide: 67,406

Cohort profile: The Australian Parkinson's Genetics Study (APGS)

• Downloaded 204 times
• Download rankings, all-time:
  • Site-wide: 123,064
  • In neurology: 493
• Year to date:
  • Site-wide: 31,897
• Since beginning of last month:
  • Site-wide: 46,351

Variation in VKORC1 is associated with vascular dementia

• Downloaded 161 times
• Download rankings, all-time:
  • Site-wide: 133,266
  • In genetics: 5,408
• Year to date:
  • Site-wide: 96,346
• Since beginning of last month:
  • Site-wide: None

Local CpG density affects the trajectory of age-associated epigenetic changes

• Downloaded 154 times
• Download rankings, all-time:
  • Site-wide: 134,878
  • In genetics: 5,453
• Year to date:
  • Site-wide: 44,328
• Since beginning of last month:
  • Site-wide: 76,817

Maximizing GWAS discovery and genomic prediction accuracy in Biobank data

• Downloaded 8 times
• Download rankings, all-time:
  • Site-wide: 154,401
  • In genomics: 7,679
• Year to date:
  • Site-wide: 154,269
• Since beginning of last month:
  • Site-wide: 58,282