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Author: Jian Yang

  • ORCiD: http://orcid.org/0000-0003-2001-2474
  • Most recently observed institution: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia; School of Life Sciences, Westlake University, Hangzhou Zhejiang, China

Rankings

  • All-time downloads: 140,540 (rank: 609 )
  • Categories:
    • bioengineering: 144 (rank: 14,897 (tie) )
    • bioinformatics: 6,310 (rank: 1,800 )
    • developmental biology: 7,475 (rank: 109 )
    • evolutionary biology: 502 (rank: 13,992 (tie) )
    • genetic and genomic medicine: 2,507 (rank: 1,067 (tie) )
    • genetics: 100,599 (rank: 18 )
    • genomics: 18,814 (rank: 706 )
    • infectious diseases: 454 (rank: 33,169 (tie) )
    • microbiology: 668 (rank: 22,027 (tie) )
    • neuroscience: 850 (rank: 28,768 (tie) )
    • pharmacology and toxicology: 417 (rank: 3,459 (tie) )
    • psychiatry and clinical psychology: 265 (rank: 3,747 (tie) )
    • radiology and imaging: 1,535 (rank: 203 (tie) )

Downloads per author, site-wide

Preprints

Recovery of trait heritability from whole genome sequence data

genetics more details view paper
  • Downloaded 11,755 times
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    • Site-wide: 701
    • In genetics: 17
  • Year to date:
    • Site-wide: 3,170
  • Since beginning of last month:
    • Site-wide: None

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

genetics more details view paper
  • Downloaded 11,033 times
  • Download rankings, all-time:
    • Site-wide: 764
    • In genetics: 20
  • Year to date:
    • Site-wide: 3,484
  • Since beginning of last month:
    • Site-wide: 6,874

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

genomics more details view paper
  • Downloaded 10,571 times
  • Download rankings, all-time:
    • Site-wide: 813
    • In genomics: 60
  • Year to date:
    • Site-wide: 1,217
  • Since beginning of last month:
    • Site-wide: 1,152

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

genetics more details view paper
  • Downloaded 9,423 times
  • Download rankings, all-time:
    • Site-wide: 937
    • In genetics: 26
  • Year to date:
    • Site-wide: 37,647
  • Since beginning of last month:
    • Site-wide: 45,385

Genetic Consequences of Social Stratification in Great Britain

genetics more details view paper
  • Downloaded 7,862 times
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    • Site-wide: 1,181
    • In genetics: 34
  • Year to date:
    • Site-wide: 9,784
  • Since beginning of last month:
    • Site-wide: 6,327

LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

genomics more details view paper
  • Downloaded 7,189 times
  • Download rankings, all-time:
    • Site-wide: 1,318
    • In genomics: 117
  • Year to date:
    • Site-wide: 78,022
  • Since beginning of last month:
    • Site-wide: 96,994

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

genetics more details view paper
  • Downloaded 6,704 times
  • Download rankings, all-time:
    • Site-wide: 1,440
    • In genetics: 45
  • Year to date:
    • Site-wide: 17,562
  • Since beginning of last month:
    • Site-wide: 10,875

Human Naïve Epiblast Cells Possess Unrestricted Lineage Potential

developmental biology more details view paper
  • Downloaded 3,735 times
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    • Site-wide: 3,281
    • In developmental biology: 28
  • Year to date:
    • Site-wide: 2,025
  • Since beginning of last month:
    • Site-wide: 3,856

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

genetics more details view paper
  • Downloaded 3,568 times
  • Download rankings, all-time:
    • Site-wide: 3,500
    • In genetics: 127
  • Year to date:
    • Site-wide: 38,747
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    • Site-wide: 41,625

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

bioinformatics more details view paper
  • Downloaded 3,405 times
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    • Site-wide: 3,729
    • In bioinformatics: 370
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    • Site-wide: 67,230
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    • Site-wide: 74,873

Haplotypes of common SNPs can explain missing heritability of complex diseases

genetics more details view paper
  • Downloaded 3,104 times
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    • Site-wide: 4,252
    • In genetics: 173
  • Year to date:
    • Site-wide: 76,406
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    • Site-wide: 67,382

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

genetics more details view paper
  • Downloaded 3,002 times
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    • Site-wide: 4,453
    • In genetics: 186
  • Year to date:
    • Site-wide: 27,097
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    • Site-wide: 26,736

A resource-efficient tool for mixed model association analysis of large-scale data

genetics more details view paper
  • Downloaded 2,864 times
  • Download rankings, all-time:
    • Site-wide: 4,750
    • In genetics: 204
  • Year to date:
    • Site-wide: 12,436
  • Since beginning of last month:
    • Site-wide: 12,935

Improved polygenic prediction by Bayesian multiple regression on summary statistics

genetics more details view paper
  • Downloaded 2,795 times
  • Download rankings, all-time:
    • Site-wide: 4,935
    • In genetics: 211
  • Year to date:
    • Site-wide: 69,007
  • Since beginning of last month:
    • Site-wide: 66,868

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.

genetics more details view paper
  • Downloaded 2,652 times
  • Download rankings, all-time:
    • Site-wide: 5,313
    • In genetics: 236
  • Year to date:
    • Site-wide: 81,705
  • Since beginning of last month:
    • Site-wide: 42,497

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

genetics more details view paper
  • Downloaded 2,443 times
  • Download rankings, all-time:
    • Site-wide: 6,042
    • In genetics: 270
  • Year to date:
    • Site-wide: 7,381
  • Since beginning of last month:
    • Site-wide: 7,686

Widespread signatures of negative selection in the genetic architecture of human complex traits

genetics more details view paper
  • Downloaded 2,300 times
  • Download rankings, all-time:
    • Site-wide: 6,582
    • In genetics: 302
  • Year to date:
    • Site-wide: 39,403
  • Since beginning of last month:
    • Site-wide: 18,991

GWAS on family history of Alzheimer's disease

genetics more details view paper
  • Downloaded 2,004 times
  • Download rankings, all-time:
    • Site-wide: 8,038
    • In genetics: 362
  • Year to date:
    • Site-wide: 75,187
  • Since beginning of last month:
    • Site-wide: 90,958

Causal associations between risk factors and common diseases inferred from GWAS summary data

genetics more details view paper
  • Downloaded 1,795 times
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    • Site-wide: 9,490
    • In genetics: 436
  • Year to date:
    • Site-wide: 87,157
  • Since beginning of last month:
    • Site-wide: 90,898

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

genetic and genomic medicine more details view paper
  • Downloaded 1,785 times
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    • Site-wide: 9,560
    • In genetic and genomic medicine: 36
  • Year to date:
    • Site-wide: 1,868
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    • Site-wide: 497

Establishment In Culture Of Expanded Potential Stem Cells

developmental biology more details view paper
  • Downloaded 1,744 times
  • Download rankings, all-time:
    • Site-wide: 9,922
    • In developmental biology: 133
  • Year to date:
    • Site-wide: 64,011
  • Since beginning of last month:
    • Site-wide: 38,936

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

genetics more details view paper
  • Downloaded 1,724 times
  • Download rankings, all-time:
    • Site-wide: 10,077
    • In genetics: 468
  • Year to date:
    • Site-wide: 89,471
  • Since beginning of last month:
    • Site-wide: 95,150

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

genetics more details view paper
  • Downloaded 1,638 times
  • Download rankings, all-time:
    • Site-wide: 10,862
    • In genetics: 505
  • Year to date:
    • Site-wide: 59,075
  • Since beginning of last month:
    • Site-wide: 48,868

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

genetics more details view paper
  • Downloaded 1,558 times
  • Download rankings, all-time:
    • Site-wide: 11,687
    • In genetics: 547
  • Year to date:
    • Site-wide: 19,673
  • Since beginning of last month:
    • Site-wide: 25,200

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

genetics more details view paper
  • Downloaded 1,531 times
  • Download rankings, all-time:
    • Site-wide: 11,952
    • In genetics: 562
  • Year to date:
    • Site-wide: 46,856
  • Since beginning of last month:
    • Site-wide: 74,292

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

genetics more details view paper
  • Downloaded 1,486 times
  • Download rankings, all-time:
    • Site-wide: 12,500
    • In genetics: 591
  • Year to date:
    • Site-wide: 91,564
  • Since beginning of last month:
    • Site-wide: 90,430

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

genetics more details view paper
  • Downloaded 1,438 times
  • Download rankings, all-time:
    • Site-wide: 13,177
    • In genetics: 625
  • Year to date:
    • Site-wide: 54,725
  • Since beginning of last month:
    • Site-wide: 99,644

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

genetics more details view paper
  • Downloaded 1,424 times
  • Download rankings, all-time:
    • Site-wide: 13,381
    • In genetics: 637
  • Year to date:
    • Site-wide: 120,583
  • Since beginning of last month:
    • Site-wide: 121,941

Expectation of the intercept from bivariate LD score regression in the presence of population stratification

genetics more details view paper
  • Downloaded 1,388 times
  • Download rankings, all-time:
    • Site-wide: 13,913
    • In genetics: 657
  • Year to date:
    • Site-wide: 21,367
  • Since beginning of last month:
    • Site-wide: 25,449

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

genetics more details view paper
  • Downloaded 1,358 times
  • Download rankings, all-time:
    • Site-wide: 14,376
    • In genetics: 681
  • Year to date:
    • Site-wide: 29,418
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    • Site-wide: 28,395

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

bioinformatics more details view paper
  • Downloaded 1,341 times
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    • Site-wide: 14,657
    • In bioinformatics: 1,744
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    • Site-wide: 57,269
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    • Site-wide: 90,420

Imprint of Assortative Mating on the Human Genome

genetics more details view paper
  • Downloaded 1,282 times
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    • Site-wide: 15,684
    • In genetics: 752
  • Year to date:
    • Site-wide: 134,115
  • Since beginning of last month:
    • Site-wide: 133,098

Organizing Pneumonia of COVID-19: Time-dependent Evolution and Outcome in CT Findings

radiology and imaging more details view paper
  • Downloaded 1,250 times
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    • Site-wide: 16,254
    • In radiology and imaging: 36
  • Year to date:
    • Site-wide: 61,010
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    • Site-wide: 98,067

Subtle stratification confounds estimates of heritability from rare variants

genetics more details view paper
  • Downloaded 1,181 times
  • Download rankings, all-time:
    • Site-wide: 17,688
    • In genetics: 845
  • Year to date:
    • Site-wide: 75,195
  • Since beginning of last month:
    • Site-wide: 53,888

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

genetics more details view paper
  • Downloaded 1,149 times
  • Download rankings, all-time:
    • Site-wide: 18,414
    • In genetics: 879
  • Year to date:
    • Site-wide: 87,175
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    • Site-wide: 83,075

OSCA: a tool for omic-data-based complex trait analysis

bioinformatics more details view paper
  • Downloaded 1,126 times
  • Download rankings, all-time:
    • Site-wide: 18,982
    • In bioinformatics: 2,234
  • Year to date:
    • Site-wide: 110,584
  • Since beginning of last month:
    • Site-wide: 108,019

Efficient estimation and applications of cross-validated genetic predictions

genetics more details view paper
  • Downloaded 1,096 times
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    • Site-wide: 19,769
    • In genetics: 944
  • Year to date:
    • Site-wide: 39,869
  • Since beginning of last month:
    • Site-wide: 50,200

Identification of 55,000 Replicated DNA Methylation QTL

genomics more details view paper
  • Downloaded 1,054 times
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    • Site-wide: 20,939
    • In genomics: 2,059
  • Year to date:
    • Site-wide: 103,366
  • Since beginning of last month:
    • Site-wide: 120,949

Efficient RNA-mediated reprogramming of human somatic cells to naive pluripotency facilitated by tankyrase inhibition

developmental biology more details view paper
  • Downloaded 1,031 times
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    • Site-wide: 21,645
    • In developmental biology: 380
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    • Site-wide: 40,503
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    • Site-wide: 33,857

Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

genetics more details view paper
  • Downloaded 891 times
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    • Site-wide: 26,673
    • In genetics: 1,261
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    • Site-wide: 89,342
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    • Site-wide: 71,585

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

genetics more details view paper
  • Downloaded 813 times
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    • Site-wide: 30,351
    • In genetics: 1,442
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    • Site-wide: 94,529
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    • Site-wide: 104,296

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

genetics more details view paper
  • Downloaded 774 times
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    • Site-wide: 32,501
    • In genetics: 1,532
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    • Site-wide: 93,298
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    • Site-wide: 62,028

Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors

genetics more details view paper
  • Downloaded 766 times
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    • Site-wide: 32,984
    • In genetics: 1,552
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    • Site-wide: 23,609
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    • Site-wide: 14,335

Quantifying genetic heterogeneity between continental populations for human height and body mass index

genetics more details view paper
  • Downloaded 750 times
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    • Site-wide: 33,966
    • In genetics: 1,603
  • Year to date:
    • Site-wide: 77,235
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    • Site-wide: 101,194

Genome-wide analyses of behavioural traits biased by misreports and longitudinal changes

genetic and genomic medicine more details view paper
  • Downloaded 722 times
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    • Site-wide: 35,689
    • In genetic and genomic medicine: 120
  • Year to date:
    • Site-wide: 54,269
  • Since beginning of last month:
    • Site-wide: 103,830

The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for human complex diseases

microbiology more details view paper
  • Downloaded 668 times
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    • Site-wide: 39,652
    • In microbiology: 2,392
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    • Site-wide: 67,799
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    • Site-wide: 53,584

Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

genetics more details view paper
  • Downloaded 659 times
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    • Site-wide: 40,433
    • In genetics: 1,876
  • Year to date:
    • Site-wide: 128,066
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    • Site-wide: 83,305

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

genetics more details view paper
  • Downloaded 629 times
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    • Site-wide: 42,868
    • In genetics: 1,984
  • Year to date:
    • Site-wide: 16,288
  • Since beginning of last month:
    • Site-wide: 21,290

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

genetics more details view paper
  • Downloaded 587 times
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    • Site-wide: 46,796
    • In genetics: 2,141
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    • Site-wide: 120,602
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    • Site-wide: 120,778

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

genetics more details view paper
  • Downloaded 582 times
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    • Site-wide: 47,208
    • In genetics: 2,171
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    • Site-wide: 121,461
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    • Site-wide: 113,845

Genetic analyses of medication-use and implications for precision medicine

genetics more details view paper
  • Downloaded 556 times
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    • Site-wide: 49,971
    • In genetics: 2,285
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    • Site-wide: 73,196
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    • Site-wide: 123,089

Xist Intron 1 Repression by TALE Transcriptional Factor Improves Somatic Cell Reprogamming in Mice

developmental biology more details view paper
  • Downloaded 549 times
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    • Site-wide: 50,713
    • In developmental biology: 1,186
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    • Site-wide: 103,686
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    • Site-wide: 119,403

The effect of X-linked dosage compensation on complex trait variation

genetics more details view paper
  • Downloaded 544 times
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    • Site-wide: 51,273
    • In genetics: 2,338
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    • Site-wide: 84,664

The Parkinsons Disease Mendelian Randomization Research Portal

neuroscience more details view paper
  • Downloaded 515 times
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    • In neuroscience: 8,023
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Evolution in Sinocyclocheilus cavefish is marked by rate shifts, reversals and origin of novel traits

evolutionary biology more details view paper
  • Downloaded 502 times
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    • Site-wide: 56,384
    • In evolutionary biology: 2,986
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    • Site-wide: 70,859
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    • Site-wide: 80,428

Towards the identification of causal genes for age-related macular degeneration

genetics more details view paper
  • Downloaded 479 times
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    • Site-wide: 59,367
    • In genetics: 2,711
  • Year to date:
    • Site-wide: 90,831
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    • Site-wide: 64,185

A pattern categorization of CT findings to predict outcome of COVID-19 pneumonia

infectious diseases more details view paper
  • Downloaded 454 times
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    • Site-wide: 62,947
    • In infectious diseases: 3,171
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    • Site-wide: 80,820
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    • Site-wide: 58,006

Exploring morphological motifs for a single neuron based on multiple 3D reconstructions

bioinformatics more details view paper
  • Downloaded 438 times
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    • Site-wide: 65,262
    • In bioinformatics: 6,335
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    • Site-wide: 78,622
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    • Site-wide: 107,028

Synthesis-Free PET Imaging Of Brown Adipose Tissue And TSPO Via Combination Of Disulfiram And 64CuCl2

pharmacology and toxicology more details view paper
  • Downloaded 417 times
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    • Site-wide: 68,640
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    • Site-wide: 115,459

DAZL is a master translational regulator of murine spermatogenesis

developmental biology more details view paper
  • Downloaded 416 times
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    • Site-wide: 68,897
    • In developmental biology: 1,741
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    • Site-wide: 90,191
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    • Site-wide: 116,323

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

genetics more details view paper
  • Downloaded 366 times
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    • Site-wide: 77,511
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    • Site-wide: 138,159
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Differences of clinical and imaging findings in multiple generations of secondary COVID-19 infection in Xi'an, China

radiology and imaging more details view paper
  • Downloaded 285 times
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    • Site-wide: 94,230
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    • Site-wide: 119,091
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    • Site-wide: 112,928

The role of glycaemic, lipid, blood pressure and obesity risk factors as mediators of the effect of height on Coronary Artery Disease and Type 2 Diabetes Mellitus: A Mendelian Randomisation Study.

genetics more details view paper
  • Downloaded 279 times
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    • Site-wide: 95,520
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    • Site-wide: 137,266
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    • Site-wide: 129,441

A parsimonious model for mass-univariate vertex-wise analysis

neuroscience more details view paper
  • Downloaded 266 times
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    • Site-wide: 98,584
    • In neuroscience: 15,153
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    • Site-wide: 13,553
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    • Site-wide: 55,121

Efficacy and Acceptability Comparisons of Cognitive Behavior Therapy, Drugs, and Their Combination for Panic Disorder in Adults: a Network Meta-analysis

psychiatry and clinical psychology more details view paper
  • Downloaded 265 times
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    • Site-wide: 77,372
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    • Site-wide: 69,082

Cross-Species Integration of Transcriptomic Effects of Tobacco and Nicotine Exposure Helps to Prioritize Genetic Effects on Human Tobacco Consumption

genetics more details view paper
  • Downloaded 199 times
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    • Site-wide: 114,096
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    • Site-wide: 113,203
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    • Site-wide: 112,158

Characterization and expression QTL analysis of TaABI4, a pre-harvest sprouting related gene in wheat

genetics more details view paper
  • Downloaded 168 times
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    • Site-wide: 121,331
    • In genetics: 5,118
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Circuit-free, optoelectronic sensing of electrodermal activities based on photon recycling of a micro-LED

bioengineering more details view paper
  • Downloaded 144 times
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    • Site-wide: 108,465
  • Since beginning of last month:
    • Site-wide: 98,120

Once delayed non-invasive remote ischemic preconditioning protects against early stroke by modulating  neuroinflammatory responses in rats

neuroscience more details view paper
  • Downloaded 69 times
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    • Site-wide: 139,768
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