Author: Yang Liu

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Preprints

Neutralization of spike 69/70 deletion, E484K, and N501Y SARS-CoV-2 by BNT162b2 vaccine-elicited sera

• Downloaded 43,771 times
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  • Site-wide: 214
  • In microbiology: 17
• Year to date:
  • Site-wide: 3,105
• Since beginning of last month:
  • Site-wide: 5,007

The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing

• Downloaded 28,283 times
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  • Site-wide: 354
  • In allergy and immunology: 3
• Year to date:
  • Site-wide: 5,173
• Since beginning of last month:
  • Site-wide: 6,241

Clinical characteristics of the recovered COVID-19 patients with re-detectable positive RNA test

• Downloaded 21,161 times
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  • Site-wide: 503
  • In infectious diseases: 186
• Year to date:
  • Site-wide: 15,271
• Since beginning of last month:
  • Site-wide: 16,985

Early dynamics of transmission and control of 2019-nCoV: a mathematical modelling study

• Downloaded 17,302 times
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  • Site-wide: 639
  • In infectious diseases: 233
• Year to date:
  • Site-wide: 15,023
• Since beginning of last month:
  • Site-wide: 13,219

Age-dependent effects in the transmission and control of COVID-19 epidemics

• Downloaded 12,798 times
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  • Site-wide: 934
  • In epidemiology: 141
• Year to date:
  • Site-wide: 13,908
• Since beginning of last month:
  • Site-wide: 8,013

Inferring the number of COVID-19 cases from recently reported deaths

• Downloaded 9,319 times
• Download rankings, all-time:
  • Site-wide: 1,382
  • In epidemiology: 178
• Year to date:
  • Site-wide: 64,691
• Since beginning of last month:
  • Site-wide: 66,522

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

• Downloaded 7,997 times
• Download rankings, all-time:
  • Site-wide: 1,697
  • In microbiology: 153
• Year to date:
  • Site-wide: 1,904
• Since beginning of last month:
  • Site-wide: 6,935

Strategies to reduce the risk of SARS-CoV-2 re-introduction from international travellers

• Downloaded 5,435 times
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  • Site-wide: 2,831
  • In epidemiology: 313
• Year to date:
  • Site-wide: 20,534
• Since beginning of last month:
  • Site-wide: 18,475

The effect of control strategies that reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China

• Downloaded 4,062 times
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  • Site-wide: 4,198
  • In public and global health: 138
• Year to date:
  • Site-wide: 76,219
• Since beginning of last month:
  • Site-wide: 103,345

Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs

• Downloaded 4,040 times
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  • Site-wide: 4,228
  • In cell biology: 72
• Year to date:
  • Site-wide: 11,698
• Since beginning of last month:
  • Site-wide: 16,942

Spatial transcriptome sequencing of FFPE tissues at cellular level

• Downloaded 3,478 times
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  • Site-wide: 5,247
  • In genomics: 532
• Year to date:
  • Site-wide: 4,557
• Since beginning of last month:
  • Site-wide: 4,634

Survival analysis of hospital length of stay of novel coronavirus (COVID-19) pneumonia patients in Sichuan, China

• Downloaded 3,404 times
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  • Site-wide: 5,424
  • In health policy: 26
• Year to date:
  • Site-wide: 9,201
• Since beginning of last month:
  • Site-wide: 10,497

The impact of non-pharmaceutical interventions on SARS-CoV-2 transmission across 130 countries and territories

• Downloaded 2,747 times
• Download rankings, all-time:
  • Site-wide: 7,399
  • In health policy: 32
• Year to date:
  • Site-wide: 45,752
• Since beginning of last month:
  • Site-wide: 44,650

Urban Air Pollution May Enhance COVID-19 Case-Fatality and Mortality Rates in the United States

• Downloaded 2,711 times
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  • Site-wide: 7,538
  • In occupational and environmental health: 28
• Year to date:
  • Site-wide: 34,316
• Since beginning of last month:
  • Site-wide: 35,763

Spatial-CITE-seq: spatially resolved high-plex protein and whole transcriptome co-mapping

• Downloaded 2,677 times
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  • Site-wide: 7,689
  • In genomics: None
• Year to date:
  • Site-wide: 430
• Since beginning of last month:
  • Site-wide: 843

DNA methylation calling tools for Oxford Nanopore sequencing: a survey and human epigenome-wide evaluation

• Downloaded 2,092 times
• Download rankings, all-time:
  • Site-wide: 11,104
  • In bioinformatics: 1,270
• Year to date:
  • Site-wide: 10,109
• Since beginning of last month:
  • Site-wide: 13,014

Large-scale single-cell analysis reveals critical immune characteristics of COVID-19 patients

• Downloaded 1,974 times
• Download rankings, all-time:
  • Site-wide: 12,089
  • In genomics: 1,125
• Year to date:
  • Site-wide: 43,959
• Since beginning of last month:
  • Site-wide: 28,998

Reconstructing the global dynamics of under-ascertained COVID-19 cases and infections

• Downloaded 1,939 times
• Download rankings, all-time:
  • Site-wide: 12,408
  • In epidemiology: 905
• Year to date:
  • Site-wide: 90,577
• Since beginning of last month:
  • Site-wide: 57,896

Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort

• Downloaded 1,603 times
• Download rankings, all-time:
  • Site-wide: 16,480
  • In genetic and genomic medicine: 90
• Year to date:
  • Site-wide: 14,676
• Since beginning of last month:
  • Site-wide: 26,343

BNT162b2-Elicited Neutralization of Delta Plus, Lambda, and Other Variants

• Downloaded 1,577 times
• Download rankings, all-time:
  • Site-wide: 16,920
  • In microbiology: 967
• Year to date:
  • Site-wide: 51,674
• Since beginning of last month:
  • Site-wide: 64,689

Organizing Pneumonia of COVID-19: Time-dependent Evolution and Outcome in CT Findings

• Downloaded 1,362 times
• Download rankings, all-time:
  • Site-wide: 21,167
  • In radiology and imaging: 45
• Year to date:
  • Site-wide: 133,038
• Since beginning of last month:
  • Site-wide: 118,602

Reprogrammed tracrRNAs enable repurposing RNAs as crRNAs and detecting RNAs

• Downloaded 1,219 times
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  • Site-wide: 25,229
  • In synthetic biology: 356
• Year to date:
  • Site-wide: 15,138
• Since beginning of last month:
  • Site-wide: 24,114

The contribution of asymptomatic SARS-CoV-2 infections to transmission - a model-based analysis of the Diamond Princess outbreak

• Downloaded 1,154 times
• Download rankings, all-time:
  • Site-wide: 27,405
  • In infectious diseases: 2,546
• Year to date:
  • Site-wide: 79,279
• Since beginning of last month:
  • Site-wide: 95,644

MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets

• Downloaded 1,068 times
• Download rankings, all-time:
  • Site-wide: 30,822
  • In genomics: 2,683
• Year to date:
  • Site-wide: 24,931
• Since beginning of last month:
  • Site-wide: 44,563

Early prediction of liver disease using conventional risk factors and gut microbiome-augmented gradient boosting

• Downloaded 1,063 times
• Download rankings, all-time:
  • Site-wide: 31,038
  • In genetic and genomic medicine: 174
• Year to date:
  • Site-wide: 21,216
• Since beginning of last month:
  • Site-wide: 70,834

Self-reported taste and smell disorders in patients with COVID-19: distinct features in China

• Downloaded 1,050 times
• Download rankings, all-time:
  • Site-wide: 31,572
  • In otolaryngology: 19
• Year to date:
  • Site-wide: 84,975
• Since beginning of last month:
  • Site-wide: 87,282

The effect of inter-city travel restrictions on geographical spread of COVID-19: Evidence from Wuhan, China

• Downloaded 952 times
• Download rankings, all-time:
  • Site-wide: 36,575
  • In epidemiology: 1,924
• Year to date:
  • Site-wide: 71,600
• Since beginning of last month:
  • Site-wide: 48,917

Links between gut microbiome composition and fatty liver disease in a large population sample

• Downloaded 899 times
• Download rankings, all-time:
  • Site-wide: 39,770
  • In gastroenterology: 41
• Year to date:
  • Site-wide: 67,200
• Since beginning of last month:
  • Site-wide: 42,752

Convalescent plasma for hospitalized patients with COVID-19 and the effect of plasma antibodies: a randomized controlled, open-label trial

• Downloaded 870 times
• Download rankings, all-time:
  • Site-wide: 41,751
  • In infectious diseases: 3,462
• Year to date:
  • Site-wide: 23,257
• Since beginning of last month:
  • Site-wide: 16,822

Loss of a plant receptor kinase recruits beneficial rhizosphere-associated Pseudomonas

• Downloaded 860 times
• Download rankings, all-time:
  • Site-wide: 42,480
  • In plant biology: 832
• Year to date:
  • Site-wide: 72,761
• Since beginning of last month:
  • Site-wide: 51,028

Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in the murine cardiopharyngeal mesoderm

• Downloaded 846 times
• Download rankings, all-time:
  • Site-wide: 43,528
  • In developmental biology: 856
• Year to date:
  • Site-wide: 135,854
• Since beginning of last month:
  • Site-wide: 110,419

Visualizing looping of two endogenous genomic loci using synthetic zinc-finger proteins with anti-FLAG and anti-HA frankenbodies in living cells

• Downloaded 789 times
• Download rankings, all-time:
  • Site-wide: 48,196
  • In cell biology: 2,078
• Year to date:
  • Site-wide: 50,816
• Since beginning of last month:
  • Site-wide: 37,786

Phase 1 safety and pharmacokinetics studies of BRII-196 and BRII-198, SARS-CoV-2 spike-targeting monoclonal antibodies

• Downloaded 775 times
• Download rankings, all-time:
  • Site-wide: 49,502
  • In infectious diseases: 4,010
• Year to date:
  • Site-wide: 13,886
• Since beginning of last month:
  • Site-wide: 8,271

The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing

• Downloaded 770 times
• Download rankings, all-time:
  • Site-wide: 49,952
  • In infectious diseases: 3,497
• Year to date:
  • Site-wide: 97,198
• Since beginning of last month:
  • Site-wide: 111,419

Detecting behavioural changes in human movement to inform the spatial scale of interventions against COVID-19

• Downloaded 765 times
• Download rankings, all-time:
  • Site-wide: 50,378
  • In epidemiology: 2,727
• Year to date:
  • Site-wide: 34,973
• Since beginning of last month:
  • Site-wide: 8,663

Transmission Dynamics of the COVID-19 Epidemics in England

• Downloaded 713 times
• Download rankings, all-time:
  • Site-wide: 55,669
  • In public and global health: 883
• Year to date:
  • Site-wide: 132,532
• Since beginning of last month:
  • Site-wide: 152,254

A Modelling Study for Designing a Multi-layered Surveillance Approach to Detect the Potential Resurgence of SARS-CoV-2

• Downloaded 690 times
• Download rankings, all-time:
  • Site-wide: 58,283
  • In infectious diseases: 3,737
• Year to date:
  • Site-wide: 113,447
• Since beginning of last month:
  • Site-wide: 128,868

Changing travel patterns in China during the early stages of the COVID-19 pandemic

• Downloaded 666 times
• Download rankings, all-time:
  • Site-wide: 61,269
  • In public and global health: 949
• Year to date:
  • Site-wide: 109,727
• Since beginning of last month:
  • Site-wide: 107,210

A CRISPR-Cas12a-based specific enhancer for more sensitive detection of SARS-CoV-2 infection

• Downloaded 648 times
• Download rankings, all-time:
  • Site-wide: 63,473
  • In infectious diseases: 3,863
• Year to date:
  • Site-wide: 113,216
• Since beginning of last month:
  • Site-wide: 126,261

A pattern categorization of CT findings to predict outcome of COVID-19 pneumonia

• Downloaded 552 times
• Download rankings, all-time:
  • Site-wide: 77,764
  • In infectious diseases: 4,283
• Year to date:
  • Site-wide: 128,924
• Since beginning of last month:
  • Site-wide: 96,240

Comparative analysis of early divergent land plants and construction of DNA tools for hyper-expression in Marchantia chloroplasts

• Downloaded 520 times
• Download rankings, all-time:
  • Site-wide: 83,673
  • In plant biology: 1,973
• Year to date:
  • Site-wide: 161,061
• Since beginning of last month:
  • Site-wide: 111,371

Accurately Differentiating COVID-19, Other Viral Infection, and Healthy Individuals Using Multimodal Features via Late Fusion Learning

• Downloaded 519 times
• Download rankings, all-time:
  • Site-wide: 83,740
  • In infectious diseases: 4,599
• Year to date:
  • Site-wide: 73,799
• Since beginning of last month:
  • Site-wide: 46,042

Antibody Cocktail Exhibits Broad Neutralization against SARS-CoV-2 and SARS-CoV-2 variants

• Downloaded 503 times
• Download rankings, all-time:
  • Site-wide: 86,992
  • In immunology: 2,547
• Year to date:
  • Site-wide: 119,090
• Since beginning of last month:
  • Site-wide: 138,663

Gut microbiome composition is predictive of incident type 2 diabetes

• Downloaded 463 times
• Download rankings, all-time:
  • Site-wide: 95,422
  • In gastroenterology: 139
• Year to date:
  • Site-wide: 19,979
• Since beginning of last month:
  • Site-wide: 99,154

Screening of Botanical Drugs against SARS-CoV-2 Entry

• Downloaded 423 times
• Download rankings, all-time:
  • Site-wide: 104,469
  • In microbiology: 6,665
• Year to date:
  • Site-wide: 130,945
• Since beginning of last month:
  • Site-wide: 155,027

Epidemiological, Clinical Characteristics and Risk Factors for Severe Condition and ICU Admission of COVID-19 Patients of Early Stage in China: A review

• Downloaded 354 times
• Download rankings, all-time:
  • Site-wide: 122,410
  • In epidemiology: 5,432
• Year to date:
  • Site-wide: 61,628
• Since beginning of last month:
  • Site-wide: 22,228

Nosocomial Pseudomonas aeruginosaregulates alginate biosynthesis and Type VI secretion system during adaptive and convergent evolution for coinfection in critically ill COVID-19 patients

• Downloaded 346 times
• Download rankings, all-time:
  • Site-wide: 124,803
  • In microbiology: 8,705
• Year to date:
  • Site-wide: 90,232
• Since beginning of last month:
  • Site-wide: 99,152

Regulation of intracellular signaling and neuron function by Bardet-Biedl Syndrome proteins in patient-specific iPSC-derived neurons

• Downloaded 342 times
• Download rankings, all-time:
  • Site-wide: 125,863
  • In cell biology: 5,706
• Year to date:
  • Site-wide: 119,949
• Since beginning of last month:
  • Site-wide: 66,827

The effect of sequence learning on sensorimotor adaptation

• Downloaded 322 times
• Download rankings, all-time:
  • Site-wide: 131,447
  • In neuroscience: 18,921
• Year to date:
  • Site-wide: 131,875
• Since beginning of last month:
  • Site-wide: 102,532

A bacterial Argonaute with efficient DNA and RNA cleavage activity guided by small DNA and RNA

• Downloaded 300 times
• Download rankings, all-time:
  • Site-wide: 138,071
  • In molecular biology: 4,316
• Year to date:
  • Site-wide: 48,267
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  • Site-wide: 34,420

Functional Contribution of Cancer-Associated Fibroblasts in Glioblastoma

• Downloaded 267 times
• Download rankings, all-time:
  • Site-wide: 148,046
  • In cancer biology: None
• Year to date:
  • Site-wide: 12,781
• Since beginning of last month:
  • Site-wide: 17,922

Retinoschisin deficiency induces persistent aberrant waves of activity affecting neuroglial signaling in the retina

• Downloaded 259 times
• Download rankings, all-time:
  • Site-wide: 150,534
  • In neuroscience: 23,630
• Year to date:
  • Site-wide: 35,181
• Since beginning of last month:
  • Site-wide: 36,033

Random-effect based test for multinomial logistic regression: choice of the reference level and its impact on the testing

• Downloaded 245 times
• Download rankings, all-time:
  • Site-wide: 154,495
  • In genetic and genomic medicine: 1,024
• Year to date:
  • Site-wide: 80,158
• Since beginning of last month:
  • Site-wide: 36,395

DeepREAL: A Deep Learning Powered Multi-scale Modeling Framework Towards Predicting Out-of-distribution Receptor Activity of Ligand Binding

• Downloaded 233 times
• Download rankings, all-time:
  • Site-wide: 157,891
  • In bioinformatics: 11,894
• Year to date:
  • Site-wide: 61,674
• Since beginning of last month:
  • Site-wide: 82,496

RNAi screening reveals requirement for PDGFRβ in JEV infection.

• Downloaded 204 times
• Download rankings, all-time:
  • Site-wide: 165,581
  • In microbiology: 11,486
• Year to date:
  • Site-wide: 185,728
• Since beginning of last month:
  • Site-wide: 180,939

The first report and biological characteristics of Helcococcus ovis isolated from clinical bovine mastitis in a Chinese dairy herd

• Downloaded 203 times
• Download rankings, all-time:
  • Site-wide: 165,854
  • In microbiology: 12,185
• Year to date:
  • Site-wide: 70,466
• Since beginning of last month:
  • Site-wide: 75,405

Functional Characterization of a Lassa Virus Fusion Inhibitors Adaptive Mutant

• Downloaded 181 times
• Download rankings, all-time:
  • Site-wide: 171,390
  • In microbiology: 12,049
• Year to date:
  • Site-wide: 141,025
• Since beginning of last month:
  • Site-wide: 180,666

Identification of residues in Lassa virus glycoprotein 1 involved in receptor switch

• Downloaded 161 times
• Download rankings, all-time:
  • Site-wide: 175,799
  • In microbiology: 12,775
• Year to date:
  • Site-wide: 97,728
• Since beginning of last month:
  • Site-wide: 69,831

Screening and Identification of Lujo Virus Entry Inhibitors from an FDA-Approved Drugs Library

• Downloaded 103 times
• Download rankings, all-time:
  • Site-wide: 185,219
  • In microbiology: 13,430
• Year to date:
  • Site-wide: 108,978
• Since beginning of last month:
  • Site-wide: 110,325