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Author: Andres Metspalu

  • ORCiD: http://orcid.org/0000-0002-3718-796X
  • Most recently observed institution: Estonian Biobank Research Team; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia

Rankings

  • All-time downloads: 90,597 (rank: 2,505 )
  • Categories:
    • bioinformatics: 923 (rank: 22,455 (tie) )
    • epidemiology: 392 (rank: 29,884 (tie) )
    • genetic and genomic medicine: 6,941 (rank: 399 )
    • genetics: 60,826 (rank: 72 )
    • genomics: 12,372 (rank: 1,989 )
    • hiv aids: 2,258 (rank: 53 (tie) )
    • psychiatry and clinical psychology: 884 (rank: 2,698 (tie) )
    • sexual and reproductive health: 2,505 (rank: 158 (tie) )

Downloads per author, site-wide

Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

genetics more details view paper
  • Downloaded 9,791 times
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    • Site-wide: 1,379
    • In genetics: 27
  • Year to date:
    • Site-wide: 40,035
  • Since beginning of last month:
    • Site-wide: 26,341

Genomewide association study identifies 30 loci associated with bipolar disorder

genetics more details view paper
  • Downloaded 7,699 times
  • Download rankings, all-time:
    • Site-wide: 1,898
    • In genetics: 42
  • Year to date:
    • Site-wide: 55,062
  • Since beginning of last month:
    • Site-wide: 21,226

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

genetics more details view paper
  • Downloaded 6,160 times
  • Download rankings, all-time:
    • Site-wide: 2,575
    • In genetics: 83
  • Year to date:
    • Site-wide: 245
  • Since beginning of last month:
    • Site-wide: 697

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

genetics more details view paper
  • Downloaded 3,416 times
  • Download rankings, all-time:
    • Site-wide: 5,880
    • In genetics: 194
  • Year to date:
    • Site-wide: 85,050
  • Since beginning of last month:
    • Site-wide: 69,639

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

genomics more details view paper
  • Downloaded 3,375 times
  • Download rankings, all-time:
    • Site-wide: 5,986
    • In genomics: 541
  • Year to date:
    • Site-wide: 148,773
  • Since beginning of last month:
    • Site-wide: 123,752

Improved polygenic prediction by Bayesian multiple regression on summary statistics

genetics more details view paper
  • Downloaded 3,045 times
  • Download rankings, all-time:
    • Site-wide: 6,963
    • In genetics: 254
  • Year to date:
    • Site-wide: 66,638
  • Since beginning of last month:
    • Site-wide: 33,794

Genome-wide association study identifies 48 common genetic variants associated with handedness

genetics more details view paper
  • Downloaded 2,947 times
  • Download rankings, all-time:
    • Site-wide: 7,281
    • In genetics: 261
  • Year to date:
    • Site-wide: 63,160
  • Since beginning of last month:
    • Site-wide: 83,428

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

genetics more details view paper
  • Downloaded 2,595 times
  • Download rankings, all-time:
    • Site-wide: 8,766
    • In genetics: 324
  • Year to date:
    • Site-wide: 178,951
  • Since beginning of last month:
    • Site-wide: 201,807

Genetic insights into the biological mechanisms governing human ovarian ageing

sexual and reproductive health more details view paper
  • Downloaded 2,556 times
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    • Site-wide: 8,984
    • In sexual and reproductive health: 13
  • Year to date:
    • Site-wide: 23,806
  • Since beginning of last month:
    • Site-wide: 59,238

Widespread signatures of negative selection in the genetic architecture of human complex traits

genetics more details view paper
  • Downloaded 2,506 times
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    • Site-wide: 9,245
    • In genetics: 353
  • Year to date:
    • Site-wide: 119,539
  • Since beginning of last month:
    • Site-wide: 68,679

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

genetic and genomic medicine more details view paper
  • Downloaded 2,495 times
  • Download rankings, all-time:
    • Site-wide: 9,309
    • In genetic and genomic medicine: 55
  • Year to date:
    • Site-wide: 7,163
  • Since beginning of last month:
    • Site-wide: 8,910

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

genetics more details view paper
  • Downloaded 2,453 times
  • Download rankings, all-time:
    • Site-wide: 9,546
    • In genetics: 362
  • Year to date:
    • Site-wide: 133,107
  • Since beginning of last month:
    • Site-wide: 121,715

A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

hiv aids more details view paper
  • Downloaded 2,333 times
  • Download rankings, all-time:
    • Site-wide: 10,344
    • In hiv aids: 6
  • Year to date:
    • Site-wide: 16,014
  • Since beginning of last month:
    • Site-wide: 18,706

FinnGen: Unique genetic insights from combining isolated population and national health register data

genetic and genomic medicine more details view paper
  • Downloaded 2,222 times
  • Download rankings, all-time:
    • Site-wide: 11,117
    • In genetic and genomic medicine: 106
  • Year to date:
    • Site-wide: 993
  • Since beginning of last month:
    • Site-wide: 782

Cell specific eQTL analysis without sorting cells

genetics more details view paper
  • Downloaded 2,079 times
  • Download rankings, all-time:
    • Site-wide: 12,289
    • In genetics: 444
  • Year to date:
    • Site-wide: 178,873
  • Since beginning of last month:
    • Site-wide: 181,427

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

genetics more details view paper
  • Downloaded 1,963 times
  • Download rankings, all-time:
    • Site-wide: 13,408
    • In genetics: 506
  • Year to date:
    • Site-wide: 160,574
  • Since beginning of last month:
    • Site-wide: 126,963

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

genetics more details view paper
  • Downloaded 1,956 times
  • Download rankings, all-time:
    • Site-wide: 13,480
    • In genetics: 504
  • Year to date:
    • Site-wide: 167,193
  • Since beginning of last month:
    • Site-wide: 204,777

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

genetics more details view paper
  • Downloaded 1,856 times
  • Download rankings, all-time:
    • Site-wide: 14,585
    • In genetics: 568
  • Year to date:
    • Site-wide: 140,620
  • Since beginning of last month:
    • Site-wide: 62,808

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

genetics more details view paper
  • Downloaded 1,765 times
  • Download rankings, all-time:
    • Site-wide: 15,764
    • In genetics: 625
  • Year to date:
    • Site-wide: 123,496
  • Since beginning of last month:
    • Site-wide: 108,032

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

genomics more details view paper
  • Downloaded 1,606 times
  • Download rankings, all-time:
    • Site-wide: 18,245
    • In genomics: 1,618
  • Year to date:
    • Site-wide: 110,495
  • Since beginning of last month:
    • Site-wide: 108,420

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

genetic and genomic medicine more details view paper
  • Downloaded 1,458 times
  • Download rankings, all-time:
    • Site-wide: 21,277
    • In genetic and genomic medicine: 121
  • Year to date:
    • Site-wide: 55,303
  • Since beginning of last month:
    • Site-wide: 171,405

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

genomics more details view paper
  • Downloaded 1,403 times
  • Download rankings, all-time:
    • Site-wide: 22,615
    • In genomics: 1,934
  • Year to date:
    • Site-wide: 124,201
  • Since beginning of last month:
    • Site-wide: 70,537

The genetic architecture of sporadic and recurrent miscarriage

genetics more details view paper
  • Downloaded 1,307 times
  • Download rankings, all-time:
    • Site-wide: 25,331
    • In genetics: 993
  • Year to date:
    • Site-wide: 132,956
  • Since beginning of last month:
    • Site-wide: 91,289

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

genetics more details view paper
  • Downloaded 1,285 times
  • Download rankings, all-time:
    • Site-wide: 26,002
    • In genetics: 1,018
  • Year to date:
    • Site-wide: 104,858
  • Since beginning of last month:
    • Site-wide: 96,599

Haplotype sharing provides insights into fine-scale population history and disease in Finland

genetics more details view paper
  • Downloaded 1,267 times
  • Download rankings, all-time:
    • Site-wide: 26,621
    • In genetics: 1,045
  • Year to date:
    • Site-wide: 119,415
  • Since beginning of last month:
    • Site-wide: 69,675

Mega-analysis of 31,396 individuals from 6 countries uncovers strong gene-environment interaction for human fertility

genomics more details view paper
  • Downloaded 1,198 times
  • Download rankings, all-time:
    • Site-wide: 29,033
    • In genomics: 2,402
  • Year to date:
    • Site-wide: 123,899
  • Since beginning of last month:
    • Site-wide: 90,135

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

genetics more details view paper
  • Downloaded 1,125 times
  • Download rankings, all-time:
    • Site-wide: 32,063
    • In genetics: 1,345
  • Year to date:
    • Site-wide: 32,339
  • Since beginning of last month:
    • Site-wide: 31,830

An epigenome-wide association study of educational attainment (n = 10,767)

genetics more details view paper
  • Downloaded 1,098 times
  • Download rankings, all-time:
    • Site-wide: 33,318
    • In genetics: 1,303
  • Year to date:
    • Site-wide: 175,865
  • Since beginning of last month:
    • Site-wide: 161,122

Genome-wide association study identifies new locus associated with OCD

psychiatry and clinical psychology more details view paper
  • Downloaded 1,027 times
  • Download rankings, all-time:
    • Site-wide: 36,842
    • In psychiatry and clinical psychology: 188
  • Year to date:
    • Site-wide: 8,983
  • Since beginning of last month:
    • Site-wide: 8,556

Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

genetics more details view paper
  • Downloaded 988 times
  • Download rankings, all-time:
    • Site-wide: 39,081
    • In genetics: 1,547
  • Year to date:
    • Site-wide: 128,478
  • Since beginning of last month:
    • Site-wide: 70,281

Personalized Risk Prediction for Type 2 Diabetes: the Potential of Genetic Risk Scores

genetics more details view paper
  • Downloaded 945 times
  • Download rankings, all-time:
    • Site-wide: 41,873
    • In genetics: 1,633
  • Year to date:
    • Site-wide: 173,933
  • Since beginning of last month:
    • Site-wide: 126,431

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

genomics more details view paper
  • Downloaded 871 times
  • Download rankings, all-time:
    • Site-wide: 47,451
    • In genomics: 3,491
  • Year to date:
    • Site-wide: 132,604
  • Since beginning of last month:
    • Site-wide: 105,014

An interaction map of circulating metabolites, immune gene networks and their genetic regulation

genomics more details view paper
  • Downloaded 871 times
  • Download rankings, all-time:
    • Site-wide: 47,459
    • In genomics: 3,472
  • Year to date:
    • Site-wide: 181,050
  • Since beginning of last month:
    • Site-wide: 146,026

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

genetics more details view paper
  • Downloaded 831 times
  • Download rankings, all-time:
    • Site-wide: 50,943
    • In genetics: 1,933
  • Year to date:
    • Site-wide: 198,305
  • Since beginning of last month:
    • Site-wide: 201,731

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

genomics more details view paper
  • Downloaded 816 times
  • Download rankings, all-time:
    • Site-wide: 52,376
    • In genomics: 3,777
  • Year to date:
    • Site-wide: 91,727
  • Since beginning of last month:
    • Site-wide: 106,733

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

genomics more details view paper
  • Downloaded 803 times
  • Download rankings, all-time:
    • Site-wide: 53,612
    • In genomics: 3,759
  • Year to date:
    • Site-wide: 192,626
  • Since beginning of last month:
    • Site-wide: 166,162

Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

genetics more details view paper
  • Downloaded 737 times
  • Download rankings, all-time:
    • Site-wide: 60,787
    • In genetics: 2,367
  • Year to date:
    • Site-wide: 180,734
  • Since beginning of last month:
    • Site-wide: 79,310

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

genetics more details view paper
  • Downloaded 727 times
  • Download rankings, all-time:
    • Site-wide: 61,955
    • In genetics: 2,423
  • Year to date:
    • Site-wide: 109,543
  • Since beginning of last month:
    • Site-wide: 97,818

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

genomics more details view paper
  • Downloaded 723 times
  • Download rankings, all-time:
    • Site-wide: 62,499
    • In genomics: 4,337
  • Year to date:
    • Site-wide: 41,660
  • Since beginning of last month:
    • Site-wide: 147,806

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

genetic and genomic medicine more details view paper
  • Downloaded 704 times
  • Download rankings, all-time:
    • Site-wide: 64,890
    • In genetic and genomic medicine: 375
  • Year to date:
    • Site-wide: 144,637
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    • Site-wide: 176,415

The landscape of autosomal-recessive pathogenic variants in European populations reveals phenotype-specific effects

genetics more details view paper
  • Downloaded 639 times
  • Download rankings, all-time:
    • Site-wide: 74,222
    • In genetics: 2,976
  • Year to date:
    • Site-wide: 79,279
  • Since beginning of last month:
    • Site-wide: 32,337

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for screening

genetics more details view paper
  • Downloaded 629 times
  • Download rankings, all-time:
    • Site-wide: 75,811
    • In genetics: 2,882
  • Year to date:
    • Site-wide: 168,195
  • Since beginning of last month:
    • Site-wide: 120,144

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

genomics more details view paper
  • Downloaded 628 times
  • Download rankings, all-time:
    • Site-wide: 75,932
    • In genomics: 4,932
  • Year to date:
    • Site-wide: 158,130
  • Since beginning of last month:
    • Site-wide: 93,768

The effect of X-linked dosage compensation on complex trait variation

genetics more details view paper
  • Downloaded 628 times
  • Download rankings, all-time:
    • Site-wide: 75,969
    • In genetics: 2,847
  • Year to date:
    • Site-wide: 158,304
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    • Site-wide: 161,299

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome

bioinformatics more details view paper
  • Downloaded 514 times
  • Download rankings, all-time:
    • Site-wide: 97,084
    • In bioinformatics: 8,279
  • Year to date:
    • Site-wide: 181,471
  • Since beginning of last month:
    • Site-wide: 125,090

Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants

genetic and genomic medicine more details view paper
  • Downloaded 495 times
  • Download rankings, all-time:
    • Site-wide: 101,312
    • In genetic and genomic medicine: 624
  • Year to date:
    • Site-wide: 92,800
  • Since beginning of last month:
    • Site-wide: 130,142

Genome-wide Screen of Otosclerosis in Population Biobanks: 18 Loci and Shared Heritability with Skeletal Structure

genetic and genomic medicine more details view paper
  • Downloaded 458 times
  • Download rankings, all-time:
    • Site-wide: 109,921
    • In genetic and genomic medicine: 730
  • Year to date:
    • Site-wide: 66,346
  • Since beginning of last month:
    • Site-wide: 33,268

PAIRUP-MS: Pathway Analysis and Imputation to Relate Unknowns in Profiles from Mass Spectrometry-based metabolite data

bioinformatics more details view paper
  • Downloaded 452 times
  • Download rankings, all-time:
    • Site-wide: 111,478
    • In bioinformatics: 9,205
  • Year to date:
    • Site-wide: 194,660
  • Since beginning of last month:
    • Site-wide: 108,098

Search for early pancreatic cancer blood biomarkers in five European prospective population biobanks using metabolomics

epidemiology more details view paper
  • Downloaded 411 times
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    • Site-wide: 121,848
    • In epidemiology: 5,031
  • Year to date:
    • Site-wide: 185,738
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    • Site-wide: 128,791

Mendelian randomization identifies the potential causal impact of dietary patterns on circulating blood metabolites

genomics more details view paper
  • Downloaded 345 times
  • Download rankings, all-time:
    • Site-wide: 140,938
    • In genomics: 7,328
  • Year to date:
    • Site-wide: 140,134
  • Since beginning of last month:
    • Site-wide: 186,656

Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture

infectious diseases more details view paper
  • Downloaded 233 times
  • Download rankings, all-time:
    • Site-wide: 173,603
    • In infectious diseases: None
  • Year to date:
    • Site-wide: 36,299
  • Since beginning of last month:
    • Site-wide: 5,630

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

dermatology more details view paper
  • Downloaded 163 times
  • Download rankings, all-time:
    • Site-wide: 190,011
    • In dermatology: None
  • Year to date:
    • Site-wide: 58,925
  • Since beginning of last month:
    • Site-wide: 2,651

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