Author: Konstantin Strauch

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Preprints

DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

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  • Site-wide: 3,218
  • In systems biology: 45
• Year to date:
  • Site-wide: 81,928
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  • Site-wide: 123,532

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,312 times
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  • Site-wide: 4,777
  • In genomics: 469
• Year to date:
  • Site-wide: 109,472
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  • Site-wide: 143,780

Genetic insights into the biological mechanisms governing human ovarian ageing

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  • Site-wide: 8,695
  • In sexual and reproductive health: 12
• Year to date:
  • Site-wide: 1,749
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  • Site-wide: 2,820

Cell specific eQTL analysis without sorting cells

• Downloaded 2,030 times
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  • Site-wide: 9,758
  • In genetics: 396
• Year to date:
  • Site-wide: 158,339
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  • Site-wide: 161,413

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,907 times
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  • Site-wide: 10,737
  • In genetics: 455
• Year to date:
  • Site-wide: 131,789
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  • Site-wide: 158,990

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 1,784 times
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  • Site-wide: 11,874
  • In genetic and genomic medicine: 54
• Year to date:
  • Site-wide: 5,826
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  • Site-wide: 5,711

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,774 times
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  • Site-wide: 11,958
  • In genetics: 509
• Year to date:
  • Site-wide: 79,631
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  • Site-wide: 132,578

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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  • Site-wide: 12,080
  • In genetics: 517
• Year to date:
  • Site-wide: 156,623
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  • Site-wide: 144,060

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

• Downloaded 1,735 times
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  • Site-wide: 12,358
  • In genetics: 525
• Year to date:
  • Site-wide: 103,718
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  • Site-wide: 124,118

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 14,724
  • In genetics: 646
• Year to date:
  • Site-wide: 10,001
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  • Site-wide: 38,889

GeneTonic: an R/Bioconductor package for streamlining the interpretation of RNA-seq data

• Downloaded 1,542 times
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  • Site-wide: 14,779
  • In bioinformatics: 1,668
• Year to date:
  • Site-wide: 2,878
• Since beginning of last month:
  • Site-wide: 1,375

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,322 times
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  • Site-wide: 18,760
  • In genomics: 1,759
• Year to date:
  • Site-wide: 111,643
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  • Site-wide: 115,020

Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies

• Downloaded 1,087 times
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  • Site-wide: 25,258
  • In systems biology: 475
• Year to date:
  • Site-wide: 141,941
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  • Site-wide: 148,167

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 25,554
  • In genetics: 1,121
• Year to date:
  • Site-wide: 30,207
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  • Site-wide: 65,273

Genome-wide methylation data mirror ancestry information

• Downloaded 998 times
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  • Site-wide: 28,681
  • In genetics: 1,265
• Year to date:
  • Site-wide: 164,144
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  • Site-wide: 160,635

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

• Downloaded 972 times
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  • Site-wide: 29,831
  • In genetic and genomic medicine: 139
• Year to date:
  • Site-wide: 42,643
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  • Site-wide: 106,214

Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation

• Downloaded 928 times
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  • Site-wide: 31,914
  • In genomics: 2,714
• Year to date:
  • Site-wide: 6,086
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  • Site-wide: 7,917

Network reconstruction for trans acting genetic loci using multi-omics data and prior information

• Downloaded 825 times
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  • Site-wide: 37,898
  • In bioinformatics: 4,070
• Year to date:
  • Site-wide: 36,858
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  • Site-wide: 69,098

Genome wide association analysis in dilated cardiomyopathy reveals two new key players in systolic heart failure on chromosome 3p25.1 and 22q11.23

• Downloaded 714 times
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  • Site-wide: 46,566
  • In genomics: 3,584
• Year to date:
  • Site-wide: 33,895
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  • Site-wide: 72,508

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 668 times
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  • Site-wide: 51,071
  • In genetics: 2,175
• Year to date:
  • Site-wide: 128,438
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  • Site-wide: 142,249

annoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusions

• Downloaded 653 times
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  • Site-wide: 52,666
  • In bioinformatics: 5,269
• Year to date:
  • Site-wide: 63,146
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  • Site-wide: 56,744

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

• Downloaded 651 times
• Download rankings, all-time:
  • Site-wide: 52,903
  • In genetics: 2,252
• Year to date:
  • Site-wide: 111,564
• Since beginning of last month:
  • Site-wide: 106,033

Discovering patterns of pleiotropy in genome-wide association studies

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  • Site-wide: 53,323
  • In genetics: 2,273
• Year to date:
  • Site-wide: 129,656
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  • Site-wide: 116,425

Cis-epistasis at the LPA locus and risk of coronary artery disease

• Downloaded 579 times
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  • Site-wide: 61,561
  • In genetics: 2,614
• Year to date:
  • Site-wide: 114,057
• Since beginning of last month:
  • Site-wide: 113,858

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 569 times
• Download rankings, all-time:
  • Site-wide: 62,851
  • In genomics: 4,483
• Year to date:
  • Site-wide: 136,691
• Since beginning of last month:
  • Site-wide: 84,288

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 529 times
• Download rankings, all-time:
  • Site-wide: 68,644
  • In genetics: 2,917
• Year to date:
  • Site-wide: 143,981
• Since beginning of last month:
  • Site-wide: 95,592

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 463 times
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  • Site-wide: 79,795
  • In genomics: 5,232
• Year to date:
  • Site-wide: 39,125
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  • Site-wide: 18,268

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter

• Downloaded 317 times
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  • Site-wide: 112,234
  • In genetics: 4,609
• Year to date:
  • Site-wide: 150,041
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  • Site-wide: 137,099

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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  • Site-wide: 113,037
  • In genetics: 4,633
• Year to date:
  • Site-wide: 150,900
• Since beginning of last month:
  • Site-wide: 122,931

Biomarker-based outcome prediction in prostate adenocarcinoma depends on the TMPRSS2-ERG status

• Downloaded 293 times
• Download rankings, all-time:
  • Site-wide: 118,491
  • In cancer biology: 3,593
• Year to date:
  • Site-wide: 146,437
• Since beginning of last month:
  • Site-wide: 153,683

Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

• Downloaded 175 times
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  • Site-wide: 148,381
  • In genetic and genomic medicine: 915
• Year to date:
  • Site-wide: 68,501
• Since beginning of last month:
  • Site-wide: 61,029

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

• Downloaded 96 times
• Download rankings, all-time:
  • Site-wide: 161,006
  • In genetic and genomic medicine: 1,036
• Year to date:
  • Site-wide: 118,852
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  • Site-wide: 19,182