Author: Roger L. Milne

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Preprints

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

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  • Site-wide: 9,687
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  • Site-wide: 50,503
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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • Site-wide: 15,145
  • In genomics: 1,572
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  • Site-wide: 86,565
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  • Site-wide: 118,107

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 16,691
  • In genetics: 819
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  • Site-wide: 5,924
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An epigenome-wide association study of educational attainment (n = 10,767)

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  • Site-wide: 21,063
  • In genetics: 1,014
• Year to date:
  • Site-wide: 64,472
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Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

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  • Site-wide: 24,142
  • In genetics: 1,168
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Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

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  • Site-wide: 26,666
  • In genetics: 1,293
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  • Site-wide: 48,561
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  • Site-wide: 41,297

Prospective Evaluation of a Breast Cancer Risk Model Integrating Classical Risk Factors and Polygenic Risk in 15 Cohorts from Six Countries

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  • Site-wide: 41,684
  • In epidemiology: 1,980
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  • Site-wide: 54,185
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Genetic insights into the biological mechanisms governing human ovarian ageing

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  • Site-wide: 43,368
  • In sexual and reproductive health: 18
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  • Site-wide: 2,236
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  • Site-wide: 6,225

Alcohol consumption is associated with widespread changes in blood DNA methylation: analysis of cross-sectional and longitudinal data

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  • Site-wide: 43,737
  • In epidemiology: 2,053
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  • Site-wide: 38,581
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  • Site-wide: 24,058

Shared heritability and functional enrichment across six solid cancers

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  • Site-wide: 49,035
  • In genomics: 3,871
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  • Site-wide: 117,853
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  • Site-wide: 117,792

Common breast cancer risk loci predispose to distinct tumor subtypes

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  • Site-wide: 53,432
  • In genetics: 2,474
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  • Site-wide: 23,265
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  • Site-wide: 50,331

Inference about causation between body mass index and DNA methylation in blood from a twin family study

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  • Site-wide: 68,386
  • In epidemiology: 2,893
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  • Site-wide: 58,289
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  • Site-wide: 33,459

Smoking and blood DNA methylation: novel associations, replication of previous findings and assessment of reversibility

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  • Site-wide: 72,066
  • In genomics: 4,967
• Year to date:
  • Site-wide: 117,752
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  • Site-wide: 132,313

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

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  • Site-wide: 75,525
  • In epidemiology: 3,157
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  • Site-wide: 78,835
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  • Site-wide: 67,825

Identifying 31 novel breast cancer susceptibility loci using data from genome-wide association studies conducted in Asian and European women

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  • Site-wide: 78,551
  • In epidemiology: 3,267
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  • Site-wide: 96,637
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Biological aging measures based on blood DNA methylation and risk of cancer: a prospective study

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  • Site-wide: 85,491
  • In epidemiology: 3,516
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  • Site-wide: 83,093
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  • Site-wide: 95,250

Genome-wide association study of peripheral blood DNA methylation and conventional mammographic density measures

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  • Site-wide: 86,611
  • In epidemiology: 3,566
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  • Site-wide: 84,181
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  • Site-wide: 58,196

Causes of variation in epigenetic aging across the lifespan

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  • Site-wide: 91,632
  • In genetic and genomic medicine: 347
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  • Site-wide: 66,706

Genetic architectures of proximal and distal colorectal cancer are partly distinct

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  • Site-wide: 97,313
  • In genetic and genomic medicine: 381
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  • Site-wide: 57,653
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  • Site-wide: 56,930

The association between low-density lipoprotein cholesterol predicted by HMGCR genetic variants and breast cancer risk may be mediated by body mass index

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  • Site-wide: 104,392
  • In epidemiology: 4,309
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  • Site-wide: 125,506
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  • Site-wide: 100,914

Novel mammogram-based measures improve breast cancer risk prediction beyond an established measure of mammographic density

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  • Site-wide: 106,657
  • In radiology and imaging: 197
• Year to date:
  • Site-wide: 49,643
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  • Site-wide: 40,802

The association between weight at birth and breast cancer risk revisited using Mendelian randomisation

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  • Site-wide: 107,655
  • In epidemiology: 4,445
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  • Site-wide: 125,504
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  • Site-wide: 115,817

Polygenic Risk Modelling for Prediction of Epithelial Ovarian Cancer Risk

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  • Site-wide: 117,292
  • In epidemiology: 4,809
• Year to date:
  • Site-wide: 47,031
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  • Site-wide: 45,320

DNA methylation signatures and the contribution of age-associated methylomic drift to carcinogenesis in early-onset colorectal cancer

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  • Site-wide: 132,256
  • In gastroenterology: 168
• Year to date:
  • Site-wide: 42,408
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  • Site-wide: 13,449

Methylation scores for smoking, alcohol consumption, and body mass index and risk of seven types of cancer

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  • Site-wide: 133,479
  • In epidemiology: 5,400
• Year to date:
  • Site-wide: 58,768
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  • Site-wide: 45,123

Smoking methylation marks for prediction of urothelial cancer risk

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  • Site-wide: 133,754
  • In epidemiology: 5,414
• Year to date:
  • Site-wide: 67,150
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  • Site-wide: 24,822