Author: Tonu Esko

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Preprints

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

• Downloaded 9,281 times
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  • Site-wide: 1,516
  • In genetic and genomic medicine: 8
• Year to date:
  • Site-wide: 2,675
• Since beginning of last month:
  • Site-wide: 1,209

Genomewide association study identifies 30 loci associated with bipolar disorder

• Downloaded 7,744 times
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  • Site-wide: 1,924
  • In genetics: 45
• Year to date:
  • Site-wide: 10,228
• Since beginning of last month:
  • Site-wide: 26,424

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

• Downloaded 3,878 times
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  • Site-wide: 5,021
  • In genetics: 160
• Year to date:
  • Site-wide: 37,527
• Since beginning of last month:
  • Site-wide: 51,804

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,967 times
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  • Site-wide: 7,436
  • In genetics: 268
• Year to date:
  • Site-wide: 46,419
• Since beginning of last month:
  • Site-wide: 79,898

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 7,455
  • In genetics: 275
• Year to date:
  • Site-wide: 10,332
• Since beginning of last month:
  • Site-wide: 8,933

The Polygenic and Monogenic Basis of Blood Traits and Diseases

• Downloaded 2,247 times
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  • Site-wide: 11,273
  • In genetic and genomic medicine: 63
• Year to date:
  • Site-wide: 110,426
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  • Site-wide: 77,454

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease

• Downloaded 2,221 times
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  • Site-wide: 11,474
  • In genomics: 1,040
• Year to date:
  • Site-wide: 139,545
• Since beginning of last month:
  • Site-wide: 94,100

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,869 times
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  • Site-wide: 14,924
  • In genetics: 591
• Year to date:
  • Site-wide: 57,548
• Since beginning of last month:
  • Site-wide: 201,740

Educational attainment and personality are genetically intertwined

• Downloaded 1,777 times
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  • Site-wide: 16,147
  • In genetics: 649
• Year to date:
  • Site-wide: 174,166
• Since beginning of last month:
  • Site-wide: 75,069

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 1,472 times
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  • Site-wide: 21,747
  • In genetic and genomic medicine: 130
• Year to date:
  • Site-wide: 94,644
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  • Site-wide: 88,217

Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci

• Downloaded 1,186 times
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  • Site-wide: 30,696
  • In genomics: 2,590
• Year to date:
  • Site-wide: 45,663
• Since beginning of last month:
  • Site-wide: 60,948

Clonal chromosomal mosaicism and loss of chromosome Y in men are risk factors for SARS-CoV-2 vulnerability in the elderly

• Downloaded 1,103 times
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  • Site-wide: 34,365
  • In genetic and genomic medicine: 215
• Year to date:
  • Site-wide: 44,841
• Since beginning of last month:
  • Site-wide: 39,776

A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

• Downloaded 1,030 times
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  • Site-wide: 38,166
  • In bioinformatics: 3,978
• Year to date:
  • Site-wide: 150,417
• Since beginning of last month:
  • Site-wide: 137,144

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

• Downloaded 938 times
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  • Site-wide: 44,141
  • In genetic and genomic medicine: 273
• Year to date:
  • Site-wide: 95,097
• Since beginning of last month:
  • Site-wide: 110,154

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

• Downloaded 832 times
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  • Site-wide: 53,020
  • In genomics: 3,818
• Year to date:
  • Site-wide: 168,112
• Since beginning of last month:
  • Site-wide: 94,167

OTTERS: A powerful TWAS framework leveraging summary-level reference data

• Downloaded 821 times
• Download rankings, all-time:
  • Site-wide: 54,047
  • In genetics: 2,360
• Year to date:
  • Site-wide: 2,815
• Since beginning of last month:
  • Site-wide: 2,063

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

• Downloaded 739 times
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  • Site-wide: 63,210
  • In genetics: 2,438
• Year to date:
  • Site-wide: 130,686
• Since beginning of last month:
  • Site-wide: 161,116

Analytical strategies to include the X-chromosome in variance heterogeneity analyses: evidence for trait-specific polygenic variance structure

• Downloaded 699 times
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  • Site-wide: 68,502
  • In genetics: 2,666
• Year to date:
  • Site-wide: 99,415
• Since beginning of last month:
  • Site-wide: 91,115

A Predictive Modelling Framework for COVID-19 Transmission to Inform the Management of Mass Events

• Downloaded 571 times
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  • Site-wide: 89,360
  • In health policy: 227
• Year to date:
  • Site-wide: 120,948
• Since beginning of last month:
  • Site-wide: 49,107

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome

• Downloaded 522 times
• Download rankings, all-time:
  • Site-wide: 99,479
  • In bioinformatics: 8,662
• Year to date:
  • Site-wide: 78,033
• Since beginning of last month:
  • Site-wide: 215,854

Genome-wide analysis of 944,133 individuals provides insights into the etiology of hemorrhoidal disease

• Downloaded 519 times
• Download rankings, all-time:
  • Site-wide: 100,021
  • In genetic and genomic medicine: 644
• Year to date:
  • Site-wide: 72,650
• Since beginning of last month:
  • Site-wide: 165,959

Genome-wide Screen of Otosclerosis in Population Biobanks: 18 Loci and Shared Heritability with Skeletal Structure

• Downloaded 479 times
• Download rankings, all-time:
  • Site-wide: 109,483
  • In genetic and genomic medicine: 727
• Year to date:
  • Site-wide: 34,682
• Since beginning of last month:
  • Site-wide: 106,666

A multidimensional Mendelian randomization study on the impact of gut dysbiosis on chronic diseases and human longevity

• Downloaded 410 times
• Download rankings, all-time:
  • Site-wide: 127,391
  • In epidemiology: 5,456
• Year to date:
  • Site-wide: 27,586
• Since beginning of last month:
  • Site-wide: 32,441

Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci

• Downloaded 379 times
• Download rankings, all-time:
  • Site-wide: 136,592
  • In genetic and genomic medicine: 944
• Year to date:
  • Site-wide: 144,152
• Since beginning of last month:
  • Site-wide: 103,069

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

• Downloaded 357 times
• Download rankings, all-time:
  • Site-wide: 143,100
  • In dermatology: 75
• Year to date:
  • Site-wide: 2,352
• Since beginning of last month:
  • Site-wide: 6,290

Mendelian randomization identifies the potential causal impact of dietary patterns on circulating blood metabolites

• Downloaded 356 times
• Download rankings, all-time:
  • Site-wide: 143,407
  • In genomics: 7,584
• Year to date:
  • Site-wide: 157,309
• Since beginning of last month:
  • Site-wide: 126,420

Genome-wide characterization of circulating metabolic biomarkers reveals substantial pleiotropy and novel disease pathways

• Downloaded 292 times
• Download rankings, all-time:
  • Site-wide: 162,778
  • In genetic and genomic medicine: 1,346
• Year to date:
  • Site-wide: 2,719
• Since beginning of last month:
  • Site-wide: 13,000

A multivariable Mendelian randomization analysis disentangling the causal relations between abdominal obesity, non-alcoholic fatty liver disease and cardiometabolic diseases

• Downloaded 266 times
• Download rankings, all-time:
  • Site-wide: 170,488
  • In epidemiology: 6,892
• Year to date:
  • Site-wide: 82,471
• Since beginning of last month:
  • Site-wide: 87,591

Mendelian randomization study of spermine oxidase and cancer risk

• Downloaded 225 times
• Download rankings, all-time:
  • Site-wide: 181,559
  • In genetic and genomic medicine: 1,343
• Year to date:
  • Site-wide: 153,069
• Since beginning of last month:
  • Site-wide: 86,969

Mendelian randomization analysis identifies blood tyrosine levels as a biomarker of non-alcoholic fatty liver disease

• Downloaded 224 times
• Download rankings, all-time:
  • Site-wide: 181,997
  • In endocrinology: 275
• Year to date:
  • Site-wide: 83,225
• Since beginning of last month:
  • Site-wide: 108,057