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Author: Jian Yang

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  • All-time downloads: 110,807 (rank: 253 out of 383,682)
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    • bioinformatics: 5,874 (rank: 1,357 out of 32,826)
    • developmental biology: 3,181 (rank: 332 out of 14,859)
    • evolutionary biology: 311 (rank: 14,326 (tie) out of 19,647)
    • genetics: 82,307 (rank: 21 out of 35,444)
    • genomics: 15,733 (rank: 676 out of 40,825)
    • microbiology: 482 (rank: 17,461 (tie) out of 43,199)
    • neuroscience: 2,548 (rank: 5,845 (tie) out of 64,312)
    • pharmacology and toxicology: 371 (rank: 2,238 (tie) out of 5,151)

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Preprints

Recovery of trait heritability from whole genome sequence data

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Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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Genetic Consequences of Social Stratification in Great Britain

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LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

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Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

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Haplotypes of common SNPs can explain missing heritability of complex diseases

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Improved polygenic prediction by Bayesian multiple regression on summary statistics

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Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.

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A resource-efficient tool for mixed model association analysis of large-scale data

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Widespread signatures of negative selection in the genetic architecture of human complex traits

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GWAS on family history of Alzheimer's disease

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Causal associations between risk factors and common diseases inferred from GWAS summary data

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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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Trophectoderm Potency is Retained Exclusively in Human Naïve Cells

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Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

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Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

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Reduced Default Mode Network Functional Connectivity in Patients with Recurrent Major Depressive Disorder

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Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

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Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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Imprint of Assortative Mating on the Human Genome

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Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

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Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

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Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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OSCA: a tool for omic-data-based complex trait analysis

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Subtle stratification confounds estimates of heritability from rare variants

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Narrow-sense heritability estimation of complex traits using identity-by-descent information.

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Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

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Expectation of the intercept from bivariate LD score regression in the presence of population stratification

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Identification of 55,000 Replicated DNA Methylation QTL

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Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

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Efficient RNA-mediated reprogramming of human somatic cells to naive pluripotency facilitated by tankyrase inhibition

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Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

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Widespread associations between grey matter structure and the human phenome

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Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

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Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

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Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

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Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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Xist Intron 1 Repression by TALE Transcriptional Factor Improves Somatic Cell Reprogamming in Mice

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The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for human complex diseases

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The Parkinsons Disease Mendelian Randomization Research Portal

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Genetic analyses of medication-use and implications for precision medicine

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Synthesis-Free PET Imaging Of Brown Adipose Tissue And TSPO Via Combination Of Disulfiram And 64CuCl2

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Exploring morphological motifs for a single neuron based on multiple 3D reconstructions

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Towards the identification of causal genes for age-related macular degeneration

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Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

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DAZL is a master translational regulator of murine spermatogenesis

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Evolution in Sinocyclocheilus cavefish is marked by rate shifts, reversals and origin of novel traits

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The role of glycaemic, lipid, blood pressure and obesity risk factors as mediators of the effect of height on Coronary Artery Disease and Type 2 Diabetes Mellitus: A Mendelian Randomisation Study.

genetics more details view paper
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Cross-Species Integration of Transcriptomic Effects of Tobacco and Nicotine Exposure Helps to Prioritize Genetic Effects on Human Tobacco Consumption

genetics more details view paper
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Once delayed non-invasive remote ischemic preconditioning protects against early stroke by modulating  neuroinflammatory responses in rats

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