Author: Reedik Mägi

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Preprints

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

• Downloaded 9,039 times
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  • Site-wide: 1,568
  • In genetics: 32
• Year to date:
  • Site-wide: 50,384
• Since beginning of last month:
  • Site-wide: 42,975

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,432 times
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  • Site-wide: 6,004
  • In genetics: 198
• Year to date:
  • Site-wide: 40,539
• Since beginning of last month:
  • Site-wide: 117,184

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,388 times
• Download rankings, all-time:
  • Site-wide: 6,126
  • In genomics: 565
• Year to date:
  • Site-wide: 74,069
• Since beginning of last month:
  • Site-wide: 141,927

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

• Downloaded 3,325 times
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  • Site-wide: 6,309
  • In genetics: 215
• Year to date:
  • Site-wide: 6,016
• Since beginning of last month:
  • Site-wide: 10,899

FinnGen: Unique genetic insights from combining isolated population and national health register data

• Downloaded 2,602 times
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  • Site-wide: 9,006
  • In genetic and genomic medicine: 59
• Year to date:
  • Site-wide: 487
• Since beginning of last month:
  • Site-wide: 842

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

• Downloaded 2,468 times
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  • Site-wide: 9,756
  • In genetics: 371
• Year to date:
  • Site-wide: 29,903
• Since beginning of last month:
  • Site-wide: 151,455

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,966 times
• Download rankings, all-time:
  • Site-wide: 13,792
  • In genetics: 531
• Year to date:
  • Site-wide: 192,585
• Since beginning of last month:
  • Site-wide: 175,129

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,939 times
• Download rankings, all-time:
  • Site-wide: 14,085
  • In genetics: 557
• Year to date:
  • Site-wide: 93,997
• Since beginning of last month:
  • Site-wide: 61,003

Global biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

• Downloaded 1,830 times
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  • Site-wide: 15,419
  • In genetic and genomic medicine: 106
• Year to date:
  • Site-wide: 1,115
• Since beginning of last month:
  • Site-wide: 4,995

Lifelong genetically lowered sclerostin and risk of cardiovascular disease.

• Downloaded 1,451 times
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  • Site-wide: 22,207
  • In genetics: 896
• Year to date:
  • Site-wide: 70,581
• Since beginning of last month:
  • Site-wide: 93,193

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,412 times
• Download rankings, all-time:
  • Site-wide: 23,230
  • In genomics: 2,011
• Year to date:
  • Site-wide: 95,384
• Since beginning of last month:
  • Site-wide: 174,893

The genetic architecture of sporadic and recurrent miscarriage

• Downloaded 1,322 times
• Download rankings, all-time:
  • Site-wide: 25,808
  • In genetics: 1,029
• Year to date:
  • Site-wide: 137,897
• Since beginning of last month:
  • Site-wide: 119,969

The individual and global impact of copy number variants on complex human traits

• Downloaded 1,314 times
• Download rankings, all-time:
  • Site-wide: 26,030
  • In genetic and genomic medicine: 157
• Year to date:
  • Site-wide: 19,017
• Since beginning of last month:
  • Site-wide: 23,694

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,306 times
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  • Site-wide: 26,327
  • In genetics: 1,064
• Year to date:
  • Site-wide: 28,798
• Since beginning of last month:
  • Site-wide: 65,558

Genome-wide association study identifies five risk loci for pernicious anemia and implicates the role of HLA-DR15 haplotype

• Downloaded 1,231 times
• Download rankings, all-time:
  • Site-wide: 28,869
  • In genetic and genomic medicine: 187
• Year to date:
  • Site-wide: 5,558
• Since beginning of last month:
  • Site-wide: 8,673

GWAS identifies novel risk locus for erectile dysfunction and implicates hypothalamic neurobiology and diabetes in etiology

• Downloaded 1,207 times
• Download rankings, all-time:
  • Site-wide: 29,792
  • In genomics: 2,493
• Year to date:
  • Site-wide: 132,200
• Since beginning of last month:
  • Site-wide: 116,406

Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity

• Downloaded 1,186 times
• Download rankings, all-time:
  • Site-wide: 30,631
  • In genomics: 2,577
• Year to date:
  • Site-wide: 35,394
• Since beginning of last month:
  • Site-wide: 91,702

Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions

• Downloaded 1,175 times
• Download rankings, all-time:
  • Site-wide: 31,087
  • In pharmacology and toxicology: 177
• Year to date:
  • Site-wide: 172,771
• Since beginning of last month:
  • Site-wide: 178,422

Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification

• Downloaded 1,163 times
• Download rankings, all-time:
  • Site-wide: 31,568
  • In genetic and genomic medicine: 206
• Year to date:
  • Site-wide: 5,925
• Since beginning of last month:
  • Site-wide: 12,955

Causal relationships between obesity and the leading causes of death in women and men

• Downloaded 1,110 times
• Download rankings, all-time:
  • Site-wide: 33,953
  • In epidemiology: 1,874
• Year to date:
  • Site-wide: 188,177
• Since beginning of last month:
  • Site-wide: 199,866

Personalized Risk Prediction for Type 2 Diabetes: the Potential of Genetic Risk Scores

• Downloaded 954 times
• Download rankings, all-time:
  • Site-wide: 42,893
  • In genetics: 1,686
• Year to date:
  • Site-wide: 132,706
• Since beginning of last month:
  • Site-wide: 198,182

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

• Downloaded 838 times
• Download rankings, all-time:
  • Site-wide: 52,361
  • In genetics: 2,042
• Year to date:
  • Site-wide: 118,128
• Since beginning of last month:
  • Site-wide: 175,290

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

• Downloaded 832 times
• Download rankings, all-time:
  • Site-wide: 52,941
  • In genomics: 3,818
• Year to date:
  • Site-wide: 137,952
• Since beginning of last month:
  • Site-wide: 93,332

Improving GWAS discovery and genomic prediction accuracy in Biobank data

• Downloaded 791 times
• Download rankings, all-time:
  • Site-wide: 57,032
  • In genomics: 4,056
• Year to date:
  • Site-wide: 53,553
• Since beginning of last month:
  • Site-wide: 98,558

GWAS meta-analysis highlights the hypothalamic-pituitary-gonadal axis (HPG axis) in the genetic regulation of menstrual cycle length

• Downloaded 764 times
• Download rankings, all-time:
  • Site-wide: 60,014
  • In genetics: 2,325
• Year to date:
  • Site-wide: 132,493
• Since beginning of last month:
  • Site-wide: 152,221

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

• Downloaded 739 times
• Download rankings, all-time:
  • Site-wide: 63,062
  • In genetics: 2,438
• Year to date:
  • Site-wide: 120,385
• Since beginning of last month:
  • Site-wide: 161,998

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 737 times
• Download rankings, all-time:
  • Site-wide: 63,354
  • In genomics: 4,383
• Year to date:
  • Site-wide: 85,802
• Since beginning of last month:
  • Site-wide: 130,997

Analytical strategies to include the X-chromosome in variance heterogeneity analyses: evidence for trait-specific polygenic variance structure

• Downloaded 699 times
• Download rankings, all-time:
  • Site-wide: 68,388
  • In genetics: 2,666
• Year to date:
  • Site-wide: 70,855
• Since beginning of last month:
  • Site-wide: 90,467

The complement system supports normal postnatal development and gonadal function in both sexes

• Downloaded 685 times
• Download rankings, all-time:
  • Site-wide: 70,305
  • In developmental biology: 1,689
• Year to date:
  • Site-wide: 163,277
• Since beginning of last month:
  • Site-wide: 94,266

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for screening

• Downloaded 638 times
• Download rankings, all-time:
  • Site-wide: 77,288
  • In genetics: 2,962
• Year to date:
  • Site-wide: 136,352
• Since beginning of last month:
  • Site-wide: 179,770

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 634 times
• Download rankings, all-time:
  • Site-wide: 78,052
  • In genomics: 5,105
• Year to date:
  • Site-wide: 111,660
• Since beginning of last month:
  • Site-wide: 205,460

Leveraging biobank-scale rare and common variant analyses to identify ASPHD1 as the main driver of reproductive traits in the 16p11.2 locus

• Downloaded 611 times
• Download rankings, all-time:
  • Site-wide: 81,687
  • In genomics: 5,352
• Year to date:
  • Site-wide: 139,631
• Since beginning of last month:
  • Site-wide: 75,903

GWAS meta-analysis and gene expression data link reproductive tract development, immune response and cellular proliferation/apoptosis with cervical cancer and clarify overlap with other cervical phenotypes

• Downloaded 528 times
• Download rankings, all-time:
  • Site-wide: 97,939
  • In genetic and genomic medicine: 663
• Year to date:
  • Site-wide: 12,629
• Since beginning of last month:
  • Site-wide: 18,477

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health

• Downloaded 503 times
• Download rankings, all-time:
  • Site-wide: 103,531
  • In genetics: 3,920
• Year to date:
  • Site-wide: 150,431
• Since beginning of last month:
  • Site-wide: 190,071

Genetics of fasting indices of glucose homeostasis using GWIS unravels tight relationships with inflammatory markers

• Downloaded 485 times
• Download rankings, all-time:
  • Site-wide: 107,702
  • In genetics: 4,075
• Year to date:
  • Site-wide: 137,090
• Since beginning of last month:
  • Site-wide: 153,700

Genome-wide Screen of Otosclerosis in Population Biobanks: 18 Loci and Shared Heritability with Skeletal Structure

• Downloaded 479 times
• Download rankings, all-time:
  • Site-wide: 109,283
  • In genetic and genomic medicine: 727
• Year to date:
  • Site-wide: 28,315
• Since beginning of last month:
  • Site-wide: 94,941

Advancing our understanding of genetic risk factors and potential personalized strategies in pelvic organ prolapse: largest GWAS to date reveals 19 novel associated loci

• Downloaded 384 times
• Download rankings, all-time:
  • Site-wide: 134,760
  • In genetic and genomic medicine: 935
• Year to date:
  • Site-wide: 101,476
• Since beginning of last month:
  • Site-wide: 137,968

Acute COVID-19 severity and 16-month mental morbidity trajectories in patient populations of six nations

• Downloaded 281 times
• Download rankings, all-time:
  • Site-wide: 165,779
  • In public and global health: 2,416
• Year to date:
  • Site-wide: 105,800
• Since beginning of last month:
  • Site-wide: 110,449

Omics-informed CNV calls reduce false positive rate and improve power for CNV-trait associations

• Downloaded 271 times
• Download rankings, all-time:
  • Site-wide: 168,718
  • In bioinformatics: 12,985
• Year to date:
  • Site-wide: 43,400
• Since beginning of last month:
  • Site-wide: 108,464

Novel discoveries and enhanced genomic prediction from modelling genetic risk of cancer age-at-onset

• Downloaded 270 times
• Download rankings, all-time:
  • Site-wide: 168,809
  • In genetic and genomic medicine: 1,244
• Year to date:
  • Site-wide: 41,826
• Since beginning of last month:
  • Site-wide: 68,342

Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture

• Downloaded 270 times
• Download rankings, all-time:
  • Site-wide: 168,844
  • In infectious diseases: 7,499
• Year to date:
  • Site-wide: 38,375
• Since beginning of last month:
  • Site-wide: 23,506

Genome-wide association study meta-analysis supports association between MUC1 and ectopic pregnancy

• Downloaded 113 times
• Download rankings, all-time:
  • Site-wide: 205,211
  • In obstetrics and gynecology: 311
• Year to date:
  • Site-wide: 38,535
• Since beginning of last month:
  • Site-wide: 17,768