Author: Lude Franke

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Preprints

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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  • Site-wide: 800
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  • Site-wide: 894

Systematic identification of human SNPs affecting regulatory element activity

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  • Site-wide: 3,397
  • In genomics: 375
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  • Site-wide: 30,202

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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  • Site-wide: 5,519
  • In genetics: 250
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  • Site-wide: 103,481
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A linear mixed model approach to study multivariate gene-environment interactions

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  • Site-wide: 5,867
  • In genetics: 269
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  • Site-wide: 56,565
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  • Site-wide: 26,581

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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  • In genetics: 280
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  • Site-wide: 7,237
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  • Site-wide: 8,374

Large-scale association analyses identify host factors influencing human gut microbiome composition

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  • Site-wide: 6,522
  • In genetics: 310
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  • Site-wide: 3,258
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  • Site-wide: 5,402

Cell specific eQTL analysis without sorting cells

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  • Site-wide: 7,661
  • In genetics: 351
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  • Site-wide: 110,115
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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 9,008
  • In genetics: 415
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  • Site-wide: 43,947

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 9,741
  • In genetics: 457
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  • Site-wide: 87,623
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  • Site-wide: 126,181

Lack of association between genetic variants at ACE2 and TMPRSS2 genes involved in SARS-CoV-2 infection and human quantitative phenotypes

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  • Site-wide: 9,961
  • In genetic and genomic medicine: 36
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  • Site-wide: 40,322
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  • Site-wide: 24,547

The Lifelines COVID-19 Cohort: a questionnaire-based study to investigate COVID-19 infection and its health and societal impacts in a Dutch population-based cohort

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  • In epidemiology: 758
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 12,270
  • In genomics: 1,322
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  • Site-wide: 82,997
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  • Site-wide: 115,633

Deconvolution of bulk blood eQTL effects into immune cell subpopulations

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  • Site-wide: 13,474
  • In genomics: 1,431
• Year to date:
  • Site-wide: 80,134
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  • Site-wide: 44,340

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

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  • Site-wide: 13,802
  • In genomics: 1,460
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  • Site-wide: 22,052
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  • Site-wide: 24,138

Improving the diagnostic yield of exome-sequencing, by predicting gene-phenotype associations using large-scale gene expression analysis

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  • Site-wide: 14,049
  • In genetics: 675
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  • Site-wide: 34,875
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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • Site-wide: 15,670
  • In genomics: 1,601
• Year to date:
  • Site-wide: 96,172
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  • Site-wide: 119,776

Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility

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  • Site-wide: 18,366
  • In genetic and genomic medicine: 68
• Year to date:
  • Site-wide: 16,100
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  • Site-wide: 17,479

RNA-Seq in 296 phased trios provides a high resolution map of genomic imprinting

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  • Site-wide: 18,962
  • In genomics: 1,900
• Year to date:
  • Site-wide: 86,839
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  • Site-wide: 83,802

An introduction to LifeLines DEEP: study design and baseline characteristics

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  • Site-wide: 21,314
  • In genomics: 2,101
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  • Site-wide: 76,923
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  • Site-wide: 67,686

GAVIN - Gene-Aware Variant INterpretation for medical sequencing

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  • Site-wide: 25,129
  • In bioinformatics: 2,936
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  • Site-wide: 90,937
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  • Site-wide: 118,323

Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases

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  • Site-wide: 26,127
  • In genomics: 2,452
• Year to date:
  • Site-wide: 1,746
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  • Site-wide: 1,348

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

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  • Site-wide: 31,754
  • In neurology: 57
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  • Site-wide: 2,152
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Genome-wide identification of directed gene networks using large-scale population genomics data

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  • Site-wide: 34,471
  • In genomics: 2,993
• Year to date:
  • Site-wide: 122,190
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  • Site-wide: 116,453

Relationship between gut microbiota and circulating metabolites in population-based cohorts

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  • Site-wide: 35,628
  • In epidemiology: 1,755
• Year to date:
  • Site-wide: 113,997
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  • Site-wide: 65,100

Genetic insights into the biological mechanisms governing human ovarian ageing

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  • Site-wide: 36,560
  • In sexual and reproductive health: 17
• Year to date:
  • Site-wide: 2,483
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  • Site-wide: 4,533

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

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  • Site-wide: 46,184
  • In genetics: 2,162
• Year to date:
  • Site-wide: 100,881
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  • Site-wide: 108,494

The role of gene expression on human sexual dimorphism: too early to call

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  • Site-wide: 58,595
  • In genetics: 2,710
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  • Site-wide: 44,042
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  • Site-wide: 62,034

Correction for both common and rare cell types in blood is important to identify genes that correlate with age

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  • Site-wide: 88,412
  • In bioinformatics: 7,867
• Year to date:
  • Site-wide: 79,691
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  • Site-wide: 69,174

Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease

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  • Site-wide: 91,594
  • In genetics: 4,096
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  • Site-wide: 81,277
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  • Site-wide: 92,431

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

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  • Site-wide: 97,574
  • In genetics: 4,329
• Year to date:
  • Site-wide: 74,150
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  • Site-wide: 103,670

KidneyNetwork: Using kidney-derived gene expression data to predict and prioritize novel genes involved in kidney disease

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  • Site-wide: 110,268
  • In genetic and genomic medicine: 501
• Year to date:
  • Site-wide: 14,537
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  • Site-wide: 10,510

Idefix: identifying accidental sample mix-ups in biobanks using polygenic scores

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  • Site-wide: 120,610
  • In bioinformatics: 9,769
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  • Site-wide: 20,588
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  • Site-wide: 71,983

Imbalanced expression for predicted high-impact, autosomal-dominant variants in a cohort of 3,818 healthy samples

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  • Site-wide: 122,862
  • In genomics: 6,674
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  • Site-wide: 90,520

Practical barriers and facilitators experienced by patients, pharmacists and physicians to the implementation of pharmacogenomic screening in Dutch outpatient hospital care - an explorative pilot study

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  • Site-wide: 132,747
  • In genetic and genomic medicine: 673
• Year to date:
  • Site-wide: 119,063
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  • Site-wide: 123,097