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Author: Po-Ru Loh

Rankings

  • All-time downloads: 130,750 (rank: 1,369 )
  • Categories:
    • bioinformatics: 18,514 (rank: 512 )
    • cancer biology: 928 (rank: 17,977 (tie) )
    • genetic and genomic medicine: 6,227 (rank: 524 )
    • genetics: 94,277 (rank: 27 )
    • genomics: 8,807 (rank: 3,305 (tie) )
    • hematology: 1,073 (rank: 579 (tie) )

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Preprints

Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection

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Fast, sensitive, and accurate integration of single cell data with Harmony

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    • In bioinformatics: 56
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Partitioning heritability by functional category using GWAS summary statistics

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  • Downloaded 9,033 times
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    • Site-wide: 1,576
    • In genetics: 34
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    • Site-wide: 5,159
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Reconstructing Austronesian population history in Island Southeast Asia

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  • Downloaded 7,808 times
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    • Site-wide: 1,898
    • In genetics: 43
  • Year to date:
    • Site-wide: 6,543
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LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

genomics more details view paper
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    • Site-wide: 2,031
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A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

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    • Site-wide: 2,553
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LDpred-funct: incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

genetics more details view paper
  • Downloaded 5,649 times
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    • Site-wide: 2,971
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Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

genetics more details view paper
  • Downloaded 4,517 times
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    • Site-wide: 4,016
    • In genetics: 112
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Protein-coding repeat polymorphisms strongly shape diverse human phenotypes

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    • Site-wide: 4,830
    • In genetics: 152
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Mixed model association for biobank-scale data sets

genetics more details view paper
  • Downloaded 3,552 times
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    • Site-wide: 5,723
    • In genetics: 186
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Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

genetics more details view paper
  • Downloaded 3,375 times
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    • Site-wide: 6,177
    • In genetics: 205
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    • Site-wide: 30,611
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Haplotypes of common SNPs can explain missing heritability of complex diseases

genetics more details view paper
  • Downloaded 3,283 times
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    • Site-wide: 6,433
    • In genetics: 217
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Fast principal components analysis reveals convergent evolution of ADH1B gene in Europe and East Asia

bioinformatics more details view paper
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    • Site-wide: 6,667
    • In bioinformatics: 617
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Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

genetics more details view paper
  • Downloaded 3,040 times
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    • Site-wide: 7,159
    • In genetics: 260
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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

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    • Site-wide: 8,250
    • In genetics: 308
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    • Site-wide: 196,134
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Haplotype-enhanced inference of somatic copy number profiles from single-cell transcriptomes

bioinformatics more details view paper
  • Downloaded 2,757 times
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    • Site-wide: 8,267
    • In bioinformatics: 850
  • Year to date:
    • Site-wide: 17,489
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    • Site-wide: 8,491

Fast and accurate long-range phasing in a UK Biobank cohort

genetics more details view paper
  • Downloaded 2,492 times
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    • Site-wide: 9,628
    • In genetics: 368
  • Year to date:
    • Site-wide: 138,106
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Estimating the proportion of disease heritability mediated by gene expression levels

genetics more details view paper
  • Downloaded 2,471 times
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    • Site-wide: 9,755
    • In genetics: 381
  • Year to date:
    • Site-wide: 5,141
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    • Site-wide: 59,815

Efficient Bayesian mixed model analysis increases association power in large cohorts

genetics more details view paper
  • Downloaded 2,456 times
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    • Site-wide: 9,849
    • In genetics: 375
  • Year to date:
    • Site-wide: 99,775
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    • Site-wide: 61,733

Reference-based phasing using the Haplotype Reference Consortium panel

genetics more details view paper
  • Downloaded 2,089 times
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    • Site-wide: 12,596
    • In genetics: 470
  • Year to date:
    • Site-wide: 30,647
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Multi-ethnic polygenic risk scores improve risk prediction in diverse populations.

bioinformatics more details view paper
  • Downloaded 1,925 times
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    • Site-wide: 14,274
    • In bioinformatics: 1,519
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Population structure of UK Biobank and ancient Eurasians reveals adaptation at genes influencing blood pressure

genetics more details view paper
  • Downloaded 1,924 times
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    • Site-wide: 14,294
    • In genetics: 564
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    • Site-wide: 57,462
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Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

genetic and genomic medicine more details view paper
  • Downloaded 1,913 times
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    • Site-wide: 14,413
    • In genetic and genomic medicine: 89
  • Year to date:
    • Site-wide: 34,681
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    • Site-wide: 23,138

Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits

genetics more details view paper
  • Downloaded 1,838 times
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    • Site-wide: 15,329
    • In genetics: 610
  • Year to date:
    • Site-wide: 99,540
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    • Site-wide: 116,868

Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes

genetics more details view paper
  • Downloaded 1,721 times
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    • Site-wide: 16,960
    • In genetics: 690
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    • Site-wide: 174,865

Monogenic and polygenic inheritance become instruments for clonal selection

genetics more details view paper
  • Downloaded 1,682 times
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    • Site-wide: 17,593
    • In genetics: 707
  • Year to date:
    • Site-wide: 195,220
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    • Site-wide: 60,807

Estimating the effective sample size in association studies of quantitative traits

genetics more details view paper
  • Downloaded 1,654 times
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    • Site-wide: 18,062
    • In genetics: 737
  • Year to date:
    • Site-wide: 11,756
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    • Site-wide: 46,155

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

genetics more details view paper
  • Downloaded 1,604 times
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    • Site-wide: 18,978
    • In genetics: 766
  • Year to date:
    • Site-wide: 137,491
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    • Site-wide: 52,302

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

genetics more details view paper
  • Downloaded 1,537 times
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    • Site-wide: 20,276
    • In genetics: 822
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    • Site-wide: 108,289
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    • Site-wide: 52,133

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

genetics more details view paper
  • Downloaded 1,491 times
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    • Site-wide: 21,316
    • In genetics: 863
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    • Site-wide: 104,039
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    • Site-wide: 207,832

Shared Genetic Architecture Of Asthma With Allergic Diseases: A Genome-wide Cross Trait Analysis Of 112,000 Individuals From UK Biobank

genetics more details view paper
  • Downloaded 1,471 times
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    • Site-wide: 21,788
    • In genetics: 883
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    • Site-wide: 138,328
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Leveraging polygenic functional enrichment to improve GWAS power

genetics more details view paper
  • Downloaded 1,456 times
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    • Site-wide: 22,120
    • In genetics: 887
  • Year to date:
    • Site-wide: 195,542
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    • Site-wide: 117,873

Combining case-control status and family history of disease increases association power

genetics more details view paper
  • Downloaded 1,450 times
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    • Site-wide: 22,271
    • In genetics: 897
  • Year to date:
    • Site-wide: 97,701
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    • Site-wide: 174,725

Large mosaic copy number variations confer autism risk

genetic and genomic medicine more details view paper
  • Downloaded 1,414 times
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    • Site-wide: 23,210
    • In genetic and genomic medicine: 137
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    • Site-wide: 110,487
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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

genomics more details view paper
  • Downloaded 1,412 times
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    • Site-wide: 23,273
    • In genomics: 2,011
  • Year to date:
    • Site-wide: 103,577
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    • Site-wide: 177,458

Subtle stratification confounds estimates of heritability from rare variants

genetics more details view paper
  • Downloaded 1,338 times
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    • Site-wide: 25,369
    • In genetics: 1,016
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    • Site-wide: 117,290

Influences of rare copy number variation on human complex traits

genetics more details view paper
  • Downloaded 1,326 times
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    • Site-wide: 25,741
    • In genetics: 1,040
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Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses

genetic and genomic medicine more details view paper
  • Downloaded 1,231 times
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    • Site-wide: 28,923
    • In genetic and genomic medicine: 173
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    • Site-wide: 94,628
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Incorporating family history of disease improves polygenic risk scores in diverse populations

genetics more details view paper
  • Downloaded 1,162 times
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    • Site-wide: 31,687
    • In genetics: 1,275
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    • Site-wide: 52,817
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    • Site-wide: 87,084

Quantification of genetic components of population differentiation in UK Biobank traits reveals signals of polygenic selection

genetics more details view paper
  • Downloaded 1,152 times
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    • Site-wide: 32,181
    • In genetics: 1,286
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    • Site-wide: 162,715
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    • Site-wide: 75,111

Low-frequency variant functional architectures reveal strength of negative selection across coding and non-coding annotations

genetics more details view paper
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    • Site-wide: 32,189
    • In genetics: 1,284
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Correcting subtle stratification in summary association statistics

genetics more details view paper
  • Downloaded 1,142 times
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    • Site-wide: 32,580
    • In genetics: 1,297
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    • Site-wide: 99,676
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    • Site-wide: 148,384

Clonal hematopoiesis and risk of chronic liver disease

hematology more details view paper
  • Downloaded 1,139 times
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    • Site-wide: 32,704
    • In hematology: 35
  • Year to date:
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Two variance component model improves genetic prediction in family data sets

genetics more details view paper
  • Downloaded 1,117 times
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    • Site-wide: 33,754
    • In genetics: 1,339
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Genes with high network connectivity are enriched for disease heritability

genetics more details view paper
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    • Site-wide: 38,614
    • In genetics: 1,516
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    • Site-wide: 177,561
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Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits

genetics more details view paper
  • Downloaded 974 times
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    • Site-wide: 41,633
    • In genetics: 1,664
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    • Site-wide: 146,607

Learning the mutational landscape of the cancer genome

cancer biology more details view paper
  • Downloaded 941 times
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    • Site-wide: 43,935
    • In cancer biology: 1,251
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Coordinated Interaction: A model and test for globally signed epistasis in complex traits

genetics more details view paper
  • Downloaded 897 times
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    • Site-wide: 47,293
    • In genetics: 1,854
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    • Site-wide: 90,638
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    • Site-wide: 101,673

The lingering effects of Neanderthal introgression on human complex traits

genetics more details view paper
  • Downloaded 847 times
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    • Site-wide: 51,698
    • In genetics: 2,141
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    • Site-wide: 7,974
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    • Site-wide: 18,781

A spectrum of recessiveness among Mendelian disease variants in UK Biobank

genetic and genomic medicine more details view paper
  • Downloaded 798 times
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    • Site-wide: 56,392
    • In genetic and genomic medicine: 359
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    • Site-wide: 40,462
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    • Site-wide: 68,879

Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability

genetics more details view paper
  • Downloaded 750 times
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    • Site-wide: 61,880
    • In genetics: 2,397
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    • Site-wide: 108,664
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The genomic landscape of clonal hematopoiesis in Japan

genetics more details view paper
  • Downloaded 749 times
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    • Site-wide: 61,955
    • In genetics: 2,394
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    • Site-wide: 169,035
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Schizophrenia-associated somatic copy number variants from 12,834 cases reveal contribution to risk and recurrent, isoform-specific NRXN1 disruptions

genetic and genomic medicine more details view paper
  • Downloaded 726 times
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    • Site-wide: 64,971
    • In genetic and genomic medicine: 420
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    • Site-wide: 29,866

Mixed Model Association with Family-Biased Case-Control Ascertainment

genetics more details view paper
  • Downloaded 576 times
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    • Site-wide: 88,321
    • In genetics: 3,369
  • Year to date:
    • Site-wide: 138,142
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    • Site-wide: 201,093

Repeat polymorphisms in non-coding DNA underlie top genetic risk loci for glaucoma and colorectal cancer.

genetic and genomic medicine more details view paper
  • Downloaded 262 times
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    • Site-wide: 171,612
    • In genetic and genomic medicine: 1,353
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