Author: Konstantin Strauch

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Preprints

DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

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  • Site-wide: 2,473
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• Year to date:
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  • Site-wide: 55,658

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 3,697
  • In genomics: 416
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  • Site-wide: 59,019
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  • Site-wide: 42,343

Cell specific eQTL analysis without sorting cells

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  • Site-wide: 7,430
  • In genetics: 350
• Year to date:
  • Site-wide: 102,684
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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 8,388
  • In genetics: 393
• Year to date:
  • Site-wide: 87,764
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  • Site-wide: 88,900

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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  • Site-wide: 9,288
  • In genetics: 442
• Year to date:
  • Site-wide: 106,573
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  • Site-wide: 112,198

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 9,872
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Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

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  • Site-wide: 9,928
  • In genetics: 475
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  • Site-wide: 69,906
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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • Site-wide: 15,227
  • In genomics: 1,578
• Year to date:
  • Site-wide: 87,318
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  • Site-wide: 120,296

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 16,765
  • In genetics: 821
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  • Site-wide: 6,231
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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • Site-wide: 18,670
  • In genetic and genomic medicine: 64
• Year to date:
  • Site-wide: 7,747
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  • Site-wide: 9,283

Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies

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  • Site-wide: 19,589
  • In systems biology: 399
• Year to date:
  • Site-wide: 74,772
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  • Site-wide: 96,975

Genome-wide methylation data mirror ancestry information

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  • Site-wide: 21,586
  • In genetics: 1,038
• Year to date:
  • Site-wide: 124,269
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  • Site-wide: 120,694

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 25,360
  • In genetics: 1,223
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  • Site-wide: 19,255
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  • Site-wide: 10,875

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

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  • Site-wide: 28,248
  • In genetic and genomic medicine: 89
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  • Site-wide: 22,204

Network reconstruction for trans acting genetic loci using multi-omics data and prior information

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  • Site-wide: 38,928
  • In bioinformatics: 4,251
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  • Site-wide: 25,376
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  • Site-wide: 19,936

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

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  • Site-wide: 41,204
  • In genetics: 1,953
• Year to date:
  • Site-wide: 77,047
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  • Site-wide: 71,094

Genetic insights into the biological mechanisms governing human ovarian ageing

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  • Site-wide: 43,555
  • In sexual and reproductive health: 18
• Year to date:
  • Site-wide: 2,346
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  • Site-wide: 7,099

Discovering patterns of pleiotropy in genome-wide association studies

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  • Site-wide: 44,238
  • In genetics: 2,073
• Year to date:
  • Site-wide: 115,324
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  • Site-wide: 97,468

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

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  • Site-wide: 45,109
  • In genetics: 2,121
• Year to date:
  • Site-wide: 93,053
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  • Site-wide: 79,064

Genome wide association analysis in dilated cardiomyopathy reveals two new key players in systolic heart failure on chromosome 3p25.1 and 22q11.23

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  • Site-wide: 49,704
  • In genomics: 3,912
• Year to date:
  • Site-wide: 21,758
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  • Site-wide: 19,036

annoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusions

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  • Site-wide: 50,445
  • In bioinformatics: 5,212
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Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

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  • Site-wide: 52,036
  • In genomics: 4,036
• Year to date:
  • Site-wide: 120,060
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  • Site-wide: 116,900

Cis-epistasis at the LPA locus and risk of coronary artery disease

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  • Site-wide: 52,722
  • In genetics: 2,450
• Year to date:
  • Site-wide: 95,351
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  • Site-wide: 120,007

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 476 times
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  • Site-wide: 55,735
  • In genetics: 2,588
• Year to date:
  • Site-wide: 118,304
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  • Site-wide: 130,812

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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  • Site-wide: 92,035
  • In genetics: 4,141
• Year to date:
  • Site-wide: 123,272
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  • Site-wide: 112,705

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter

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  • Site-wide: 92,357
  • In genetics: 4,151
• Year to date:
  • Site-wide: 130,510
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  • Site-wide: 127,613

Biomarker-based outcome prediction in prostate adenocarcinoma depends on the TMPRSS2-ERG status

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  • Site-wide: 96,599
  • In cancer biology: 2,942
• Year to date:
  • Site-wide: 106,786
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  • Site-wide: 106,750

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 210 times
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  • Site-wide: 104,866
  • In genomics: 6,130
• Year to date:
  • Site-wide: 98,746
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  • Site-wide: 75,307