Author: Lude Franke

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Preprints

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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  • Site-wide: 817
  • In genomics: 68
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  • Site-wide: 3,283
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  • Site-wide: None

Systematic identification of human SNPs affecting regulatory element activity

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  • Site-wide: 3,152
  • In genomics: 362
• Year to date:
  • Site-wide: 14,580
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  • Site-wide: 14,509

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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  • Site-wide: 5,035
  • In genetics: 231
• Year to date:
  • Site-wide: 71,736
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  • Site-wide: 67,007

A linear mixed model approach to study multivariate gene-environment interactions

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  • Site-wide: 5,433
  • In genetics: 259
• Year to date:
  • Site-wide: 54,119
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  • Site-wide: 44,407

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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  • Site-wide: 6,415
  • In genetics: 320
• Year to date:
  • Site-wide: 15,066
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  • Site-wide: None

Cell specific eQTL analysis without sorting cells

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  • Site-wide: 6,963
  • In genetics: 340
• Year to date:
  • Site-wide: 96,674
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  • Site-wide: 80,289

Large-scale association analyses identify host factors influencing human gut microbiome composition

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  • Site-wide: 7,106
  • In genetics: 346
• Year to date:
  • Site-wide: 2,623
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  • Site-wide: None

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 8,356
  • In genetics: 408
• Year to date:
  • Site-wide: 37,265
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  • Site-wide: 39,212

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 8,893
  • In genetics: 440
• Year to date:
  • Site-wide: 56,881
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  • Site-wide: 53,954

Lack of association between genetic variants at ACE2 and TMPRSS2 genes involved in SARS-CoV-2 infection and human quantitative phenotypes

• Downloaded 1,639 times
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  • Site-wide: 9,428
  • In genetic and genomic medicine: 29
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  • Site-wide: 36,804
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  • Site-wide: 58,017

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 11,309
  • In genomics: 1,258
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  • Site-wide: 60,078
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  • Site-wide: 54,082

The Lifelines COVID-19 Cohort: a questionnaire-based study to investigate COVID-19 infection and its health and societal impacts in a Dutch population-based cohort

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  • Site-wide: 11,538
  • In epidemiology: 793
• Year to date:
  • Site-wide: 6,109
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  • Site-wide: 4,806

Deconvolution of bulk blood eQTL effects into immune cell subpopulations

• Downloaded 1,351 times
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  • Site-wide: 12,511
  • In genomics: 1,373
• Year to date:
  • Site-wide: 91,919
• Since beginning of last month:
  • Site-wide: 83,803

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

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  • Site-wide: 13,452
  • In genomics: 1,461
• Year to date:
  • Site-wide: 15,841
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  • Site-wide: 12,254

Improving the diagnostic yield of exome-sequencing, by predicting gene-phenotype associations using large-scale gene expression analysis

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  • Site-wide: 13,869
  • In genetics: 711
• Year to date:
  • Site-wide: 62,495
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  • Site-wide: None

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,240 times
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  • Site-wide: 14,256
  • In genomics: 1,515
• Year to date:
  • Site-wide: 57,008
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  • Site-wide: 45,980

RNA-Seq in 296 phased trios provides a high resolution map of genomic imprinting

• Downloaded 1,083 times
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  • Site-wide: 17,505
  • In genomics: 1,822
• Year to date:
  • Site-wide: 57,242
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  • Site-wide: 45,953

Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility

• Downloaded 1,013 times
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  • Site-wide: 19,355
  • In genetic and genomic medicine: 58
• Year to date:
  • Site-wide: 15,730
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  • Site-wide: 14,821

An introduction to LifeLines DEEP: study design and baseline characteristics

• Downloaded 989 times
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  • Site-wide: 20,002
  • In genomics: 2,028
• Year to date:
  • Site-wide: 69,503
• Since beginning of last month:
  • Site-wide: 95,817

GAVIN - Gene-Aware Variant INterpretation for medical sequencing

• Downloaded 890 times
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  • Site-wide: 23,289
  • In bioinformatics: 2,788
• Year to date:
  • Site-wide: 68,181
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  • Site-wide: 37,397

Genome-wide identification of directed gene networks using large-scale population genomics data

• Downloaded 714 times
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  • Site-wide: 31,685
  • In genomics: 2,854
• Year to date:
  • Site-wide: 92,843
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  • Site-wide: 94,429

Relationship between gut microbiota and circulating metabolites in population-based cohorts

• Downloaded 688 times
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  • Site-wide: 33,302
  • In epidemiology: 1,631
• Year to date:
  • Site-wide: 116,214
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  • Site-wide: 95,249

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

• Downloaded 561 times
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  • Site-wide: 43,374
  • In genetics: 2,087
• Year to date:
  • Site-wide: 83,134
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  • Site-wide: 46,343

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 470 times
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  • Site-wide: 53,383
  • In sexual and reproductive health: 20
• Year to date:
  • Site-wide: 1,404
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  • Site-wide: 1,626

The role of gene expression on human sexual dimorphism: too early to call

• Downloaded 443 times
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  • Site-wide: 56,850
  • In genetics: 2,692
• Year to date:
  • Site-wide: 25,145
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  • Site-wide: 21,691

Correction for both common and rare cell types in blood is important to identify genes that correlate with age

• Downloaded 274 times
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  • Site-wide: 85,868
  • In bioinformatics: 7,709
• Year to date:
  • Site-wide: 77,516
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  • Site-wide: 75,483

Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease

• Downloaded 272 times
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  • Site-wide: 86,453
  • In genetics: 3,966
• Year to date:
  • Site-wide: 49,073
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  • Site-wide: 39,967

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

• Downloaded 247 times
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  • Site-wide: 91,728
  • In genetics: 4,184
• Year to date:
  • Site-wide: 39,325
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  • Site-wide: 34,316

Imbalanced expression for predicted high-impact, autosomal-dominant variants in a cohort of 3,818 healthy samples

• Downloaded 130 times
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  • Site-wide: 115,848
  • In genomics: 6,433
• Year to date:
  • Site-wide: 107,069
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  • Site-wide: 93,188

Practical barriers and facilitators experienced by patients, pharmacists and physicians to the implementation of pharmacogenomic screening in Dutch outpatient hospital care - an explorative pilot study

• Downloaded 75 times
• Download rankings, all-time:
  • Site-wide: 124,917
  • In genetic and genomic medicine: 580
• Year to date:
  • Site-wide: 115,321
• Since beginning of last month:
  • Site-wide: 102,878