Author: Christian Gieger

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Preprints

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

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DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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Genome-wide association study identifies 48 common genetic variants associated with handedness

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Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

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New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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Genome-wide Association Study Of Plasma Proteins Identifies Putatively Causal Genes, Proteins, And Pathways For Cardiovascular Disease

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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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RL-SKAT: An exact and efficient score test for heritability and set tests

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Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • In genetic and genomic medicine: 64
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Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies

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An epigenome-wide association study of educational attainment (n = 10,767)

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Genome-wide methylation data mirror ancestry information

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A genome-wide genetic pleiotropy approach identified shared loci between multiple system atrophy and inflammatory bowel disease

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Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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Network-based metabolite ratios for an improved functional characterization of genome-wide association study results

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Network reconstruction for trans acting genetic loci using multi-omics data and prior information

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Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

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Defining the genetic control of human blood plasma N-glycome using genome-wide association study

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Genetic insights into the biological mechanisms governing human ovarian ageing

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Alcohol consumption is associated with widespread changes in blood DNA methylation: analysis of cross-sectional and longitudinal data

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Epigenetic derepression of FKBP5 by aging and stress contributes to NF-kB-driven inflammation and cardiovascular risk

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Global variability of the human IgG glycome

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Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

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Cis-epistasis at the LPA locus and risk of coronary artery disease

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Elucidating the genetic risk of obesity through the human blood plasma proteome

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Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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