Author: Po-Ru Loh
- ORCiD: http://orcid.org/0000-0001-5542-9064
- Most recently observed institution: Brigham and Women's Hospital and Harvard Medical School
Rankings
- All-time downloads: 130,750 (rank: 1,369 )
- Categories:
- bioinformatics: 18,514 (rank: 512 )
- cancer biology: 928 (rank: 17,977 (tie) )
- genetic and genomic medicine: 6,227 (rank: 524 )
- genetics: 94,277 (rank: 27 )
- genomics: 8,807 (rank: 3,305 (tie) )
- hematology: 1,073 (rank: 579 (tie) )
Downloads per author, site-wide
Preprints
Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection
genetic and genomic medicine more details view paperNo download data for this paper yet.
Fast, sensitive, and accurate integration of single cell data with Harmony
bioinformatics more details view paper- Downloaded 10,759 times
- Download rankings, all-time:
- Site-wide: 1,269
- In bioinformatics: 56
- Year to date:
- Site-wide: 7,440
- Since beginning of last month:
- Site-wide: 2,978
Partitioning heritability by functional category using GWAS summary statistics
genetics more details view paper- Downloaded 9,033 times
- Download rankings, all-time:
- Site-wide: 1,576
- In genetics: 34
- Year to date:
- Site-wide: 5,159
- Since beginning of last month:
- Site-wide: 6,059
Reconstructing Austronesian population history in Island Southeast Asia
genetics more details view paper- Downloaded 7,808 times
- Download rankings, all-time:
- Site-wide: 1,898
- In genetics: 43
- Year to date:
- Site-wide: 6,543
- Since beginning of last month:
- Site-wide: 6,562
LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies
genomics more details view paper- Downloaded 7,420 times
- Download rankings, all-time:
- Site-wide: 2,031
- In genomics: 144
- Year to date:
- Site-wide: 25,522
- Since beginning of last month:
- Site-wide: 117,043
A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries
genetics more details view paper- Downloaded 6,305 times
- Download rankings, all-time:
- Site-wide: 2,553
- In genetics: 72
- Year to date:
- Site-wide: 4,705
- Since beginning of last month:
- Site-wide: 7,746
LDpred-funct: incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets
genetics more details view paper- Downloaded 5,649 times
- Download rankings, all-time:
- Site-wide: 2,971
- In genetics: 81
- Year to date:
- Site-wide: 59,664
- Since beginning of last month:
- Site-wide: 26,408
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
genetics more details view paper- Downloaded 4,517 times
- Download rankings, all-time:
- Site-wide: 4,016
- In genetics: 112
- Year to date:
- Site-wide: 59,326
- Since beginning of last month:
- Site-wide: 150,715
Protein-coding repeat polymorphisms strongly shape diverse human phenotypes
genetics more details view paper- Downloaded 3,985 times
- Download rankings, all-time:
- Site-wide: 4,830
- In genetics: 152
- Year to date:
- Site-wide: 27,594
- Since beginning of last month:
- Site-wide: 57,830
Mixed model association for biobank-scale data sets
genetics more details view paper- Downloaded 3,552 times
- Download rankings, all-time:
- Site-wide: 5,723
- In genetics: 186
- Year to date:
- Site-wide: 19,290
- Since beginning of last month:
- Site-wide: 119,021
Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis
genetics more details view paper- Downloaded 3,375 times
- Download rankings, all-time:
- Site-wide: 6,177
- In genetics: 205
- Year to date:
- Site-wide: 30,611
- Since beginning of last month:
- Site-wide: 145,434
Haplotypes of common SNPs can explain missing heritability of complex diseases
genetics more details view paper- Downloaded 3,283 times
- Download rankings, all-time:
- Site-wide: 6,433
- In genetics: 217
- Year to date:
- Site-wide: 45,783
- Since beginning of last month:
- Site-wide: 154,114
Fast principal components analysis reveals convergent evolution of ADH1B gene in Europe and East Asia
bioinformatics more details view paper- Downloaded 3,206 times
- Download rankings, all-time:
- Site-wide: 6,667
- In bioinformatics: 617
- Year to date:
- Site-wide: 25,809
- Since beginning of last month:
- Site-wide: 146,765
Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection
genetics more details view paper- Downloaded 3,040 times
- Download rankings, all-time:
- Site-wide: 7,159
- In genetics: 260
- Year to date:
- Site-wide: 99,618
- Since beginning of last month:
- Site-wide: 198,484
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
genetics more details view paper- Downloaded 2,761 times
- Download rankings, all-time:
- Site-wide: 8,250
- In genetics: 308
- Year to date:
- Site-wide: 196,134
- Since beginning of last month:
- Site-wide: 176,390
Haplotype-enhanced inference of somatic copy number profiles from single-cell transcriptomes
bioinformatics more details view paper- Downloaded 2,757 times
- Download rankings, all-time:
- Site-wide: 8,267
- In bioinformatics: 850
- Year to date:
- Site-wide: 17,489
- Since beginning of last month:
- Site-wide: 8,491
Fast and accurate long-range phasing in a UK Biobank cohort
genetics more details view paper- Downloaded 2,492 times
- Download rankings, all-time:
- Site-wide: 9,628
- In genetics: 368
- Year to date:
- Site-wide: 138,106
- Since beginning of last month:
- Site-wide: 174,885
Estimating the proportion of disease heritability mediated by gene expression levels
genetics more details view paper- Downloaded 2,471 times
- Download rankings, all-time:
- Site-wide: 9,755
- In genetics: 381
- Year to date:
- Site-wide: 5,141
- Since beginning of last month:
- Site-wide: 59,815
Efficient Bayesian mixed model analysis increases association power in large cohorts
genetics more details view paper- Downloaded 2,456 times
- Download rankings, all-time:
- Site-wide: 9,849
- In genetics: 375
- Year to date:
- Site-wide: 99,775
- Since beginning of last month:
- Site-wide: 61,733
Reference-based phasing using the Haplotype Reference Consortium panel
genetics more details view paper- Downloaded 2,089 times
- Download rankings, all-time:
- Site-wide: 12,596
- In genetics: 470
- Year to date:
- Site-wide: 30,647
- Since beginning of last month:
- Site-wide: 75,447
Multi-ethnic polygenic risk scores improve risk prediction in diverse populations.
bioinformatics more details view paper- Downloaded 1,925 times
- Download rankings, all-time:
- Site-wide: 14,274
- In bioinformatics: 1,519
- Year to date:
- Site-wide: None
- Since beginning of last month:
- Site-wide: 201,589
Population structure of UK Biobank and ancient Eurasians reveals adaptation at genes influencing blood pressure
genetics more details view paper- Downloaded 1,924 times
- Download rankings, all-time:
- Site-wide: 14,294
- In genetics: 564
- Year to date:
- Site-wide: 57,462
- Since beginning of last month:
- Site-wide: 24,179
Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer
genetic and genomic medicine more details view paper- Downloaded 1,913 times
- Download rankings, all-time:
- Site-wide: 14,413
- In genetic and genomic medicine: 89
- Year to date:
- Site-wide: 34,681
- Since beginning of last month:
- Site-wide: 23,138
Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits
genetics more details view paper- Downloaded 1,838 times
- Download rankings, all-time:
- Site-wide: 15,329
- In genetics: 610
- Year to date:
- Site-wide: 99,540
- Since beginning of last month:
- Site-wide: 116,868
Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes
genetics more details view paper- Downloaded 1,721 times
- Download rankings, all-time:
- Site-wide: 16,960
- In genetics: 690
- Year to date:
- Site-wide: 57,552
- Since beginning of last month:
- Site-wide: 174,865
Monogenic and polygenic inheritance become instruments for clonal selection
genetics more details view paper- Downloaded 1,682 times
- Download rankings, all-time:
- Site-wide: 17,593
- In genetics: 707
- Year to date:
- Site-wide: 195,220
- Since beginning of last month:
- Site-wide: 60,807
Estimating the effective sample size in association studies of quantitative traits
genetics more details view paper- Downloaded 1,654 times
- Download rankings, all-time:
- Site-wide: 18,062
- In genetics: 737
- Year to date:
- Site-wide: 11,756
- Since beginning of last month:
- Site-wide: 46,155
Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers
genetics more details view paper- Downloaded 1,604 times
- Download rankings, all-time:
- Site-wide: 18,978
- In genetics: 766
- Year to date:
- Site-wide: 137,491
- Since beginning of last month:
- Site-wide: 52,302
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
genetics more details view paper- Downloaded 1,537 times
- Download rankings, all-time:
- Site-wide: 20,276
- In genetics: 822
- Year to date:
- Site-wide: 108,289
- Since beginning of last month:
- Site-wide: 52,133
Mixed Model with Correction for Case-Control Ascertainment Increases Association Power
genetics more details view paper- Downloaded 1,491 times
- Download rankings, all-time:
- Site-wide: 21,316
- In genetics: 863
- Year to date:
- Site-wide: 104,039
- Since beginning of last month:
- Site-wide: 207,832
Shared Genetic Architecture Of Asthma With Allergic Diseases: A Genome-wide Cross Trait Analysis Of 112,000 Individuals From UK Biobank
genetics more details view paper- Downloaded 1,471 times
- Download rankings, all-time:
- Site-wide: 21,788
- In genetics: 883
- Year to date:
- Site-wide: 138,328
- Since beginning of last month:
- Site-wide: 43,631
Leveraging polygenic functional enrichment to improve GWAS power
genetics more details view paper- Downloaded 1,456 times
- Download rankings, all-time:
- Site-wide: 22,120
- In genetics: 887
- Year to date:
- Site-wide: 195,542
- Since beginning of last month:
- Site-wide: 117,873
Combining case-control status and family history of disease increases association power
genetics more details view paper- Downloaded 1,450 times
- Download rankings, all-time:
- Site-wide: 22,271
- In genetics: 897
- Year to date:
- Site-wide: 97,701
- Since beginning of last month:
- Site-wide: 174,725
Large mosaic copy number variations confer autism risk
genetic and genomic medicine more details view paper- Downloaded 1,414 times
- Download rankings, all-time:
- Site-wide: 23,210
- In genetic and genomic medicine: 137
- Year to date:
- Site-wide: 110,487
- Since beginning of last month:
- Site-wide: 191,410
Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility
genomics more details view paper- Downloaded 1,412 times
- Download rankings, all-time:
- Site-wide: 23,273
- In genomics: 2,011
- Year to date:
- Site-wide: 103,577
- Since beginning of last month:
- Site-wide: 177,458
Subtle stratification confounds estimates of heritability from rare variants
genetics more details view paper- Downloaded 1,338 times
- Download rankings, all-time:
- Site-wide: 25,369
- In genetics: 1,016
- Year to date:
- Site-wide: 59,543
- Since beginning of last month:
- Site-wide: 117,290
Influences of rare copy number variation on human complex traits
genetics more details view paper- Downloaded 1,326 times
- Download rankings, all-time:
- Site-wide: 25,741
- In genetics: 1,040
- Year to date:
- Site-wide: 33,504
- Since beginning of last month:
- Site-wide: 46,621
Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses
genetic and genomic medicine more details view paper- Downloaded 1,231 times
- Download rankings, all-time:
- Site-wide: 28,923
- In genetic and genomic medicine: 173
- Year to date:
- Site-wide: 94,628
- Since beginning of last month:
- Site-wide: 59,471
Incorporating family history of disease improves polygenic risk scores in diverse populations
genetics more details view paper- Downloaded 1,162 times
- Download rankings, all-time:
- Site-wide: 31,687
- In genetics: 1,275
- Year to date:
- Site-wide: 52,817
- Since beginning of last month:
- Site-wide: 87,084
Quantification of genetic components of population differentiation in UK Biobank traits reveals signals of polygenic selection
genetics more details view paper- Downloaded 1,152 times
- Download rankings, all-time:
- Site-wide: 32,181
- In genetics: 1,286
- Year to date:
- Site-wide: 162,715
- Since beginning of last month:
- Site-wide: 75,111
Low-frequency variant functional architectures reveal strength of negative selection across coding and non-coding annotations
genetics more details view paper- Downloaded 1,151 times
- Download rankings, all-time:
- Site-wide: 32,189
- In genetics: 1,284
- Year to date:
- Site-wide: 99,427
- Since beginning of last month:
- Site-wide: 151,800
Correcting subtle stratification in summary association statistics
genetics more details view paper- Downloaded 1,142 times
- Download rankings, all-time:
- Site-wide: 32,580
- In genetics: 1,297
- Year to date:
- Site-wide: 99,676
- Since beginning of last month:
- Site-wide: 148,384
Clonal hematopoiesis and risk of chronic liver disease
hematology more details view paper- Downloaded 1,139 times
- Download rankings, all-time:
- Site-wide: 32,704
- In hematology: 35
- Year to date:
- Site-wide: 7,152
- Since beginning of last month:
- Site-wide: 7,726
Two variance component model improves genetic prediction in family data sets
genetics more details view paper- Downloaded 1,117 times
- Download rankings, all-time:
- Site-wide: 33,754
- In genetics: 1,339
- Year to date:
- Site-wide: 79,106
- Since beginning of last month:
- Site-wide: 174,793
Genes with high network connectivity are enriched for disease heritability
genetics more details view paper- Downloaded 1,022 times
- Download rankings, all-time:
- Site-wide: 38,614
- In genetics: 1,516
- Year to date:
- Site-wide: 177,561
- Since beginning of last month:
- Site-wide: 201,125
Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits
genetics more details view paper- Downloaded 974 times
- Download rankings, all-time:
- Site-wide: 41,633
- In genetics: 1,664
- Year to date:
- Site-wide: 46,630
- Since beginning of last month:
- Site-wide: 146,607
Learning the mutational landscape of the cancer genome
cancer biology more details view paper- Downloaded 941 times
- Download rankings, all-time:
- Site-wide: 43,935
- In cancer biology: 1,251
- Year to date:
- Site-wide: 32,883
- Since beginning of last month:
- Site-wide: 42,135
Coordinated Interaction: A model and test for globally signed epistasis in complex traits
genetics more details view paper- Downloaded 897 times
- Download rankings, all-time:
- Site-wide: 47,293
- In genetics: 1,854
- Year to date:
- Site-wide: 90,638
- Since beginning of last month:
- Site-wide: 101,673
The lingering effects of Neanderthal introgression on human complex traits
genetics more details view paper- Downloaded 847 times
- Download rankings, all-time:
- Site-wide: 51,698
- In genetics: 2,141
- Year to date:
- Site-wide: 7,974
- Since beginning of last month:
- Site-wide: 18,781
A spectrum of recessiveness among Mendelian disease variants in UK Biobank
genetic and genomic medicine more details view paper- Downloaded 798 times
- Download rankings, all-time:
- Site-wide: 56,392
- In genetic and genomic medicine: 359
- Year to date:
- Site-wide: 40,462
- Since beginning of last month:
- Site-wide: 68,879
Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability
genetics more details view paper- Downloaded 750 times
- Download rankings, all-time:
- Site-wide: 61,880
- In genetics: 2,397
- Year to date:
- Site-wide: 108,664
- Since beginning of last month:
- Site-wide: 179,179
The genomic landscape of clonal hematopoiesis in Japan
genetics more details view paper- Downloaded 749 times
- Download rankings, all-time:
- Site-wide: 61,955
- In genetics: 2,394
- Year to date:
- Site-wide: 169,035
- Since beginning of last month:
- Site-wide: 142,377
Schizophrenia-associated somatic copy number variants from 12,834 cases reveal contribution to risk and recurrent, isoform-specific NRXN1 disruptions
genetic and genomic medicine more details view paper- Downloaded 726 times
- Download rankings, all-time:
- Site-wide: 64,971
- In genetic and genomic medicine: 420
- Year to date:
- Site-wide: 24,023
- Since beginning of last month:
- Site-wide: 29,866
Mixed Model Association with Family-Biased Case-Control Ascertainment
genetics more details view paper- Downloaded 576 times
- Download rankings, all-time:
- Site-wide: 88,321
- In genetics: 3,369
- Year to date:
- Site-wide: 138,142
- Since beginning of last month:
- Site-wide: 201,093
Repeat polymorphisms in non-coding DNA underlie top genetic risk loci for glaucoma and colorectal cancer.
genetic and genomic medicine more details view paper- Downloaded 262 times
- Download rankings, all-time:
- Site-wide: 171,612
- In genetic and genomic medicine: 1,353
- Year to date:
- Site-wide: 6,743
- Since beginning of last month:
- Site-wide: 13,036
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