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Author: Shamil R. Sunyaev

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  • All-time downloads: 11,764 (rank: 6,924 (tie) out of 404,161)
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    • biochemistry: 598 (rank: 6,137 (tie) out of 19,151)
    • bioinformatics: 1,000 (rank: 11,541 (tie) out of 34,272)
    • evolutionary biology: 1,858 (rank: 2,232 (tie) out of 20,691)
    • genetics: 5,684 (rank: 2,983 (tie) out of 36,792)
    • genomics: 2,624 (rank: 7,537 (tie) out of 42,763)

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Preprints

Phenotype-specific information improves prediction of functional impact for noncoding variants

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Quantifying the unobserved protein-coding variants in human populations provides a roadmap for large-scale sequencing projects

genetics more details view paper
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Population-specific causal disease effect sizes in functionally important regions impacted by selection

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Population sequencing data reveal a compendium of mutational processes in human germline

genetics more details view paper
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Low-frequency variant functional architectures reveal strength of negative selection across coding and non-coding annotations

genetics more details view paper
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Leveraging distant relatedness to quantify human mutation and gene conversion rates

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Fine-scale haplotype structure reveals strong signatures of positive selection in a recombining bacterial pathogen

evolutionary biology more details view paper
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Error-prone bypass of DNA lesions during lagging strand replication is a common source of germline and cancer mutations

biochemistry more details view paper
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No evidence that natural selection has been less effective at removing deleterious mutations in Europeans than in West Africans

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Unexpected variability of allelic imbalance estimates from RNA sequencing

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A literature review at genome scale: improving clinical variant assessment

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Maintenance of adaptive dynamics and no detectable load in a bottlenecked range-edge out-crossing plant population

evolutionary biology more details view paper
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Purifying selection on noncoding deletions of human regulatory elements detected using their cellular pleiotropy

evolutionary biology more details view paper
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