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Author: Jian Yang

Rankings

  • All-time downloads: 146,154 (rank: 618 )
  • Categories:
    • biochemistry: 198 (rank: 23,141 (tie) )
    • bioengineering: 153 (rank: 16,010 (tie) )
    • bioinformatics: 6,381 (rank: 1,896 )
    • developmental biology: 7,742 (rank: 112 )
    • evolutionary biology: 520 (rank: 14,318 (tie) )
    • genetic and genomic medicine: 2,942 (rank: 1,090 (tie) )
    • genetics: 103,562 (rank: 18 )
    • genomics: 19,377 (rank: 703 )
    • infectious diseases: 468 (rank: 36,776 (tie) )
    • intensive care and critical care medicine: 863 (rank: 1,272 (tie) )
    • microbiology: 726 (rank: 22,427 (tie) )
    • neuroscience: 890 (rank: 29,652 (tie) )
    • pharmacology and toxicology: 424 (rank: 3,793 (tie) )
    • psychiatry and clinical psychology: 304 (rank: 3,946 (tie) )
    • radiology and imaging: 1,604 (rank: 217 (tie) )

Downloads per author, site-wide

Preprints

Ancient genomes redate the extinction of Sussemionus, a subgenus of Equus, to late Holocene

genomics more details view paper

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Recovery of trait heritability from whole genome sequence data

genetics more details view paper
  • Downloaded 12,829 times
  • Download rankings, all-time:
    • Site-wide: 691
    • In genetics: 15
  • Year to date:
    • Site-wide: 1,506
  • Since beginning of last month:
    • Site-wide: 23,899

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

genetics more details view paper
  • Downloaded 11,234 times
  • Download rankings, all-time:
    • Site-wide: 827
    • In genetics: 21
  • Year to date:
    • Site-wide: 3,945
  • Since beginning of last month:
    • Site-wide: 63,061

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

genomics more details view paper
  • Downloaded 11,087 times
  • Download rankings, all-time:
    • Site-wide: 848
    • In genomics: 60
  • Year to date:
    • Site-wide: 1,317
  • Since beginning of last month:
    • Site-wide: 12,904

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

genetics more details view paper
  • Downloaded 9,444 times
  • Download rankings, all-time:
    • Site-wide: 1,026
    • In genetics: 26
  • Year to date:
    • Site-wide: 49,629
  • Since beginning of last month:
    • Site-wide: 107,504

Genetic Consequences of Social Stratification in Great Britain

genetics more details view paper
  • Downloaded 7,979 times
  • Download rankings, all-time:
    • Site-wide: 1,284
    • In genetics: 34
  • Year to date:
    • Site-wide: 10,468
  • Since beginning of last month:
    • Site-wide: 77,084

LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

genomics more details view paper
  • Downloaded 7,211 times
  • Download rankings, all-time:
    • Site-wide: 1,455
    • In genomics: 119
  • Year to date:
    • Site-wide: 86,803
  • Since beginning of last month:
    • Site-wide: 94,260

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

genetics more details view paper
  • Downloaded 6,761 times
  • Download rankings, all-time:
    • Site-wide: 1,573
    • In genetics: 46
  • Year to date:
    • Site-wide: 21,137
  • Since beginning of last month:
    • Site-wide: 94,194

Human Naïve Epiblast Cells Possess Unrestricted Lineage Potential

developmental biology more details view paper
  • Downloaded 3,873 times
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    • Site-wide: 3,424
    • In developmental biology: 30
  • Year to date:
    • Site-wide: 2,733
  • Since beginning of last month:
    • Site-wide: 53,198

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

genetics more details view paper
  • Downloaded 3,604 times
  • Download rankings, all-time:
    • Site-wide: 3,791
    • In genetics: 133
  • Year to date:
    • Site-wide: 45,417
  • Since beginning of last month:
    • Site-wide: 107,866

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

bioinformatics more details view paper
  • Downloaded 3,414 times
  • Download rankings, all-time:
    • Site-wide: 4,070
    • In bioinformatics: 390
  • Year to date:
    • Site-wide: 89,591
  • Since beginning of last month:
    • Site-wide: None

Haplotypes of common SNPs can explain missing heritability of complex diseases

genetics more details view paper
  • Downloaded 3,159 times
  • Download rankings, all-time:
    • Site-wide: 4,585
    • In genetics: 180
  • Year to date:
    • Site-wide: 63,389
  • Since beginning of last month:
    • Site-wide: 18,801

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

genetics more details view paper
  • Downloaded 3,061 times
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    • Site-wide: 4,754
    • In genetics: 189
  • Year to date:
    • Site-wide: 29,406
  • Since beginning of last month:
    • Site-wide: 12,886

A resource-efficient tool for mixed model association analysis of large-scale data

genetics more details view paper
  • Downloaded 2,979 times
  • Download rankings, all-time:
    • Site-wide: 4,942
    • In genetics: 204
  • Year to date:
    • Site-wide: 12,595
  • Since beginning of last month:
    • Site-wide: 50,310

Improved polygenic prediction by Bayesian multiple regression on summary statistics

genetics more details view paper
  • Downloaded 2,839 times
  • Download rankings, all-time:
    • Site-wide: 5,301
    • In genetics: 218
  • Year to date:
    • Site-wide: 65,209
  • Since beginning of last month:
    • Site-wide: 52,900

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.

genetics more details view paper
  • Downloaded 2,674 times
  • Download rankings, all-time:
    • Site-wide: 5,757
    • In genetics: 244
  • Year to date:
    • Site-wide: 89,574
  • Since beginning of last month:
    • Site-wide: 107,343

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

genetics more details view paper
  • Downloaded 2,513 times
  • Download rankings, all-time:
    • Site-wide: 6,342
    • In genetics: 272
  • Year to date:
    • Site-wide: 9,669
  • Since beginning of last month:
    • Site-wide: 70,553

Widespread signatures of negative selection in the genetic architecture of human complex traits

genetics more details view paper
  • Downloaded 2,328 times
  • Download rankings, all-time:
    • Site-wide: 7,083
    • In genetics: 311
  • Year to date:
    • Site-wide: 49,021
  • Since beginning of last month:
    • Site-wide: 76,135

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

genetic and genomic medicine more details view paper
  • Downloaded 2,188 times
  • Download rankings, all-time:
    • Site-wide: 7,753
    • In genetic and genomic medicine: 34
  • Year to date:
    • Site-wide: 1,948
  • Since beginning of last month:
    • Site-wide: 12,024

GWAS on family history of Alzheimer's disease

genetics more details view paper
  • Downloaded 2,011 times
  • Download rankings, all-time:
    • Site-wide: 8,788
    • In genetics: 379
  • Year to date:
    • Site-wide: 100,427
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    • Site-wide: None

Causal associations between risk factors and common diseases inferred from GWAS summary data

genetics more details view paper
  • Downloaded 1,810 times
  • Download rankings, all-time:
    • Site-wide: 10,263
    • In genetics: 453
  • Year to date:
    • Site-wide: 102,136
  • Since beginning of last month:
    • Site-wide: 107,514

Establishment In Culture Of Expanded Potential Stem Cells

developmental biology more details view paper
  • Downloaded 1,765 times
  • Download rankings, all-time:
    • Site-wide: 10,650
    • In developmental biology: 141
  • Year to date:
    • Site-wide: 76,722
  • Since beginning of last month:
    • Site-wide: None

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

genetics more details view paper
  • Downloaded 1,743 times
  • Download rankings, all-time:
    • Site-wide: 10,862
    • In genetics: 480
  • Year to date:
    • Site-wide: 99,092
  • Since beginning of last month:
    • Site-wide: 107,037

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

genetics more details view paper
  • Downloaded 1,662 times
  • Download rankings, all-time:
    • Site-wide: 11,638
    • In genetics: 522
  • Year to date:
    • Site-wide: 69,511
  • Since beginning of last month:
    • Site-wide: 96,042

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

genetics more details view paper
  • Downloaded 1,621 times
  • Download rankings, all-time:
    • Site-wide: 12,081
    • In genetics: 550
  • Year to date:
    • Site-wide: 22,567
  • Since beginning of last month:
    • Site-wide: 77,559

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

genetics more details view paper
  • Downloaded 1,581 times
  • Download rankings, all-time:
    • Site-wide: 12,492
    • In genetics: 566
  • Year to date:
    • Site-wide: 47,383
  • Since beginning of last month:
    • Site-wide: 37,928

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

genetics more details view paper
  • Downloaded 1,496 times
  • Download rankings, all-time:
    • Site-wide: 13,548
    • In genetics: 617
  • Year to date:
    • Site-wide: 112,666
  • Since beginning of last month:
    • Site-wide: 90,986

Expectation of the intercept from bivariate LD score regression in the presence of population stratification

genetics more details view paper
  • Downloaded 1,483 times
  • Download rankings, all-time:
    • Site-wide: 13,742
    • In genetics: 630
  • Year to date:
    • Site-wide: 20,395
  • Since beginning of last month:
    • Site-wide: 108,461

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

genetics more details view paper
  • Downloaded 1,454 times
  • Download rankings, all-time:
    • Site-wide: 14,160
    • In genetics: 645
  • Year to date:
    • Site-wide: 70,850
  • Since beginning of last month:
    • Site-wide: 113,066

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

genetics more details view paper
  • Downloaded 1,432 times
  • Download rankings, all-time:
    • Site-wide: 14,507
    • In genetics: 662
  • Year to date:
    • Site-wide: 136,488
  • Since beginning of last month:
    • Site-wide: None

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

genetics more details view paper
  • Downloaded 1,392 times
  • Download rankings, all-time:
    • Site-wide: 15,138
    • In genetics: 698
  • Year to date:
    • Site-wide: 36,511
  • Since beginning of last month:
    • Site-wide: 78,119

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

bioinformatics more details view paper
  • Downloaded 1,372 times
  • Download rankings, all-time:
    • Site-wide: 15,507
    • In bioinformatics: 1,806
  • Year to date:
    • Site-wide: 64,185
  • Since beginning of last month:
    • Site-wide: 95,571

Imprint of Assortative Mating on the Human Genome

genetics more details view paper
  • Downloaded 1,300 times
  • Download rankings, all-time:
    • Site-wide: 16,824
    • In genetics: 781
  • Year to date:
    • Site-wide: 132,195
  • Since beginning of last month:
    • Site-wide: 62,953

Organizing Pneumonia of COVID-19: Time-dependent Evolution and Outcome in CT Findings

radiology and imaging more details view paper
  • Downloaded 1,288 times
  • Download rankings, all-time:
    • Site-wide: 17,055
    • In radiology and imaging: 38
  • Year to date:
    • Site-wide: 62,992
  • Since beginning of last month:
    • Site-wide: 47,719

Subtle stratification confounds estimates of heritability from rare variants

genetics more details view paper
  • Downloaded 1,197 times
  • Download rankings, all-time:
    • Site-wide: 18,986
    • In genetics: 882
  • Year to date:
    • Site-wide: 90,666
  • Since beginning of last month:
    • Site-wide: 93,981

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

genetics more details view paper
  • Downloaded 1,164 times
  • Download rankings, all-time:
    • Site-wide: 19,783
    • In genetics: 910
  • Year to date:
    • Site-wide: 102,139
  • Since beginning of last month:
    • Site-wide: 94,072

Efficient estimation and applications of cross-validated genetic predictions

genetics more details view paper
  • Downloaded 1,156 times
  • Download rankings, all-time:
    • Site-wide: 19,980
    • In genetics: 918
  • Year to date:
    • Site-wide: 39,062
  • Since beginning of last month:
    • Site-wide: 34,661

OSCA: a tool for omic-data-based complex trait analysis

bioinformatics more details view paper
  • Downloaded 1,130 times
  • Download rankings, all-time:
    • Site-wide: 20,667
    • In bioinformatics: 2,376
  • Year to date:
    • Site-wide: 135,004
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    • Site-wide: None

Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors

genetics more details view paper
  • Downloaded 1,124 times
  • Download rankings, all-time:
    • Site-wide: 20,814
    • In genetics: 960
  • Year to date:
    • Site-wide: 8,277
  • Since beginning of last month:
    • Site-wide: 1,966

Identification of 55,000 Replicated DNA Methylation QTL

genomics more details view paper
  • Downloaded 1,079 times
  • Download rankings, all-time:
    • Site-wide: 22,145
    • In genomics: 2,103
  • Year to date:
    • Site-wide: 102,070
  • Since beginning of last month:
    • Site-wide: 27,942

Efficient RNA-mediated reprogramming of human somatic cells to naive pluripotency facilitated by tankyrase inhibition

developmental biology more details view paper
  • Downloaded 1,061 times
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    • Site-wide: 22,675
    • In developmental biology: 399
  • Year to date:
    • Site-wide: 49,537
  • Since beginning of last month:
    • Site-wide: 111,118

Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

genetics more details view paper
  • Downloaded 903 times
  • Download rankings, all-time:
    • Site-wide: 28,642
    • In genetics: 1,312
  • Year to date:
    • Site-wide: 107,163
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    • Site-wide: None

Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19

intensive care and critical care medicine more details view paper
  • Downloaded 863 times
  • Download rankings, all-time:
    • Site-wide: 30,556
    • In intensive care and critical care medicine: 105
  • Year to date:
    • Site-wide: 4,078
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    • Site-wide: 148

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

genetics more details view paper
  • Downloaded 816 times
  • Download rankings, all-time:
    • Site-wide: 32,973
    • In genetics: 1,519
  • Year to date:
    • Site-wide: 123,816
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    • Site-wide: None

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

genetics more details view paper
  • Downloaded 782 times
  • Download rankings, all-time:
    • Site-wide: 35,055
    • In genetics: 1,596
  • Year to date:
    • Site-wide: 115,606
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    • Site-wide: None

Quantifying genetic heterogeneity between continental populations for human height and body mass index

genetics more details view paper
  • Downloaded 769 times
  • Download rankings, all-time:
    • Site-wide: 35,870
    • In genetics: 1,629
  • Year to date:
    • Site-wide: 90,245
  • Since beginning of last month:
    • Site-wide: 78,431

Genome-wide analyses of behavioural traits biased by misreports and longitudinal changes

genetic and genomic medicine more details view paper
  • Downloaded 754 times
  • Download rankings, all-time:
    • Site-wide: 36,892
    • In genetic and genomic medicine: 144
  • Year to date:
    • Site-wide: 61,220
  • Since beginning of last month:
    • Site-wide: 33,406

The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for human complex diseases

microbiology more details view paper
  • Downloaded 726 times
  • Download rankings, all-time:
    • Site-wide: 38,821
    • In microbiology: 2,346
  • Year to date:
    • Site-wide: 56,939
  • Since beginning of last month:
    • Site-wide: 10,790

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

genetics more details view paper
  • Downloaded 686 times
  • Download rankings, all-time:
    • Site-wide: 41,895
    • In genetics: 1,882
  • Year to date:
    • Site-wide: 19,990
  • Since beginning of last month:
    • Site-wide: 72,639

Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

genetics more details view paper
  • Downloaded 663 times
  • Download rankings, all-time:
    • Site-wide: 43,827
    • In genetics: 1,959
  • Year to date:
    • Site-wide: 146,552
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    • Site-wide: None

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

genetics more details view paper
  • Downloaded 602 times
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    • Site-wide: 49,548
    • In genetics: 2,187
  • Year to date:
    • Site-wide: 120,173
  • Since beginning of last month:
    • Site-wide: 38,747

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

genetics more details view paper
  • Downloaded 595 times
  • Download rankings, all-time:
    • Site-wide: 50,231
    • In genetics: 2,230
  • Year to date:
    • Site-wide: 136,903
  • Since beginning of last month:
    • Site-wide: 107,919

Genetic analyses of medication-use and implications for precision medicine

genetics more details view paper
  • Downloaded 580 times
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    • Site-wide: 51,925
    • In genetics: 2,299
  • Year to date:
    • Site-wide: 81,568
  • Since beginning of last month:
    • Site-wide: 63,434

Xist Intron 1 Repression by TALE Transcriptional Factor Improves Somatic Cell Reprogamming in Mice

developmental biology more details view paper
  • Downloaded 564 times
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    • Site-wide: 53,769
    • In developmental biology: 1,262
  • Year to date:
    • Site-wide: 114,654
  • Since beginning of last month:
    • Site-wide: 61,332

The effect of X-linked dosage compensation on complex trait variation

genetics more details view paper
  • Downloaded 550 times
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    • Site-wide: 55,388
    • In genetics: 2,434
  • Year to date:
    • Site-wide: 136,606
  • Since beginning of last month:
    • Site-wide: 110,683

The Parkinsons Disease Mendelian Randomization Research Portal

neuroscience more details view paper
  • Downloaded 523 times
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    • Site-wide: 58,855
    • In neuroscience: 8,525
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    • Site-wide: 138,942
  • Since beginning of last month:
    • Site-wide: 109,176

Evolution in Sinocyclocheilus cavefish is marked by rate shifts, reversals and origin of novel traits

evolutionary biology more details view paper
  • Downloaded 520 times
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    • Site-wide: 59,327
    • In evolutionary biology: 3,049
  • Year to date:
    • Site-wide: 85,565
  • Since beginning of last month:
    • Site-wide: 88,615

Towards the identification of causal genes for age-related macular degeneration

genetics more details view paper
  • Downloaded 493 times
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    • Site-wide: 63,000
    • In genetics: 2,779
  • Year to date:
    • Site-wide: 106,400
  • Since beginning of last month:
    • Site-wide: 101,005

DAZL is a master translational regulator of murine spermatogenesis

developmental biology more details view paper
  • Downloaded 479 times
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    • Site-wide: 64,954
    • In developmental biology: 1,598
  • Year to date:
    • Site-wide: 65,077
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    • Site-wide: 30,478

A pattern categorization of CT findings to predict outcome of COVID-19 pneumonia

infectious diseases more details view paper
  • Downloaded 468 times
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    • Site-wide: 66,590
    • In infectious diseases: 3,530
  • Year to date:
    • Site-wide: 97,627
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    • Site-wide: None

Exploring morphological motifs for a single neuron based on multiple 3D reconstructions

bioinformatics more details view paper
  • Downloaded 465 times
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    • Site-wide: 67,215
    • In bioinformatics: 6,459
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    • Site-wide: 84,031
  • Since beginning of last month:
    • Site-wide: 35,274

Synthesis-Free PET Imaging Of Brown Adipose Tissue And TSPO Via Combination Of Disulfiram And 64CuCl2

pharmacology and toxicology more details view paper
  • Downloaded 424 times
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    • Site-wide: 73,774
    • In pharmacology and toxicology: 471
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    • Site-wide: 136,624
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    • Site-wide: None

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

genetics more details view paper
  • Downloaded 375 times
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    • Site-wide: 82,774
    • In genetics: 3,607
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    • Site-wide: 147,344
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    • Site-wide: None

Differences of clinical and imaging findings in multiple generations of secondary COVID-19 infection in Xi'an, China

radiology and imaging more details view paper
  • Downloaded 316 times
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    • Site-wide: 95,477
    • In radiology and imaging: 168
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    • Site-wide: 104,360
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    • Site-wide: 47,978

Efficacy and Acceptability Comparisons of Cognitive Behavior Therapy, Drugs, and Their Combination for Panic Disorder in Adults: a Network Meta-analysis

psychiatry and clinical psychology more details view paper
  • Downloaded 304 times
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    • Site-wide: 98,142
    • In psychiatry and clinical psychology: 398
  • Year to date:
    • Site-wide: 73,839
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    • Site-wide: 56,146

A parsimonious model for mass-univariate vertex-wise analysis

neuroscience more details view paper
  • Downloaded 296 times
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    • Site-wide: 99,843
    • In neuroscience: 15,082
  • Year to date:
    • Site-wide: 19,271
  • Since beginning of last month:
    • Site-wide: 21,182

The role of glycaemic, lipid, blood pressure and obesity risk factors as mediators of the effect of height on Coronary Artery Disease and Type 2 Diabetes Mellitus: A Mendelian Randomisation Study.

genetics more details view paper
  • Downloaded 284 times
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    • Site-wide: 102,792
    • In genetics: 4,363
  • Year to date:
    • Site-wide: 149,902
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    • Site-wide: None

Cross-Species Integration of Transcriptomic Effects of Tobacco and Nicotine Exposure Helps to Prioritize Genetic Effects on Human Tobacco Consumption

genetics more details view paper
  • Downloaded 243 times
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    • Site-wide: 112,653
    • In genetics: 4,748
  • Year to date:
    • Site-wide: 88,323
  • Since beginning of last month:
    • Site-wide: 62,954

Sequencing uracil in DNA at single-nucleotide resolution

biochemistry more details view paper
  • Downloaded 198 times
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    • Site-wide: 124,132
    • In biochemistry: 3,695
  • Year to date:
    • Site-wide: 32,395
  • Since beginning of last month:
    • Site-wide: 54,080

Characterization and expression QTL analysis of TaABI4, a pre-harvest sprouting related gene in wheat

genetics more details view paper
  • Downloaded 191 times
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    • Site-wide: 125,776
    • In genetics: 5,175
  • Year to date:
    • Site-wide: 82,105
  • Since beginning of last month:
    • Site-wide: 86,324

Circuit-free, optoelectronic sensing of electrodermal activities based on photon recycling of a micro-LED

bioengineering more details view paper
  • Downloaded 153 times
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    • Site-wide: 134,466
    • In bioengineering: 2,736
  • Year to date:
    • Site-wide: 127,290
  • Since beginning of last month:
    • Site-wide: 85,968

Once delayed non-invasive remote ischemic preconditioning protects against early stroke by modulating  neuroinflammatory responses in rats

neuroscience more details view paper
  • Downloaded 71 times
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    • Site-wide: 149,618
    • In neuroscience: 22,403
  • Year to date:
    • Site-wide: 153,348
  • Since beginning of last month:
    • Site-wide: 118,607

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