Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,506 bioRxiv papers from 264,779 authors.

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • In genetics: 11 out of 3,295
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  • Site-wide: 1,919 out of 57,506
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  • Site-wide: 8,372 out of 57,506

Recovery of trait heritability from whole genome sequence data

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  • Site-wide: 183 out of 57,506
  • In genetics: 18 out of 3,295
• Year to date:
  • Site-wide: 24 out of 57,506
• Since beginning of last month:
  • Site-wide: 352 out of 57,506

New mutations, old statistical challenges

• Downloaded 6,742 times
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  • Site-wide: 206 out of 57,506
  • In genetics: 22 out of 3,295
• Year to date:
  • Site-wide: 14,052 out of 57,506
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  • Site-wide: 24,130 out of 57,506

Genetic Consequences of Social Stratification in Great Britain

• Downloaded 6,016 times
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  • Site-wide: 261 out of 57,506
  • In genetics: 27 out of 3,295
• Year to date:
  • Site-wide: 615 out of 57,506
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  • Site-wide: 2,813 out of 57,506

MTAG: Multi-Trait Analysis of GWAS

• Downloaded 6,007 times
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  • Site-wide: 262 out of 57,506
  • In genomics: 78 out of 4,027
• Year to date:
  • Site-wide: 4,863 out of 57,506
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  • Site-wide: 5,220 out of 57,506

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

• Downloaded 5,938 times
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  • Site-wide: 269 out of 57,506
  • In genetics: 29 out of 3,295
• Year to date:
  • Site-wide: 91 out of 57,506
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  • Site-wide: 200 out of 57,506

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

• Downloaded 5,326 times
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  • Site-wide: 330 out of 57,506
  • In genetics: 41 out of 3,295
• Year to date:
  • Site-wide: 604 out of 57,506
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  • Site-wide: 1,859 out of 57,506

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

• Downloaded 5,027 times
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  • Site-wide: 364 out of 57,506
  • In genomics: 96 out of 4,027
• Year to date:
  • Site-wide: 140 out of 57,506
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  • Site-wide: 291 out of 57,506

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

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  • Site-wide: 900 out of 57,506
  • In bioinformatics: 181 out of 5,863
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  • Site-wide: 22,708 out of 57,506
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  • Site-wide: 17,140 out of 57,506

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

• Downloaded 2,481 times
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  • In genetics: 137 out of 3,295
• Year to date:
  • Site-wide: 25,899 out of 57,506
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  • Site-wide: 26,899 out of 57,506

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.

• Downloaded 2,358 times
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  • Site-wide: 1,540 out of 57,506
  • In genetics: 149 out of 3,295
• Year to date:
  • Site-wide: 20,272 out of 57,506
• Since beginning of last month:
  • Site-wide: 21,181 out of 57,506

Widespread signatures of negative selection in the genetic architecture of human complex traits

• Downloaded 2,033 times
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  • Site-wide: 1,969 out of 57,506
  • In genetics: 194 out of 3,295
• Year to date:
  • Site-wide: 31,878 out of 57,506
• Since beginning of last month:
  • Site-wide: 36,277 out of 57,506

Improved polygenic prediction by Bayesian multiple regression on summary statistics

• Downloaded 1,748 times
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  • Site-wide: 2,568 out of 57,506
  • In genetics: 233 out of 3,295
• Year to date:
  • Site-wide: 347 out of 57,506
• Since beginning of last month:
  • Site-wide: 984 out of 57,506

GWAS on family history of Alzheimer's disease

• Downloaded 1,719 times
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  • Site-wide: 2,651 out of 57,506
  • In genetics: 242 out of 3,295
• Year to date:
  • Site-wide: 15,386 out of 57,506
• Since beginning of last month:
  • Site-wide: 24,179 out of 57,506

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

• Downloaded 1,588 times
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  • Site-wide: 3,034 out of 57,506
  • In genetics: 274 out of 3,295
• Year to date:
  • Site-wide: 41,869 out of 57,506
• Since beginning of last month:
  • Site-wide: 35,545 out of 57,506

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

• Downloaded 1,316 times
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  • Site-wide: 4,133 out of 57,506
  • In genetics: 351 out of 3,295
• Year to date:
  • Site-wide: 48,860 out of 57,506
• Since beginning of last month:
  • Site-wide: 45,027 out of 57,506

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,260 times
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  • Site-wide: 4,425 out of 57,506
  • In genomics: 794 out of 4,027
• Year to date:
  • Site-wide: 16,080 out of 57,506
• Since beginning of last month:
  • Site-wide: 30,881 out of 57,506

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

• Downloaded 1,178 times
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  • Site-wide: 4,918 out of 57,506
  • In genetics: 409 out of 3,295
• Year to date:
  • Site-wide: 8,296 out of 57,506
• Since beginning of last month:
  • Site-wide: 11,490 out of 57,506

Imprint of Assortative Mating on the Human Genome

• Downloaded 1,072 times
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  • Site-wide: 5,775 out of 57,506
  • In genetics: 477 out of 3,295
• Year to date:
  • Site-wide: 9,969 out of 57,506
• Since beginning of last month:
  • Site-wide: 10,731 out of 57,506

Equivalence of LD-Score Regression and Individual-Level-Data Methods

• Downloaded 1,005 times
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  • Site-wide: 6,414 out of 57,506
  • In genetics: 523 out of 3,295
• Year to date:
  • Site-wide: 10,315 out of 57,506
• Since beginning of last month:
  • Site-wide: 15,541 out of 57,506

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

• Downloaded 923 times
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  • Site-wide: 7,354 out of 57,506
  • In genetics: 584 out of 3,295
• Year to date:
  • Site-wide: 1,223 out of 57,506
• Since beginning of last month:
  • Site-wide: 7,902 out of 57,506

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 909 times
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  • Site-wide: 7,536 out of 57,506
  • In bioinformatics: 1,349 out of 5,863
• Year to date:
  • Site-wide: 3,064 out of 57,506
• Since beginning of last month:
  • Site-wide: 22,038 out of 57,506

A resource-efficient tool for mixed model association analysis of large-scale data

• Downloaded 890 times
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  • Site-wide: 7,777 out of 57,506
  • In genetics: 609 out of 3,295
• Year to date:
  • Site-wide: 1,297 out of 57,506
• Since beginning of last month:
  • Site-wide: 2,890 out of 57,506

Identification of 55,000 Replicated DNA Methylation QTL

• Downloaded 846 times
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  • Site-wide: 8,407 out of 57,506
  • In genomics: 1,289 out of 4,027
• Year to date:
  • Site-wide: 29,560 out of 57,506
• Since beginning of last month:
  • Site-wide: 19,393 out of 57,506

Epigenetic prediction of complex traits and death

• Downloaded 841 times
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  • Site-wide: 8,503 out of 57,506
  • In genomics: 1,306 out of 4,027
• Year to date:
  • Site-wide: 34,472 out of 57,506
• Since beginning of last month:
  • Site-wide: 38,682 out of 57,506

Expectation of the intercept from bivariate LD score regression in the presence of population stratification

• Downloaded 714 times
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  • Site-wide: 10,806 out of 57,506
  • In genetics: 784 out of 3,295
• Year to date:
  • Site-wide: 10,698 out of 57,506
• Since beginning of last month:
  • Site-wide: 6,432 out of 57,506

Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms

• Downloaded 712 times
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  • Site-wide: 10,866 out of 57,506
  • In genetics: 786 out of 3,295
• Year to date:
  • Site-wide: 4,593 out of 57,506
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  • Site-wide: 5,072 out of 57,506

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

• Downloaded 676 times
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  • Site-wide: 11,697 out of 57,506
  • In genetics: 843 out of 3,295
• Year to date:
  • Site-wide: 34,533 out of 57,506
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  • Site-wide: 47,476 out of 57,506

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 652 times
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  • Site-wide: 12,320 out of 57,506
  • In genetics: 885 out of 3,295
• Year to date:
  • Site-wide: 25,277 out of 57,506
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  • Site-wide: 47,808 out of 57,506

Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

• Downloaded 644 times
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  • Site-wide: 12,522 out of 57,506
  • In genetics: 902 out of 3,295
• Year to date:
  • Site-wide: 15,261 out of 57,506
• Since beginning of last month:
  • Site-wide: 16,381 out of 57,506

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 598 times
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  • Site-wide: 13,805 out of 57,506
  • In genetics: 984 out of 3,295
• Year to date:
  • Site-wide: 2,613 out of 57,506
• Since beginning of last month:
  • Site-wide: 165 out of 57,506

Bayesian reassessment of the epigenetic architecture of complex traits

• Downloaded 573 times
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  • Site-wide: 14,674 out of 57,506
  • In genomics: 1,896 out of 4,027
• Year to date:
  • Site-wide: 10,776 out of 57,506
• Since beginning of last month:
  • Site-wide: 17,726 out of 57,506

Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

• Downloaded 555 times
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  • Site-wide: 15,335 out of 57,506
  • In genetics: 1,066 out of 3,295
• Year to date:
  • Site-wide: 47,990 out of 57,506
• Since beginning of last month:
  • Site-wide: 52,806 out of 57,506

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 536 times
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  • Site-wide: 16,017 out of 57,506
  • In genetics: 1,110 out of 3,295
• Year to date:
  • Site-wide: 37,922 out of 57,506
• Since beginning of last month:
  • Site-wide: 25,787 out of 57,506

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

• Downloaded 466 times
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  • Site-wide: 19,003 out of 57,506
  • In genetics: 1,306 out of 3,295
• Year to date:
  • Site-wide: 54,360 out of 57,506
• Since beginning of last month:
  • Site-wide: 54,448 out of 57,506

The effect of X-linked dosage compensation on complex trait variation

• Downloaded 379 times
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  • Site-wide: 23,845 out of 57,506
  • In genetics: 1,584 out of 3,295
• Year to date:
  • Site-wide: 20,956 out of 57,506
• Since beginning of last month:
  • Site-wide: 19,821 out of 57,506

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

• Downloaded 378 times
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  • Site-wide: 23,911 out of 57,506
  • In genetics: 1,588 out of 3,295
• Year to date:
  • Site-wide: 5,597 out of 57,506
• Since beginning of last month:
  • Site-wide: 8,990 out of 57,506

Widespread associations between grey matter structure and the human phenome

• Downloaded 360 times
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  • Site-wide: 25,120 out of 57,506
  • In neuroscience: 4,247 out of 10,103
• Year to date:
  • Site-wide: 6,069 out of 57,506
• Since beginning of last month:
  • Site-wide: 413 out of 57,506

No evidence for social genetic effects or genetic similarity among friends beyond that due to population stratification: a reappraisal of Domingue et al (2018)

• Downloaded 357 times
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  • Site-wide: 25,312 out of 57,506
  • In genetics: 1,665 out of 3,295
• Year to date:
  • Site-wide: 6,157 out of 57,506
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  • Site-wide: 7,329 out of 57,506

Genetic analyses of medication-use and implications for precision medicine

• Downloaded 325 times
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  • Site-wide: 27,727 out of 57,506
  • In genetics: 1,798 out of 3,295
• Year to date:
  • Site-wide: 14,211 out of 57,506
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  • Site-wide: 50,231 out of 57,506

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

• Downloaded 243 times
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  • Site-wide: 35,283 out of 57,506
  • In neuroscience: 6,058 out of 10,103
• Year to date:
  • Site-wide: 11,363 out of 57,506
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  • Site-wide: 15,889 out of 57,506

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 233 times
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  • Site-wide: 36,254 out of 57,506
  • In neuroscience: 6,263 out of 10,103
• Year to date:
  • Site-wide: 12,110 out of 57,506
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  • Site-wide: 11,541 out of 57,506

An epigenome-wide association study of sex-specific chronological ageing

• Downloaded 206 times
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  • Site-wide: 39,263 out of 57,506
  • In genomics: 3,390 out of 4,027
• Year to date:
  • Site-wide: 14,389 out of 57,506
• Since beginning of last month:
  • Site-wide: 18,373 out of 57,506

Epigenetic signatures of starting and stopping smoking

• Downloaded 197 times
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  • Site-wide: 40,443 out of 57,506
  • In genomics: 3,428 out of 4,027
• Year to date:
  • Site-wide: 55,621 out of 57,506
• Since beginning of last month:
  • Site-wide: 54,690 out of 57,506