Author: Reedik Mägi

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Preprints

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

• Downloaded 8,606 times
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  • Site-wide: 911
  • In genetics: 27
• Year to date:
  • Site-wide: 48,502
• Since beginning of last month:
  • Site-wide: None

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,223 times
• Download rankings, all-time:
  • Site-wide: 3,496
  • In genomics: 397
• Year to date:
  • Site-wide: 66,987
• Since beginning of last month:
  • Site-wide: 47,002

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,069 times
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  • Site-wide: 3,736
  • In genetics: 166
• Year to date:
  • Site-wide: 37,943
• Since beginning of last month:
  • Site-wide: 48,112

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

• Downloaded 2,294 times
• Download rankings, all-time:
  • Site-wide: 5,709
  • In genetics: 272
• Year to date:
  • Site-wide: 92,984
• Since beginning of last month:
  • Site-wide: 58,168

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

• Downloaded 2,176 times
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  • Site-wide: 6,132
  • In genetics: 302
• Year to date:
  • Site-wide: 7,150
• Since beginning of last month:
  • Site-wide: 5,860

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,826 times
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  • Site-wide: 7,952
  • In genetics: 387
• Year to date:
  • Site-wide: None
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  • Site-wide: None

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,637 times
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  • Site-wide: 9,430
  • In genetics: 464
• Year to date:
  • Site-wide: 76,010
• Since beginning of last month:
  • Site-wide: 75,008

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,240 times
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  • Site-wide: 14,210
  • In genomics: 1,513
• Year to date:
  • Site-wide: 54,719
• Since beginning of last month:
  • Site-wide: 41,189

Lifelong genetically lowered sclerostin and risk of cardiovascular disease.

• Downloaded 1,213 times
• Download rankings, all-time:
  • Site-wide: 14,694
  • In genetics: 752
• Year to date:
  • Site-wide: 39,376
• Since beginning of last month:
  • Site-wide: 26,451

The genetic architecture of sporadic and recurrent miscarriage

• Downloaded 1,112 times
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  • Site-wide: 16,787
  • In genetics: 853
• Year to date:
  • Site-wide: 47,950
• Since beginning of last month:
  • Site-wide: 26,572

Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions

• Downloaded 969 times
• Download rankings, all-time:
  • Site-wide: 20,529
  • In pharmacology and toxicology: 108
• Year to date:
  • Site-wide: 76,531
• Since beginning of last month:
  • Site-wide: None

Causal relationships between obesity and the leading causes of death in women and men

• Downloaded 964 times
• Download rankings, all-time:
  • Site-wide: 20,683
  • In epidemiology: 1,184
• Year to date:
  • Site-wide: 67,675
• Since beginning of last month:
  • Site-wide: 78,464

GWAS identifies novel risk locus for erectile dysfunction and implicates hypothalamic neurobiology and diabetes in etiology

• Downloaded 906 times
• Download rankings, all-time:
  • Site-wide: 22,625
  • In genomics: 2,233
• Year to date:
  • Site-wide: 96,084
• Since beginning of last month:
  • Site-wide: 90,859

Personalized Risk Prediction for Type 2 Diabetes: the Potential of Genetic Risk Scores

• Downloaded 836 times
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  • Site-wide: 25,338
  • In genetics: 1,255
• Year to date:
  • Site-wide: 54,826
• Since beginning of last month:
  • Site-wide: 35,318

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

• Downloaded 755 times
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  • Site-wide: 29,259
  • In genetics: 1,452
• Year to date:
  • Site-wide: 119,268
• Since beginning of last month:
  • Site-wide: 74,463

Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity

• Downloaded 711 times
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  • Site-wide: 31,793
  • In genomics: 2,858
• Year to date:
  • Site-wide: 41,903
• Since beginning of last month:
  • Site-wide: 21,256

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 711 times
• Download rankings, all-time:
  • Site-wide: 31,775
  • In genetics: 1,578
• Year to date:
  • Site-wide: 14,335
• Since beginning of last month:
  • Site-wide: 10,256

GWAS meta-analysis highlights the hypothalamic-pituitary-gonadal axis (HPG axis) in the genetic regulation of menstrual cycle length

• Downloaded 580 times
• Download rankings, all-time:
  • Site-wide: 41,459
  • In genetics: 1,993
• Year to date:
  • Site-wide: 102,029
• Since beginning of last month:
  • Site-wide: None

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

• Downloaded 576 times
• Download rankings, all-time:
  • Site-wide: 41,782
  • In genomics: 3,451
• Year to date:
  • Site-wide: 43,544
• Since beginning of last month:
  • Site-wide: 30,068

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

• Downloaded 551 times
• Download rankings, all-time:
  • Site-wide: 44,227
  • In genetics: 2,133
• Year to date:
  • Site-wide: 38,617
• Since beginning of last month:
  • Site-wide: 46,519

The complement system supports normal postnatal development and gonadal function in both sexes

• Downloaded 540 times
• Download rankings, all-time:
  • Site-wide: 45,269
  • In developmental biology: 1,067
• Year to date:
  • Site-wide: 47,884
• Since beginning of last month:
  • Site-wide: 46,923

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for screening

• Downloaded 507 times
• Download rankings, all-time:
  • Site-wide: 48,723
  • In genetics: 2,327
• Year to date:
  • Site-wide: 81,476
• Since beginning of last month:
  • Site-wide: 65,110

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 49,473
  • In genomics: 3,916
• Year to date:
  • Site-wide: 107,853
• Since beginning of last month:
  • Site-wide: 95,163

Analytical strategies to include the X-chromosome in variance heterogeneity analyses: evidence for trait-specific polygenic variance structure

• Downloaded 456 times
• Download rankings, all-time:
  • Site-wide: 54,983
  • In genetics: 2,607
• Year to date:
  • Site-wide: 95,628
• Since beginning of last month:
  • Site-wide: 74,939

Leveraging biobank-scale rare and common variant analyses to identify ASPHD1 as the main driver of reproductive traits in the 16p11.2 locus

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 69,047
  • In genomics: 4,829
• Year to date:
  • Site-wide: 88,712
• Since beginning of last month:
  • Site-wide: 76,270

Genetics of fasting indices of glucose homeostasis using GWIS unravels tight relationships with inflammatory markers

• Downloaded 355 times
• Download rankings, all-time:
  • Site-wide: 70,207
  • In genetics: 3,277
• Year to date:
  • Site-wide: 43,074
• Since beginning of last month:
  • Site-wide: 39,976

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 89,893
  • In genetics: 4,102
• Year to date:
  • Site-wide: 41,372
• Since beginning of last month:
  • Site-wide: 32,436

Genome-wide association study identifies five risk loci for pernicious anemia and implicates the role of HLA-DR15 haplotype

• Downloaded 231 times
• Download rankings, all-time:
  • Site-wide: 95,067
  • In genetic and genomic medicine: 349
• Year to date:
  • Site-wide: 16,652
• Since beginning of last month:
  • Site-wide: 14,174

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 101,916
  • In genomics: 6,014
• Year to date:
  • Site-wide: 99,026
• Since beginning of last month:
  • Site-wide: 100,787

Genome-wide Screen of Otosclerosis in Population Biobanks: 18 Loci and Shared Heritability with Skeletal Structure

• Downloaded 123 times
• Download rankings, all-time:
  • Site-wide: 116,876
  • In genetic and genomic medicine: 519
• Year to date:
  • Site-wide: 56,026
• Since beginning of last month:
  • Site-wide: 68,250