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Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,441 bioRxiv papers from 264,501 authors.

Author: Mark J. Daly

  • Most recently observed institution: Broad Institute / Massachusetts General Hospital

Rankings

  • All-time downloads: 139,846 (rank: 34 out of 264,779)
  • Categories:
    • evolutionary biology: 2,509 (rank: 632 (tie) out of 14,389)
    • genetics: 65,891 (rank: 33 out of 25,216)
    • genomics: 71,242 (rank: 93 out of 30,243)
    • immunology: 204 (rank: 7,262 (tie) out of 11,212)

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Preprints

An Atlas of Genetic Correlations across Human Diseases and Traits

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Variation across 141,456 human exomes and genomes reveals the spectrum of loss-of-function intolerance across human protein-coding genes

genomics more details view paper
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Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

genetics more details view paper
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LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

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An open resource of structural variation for medical and population genetics

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Common risk variants identified in autism spectrum disorder

genetics more details view paper
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Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

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Regional missense constraint improves variant deleteriousness prediction

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Current clinical use of polygenic scores will risk exacerbating health disparities

genetics more details view paper
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Rewiring of the cellular and inter-cellular landscape of the human colon during ulcerative colitis

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Scaling accurate genetic variant discovery to tens of thousands of samples

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Association mapping of inflammatory bowel disease loci to single variant resolution

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Medical relevance of protein-truncating variants across 337,208 individuals in the UK Biobank study

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Evaluating potential drug targets through human loss-of-function genetic variation

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Human demographic history impacts genetic risk prediction across diverse populations

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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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Signals of polygenic adaptation on height have been overestimated due to uncorrected population structure in genome-wide association studies

evolutionary biology more details view paper
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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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Human knockouts in a cohort with a high rate of consanguinity

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Limited contribution of rare, noncoding variation to autism spectrum disorder from sequencing of 2,076 genomes in quartet families

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Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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A protein truncating R179X variant in RNF186 confers protection against ulcerative colitis

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Transcript expression-aware annotation improves rare variant discovery and interpretation

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Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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Abundant contribution of short tandem repeats to gene expression variation in humans

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Bayesian model comparison for rare variant association studies of multiple phenotypes

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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

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Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

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Gene family information facilitates variant interpretation and identification of disease-associated genes

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Refining the role of de novo protein truncating variants in neurodevelopmental disorders using population reference samples

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Ultra-rare genetic variation in the epilepsies: a whole-exome sequencing study of 17,606 individuals

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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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An Unexpectedly Complex Architecture for Skin Pigmentation in Africans

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Estimating the Selective Effect of Heterozygous Protein Truncating Variants from Human Exome Data

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ASD and ADHD have a similar burden of rare protein-truncating variants

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Discovery of an autoimmunity-associated IL2RA enhancer by unbiased targeting of transcriptional activation

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Base-Specific Mutational Intolerance Near Splice-Sites Clarifies Role Of Non-Essential Splice Nucleotides

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A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

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The ExAC Browser: Displaying reference data information from over 60,000 exomes

genomics more details view paper
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Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

genetics more details view paper
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Haplotype sharing provides insights into fine-scale population history and disease in Finland

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Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

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Geographic variation and bias in polygenic scores of complex diseases and traits in Finland

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Network analysis of genome-wide selective constraint reveals a gene network active in early fetal brain intolerant of mutation

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Genetics of human plasma lipidome: Understanding lipid metabolism and its link to diseases beyond traditional lipids

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Mosaic Mutations in Blood DNA Sequence Are Associated with Solid Tumor Cancers

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Paternal-age-related de novo mutations and risk for five disorders

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Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts

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Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

genomics more details view paper
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Case-control analysis identifies shared properties of rare germline variation in cancer predisposing genes

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Schizophrenia risk conferred by protein-coding de novo mutations

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Novel protective associations with age-related macular degeneration: A common variant near CTRB1 and a rare variant in PELI3

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Bootstrat: Population Informed Bootstrapping for Rare Variant Tests

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Polygenic risk for schizophrenia is associated with social cognition across development

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Contribution of rare and common variants to intellectual disability in a high-risk population sub-isolate of Northern Finland

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A method to exploit the structure of genetic ancestry space to enhance case-control studies

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Applicability of the mutation-selection balance model to population genetics of heterozygous protein-truncating variants in humans

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Insights into protein structural, physicochemical, and functional consequences of missense variants in 1,330 disease-associated human genes

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Common variant burden contributes significantly to the familial aggregation of migraine in 1,589 families

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Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection

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