Author: Graham G Giles

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Preprints

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

• Downloaded 1,658 times
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  • Site-wide: 9,284
  • In genetics: 457
• Year to date:
  • Site-wide: 46,175
• Since beginning of last month:
  • Site-wide: 59,483

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,240 times
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  • Site-wide: 14,279
  • In genomics: 1,515
• Year to date:
  • Site-wide: 58,193
• Since beginning of last month:
  • Site-wide: 49,066

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 984 times
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  • Site-wide: 20,167
  • In genetics: 999
• Year to date:
  • Site-wide: 48,417
• Since beginning of last month:
  • Site-wide: 42,540

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

• Downloaded 822 times
• Download rankings, all-time:
  • Site-wide: 26,077
  • In genetics: 1,292
• Year to date:
  • Site-wide: 42,093
• Since beginning of last month:
  • Site-wide: 49,550

Appraising the causal relevance of DNA methylation for risk of lung cancer

• Downloaded 628 times
• Download rankings, all-time:
  • Site-wide: 37,612
  • In epidemiology: 1,804
• Year to date:
  • Site-wide: 106,946
• Since beginning of last month:
  • Site-wide: None

Combining genome-wide studies of breast, prostate, ovarian and endometrial cancers maps cross-cancer susceptibility loci and identifies new genetic associations

• Downloaded 600 times
• Download rankings, all-time:
  • Site-wide: 39,817
  • In genetics: 1,928
• Year to date:
  • Site-wide: 22,515
• Since beginning of last month:
  • Site-wide: 26,547

Prospective Evaluation of a Breast Cancer Risk Model Integrating Classical Risk Factors and Polygenic Risk in 15 Cohorts from Six Countries

• Downloaded 586 times
• Download rankings, all-time:
  • Site-wide: 41,069
  • In epidemiology: 1,934
• Year to date:
  • Site-wide: 50,362
• Since beginning of last month:
  • Site-wide: 38,486

Alcohol consumption is associated with widespread changes in blood DNA methylation: analysis of cross-sectional and longitudinal data

• Downloaded 546 times
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  • Site-wide: 44,862
  • In epidemiology: 2,063
• Year to date:
  • Site-wide: 44,460
• Since beginning of last month:
  • Site-wide: 35,477

Shared heritability and functional enrichment across six solid cancers

• Downloaded 525 times
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  • Site-wide: 46,972
  • In genomics: 3,788
• Year to date:
  • Site-wide: 104,459
• Since beginning of last month:
  • Site-wide: 72,475

Common breast cancer risk loci predispose to distinct tumor subtypes

• Downloaded 480 times
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  • Site-wide: 52,096
  • In genetics: 2,482
• Year to date:
  • Site-wide: 13,166
• Since beginning of last month:
  • Site-wide: 5,548

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 470 times
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  • Site-wide: 53,437
  • In sexual and reproductive health: 20
• Year to date:
  • Site-wide: 1,423
• Since beginning of last month:
  • Site-wide: 1,686

Polygenic hazard score predicts aggressive and fatal prostate cancer in multi-ethnic populations

• Downloaded 413 times
• Download rankings, all-time:
  • Site-wide: 61,048
  • In genetic and genomic medicine: 183
• Year to date:
  • Site-wide: 33,513
• Since beginning of last month:
  • Site-wide: 40,136

Physical activity and risks of breast and colorectal cancer: A Mendelian randomization analysis

• Downloaded 373 times
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  • Site-wide: 67,448
  • In genetics: 3,153
• Year to date:
  • Site-wide: 95,681
• Since beginning of last month:
  • Site-wide: 93,695

Inference about causation between body mass index and DNA methylation in blood from a twin family study

• Downloaded 363 times
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  • Site-wide: 69,045
  • In epidemiology: 2,870
• Year to date:
  • Site-wide: 73,894
• Since beginning of last month:
  • Site-wide: 47,965

Smoking and blood DNA methylation: novel associations, replication of previous findings and assessment of reversibility

• Downloaded 363 times
• Download rankings, all-time:
  • Site-wide: 69,092
  • In genomics: 4,835
• Year to date:
  • Site-wide: 95,302
• Since beginning of last month:
  • Site-wide: 92,381

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

• Downloaded 337 times
• Download rankings, all-time:
  • Site-wide: 73,657
  • In epidemiology: 3,049
• Year to date:
  • Site-wide: 68,605
• Since beginning of last month:
  • Site-wide: 54,569

Biological aging measures based on blood DNA methylation and risk of cancer: a prospective study

• Downloaded 291 times
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  • Site-wide: 82,452
  • In epidemiology: 3,375
• Year to date:
  • Site-wide: 64,098
• Since beginning of last month:
  • Site-wide: 30,829

Cross-cancer genome-wide association study of endometrial cancer and epithelial ovarian cancer identifies genetic risk regions associated with risk of both cancers

• Downloaded 282 times
• Download rankings, all-time:
  • Site-wide: 84,335
  • In oncology: 130
• Year to date:
  • Site-wide: 59,181
• Since beginning of last month:
  • Site-wide: 85,671

Genome-wide association study of peripheral blood DNA methylation and conventional mammographic density measures

• Downloaded 271 times
• Download rankings, all-time:
  • Site-wide: 86,580
  • In epidemiology: 3,542
• Year to date:
  • Site-wide: 117,876
• Since beginning of last month:
  • Site-wide: None

Causes of variation in epigenetic aging across the lifespan

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 90,134
  • In genetic and genomic medicine: 310
• Year to date:
  • Site-wide: 97,267
• Since beginning of last month:
  • Site-wide: 81,993

Associations between environmental breast cancer risk factors and DNA methylation-based risk-predicting measures

• Downloaded 230 times
• Download rankings, all-time:
  • Site-wide: 95,565
  • In epidemiology: 3,863
• Year to date:
  • Site-wide: 109,016
• Since beginning of last month:
  • Site-wide: 75,977

Genetic architectures of proximal and distal colorectal cancer are partly distinct

• Downloaded 223 times
• Download rankings, all-time:
  • Site-wide: 97,026
  • In genetic and genomic medicine: 364
• Year to date:
  • Site-wide: 59,187
• Since beginning of last month:
  • Site-wide: 40,464

The association between low-density lipoprotein cholesterol predicted by HMGCR genetic variants and breast cancer risk may be mediated by body mass index

• Downloaded 205 times
• Download rankings, all-time:
  • Site-wide: 100,773
  • In epidemiology: 4,115
• Year to date:
  • Site-wide: 118,061
• Since beginning of last month:
  • Site-wide: 94,444

The association between weight at birth and breast cancer risk revisited using Mendelian randomisation

• Downloaded 192 times
• Download rankings, all-time:
  • Site-wide: 103,645
  • In epidemiology: 4,235
• Year to date:
  • Site-wide: 107,617
• Since beginning of last month:
  • Site-wide: 94,459

Novel mammogram-based measures improve breast cancer risk prediction beyond an established measure of mammographic density

• Downloaded 178 times
• Download rankings, all-time:
  • Site-wide: 106,615
  • In radiology and imaging: 199
• Year to date:
  • Site-wide: 48,231
• Since beginning of last month:
  • Site-wide: 47,260

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

• Downloaded 156 times
• Download rankings, all-time:
  • Site-wide: 111,052
  • In cancer biology: 3,438
• Year to date:
  • Site-wide: 83,926
• Since beginning of last month:
  • Site-wide: 82,596

Polygenic Risk Modelling for Prediction of Epithelial Ovarian Cancer Risk

• Downloaded 133 times
• Download rankings, all-time:
  • Site-wide: 115,416
  • In epidemiology: 4,684
• Year to date:
  • Site-wide: 38,061
• Since beginning of last month:
  • Site-wide: 34,587

Methylation scores for smoking, alcohol consumption, and body mass index and risk of seven types of cancer

• Downloaded 19 times
• Download rankings, all-time:
  • Site-wide: 128,005
  • In epidemiology: 5,142
• Year to date:
  • Site-wide: 64,612
• Since beginning of last month:
  • Site-wide: 24,910