Author: Reedik Mägi

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Preprints

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

• Downloaded 8,700 times
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  • Site-wide: 1,103
  • In genetics: 27
• Year to date:
  • Site-wide: 51,080
• Since beginning of last month:
  • Site-wide: 98,000

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,276 times
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  • Site-wide: 4,221
  • In genomics: 438
• Year to date:
  • Site-wide: 80,032
• Since beginning of last month:
  • Site-wide: 75,410

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,214 times
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  • Site-wide: 4,345
  • In genetics: 168
• Year to date:
  • Site-wide: 32,974
• Since beginning of last month:
  • Site-wide: 76,267

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

• Downloaded 2,499 times
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  • Site-wide: 6,238
  • In genetics: 271
• Year to date:
  • Site-wide: 8,998
• Since beginning of last month:
  • Site-wide: 16,362

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

• Downloaded 2,329 times
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  • Site-wide: 6,917
  • In genetics: 308
• Year to date:
  • Site-wide: 107,652
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  • Site-wide: 84,422

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,879 times
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  • Site-wide: 9,497
  • In genetics: 416
• Year to date:
  • Site-wide: 98,578
• Since beginning of last month:
  • Site-wide: 95,804

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,724 times
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  • Site-wide: 10,761
  • In genetics: 481
• Year to date:
  • Site-wide: 59,528
• Since beginning of last month:
  • Site-wide: 76,314

Lifelong genetically lowered sclerostin and risk of cardiovascular disease.

• Downloaded 1,277 times
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  • Site-wide: 16,835
  • In genetics: 793
• Year to date:
  • Site-wide: 62,739
• Since beginning of last month:
  • Site-wide: 59,364

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,258 times
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  • Site-wide: 17,192
  • In genomics: 1,697
• Year to date:
  • Site-wide: 116,474
• Since beginning of last month:
  • Site-wide: 129,296

The genetic architecture of sporadic and recurrent miscarriage

• Downloaded 1,184 times
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  • Site-wide: 18,832
  • In genetics: 882
• Year to date:
  • Site-wide: 61,272
• Since beginning of last month:
  • Site-wide: 127,781

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,073 times
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  • Site-wide: 21,773
  • In genetics: 998
• Year to date:
  • Site-wide: 9,676
• Since beginning of last month:
  • Site-wide: 22,289

Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions

• Downloaded 1,043 times
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  • Site-wide: 22,730
  • In pharmacology and toxicology: 124
• Year to date:
  • Site-wide: 66,623
• Since beginning of last month:
  • Site-wide: 57,141

Causal relationships between obesity and the leading causes of death in women and men

• Downloaded 1,004 times
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  • Site-wide: 23,996
  • In epidemiology: 1,393
• Year to date:
  • Site-wide: 93,520
• Since beginning of last month:
  • Site-wide: 56,640

GWAS identifies novel risk locus for erectile dysfunction and implicates hypothalamic neurobiology and diabetes in etiology

• Downloaded 924 times
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  • Site-wide: 27,082
  • In genomics: 2,478
• Year to date:
  • Site-wide: 134,261
• Since beginning of last month:
  • Site-wide: 97,071

Personalized Risk Prediction for Type 2 Diabetes: the Potential of Genetic Risk Scores

• Downloaded 878 times
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  • Site-wide: 29,100
  • In genetics: 1,338
• Year to date:
  • Site-wide: 87,117
• Since beginning of last month:
  • Site-wide: 112,081

Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity

• Downloaded 866 times
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  • Site-wide: 29,648
  • In genomics: 2,646
• Year to date:
  • Site-wide: 31,459
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  • Site-wide: 25,608

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

• Downloaded 773 times
• Download rankings, all-time:
  • Site-wide: 34,721
  • In genetics: 1,592
• Year to date:
  • Site-wide: 140,445
• Since beginning of last month:
  • Site-wide: 112,013

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

• Downloaded 634 times
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  • Site-wide: 45,248
  • In genomics: 3,598
• Year to date:
  • Site-wide: 68,653
• Since beginning of last month:
  • Site-wide: 100,625

GWAS meta-analysis highlights the hypothalamic-pituitary-gonadal axis (HPG axis) in the genetic regulation of menstrual cycle length

• Downloaded 613 times
• Download rankings, all-time:
  • Site-wide: 47,229
  • In genetics: 2,122
• Year to date:
  • Site-wide: 113,179
• Since beginning of last month:
  • Site-wide: 146,298

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

• Downloaded 594 times
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  • Site-wide: 49,107
  • In genetics: 2,200
• Year to date:
  • Site-wide: 77,088
• Since beginning of last month:
  • Site-wide: 88,255

The complement system supports normal postnatal development and gonadal function in both sexes

• Downloaded 559 times
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  • Site-wide: 53,035
  • In developmental biology: 1,239
• Year to date:
  • Site-wide: 109,367
• Since beginning of last month:
  • Site-wide: 126,075

Genome-wide association study identifies five risk loci for pernicious anemia and implicates the role of HLA-DR15 haplotype

• Downloaded 540 times
• Download rankings, all-time:
  • Site-wide: 55,239
  • In genetic and genomic medicine: 220
• Year to date:
  • Site-wide: 11,966
• Since beginning of last month:
  • Site-wide: 14,031

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for screening

• Downloaded 535 times
• Download rankings, all-time:
  • Site-wide: 55,887
  • In genetics: 2,483
• Year to date:
  • Site-wide: 113,238
• Since beginning of last month:
  • Site-wide: 74,816

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 518 times
• Download rankings, all-time:
  • Site-wide: 58,100
  • In genomics: 4,310
• Year to date:
  • Site-wide: 138,757
• Since beginning of last month:
  • Site-wide: 107,426

Analytical strategies to include the X-chromosome in variance heterogeneity analyses: evidence for trait-specific polygenic variance structure

• Downloaded 500 times
• Download rankings, all-time:
  • Site-wide: 60,508
  • In genetics: 2,692
• Year to date:
  • Site-wide: 96,590
• Since beginning of last month:
  • Site-wide: 37,285

Leveraging biobank-scale rare and common variant analyses to identify ASPHD1 as the main driver of reproductive traits in the 16p11.2 locus

• Downloaded 413 times
• Download rankings, all-time:
  • Site-wide: 73,827
  • In genomics: 5,030
• Year to date:
  • Site-wide: 88,073
• Since beginning of last month:
  • Site-wide: 58,050

Genetics of fasting indices of glucose homeostasis using GWIS unravels tight relationships with inflammatory markers

• Downloaded 387 times
• Download rankings, all-time:
  • Site-wide: 78,463
  • In genetics: 3,440
• Year to date:
  • Site-wide: 90,020
• Since beginning of last month:
  • Site-wide: 100,234

Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification

• Downloaded 368 times
• Download rankings, all-time:
  • Site-wide: 82,206
  • In genetic and genomic medicine: 347
• Year to date:
  • Site-wide: 12,550
• Since beginning of last month:
  • Site-wide: 35,918

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health

• Downloaded 332 times
• Download rankings, all-time:
  • Site-wide: 89,464
  • In genetics: 3,900
• Year to date:
  • Site-wide: 56,751
• Since beginning of last month:
  • Site-wide: 26,193

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 279 times
• Download rankings, all-time:
  • Site-wide: 101,549
  • In genomics: 6,101
• Year to date:
  • Site-wide: 66,266
• Since beginning of last month:
  • Site-wide: 11,903

Genome-wide Screen of Otosclerosis in Population Biobanks: 18 Loci and Shared Heritability with Skeletal Structure

• Downloaded 210 times
• Download rankings, all-time:
  • Site-wide: 118,282
  • In genetic and genomic medicine: 614
• Year to date:
  • Site-wide: 55,757
• Since beginning of last month:
  • Site-wide: 93,464

Advancing our understanding of genetic risk factors and potential personalized strategies in pelvic organ prolapse: largest GWAS to date reveals 19 novel associated loci

• Downloaded 85 times
• Download rankings, all-time:
  • Site-wide: 144,872
  • In genetic and genomic medicine: 834
• Year to date:
  • Site-wide: 69,793
• Since beginning of last month:
  • Site-wide: 4,531

GWAS meta-analysis and gene expression data link reproductive tract development, immune response and cellular proliferation/apoptosis with cervical cancer and clarify overlap with other cervical phenotypes

• Downloaded 66 times
• Download rankings, all-time:
  • Site-wide: 147,155
  • In genetic and genomic medicine: 854
• Year to date:
  • Site-wide: 84,599
• Since beginning of last month:
  • Site-wide: 8,031