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Author: Jian Yang

Rankings

  • All-time downloads: 168,483 (rank: 843 )
  • Categories:
    • biochemistry: 364 (rank: 21,338 (tie) )
    • bioengineering: 224 (rank: 17,804 (tie) )
    • bioinformatics: 6,595 (rank: 2,131 )
    • developmental biology: 8,410 (rank: 121 )
    • evolutionary biology: 823 (rank: 11,148 (tie) )
    • genetic and genomic medicine: 3,521 (rank: 1,251 (tie) )
    • genetics: 113,478 (rank: 15 )
    • genomics: 21,861 (rank: 645 )
    • infectious diseases: 531 (rank: 44,451 (tie) )
    • intensive care and critical care medicine: 1,960 (rank: 752 (tie) )
    • microbiology: 896 (rank: 22,735 (tie) )
    • molecular biology: 112 (rank: 34,983 (tie) )
    • neuroscience: 1,093 (rank: 29,841 (tie) )
    • pharmacology and toxicology: 448 (rank: 4,698 (tie) )
    • psychiatry and clinical psychology: 375 (rank: 4,884 (tie) )
    • radiology and imaging: 1,732 (rank: 235 (tie) )
    • zoology: 180 (rank: 3,570 (tie) )

Downloads per author, site-wide

Preprints

Recovery of trait heritability from whole genome sequence data

genetics more details view paper
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    • Site-wide: 792
    • In genetics: 14
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    • Site-wide: 2,571
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    • Site-wide: 5,513

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

genomics more details view paper
  • Downloaded 12,580 times
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    • Site-wide: 956
    • In genomics: 54
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    • Site-wide: 4,229
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    • Site-wide: 5,858

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

genetics more details view paper
  • Downloaded 12,020 times
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    • Site-wide: 1,016
    • In genetics: 20
  • Year to date:
    • Site-wide: 7,308
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    • Site-wide: 4,709

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

genetics more details view paper
  • Downloaded 9,695 times
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    • Site-wide: 1,320
    • In genetics: 26
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    • Site-wide: 36,946
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    • Site-wide: 25,451

Genetic Consequences of Social Stratification in Great Britain

genetics more details view paper
  • Downloaded 8,685 times
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    • Site-wide: 1,525
    • In genetics: 32
  • Year to date:
    • Site-wide: 9,598
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    • Site-wide: 11,218

LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

genomics more details view paper
  • Downloaded 7,342 times
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    • Site-wide: 1,874
    • In genomics: 128
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    • Site-wide: 66,333
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    • Site-wide: 71,987

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

genetics more details view paper
  • Downloaded 7,071 times
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    • Site-wide: 1,983
    • In genetics: 46
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    • Site-wide: 38,958

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

genetics more details view paper
  • Downloaded 4,927 times
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    • Site-wide: 3,222
    • In genetics: 128
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    • Site-wide: 197
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    • Site-wide: 867

Human Naïve Epiblast Cells Possess Unrestricted Lineage Potential

developmental biology more details view paper
  • Downloaded 4,368 times
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    • Site-wide: 3,787
    • In developmental biology: 31
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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

genetics more details view paper
  • Downloaded 3,777 times
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    • Site-wide: 4,659
    • In genetics: 141
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    • Site-wide: 76,053

A resource-efficient tool for mixed model association analysis of large-scale data

genetics more details view paper
  • Downloaded 3,518 times
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    • Site-wide: 5,166
    • In genetics: 186
  • Year to date:
    • Site-wide: 12,223
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    • Site-wide: 9,043

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

bioinformatics more details view paper
  • Downloaded 3,465 times
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    • Site-wide: 5,282
    • In bioinformatics: 436
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    • Site-wide: 176,940

Haplotypes of common SNPs can explain missing heritability of complex diseases

genetics more details view paper
  • Downloaded 3,231 times
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    • Site-wide: 5,846
    • In genetics: 198
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    • Site-wide: 154,478
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Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

genetics more details view paper
  • Downloaded 3,173 times
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    • Site-wide: 5,998
    • In genetics: 208
  • Year to date:
    • Site-wide: 61,363
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    • Site-wide: 25,412

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

genetics more details view paper
  • Downloaded 2,976 times
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    • Site-wide: 6,590
    • In genetics: 253
  • Year to date:
    • Site-wide: 13,634
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    • Site-wide: 13,214

Improved polygenic prediction by Bayesian multiple regression on summary statistics

genetics more details view paper
  • Downloaded 2,975 times
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    • Site-wide: 6,591
    • In genetics: 239
  • Year to date:
    • Site-wide: 61,293
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    • Site-wide: 54,284

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

genetic and genomic medicine more details view paper
  • Downloaded 2,909 times
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    • Site-wide: 6,797
    • In genetic and genomic medicine: 35
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    • Site-wide: 8,452
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    • Site-wide: 6,508

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.

genetics more details view paper
  • Downloaded 2,740 times
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    • Site-wide: 7,421
    • In genetics: 274
  • Year to date:
    • Site-wide: 142,817
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    • Site-wide: 139,953

Widespread signatures of negative selection in the genetic architecture of human complex traits

genetics more details view paper
  • Downloaded 2,467 times
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    • Site-wide: 8,665
    • In genetics: 331
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    • Site-wide: 108,123
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    • Site-wide: 93,486

Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19

intensive care and critical care medicine more details view paper
  • Downloaded 2,153 times
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    • Site-wide: 10,571
    • In intensive care and critical care medicine: 52
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    • Site-wide: 4,499
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    • Site-wide: 17,218

GWAS on family history of Alzheimer's disease

genetics more details view paper
  • Downloaded 2,093 times
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    • Site-wide: 11,095
    • In genetics: 406
  • Year to date:
    • Site-wide: 133,936
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    • Site-wide: 104,542

Establishment In Culture Of Expanded Potential Stem Cells

developmental biology more details view paper
  • Downloaded 1,893 times
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    • Site-wide: 12,864
    • In developmental biology: 150
  • Year to date:
    • Site-wide: 117,175
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    • Site-wide: 94,047

Causal associations between risk factors and common diseases inferred from GWAS summary data

genetics more details view paper
  • Downloaded 1,854 times
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    • Site-wide: 13,244
    • In genetics: 499
  • Year to date:
    • Site-wide: 164,787
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    • Site-wide: 116,409

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

genetics more details view paper
  • Downloaded 1,817 times
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    • Site-wide: 13,636
    • In genetics: 517
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    • Site-wide: 145,649
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    • Site-wide: 91,115

Expectation of the intercept from bivariate LD score regression in the presence of population stratification

genetics more details view paper
  • Downloaded 1,808 times
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    • Site-wide: 13,720
    • In genetics: 578
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    • Site-wide: 29,574
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    • Site-wide: 32,075

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

genetics more details view paper
  • Downloaded 1,776 times
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    • Site-wide: 14,124
    • In genetics: 551
  • Year to date:
    • Site-wide: 61,453
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    • Site-wide: 91,943

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

genetics more details view paper
  • Downloaded 1,763 times
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    • Site-wide: 14,308
    • In genetics: 564
  • Year to date:
    • Site-wide: 101,866
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    • Site-wide: 111,862

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

genetics more details view paper
  • Downloaded 1,659 times
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    • Site-wide: 15,619
    • In genetics: 624
  • Year to date:
    • Site-wide: 104,292
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    • Site-wide: 114,865

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

genetics more details view paper
  • Downloaded 1,603 times
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    • Site-wide: 16,473
    • In genetics: 648
  • Year to date:
    • Site-wide: 114,559
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    • Site-wide: 185,024

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

genetics more details view paper
  • Downloaded 1,553 times
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    • Site-wide: 17,317
    • In genetics: 697
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    • Site-wide: 88,923
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    • Site-wide: 78,731

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

bioinformatics more details view paper
  • Downloaded 1,502 times
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    • Site-wide: 18,210
    • In bioinformatics: 1,897
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    • Site-wide: 78,216
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    • Site-wide: 113,231

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

genetics more details view paper
  • Downloaded 1,501 times
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    • Site-wide: 18,214
    • In genetics: 719
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    • Site-wide: 178,389
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    • Site-wide: 186,074

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

genetics more details view paper
  • Downloaded 1,466 times
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    • Site-wide: 18,890
    • In genetics: 751
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    • Site-wide: 180,345
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    • Site-wide: 146,263

Imprint of Assortative Mating on the Human Genome

genetics more details view paper
  • Downloaded 1,373 times
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    • Site-wide: 20,929
    • In genetics: 836
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    • Site-wide: 148,877
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    • Site-wide: 133,114

Organizing Pneumonia of COVID-19: Time-dependent Evolution and Outcome in CT Findings

radiology and imaging more details view paper
  • Downloaded 1,362 times
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    • Site-wide: 21,167
    • In radiology and imaging: 45
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    • Site-wide: 133,038
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    • Site-wide: 118,602

Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors

genetics more details view paper
  • Downloaded 1,362 times
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    • Site-wide: 21,171
    • In genetics: 896
  • Year to date:
    • Site-wide: 46,894
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    • Site-wide: 57,860

Subtle stratification confounds estimates of heritability from rare variants

genetics more details view paper
  • Downloaded 1,284 times
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    • Site-wide: 23,232
    • In genetics: 926
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    • Site-wide: 118,177
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    • Site-wide: 104,351

Efficient estimation and applications of cross-validated genetic predictions

genetics more details view paper
  • Downloaded 1,275 times
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    • Site-wide: 23,484
    • In genetics: 950
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    • Site-wide: 85,199
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Efficient RNA-mediated reprogramming of human somatic cells to naive pluripotency facilitated by tankyrase inhibition

developmental biology more details view paper
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    • Site-wide: 24,241
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Narrow-sense heritability estimation of complex traits using identity-by-descent information.

genetics more details view paper
  • Downloaded 1,233 times
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    • Site-wide: 24,771
    • In genetics: 974
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    • Site-wide: 148,750
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    • Site-wide: 160,202

OSCA: a tool for omic-data-based complex trait analysis

bioinformatics more details view paper
  • Downloaded 1,192 times
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    • Site-wide: 26,091
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A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

genomics more details view paper
  • Downloaded 1,166 times
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    • Site-wide: 26,951
    • In genomics: 2,592
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    • Site-wide: 9,612
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    • Site-wide: 36,447

Identification of 55,000 Replicated DNA Methylation QTL

genomics more details view paper
  • Downloaded 1,116 times
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    • Site-wide: 28,830
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    • Site-wide: 153,708
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    • Site-wide: 129,828

Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

genetics more details view paper
  • Downloaded 985 times
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    • Site-wide: 34,743
    • In genetics: 1,381
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    • Site-wide: 99,129
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    • Site-wide: 104,565

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

genetics more details view paper
  • Downloaded 876 times
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    • Site-wide: 41,269
    • In genetics: 1,643
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    • Site-wide: 121,117
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    • Site-wide: 166,062

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

genetics more details view paper
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    • Site-wide: 42,613
    • In genetics: 1,661
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    • Site-wide: 173,873
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Genome-wide analyses of behavioural traits biased by misreports and longitudinal changes

genetic and genomic medicine more details view paper
  • Downloaded 835 times
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    • Site-wide: 44,420
    • In genetic and genomic medicine: 222
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    • Site-wide: 126,046

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

genetics more details view paper
  • Downloaded 831 times
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    • Site-wide: 44,719
    • In genetics: 1,752
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    • Site-wide: 152,175
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    • Site-wide: 135,972

The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for human complex diseases

microbiology more details view paper
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    • Site-wide: 46,015
    • In microbiology: 2,612
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    • Site-wide: 85,020
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    • Site-wide: 152,610

Quantifying genetic heterogeneity between continental populations for human height and body mass index

genetics more details view paper
  • Downloaded 803 times
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    • Site-wide: 46,939
    • In genetics: 1,816
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    • Site-wide: 183,467
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Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

genetics more details view paper
  • Downloaded 703 times
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    • Site-wide: 56,818
    • In genetics: 2,163
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    • Site-wide: 170,143

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

genetics more details view paper
  • Downloaded 648 times
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    • Site-wide: 63,515
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    • Site-wide: 134,953
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    • Site-wide: 148,850

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

genetics more details view paper
  • Downloaded 648 times
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    • Site-wide: 63,560
    • In genetics: 2,444
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    • Site-wide: 170,176

Genetic analyses of medication-use and implications for precision medicine

genetics more details view paper
  • Downloaded 640 times
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    • Site-wide: 64,573
    • In genetics: 2,468
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    • Site-wide: 181,510
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    • Site-wide: 141,157

Evolution in Sinocyclocheilus cavefish is marked by rate shifts, reversals and origin of novel traits

evolutionary biology more details view paper
  • Downloaded 627 times
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    • Site-wide: 66,265
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    • Site-wide: 161,529
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    • Site-wide: 158,022

The effect of X-linked dosage compensation on complex trait variation

genetics more details view paper
  • Downloaded 608 times
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    • Site-wide: 68,914
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    • Site-wide: 114,737

Xist Intron 1 Repression by TALE Transcriptional Factor Improves Somatic Cell Reprogamming in Mice

developmental biology more details view paper
  • Downloaded 593 times
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    • Site-wide: 71,251
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Towards the identification of causal genes for age-related macular degeneration

genetics more details view paper
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The Parkinsons Disease Mendelian Randomization Research Portal

neuroscience more details view paper
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DAZL is a master translational regulator of murine spermatogenesis

developmental biology more details view paper
  • Downloaded 555 times
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    • Site-wide: 77,358
    • In developmental biology: 1,800
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A pattern categorization of CT findings to predict outcome of COVID-19 pneumonia

infectious diseases more details view paper
  • Downloaded 552 times
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    • Site-wide: 77,764
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Exploring morphological motifs for a single neuron based on multiple 3D reconstructions

bioinformatics more details view paper
  • Downloaded 521 times
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A parsimonious model for mass-univariate vertex-wise analysis

neuroscience more details view paper
  • Downloaded 484 times
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Synthesis-Free PET Imaging Of Brown Adipose Tissue And TSPO Via Combination Of Disulfiram And 64CuCl2

pharmacology and toxicology more details view paper
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Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

genetics more details view paper
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Sequencing uracil in DNA at single-nucleotide resolution

biochemistry more details view paper
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Differences of clinical and imaging findings in multiple generations of secondary COVID-19 infection in Xi'an, China

radiology and imaging more details view paper
  • Downloaded 411 times
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    • Site-wide: 107,512
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    • Site-wide: 103,556

Efficacy and Acceptability Comparisons of Cognitive Behavior Therapy, Drugs, and Their Combination for Panic Disorder in Adults: a Network Meta-analysis

psychiatry and clinical psychology more details view paper
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The role of glycaemic, lipid, blood pressure and obesity risk factors as mediators of the effect of height on Coronary Artery Disease and Type 2 Diabetes Mellitus: A Mendelian Randomisation Study.

genetics more details view paper
  • Downloaded 335 times
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    • Site-wide: 177,879

Cross-Species Integration of Transcriptomic Effects of Tobacco and Nicotine Exposure Helps to Prioritize Genetic Effects on Human Tobacco Consumption

genetics more details view paper
  • Downloaded 324 times
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Ancient genomes redate the extinction of Sussemionus, a subgenus of Equus, to late Holocene

genomics more details view paper
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Evolving in the darkness: phylogenomics of Sinocyclocheilus cavefishes highlights recent diversification and cryptic diversity

evolutionary biology more details view paper
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Characterization and expression QTL analysis of TaABI4, a pre-harvest sprouting related gene in wheat

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Circuit-free, optoelectronic sensing of electrodermal activities based on photon recycling of a micro-LED

bioengineering more details view paper
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Sensory convergence in the world s largest cavefish diversification: patterns of neuromast evolution, distribution and associated behaviour in Sinocyclocheilus

zoology more details view paper
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Robust genome editing via modRNA-based Cas9 or base editor in human pluripotent stem cells

bioengineering more details view paper
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BigNeuron: A resource to benchmark and predict best-performing algorithms for automated reconstruction of neuronal morphology

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Designing a novel monitoring approach for the effects of space travel on astronauts' health

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Adapting to novel environments together: evolutionary and ecological correlates of the bacterial microbiome of the worlds largest cavefish diversification

microbiology more details view paper
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Once delayed non-invasive remote ischemic preconditioning protects against early stroke by modulating  neuroinflammatory responses in rats

neuroscience more details view paper
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Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathy

neuroscience more details view paper
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Larger cerebral cortex is genetically correlated with greater frontal area and dorsal thickness

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