Author: Peter M. Visscher

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Preprints

Recovery of trait heritability from whole genome sequence data

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  • Site-wide: 792
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  • Site-wide: 2,571
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  • Site-wide: 5,513

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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  • Site-wide: 956
  • In genomics: 54
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  • Site-wide: 4,229
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  • Site-wide: 5,858

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

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  • Site-wide: 1,016
  • In genetics: 20
• Year to date:
  • Site-wide: 7,308
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  • Site-wide: 4,709

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,695 times
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  • Site-wide: 1,320
  • In genetics: 26
• Year to date:
  • Site-wide: 36,946
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  • Site-wide: 25,451

Genetic Consequences of Social Stratification in Great Britain

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  • Site-wide: 1,525
  • In genetics: 32
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  • Site-wide: 9,598
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  • Site-wide: 11,218

New mutations, old statistical challenges

• Downloaded 7,293 times
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  • Site-wide: 1,889
  • In genetics: 44
• Year to date:
  • Site-wide: 117,671
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  • Site-wide: 146,556

MTAG: Multi-Trait Analysis of GWAS

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  • Site-wide: 1,915
  • In genomics: 132
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  • Site-wide: 18,894
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  • Site-wide: 33,308

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

• Downloaded 7,071 times
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  • Site-wide: 1,983
  • In genetics: 46
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  • Site-wide: 25,819
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  • Site-wide: 38,958

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

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  • Site-wide: 3,222
  • In genetics: 128
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  • Site-wide: 867

A resource-efficient tool for mixed model association analysis of large-scale data

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  • Site-wide: 5,166
  • In genetics: 186
• Year to date:
  • Site-wide: 12,223
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  • Site-wide: 9,043

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

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  • Site-wide: 5,998
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• Year to date:
  • Site-wide: 61,363
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  • Site-wide: 25,412

Improved polygenic prediction by Bayesian multiple regression on summary statistics

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  • Site-wide: 6,591
  • In genetics: 239
• Year to date:
  • Site-wide: 61,293
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  • Site-wide: 54,284

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

• Downloaded 2,909 times
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  • Site-wide: 6,797
  • In genetic and genomic medicine: 35
• Year to date:
  • Site-wide: 8,452
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  • Site-wide: 6,508

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.

• Downloaded 2,740 times
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  • Site-wide: 7,421
  • In genetics: 274
• Year to date:
  • Site-wide: 142,817
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  • Site-wide: 139,953

Widespread signatures of negative selection in the genetic architecture of human complex traits

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  • Site-wide: 8,665
  • In genetics: 331
• Year to date:
  • Site-wide: 108,123
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  • Site-wide: 93,486

GWAS on family history of Alzheimer's disease

• Downloaded 2,093 times
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  • Site-wide: 11,095
  • In genetics: 406
• Year to date:
  • Site-wide: 133,936
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  • Site-wide: 104,542

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 12,499
  • In genetics: 470
• Year to date:
  • Site-wide: 153,544
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  • Site-wide: 115,147

Causal associations between risk factors and common diseases inferred from GWAS summary data

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  • Site-wide: 13,244
  • In genetics: 499
• Year to date:
  • Site-wide: 164,787
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  • Site-wide: 116,409

Expectation of the intercept from bivariate LD score regression in the presence of population stratification

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  • Site-wide: 13,720
  • In genetics: 578
• Year to date:
  • Site-wide: 29,574
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  • Site-wide: 32,075

Equivalence of LD-Score Regression and Individual-Level-Data Methods

• Downloaded 1,779 times
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  • Site-wide: 14,075
  • In genetics: 570
• Year to date:
  • Site-wide: 61,371
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  • Site-wide: 45,136

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

• Downloaded 1,776 times
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  • Site-wide: 14,124
  • In genetics: 551
• Year to date:
  • Site-wide: 61,453
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  • Site-wide: 91,943

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

• Downloaded 1,763 times
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  • Site-wide: 14,308
  • In genetics: 564
• Year to date:
  • Site-wide: 101,866
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  • Site-wide: 111,862

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

• Downloaded 1,659 times
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  • Site-wide: 15,619
  • In genetics: 624
• Year to date:
  • Site-wide: 104,292
• Since beginning of last month:
  • Site-wide: 114,865

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,603 times
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  • Site-wide: 16,473
  • In genetics: 648
• Year to date:
  • Site-wide: 114,559
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  • Site-wide: 185,024

Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms

• Downloaded 1,580 times
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  • Site-wide: 16,862
  • In genetics: 683
• Year to date:
  • Site-wide: 101,774
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  • Site-wide: 71,928

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,560 times
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  • Site-wide: 17,196
  • In genomics: 1,529
• Year to date:
  • Site-wide: 108,212
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  • Site-wide: 112,183

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

• Downloaded 1,553 times
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  • Site-wide: 17,317
  • In genetics: 697
• Year to date:
  • Site-wide: 88,923
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  • Site-wide: 78,731

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

• Downloaded 1,502 times
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  • Site-wide: 18,210
  • In bioinformatics: 1,897
• Year to date:
  • Site-wide: 78,216
• Since beginning of last month:
  • Site-wide: 113,231

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

• Downloaded 1,501 times
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  • Site-wide: 18,214
  • In genetics: 719
• Year to date:
  • Site-wide: 178,389
• Since beginning of last month:
  • Site-wide: 186,074

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

• Downloaded 1,466 times
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  • Site-wide: 18,890
  • In genetics: 751
• Year to date:
  • Site-wide: 180,345
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  • Site-wide: 146,263

Probabilistic inference of the genetic architecture of functional enrichment of complex traits

• Downloaded 1,463 times
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  • Site-wide: 18,955
  • In genetic and genomic medicine: 97
• Year to date:
  • Site-wide: 41,892
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  • Site-wide: 28,280

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 1,424 times
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  • Site-wide: 19,766
  • In genetic and genomic medicine: 98
• Year to date:
  • Site-wide: 31,747
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  • Site-wide: 58,624

Bayesian reassessment of the epigenetic architecture of complex traits

• Downloaded 1,382 times
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  • Site-wide: 20,711
  • In genomics: 1,779
• Year to date:
  • Site-wide: 152,528
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  • Site-wide: 139,848

Imprint of Assortative Mating on the Human Genome

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  • Site-wide: 20,929
  • In genetics: 836
• Year to date:
  • Site-wide: 148,877
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  • Site-wide: 133,114

Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors

• Downloaded 1,362 times
• Download rankings, all-time:
  • Site-wide: 21,171
  • In genetics: 896
• Year to date:
  • Site-wide: 46,894
• Since beginning of last month:
  • Site-wide: 57,860

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 1,233 times
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  • Site-wide: 24,771
  • In genetics: 974
• Year to date:
  • Site-wide: 148,750
• Since beginning of last month:
  • Site-wide: 160,202

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 1,192 times
• Download rankings, all-time:
  • Site-wide: 26,091
  • In bioinformatics: 2,723
• Year to date:
  • Site-wide: 118,631
• Since beginning of last month:
  • Site-wide: 93,209

Identification of 55,000 Replicated DNA Methylation QTL

• Downloaded 1,116 times
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  • Site-wide: 28,830
  • In genomics: 2,357
• Year to date:
  • Site-wide: 153,708
• Since beginning of last month:
  • Site-wide: 129,828

Polygenic risk for Alzheimer's disease predicts sleep slow-waves and daytime sleepiness in youth

• Downloaded 1,097 times
• Download rankings, all-time:
  • Site-wide: 29,566
  • In neurology: 82
• Year to date:
  • Site-wide: 61,018
• Since beginning of last month:
  • Site-wide: 70,959

Epigenetic prediction of complex traits and death

• Downloaded 1,090 times
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  • Site-wide: 29,883
  • In genomics: 2,437
• Year to date:
  • Site-wide: 133,497
• Since beginning of last month:
  • Site-wide: 85,308

Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

• Downloaded 985 times
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  • Site-wide: 34,743
  • In genetics: 1,381
• Year to date:
  • Site-wide: 99,129
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  • Site-wide: 104,565

Epigenetic scores for the circulating proteome as tools for disease prediction

• Downloaded 984 times
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  • Site-wide: 34,783
  • In genomics: 2,874
• Year to date:
  • Site-wide: 34,630
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  • Site-wide: 58,821

Widespread associations between grey matter structure and the human phenome

• Downloaded 891 times
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  • Site-wide: 40,258
  • In neuroscience: 4,974
• Year to date:
  • Site-wide: 149,202
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  • Site-wide: 131,097

Genome-wide association study of gastrointestinal disorders reinforces the link between the digestive tract and the nervous system

• Downloaded 889 times
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  • Site-wide: 40,408
  • In genomics: 3,091
• Year to date:
  • Site-wide: 112,852
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  • Site-wide: 84,912

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

• Downloaded 888 times
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  • Site-wide: 40,473
  • In genetics: 1,572
• Year to date:
  • Site-wide: 185,345
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  • Site-wide: 187,644

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

• Downloaded 876 times
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  • Site-wide: 41,269
  • In genetics: 1,643
• Year to date:
  • Site-wide: 121,117
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  • Site-wide: 166,062

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

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  • Site-wide: 42,613
  • In genetics: 1,661
• Year to date:
  • Site-wide: 173,873
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  • Site-wide: 159,929

Genome-wide analyses of behavioural traits biased by misreports and longitudinal changes

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  • Site-wide: 44,420
  • In genetic and genomic medicine: 222
• Year to date:
  • Site-wide: 147,771
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  • Site-wide: 126,046

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

• Downloaded 831 times
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  • Site-wide: 44,719
  • In genetics: 1,752
• Year to date:
  • Site-wide: 152,175
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  • Site-wide: 135,972

Quantifying genetic heterogeneity between continental populations for human height and body mass index

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  • Site-wide: 46,939
  • In genetics: 1,816
• Year to date:
  • Site-wide: 183,467
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  • Site-wide: 166,074

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 724 times
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  • Site-wide: 54,511
  • In genetics: 2,095
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  • Site-wide: 180,432
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  • Site-wide: 183,064

Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

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  • Site-wide: 56,818
  • In genetics: 2,163
• Year to date:
  • Site-wide: 187,869
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  • Site-wide: 170,143

Improving GWAS discovery and genomic prediction accuracy in Biobank data

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  • Site-wide: 56,846
  • In genomics: 4,457
• Year to date:
  • Site-wide: 21,822
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  • Site-wide: 23,104

Assortative Mating Biases Marker-based Heritability Estimators

• Downloaded 701 times
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  • Site-wide: 57,054
  • In genetics: 2,404
• Year to date:
  • Site-wide: 37,741
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  • Site-wide: 34,000

No evidence for social genetic effects or genetic similarity among friends beyond that due to population stratification: a reappraisal of Domingue et al (2018)

• Downloaded 649 times
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  • Site-wide: 63,381
  • In genetics: 2,430
• Year to date:
  • Site-wide: 176,095
• Since beginning of last month:
  • Site-wide: 178,326

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

• Downloaded 648 times
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  • Site-wide: 63,560
  • In genetics: 2,444
• Year to date:
  • Site-wide: 159,559
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  • Site-wide: 170,176

Genetic analyses of medication-use and implications for precision medicine

• Downloaded 640 times
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  • Site-wide: 64,573
  • In genetics: 2,468
• Year to date:
  • Site-wide: 181,510
• Since beginning of last month:
  • Site-wide: 141,157

The Australian Parkinson's Genetics Study (APGS) - pilot (N = 1,532)

• Downloaded 609 times
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  • Site-wide: 68,785
  • In neurology: 291
• Year to date:
  • Site-wide: 16,030
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  • Site-wide: 11,522

The effect of X-linked dosage compensation on complex trait variation

• Downloaded 608 times
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  • Site-wide: 68,914
  • In genetics: 2,685
• Year to date:
  • Site-wide: 117,688
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  • Site-wide: 114,737

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

• Downloaded 561 times
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  • Site-wide: 76,265
  • In genomics: 4,855
• Year to date:
  • Site-wide: 146,806
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  • Site-wide: 178,749

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

• Downloaded 486 times
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  • Site-wide: 90,376
  • In neuroscience: 12,411
• Year to date:
  • Site-wide: 134,701
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  • Site-wide: 163,623

A parsimonious model for mass-univariate vertex-wise analysis

• Downloaded 484 times
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  • Site-wide: 90,796
  • In neuroscience: 16,004
• Year to date:
  • Site-wide: 36,029
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  • Site-wide: 36,008

Creating and validating a DNA methylation-based proxy for Interleukin-6

• Downloaded 472 times
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  • Site-wide: 93,216
  • In genetic and genomic medicine: 511
• Year to date:
  • Site-wide: 74,619
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  • Site-wide: 119,411

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

• Downloaded 471 times
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  • Site-wide: 93,546
  • In genetics: 3,556
• Year to date:
  • Site-wide: 142,178
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  • Site-wide: 182,306

An epigenome-wide association study of sex-specific chronological ageing

• Downloaded 369 times
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  • Site-wide: 118,450
  • In genomics: 6,408
• Year to date:
  • Site-wide: 179,918
• Since beginning of last month:
  • Site-wide: 184,093

Epigenetic signatures of starting and stopping smoking

• Downloaded 330 times
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  • Site-wide: 129,320
  • In genomics: 6,771
• Year to date:
  • Site-wide: 173,119
• Since beginning of last month:
  • Site-wide: 146,519

Local CpG density affects the trajectory of age-associated epigenetic changes

• Downloaded 274 times
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  • Site-wide: 145,901
  • In genetics: 5,514
• Year to date:
  • Site-wide: 88,278
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  • Site-wide: 80,730

Using prior information from humans to prioritize genes and gene-associated variants for complex traits in livestock

• Downloaded 269 times
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  • Site-wide: 147,328
  • In genetics: 5,370
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  • Site-wide: 183,277
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  • Site-wide: 152,442

Variation in VKORC1 is associated with vascular dementia

• Downloaded 190 times
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  • Site-wide: 169,106
  • In genetics: 5,981
• Year to date:
  • Site-wide: 187,246
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  • Site-wide: 157,363

Larger cerebral cortex is genetically correlated with greater frontal area and dorsal thickness

• Downloaded 76 times
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  • Site-wide: 188,185
  • In neuroscience: None
• Year to date:
  • Site-wide: 60,956
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  • Site-wide: 12,494