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Author: Tonu Esko

Rankings

  • All-time downloads: 48,363 (rank: 5,407 )
  • Categories:
    • bioinformatics: 1,542 (rank: 15,188 (tie) )
    • dermatology: 277 (rank: 584 (tie) )
    • endocrinology: 216 (rank: 2,451 (tie) )
    • epidemiology: 646 (rank: 22,904 (tie) )
    • genetic and genomic medicine: 16,675 (rank: 34 )
    • genetics: 23,251 (rank: 548 )
    • genomics: 4,563 (rank: 7,446 )
    • health policy: 564 (rank: 1,334 (tie) )

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Preprints

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

genetic and genomic medicine more details view paper
  • Downloaded 9,281 times
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    • Site-wide: 1,516
    • In genetic and genomic medicine: 8
  • Year to date:
    • Site-wide: 2,675
  • Since beginning of last month:
    • Site-wide: 1,209

Genomewide association study identifies 30 loci associated with bipolar disorder

genetics more details view paper
  • Downloaded 7,744 times
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    • Site-wide: 1,924
    • In genetics: 45
  • Year to date:
    • Site-wide: 10,228
  • Since beginning of last month:
    • Site-wide: 26,424

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

genetics more details view paper
  • Downloaded 3,878 times
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    • Site-wide: 5,021
    • In genetics: 160
  • Year to date:
    • Site-wide: 37,527
  • Since beginning of last month:
    • Site-wide: 51,804

Genome-wide association study identifies 48 common genetic variants associated with handedness

genetics more details view paper
  • Downloaded 2,967 times
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    • Site-wide: 7,436
    • In genetics: 268
  • Year to date:
    • Site-wide: 46,419
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    • Site-wide: 79,898

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

genetics more details view paper
  • Downloaded 2,959 times
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    • Site-wide: 7,455
    • In genetics: 275
  • Year to date:
    • Site-wide: 10,332
  • Since beginning of last month:
    • Site-wide: 8,933

The Polygenic and Monogenic Basis of Blood Traits and Diseases

genetic and genomic medicine more details view paper
  • Downloaded 2,247 times
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    • Site-wide: 11,273
    • In genetic and genomic medicine: 63
  • Year to date:
    • Site-wide: 110,426
  • Since beginning of last month:
    • Site-wide: 77,454

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease

genomics more details view paper
  • Downloaded 2,221 times
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    • Site-wide: 11,474
    • In genomics: 1,040
  • Year to date:
    • Site-wide: 139,545
  • Since beginning of last month:
    • Site-wide: 94,100

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

genetics more details view paper
  • Downloaded 1,869 times
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    • Site-wide: 14,924
    • In genetics: 591
  • Year to date:
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  • Since beginning of last month:
    • Site-wide: 201,740

Educational attainment and personality are genetically intertwined

genetics more details view paper
  • Downloaded 1,777 times
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    • Site-wide: 16,147
    • In genetics: 649
  • Year to date:
    • Site-wide: 174,166
  • Since beginning of last month:
    • Site-wide: 75,069

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

genetic and genomic medicine more details view paper
  • Downloaded 1,472 times
  • Download rankings, all-time:
    • Site-wide: 21,747
    • In genetic and genomic medicine: 130
  • Year to date:
    • Site-wide: 94,644
  • Since beginning of last month:
    • Site-wide: 88,217

Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci

genomics more details view paper
  • Downloaded 1,186 times
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    • Site-wide: 30,696
    • In genomics: 2,590
  • Year to date:
    • Site-wide: 45,663
  • Since beginning of last month:
    • Site-wide: 60,948

Clonal chromosomal mosaicism and loss of chromosome Y in men are risk factors for SARS-CoV-2 vulnerability in the elderly

genetic and genomic medicine more details view paper
  • Downloaded 1,103 times
  • Download rankings, all-time:
    • Site-wide: 34,365
    • In genetic and genomic medicine: 215
  • Year to date:
    • Site-wide: 44,841
  • Since beginning of last month:
    • Site-wide: 39,776

A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

bioinformatics more details view paper
  • Downloaded 1,030 times
  • Download rankings, all-time:
    • Site-wide: 38,166
    • In bioinformatics: 3,978
  • Year to date:
    • Site-wide: 150,417
  • Since beginning of last month:
    • Site-wide: 137,144

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

genetic and genomic medicine more details view paper
  • Downloaded 938 times
  • Download rankings, all-time:
    • Site-wide: 44,141
    • In genetic and genomic medicine: 273
  • Year to date:
    • Site-wide: 95,097
  • Since beginning of last month:
    • Site-wide: 110,154

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

genomics more details view paper
  • Downloaded 832 times
  • Download rankings, all-time:
    • Site-wide: 53,020
    • In genomics: 3,818
  • Year to date:
    • Site-wide: 168,112
  • Since beginning of last month:
    • Site-wide: 94,167

OTTERS: A powerful TWAS framework leveraging summary-level reference data

genetics more details view paper
  • Downloaded 821 times
  • Download rankings, all-time:
    • Site-wide: 54,047
    • In genetics: 2,360
  • Year to date:
    • Site-wide: 2,815
  • Since beginning of last month:
    • Site-wide: 2,063

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

genetics more details view paper
  • Downloaded 739 times
  • Download rankings, all-time:
    • Site-wide: 63,210
    • In genetics: 2,438
  • Year to date:
    • Site-wide: 130,686
  • Since beginning of last month:
    • Site-wide: 161,116

Analytical strategies to include the X-chromosome in variance heterogeneity analyses: evidence for trait-specific polygenic variance structure

genetics more details view paper
  • Downloaded 699 times
  • Download rankings, all-time:
    • Site-wide: 68,502
    • In genetics: 2,666
  • Year to date:
    • Site-wide: 99,415
  • Since beginning of last month:
    • Site-wide: 91,115

A Predictive Modelling Framework for COVID-19 Transmission to Inform the Management of Mass Events

health policy more details view paper
  • Downloaded 571 times
  • Download rankings, all-time:
    • Site-wide: 89,360
    • In health policy: 227
  • Year to date:
    • Site-wide: 120,948
  • Since beginning of last month:
    • Site-wide: 49,107

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome

bioinformatics more details view paper
  • Downloaded 522 times
  • Download rankings, all-time:
    • Site-wide: 99,479
    • In bioinformatics: 8,662
  • Year to date:
    • Site-wide: 78,033
  • Since beginning of last month:
    • Site-wide: 215,854

Genome-wide analysis of 944,133 individuals provides insights into the etiology of hemorrhoidal disease

genetic and genomic medicine more details view paper
  • Downloaded 519 times
  • Download rankings, all-time:
    • Site-wide: 100,021
    • In genetic and genomic medicine: 644
  • Year to date:
    • Site-wide: 72,650
  • Since beginning of last month:
    • Site-wide: 165,959

Genome-wide Screen of Otosclerosis in Population Biobanks: 18 Loci and Shared Heritability with Skeletal Structure

genetic and genomic medicine more details view paper
  • Downloaded 479 times
  • Download rankings, all-time:
    • Site-wide: 109,483
    • In genetic and genomic medicine: 727
  • Year to date:
    • Site-wide: 34,682
  • Since beginning of last month:
    • Site-wide: 106,666

A multidimensional Mendelian randomization study on the impact of gut dysbiosis on chronic diseases and human longevity

epidemiology more details view paper
  • Downloaded 410 times
  • Download rankings, all-time:
    • Site-wide: 127,391
    • In epidemiology: 5,456
  • Year to date:
    • Site-wide: 27,586
  • Since beginning of last month:
    • Site-wide: 32,441

Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci

genetic and genomic medicine more details view paper
  • Downloaded 379 times
  • Download rankings, all-time:
    • Site-wide: 136,592
    • In genetic and genomic medicine: 944
  • Year to date:
    • Site-wide: 144,152
  • Since beginning of last month:
    • Site-wide: 103,069

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

dermatology more details view paper
  • Downloaded 357 times
  • Download rankings, all-time:
    • Site-wide: 143,100
    • In dermatology: 75
  • Year to date:
    • Site-wide: 2,352
  • Since beginning of last month:
    • Site-wide: 6,290

Mendelian randomization identifies the potential causal impact of dietary patterns on circulating blood metabolites

genomics more details view paper
  • Downloaded 356 times
  • Download rankings, all-time:
    • Site-wide: 143,407
    • In genomics: 7,584
  • Year to date:
    • Site-wide: 157,309
  • Since beginning of last month:
    • Site-wide: 126,420

Genome-wide characterization of circulating metabolic biomarkers reveals substantial pleiotropy and novel disease pathways

genetic and genomic medicine more details view paper
  • Downloaded 292 times
  • Download rankings, all-time:
    • Site-wide: 162,778
    • In genetic and genomic medicine: 1,346
  • Year to date:
    • Site-wide: 2,719
  • Since beginning of last month:
    • Site-wide: 13,000

A multivariable Mendelian randomization analysis disentangling the causal relations between abdominal obesity, non-alcoholic fatty liver disease and cardiometabolic diseases

epidemiology more details view paper
  • Downloaded 266 times
  • Download rankings, all-time:
    • Site-wide: 170,488
    • In epidemiology: 6,892
  • Year to date:
    • Site-wide: 82,471
  • Since beginning of last month:
    • Site-wide: 87,591

Mendelian randomization study of spermine oxidase and cancer risk

genetic and genomic medicine more details view paper
  • Downloaded 225 times
  • Download rankings, all-time:
    • Site-wide: 181,559
    • In genetic and genomic medicine: 1,343
  • Year to date:
    • Site-wide: 153,069
  • Since beginning of last month:
    • Site-wide: 86,969

Mendelian randomization analysis identifies blood tyrosine levels as a biomarker of non-alcoholic fatty liver disease

endocrinology more details view paper
  • Downloaded 224 times
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    • Site-wide: 181,997
    • In endocrinology: 275
  • Year to date:
    • Site-wide: 83,225
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    • Site-wide: 108,057

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