Author: tonu esko

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Preprints

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,487
  • In genetics: 41
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  • Site-wide: 25,713
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  • Site-wide: 30,384

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

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  • Site-wide: 2,392
  • In genetic and genomic medicine: 11
• Year to date:
  • Site-wide: 999
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  • Site-wide: 1,200

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

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  • Site-wide: 3,962
  • In genetics: 136
• Year to date:
  • Site-wide: 49,418
• Since beginning of last month:
  • Site-wide: 111,044

Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • Site-wide: 5,980
  • In genetics: 246
• Year to date:
  • Site-wide: 29,356
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  • Site-wide: 40,779

The Polygenic and Monogenic Basis of Blood Traits and Diseases

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  • Site-wide: 8,623
  • In genetic and genomic medicine: 38
• Year to date:
  • Site-wide: 36,726
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  • Site-wide: 73,020

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease

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  • Site-wide: 8,968
  • In genomics: 903
• Year to date:
  • Site-wide: 57,886
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  • Site-wide: 44,369

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 11,301
  • In genetics: 488
• Year to date:
  • Site-wide: 102,549
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  • Site-wide: 103,786

Educational attainment and personality are genetically intertwined

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  • Site-wide: 12,476
  • In genetics: 552
• Year to date:
  • Site-wide: 97,650
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  • Site-wide: 124,294

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 12,985
  • In genetics: 577
• Year to date:
  • Site-wide: 4,535
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  • Site-wide: 3,368

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

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  • Site-wide: 21,080
  • In genetic and genomic medicine: 94
• Year to date:
  • Site-wide: 7,301
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  • Site-wide: 5,611

Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci

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  • Site-wide: 24,813
  • In genomics: 2,297
• Year to date:
  • Site-wide: 84,360
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  • Site-wide: 74,228

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

• Downloaded 743 times
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  • Site-wide: 40,125
  • In genetic and genomic medicine: 174
• Year to date:
  • Site-wide: 14,351
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  • Site-wide: 13,313

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

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  • Site-wide: 46,179
  • In genomics: 3,620
• Year to date:
  • Site-wide: 72,057
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  • Site-wide: 68,596

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

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  • Site-wide: 50,672
  • In genetics: 2,217
• Year to date:
  • Site-wide: 82,701
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  • Site-wide: 60,787

Analytical strategies to include the X-chromosome in variance heterogeneity analyses: evidence for trait-specific polygenic variance structure

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  • Site-wide: 61,281
  • In genetics: 2,657
• Year to date:
  • Site-wide: 93,475
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  • Site-wide: 68,690

A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

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  • Site-wide: 63,647
  • In bioinformatics: 6,171
• Year to date:
  • Site-wide: 11,273
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  • Site-wide: 18,224

Genome-wide analysis of 944,133 individuals provides insights into the etiology of hemorrhoidal disease

• Downloaded 420 times
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  • Site-wide: 79,350
  • In genetic and genomic medicine: 360
• Year to date:
  • Site-wide: 33,077
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  • Site-wide: 54,332

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome

• Downloaded 408 times
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  • Site-wide: 81,788
  • In bioinformatics: 7,418
• Year to date:
  • Site-wide: 90,302
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  • Site-wide: 85,020

A Predictive Modelling Framework for COVID-19 Transmission to Inform the Management of Mass Events

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  • Site-wide: 93,129
  • In health policy: 220
• Year to date:
  • Site-wide: 19,726
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  • Site-wide: 14,540

Genome-wide Screen of Otosclerosis in Population Biobanks: 18 Loci and Shared Heritability with Skeletal Structure

• Downloaded 253 times
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  • Site-wide: 117,669
  • In genetic and genomic medicine: 639
• Year to date:
  • Site-wide: 57,234
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  • Site-wide: 41,909

Mendelian randomization identifies the potential causal impact of dietary patterns on circulating blood metabolites

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  • Site-wide: 124,525
  • In genomics: 6,872
• Year to date:
  • Site-wide: 62,832
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  • Site-wide: 79,912

Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci

• Downloaded 155 times
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  • Site-wide: 141,885
  • In genetic and genomic medicine: 819
• Year to date:
  • Site-wide: 56,024
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  • Site-wide: 77,802

Mendelian randomization study of spermine oxidase and cancer risk

• Downloaded 139 times
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  • Site-wide: 145,384
  • In genetic and genomic medicine: 862
• Year to date:
  • Site-wide: 103,760
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  • Site-wide: 105,681

A multidimensional Mendelian randomization study on the impact of gut dysbiosis on chronic diseases and human longevity

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  • Site-wide: 146,880
  • In epidemiology: 6,077
• Year to date:
  • Site-wide: 66,364
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  • Site-wide: 18,395

A multivariable Mendelian randomization analysis disentangling the causal relations between abdominal obesity, non-alcoholic fatty liver disease and cardiometabolic diseases

• Downloaded 25 times
• Download rankings, all-time:
  • Site-wide: 158,096
  • In epidemiology: 6,503
• Year to date:
  • Site-wide: 156,492
• Since beginning of last month:
  • Site-wide: 49,076