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Author: Po-Ru Loh

Rankings

  • All-time downloads: 104,525 (rank: 1,498 )
  • Categories:
    • bioinformatics: 13,817 (rank: 543 )
    • cancer biology: 356 (rank: 27,767 (tie) )
    • genetic and genomic medicine: 3,586 (rank: 1,018 )
    • genetics: 78,227 (rank: 39 )
    • genomics: 8,539 (rank: 2,799 (tie) )

Downloads per author, site-wide

Preprints

Fast, sensitive, and accurate integration of single cell data with Harmony

bioinformatics more details view paper
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Partitioning heritability by functional category using GWAS summary statistics

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  • Downloaded 8,203 times
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    • Site-wide: 1,337
    • In genetics: 32
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LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

genomics more details view paper
  • Downloaded 7,245 times
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    • Site-wide: 1,555
    • In genomics: 121
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Reconstructing Austronesian population history in Island Southeast Asia

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    • In genetics: 58
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LDpred-funct: incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

genetics more details view paper
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    • Site-wide: 2,463
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Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

genetics more details view paper
  • Downloaded 4,391 times
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    • Site-wide: 3,063
    • In genetics: 97
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Mixed model association for biobank-scale data sets

genetics more details view paper
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    • Site-wide: 4,401
    • In genetics: 157
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Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

genetics more details view paper
  • Downloaded 3,249 times
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    • Site-wide: 4,665
    • In genetics: 177
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Protein-coding repeat polymorphisms strongly shape diverse human phenotypes

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Haplotypes of common SNPs can explain missing heritability of complex diseases

genetics more details view paper
  • Downloaded 3,165 times
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    • Site-wide: 4,825
    • In genetics: 185
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Fast principal components analysis reveals convergent evolution of ADH1B gene in Europe and East Asia

bioinformatics more details view paper
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    • Site-wide: 5,061
    • In bioinformatics: 483
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Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

genetics more details view paper
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    • In genetics: 225
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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

genetics more details view paper
  • Downloaded 2,632 times
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    • Site-wide: 6,311
    • In genetics: 263
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Fast and accurate long-range phasing in a UK Biobank cohort

genetics more details view paper
  • Downloaded 2,385 times
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    • Site-wide: 7,303
    • In genetics: 309
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Efficient Bayesian mixed model analysis increases association power in large cohorts

genetics more details view paper
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    • Site-wide: 7,620
    • In genetics: 327
  • Year to date:
    • Site-wide: 107,320
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Estimating the proportion of disease heritability mediated by gene expression levels

genetics more details view paper
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    • Site-wide: 7,784
    • In genetics: 335
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Reference-based phasing using the Haplotype Reference Consortium panel

genetics more details view paper
  • Downloaded 1,928 times
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    • Site-wide: 9,929
    • In genetics: 412
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    • Site-wide: 93,078
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    • Site-wide: 118,308

Multi-ethnic polygenic risk scores improve risk prediction in diverse populations.

bioinformatics more details view paper
  • Downloaded 1,817 times
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    • Site-wide: 10,873
    • In bioinformatics: 1,231
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    • Site-wide: 81,430
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    • Site-wide: 126,537

Population structure of UK Biobank and ancient Eurasians reveals adaptation at genes influencing blood pressure

genetics more details view paper
  • Downloaded 1,768 times
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    • Site-wide: 11,317
    • In genetics: 483
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    • Site-wide: 99,122
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Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits

genetics more details view paper
  • Downloaded 1,723 times
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    • Site-wide: 11,763
    • In genetics: 514
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    • Site-wide: 136,989
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Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes

genetics more details view paper
  • Downloaded 1,637 times
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    • Site-wide: 12,676
    • In genetics: 560
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Monogenic and polygenic inheritance become instruments for clonal selection

genetics more details view paper
  • Downloaded 1,544 times
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    • Site-wide: 13,766
    • In genetics: 610
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    • Site-wide: 93,187
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    • Site-wide: 116,770

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

genetics more details view paper
  • Downloaded 1,462 times
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    • Site-wide: 15,055
    • In genetics: 674
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    • Site-wide: 108,929
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    • Site-wide: 83,710

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

genetics more details view paper
  • Downloaded 1,450 times
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    • Site-wide: 15,224
    • In genetics: 680
  • Year to date:
    • Site-wide: 70,718
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    • Site-wide: 99,962

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

genetics more details view paper
  • Downloaded 1,437 times
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    • Site-wide: 15,440
    • In genetics: 694
  • Year to date:
    • Site-wide: 149,349
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    • Site-wide: 157,328

Leveraging polygenic functional enrichment to improve GWAS power

genetics more details view paper
  • Downloaded 1,379 times
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    • Site-wide: 16,436
    • In genetics: 744
  • Year to date:
    • Site-wide: 131,336
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    • Site-wide: 83,622

Shared Genetic Architecture Of Asthma With Allergic Diseases: A Genome-wide Cross Trait Analysis Of 112,000 Individuals From UK Biobank

genetics more details view paper
  • Downloaded 1,326 times
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    • Site-wide: 17,418
    • In genetics: 788
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    • Site-wide: 92,097
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Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

genetic and genomic medicine more details view paper
  • Downloaded 1,307 times
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    • Site-wide: 17,798
    • In genetic and genomic medicine: 81
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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

genomics more details view paper
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    • Site-wide: 18,032
    • In genomics: 1,732
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Combining case-control status and family history of disease increases association power

genetics more details view paper
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    • Site-wide: 18,413
    • In genetics: 837
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Large mosaic copy number variations confer autism risk

genetic and genomic medicine more details view paper
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    • Site-wide: 18,692
    • In genetic and genomic medicine: 84
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Subtle stratification confounds estimates of heritability from rare variants

genetics more details view paper
  • Downloaded 1,218 times
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    • Site-wide: 19,746
    • In genetics: 893
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    • Site-wide: 94,452
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Estimating the effective sample size in association studies of quantitative traits

genetics more details view paper
  • Downloaded 1,175 times
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    • In genetics: 933
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Low-frequency variant functional architectures reveal strength of negative selection across coding and non-coding annotations

genetics more details view paper
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    • Site-wide: 23,578
    • In genetics: 1,046
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Two variance component model improves genetic prediction in family data sets

genetics more details view paper
  • Downloaded 1,050 times
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    • Site-wide: 24,642
    • In genetics: 1,100
  • Year to date:
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    • Site-wide: 157,283

Correcting subtle stratification in summary association statistics

genetics more details view paper
  • Downloaded 1,042 times
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    • Site-wide: 24,927
    • In genetics: 1,112
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Quantification of genetic components of population differentiation in UK Biobank traits reveals signals of polygenic selection

genetics more details view paper
  • Downloaded 1,037 times
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    • Site-wide: 25,122
    • In genetics: 1,120
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    • Site-wide: 110,429
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Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses

genetic and genomic medicine more details view paper
  • Downloaded 1,015 times
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    • Site-wide: 25,899
    • In genetic and genomic medicine: 112
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    • Site-wide: 10,860
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    • Site-wide: 21,961

Genes with high network connectivity are enriched for disease heritability

genetics more details view paper
  • Downloaded 968 times
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    • Site-wide: 27,819
    • In genetics: 1,244
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    • Site-wide: 131,254
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Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits

genetics more details view paper
  • Downloaded 875 times
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    • Site-wide: 32,113
    • In genetics: 1,440
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Coordinated Interaction: A model and test for globally signed epistasis in complex traits

genetics more details view paper
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Incorporating family history of disease improves polygenic risk scores in diverse populations

genetics more details view paper
  • Downloaded 757 times
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    • Site-wide: 39,388
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Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability

genetics more details view paper
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    • Site-wide: 46,090
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The genomic landscape of clonal hematopoiesis in Japan

genetics more details view paper
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Mixed Model Association with Family-Biased Case-Control Ascertainment

genetics more details view paper
  • Downloaded 514 times
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    • Site-wide: 64,575
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Learning the mutational landscape of the cancer genome

cancer biology more details view paper
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