Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,580 bioRxiv papers from 297,970 authors.

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Preprints

LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

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Partitioning heritability by functional category using GWAS summary statistics

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  • In genetics: 27 out of 3,796
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Fast, sensitive, and accurate integration of single cell data with Harmony

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  • In bioinformatics: 67 out of 6,650
• Year to date:
  • Site-wide: 130 out of 67,580
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  • Site-wide: 156 out of 67,580

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

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  • In genetics: 68 out of 3,796
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Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

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  • In genetics: 111 out of 3,796
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  • Site-wide: 38,851 out of 67,580
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  • Site-wide: 47,112 out of 67,580

Mixed model association for biobank-scale data sets

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  • In genetics: 113 out of 3,796
• Year to date:
  • Site-wide: 10,822 out of 67,580
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  • Site-wide: 33,910 out of 67,580

Haplotypes of common SNPs can explain missing heritability of complex diseases

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  • In genetics: 115 out of 3,796
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  • Site-wide: 37,694 out of 67,580
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  • Site-wide: 31,958 out of 67,580

Reconstructing Austronesian population history in Island Southeast Asia

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  • In genetics: 123 out of 3,796
• Year to date:
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  • Site-wide: 3,303 out of 67,580

Fast principal components analysis reveals convergent evolution of ADH1B gene in Europe and East Asia

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  • In bioinformatics: 284 out of 6,650
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Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

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  • In genetics: 149 out of 3,796
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  • Site-wide: 26,144 out of 67,580
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  • Site-wide: 55,627 out of 67,580

Modeling functional enrichment improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

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  • In genetics: 168 out of 3,796
• Year to date:
  • Site-wide: 952 out of 67,580
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  • Site-wide: 2,163 out of 67,580

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

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  • In genetics: 174 out of 3,796
• Year to date:
  • Site-wide: 16,965 out of 67,580
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  • Site-wide: 16,094 out of 67,580

Fast and accurate long-range phasing in a UK Biobank cohort

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  • In genetics: 199 out of 3,796
• Year to date:
  • Site-wide: 31,030 out of 67,580
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  • Site-wide: 35,794 out of 67,580

Efficient Bayesian mixed model analysis increases association power in large cohorts

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  • Site-wide: 2,210 out of 67,580
  • In genetics: 204 out of 3,796
• Year to date:
  • Site-wide: 41,198 out of 67,580
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  • Site-wide: 54,994 out of 67,580

Estimating the proportion of disease heritability mediated by gene expression levels

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  • In genetics: 219 out of 3,796
• Year to date:
  • Site-wide: 16,077 out of 67,580
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  • Site-wide: 22,006 out of 67,580

Reference-based phasing using the Haplotype Reference Consortium panel

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  • Site-wide: 3,319 out of 67,580
  • In genetics: 287 out of 3,796
• Year to date:
  • Site-wide: 38,926 out of 67,580
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  • Site-wide: 24,496 out of 67,580

Population structure of UK Biobank and ancient Eurasians reveals adaptation at genes influencing blood pressure

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  • In genetics: 324 out of 3,796
• Year to date:
  • Site-wide: 50,963 out of 67,580
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  • Site-wide: 38,922 out of 67,580

Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits

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  • In genetics: 329 out of 3,796
• Year to date:
  • Site-wide: 25,341 out of 67,580
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  • Site-wide: 39,226 out of 67,580

Multi-ethnic polygenic risk scores improve risk prediction in diverse populations.

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  • Site-wide: 3,900 out of 67,580
  • In bioinformatics: 773 out of 6,650
• Year to date:
  • Site-wide: 23,247 out of 67,580
• Since beginning of last month:
  • Site-wide: 55,535 out of 67,580

Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes

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  • In genetics: 350 out of 3,796
• Year to date:
  • Site-wide: 48,662 out of 67,580
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  • Site-wide: 49,937 out of 67,580

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

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  • Site-wide: 4,845 out of 67,580
  • In genetics: 395 out of 3,796
• Year to date:
  • Site-wide: 59,129 out of 67,580
• Since beginning of last month:
  • Site-wide: 54,906 out of 67,580

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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  • Site-wide: 6,167 out of 67,580
  • In genetics: 487 out of 3,796
• Year to date:
  • Site-wide: 2,487 out of 67,580
• Since beginning of last month:
  • Site-wide: 3,363 out of 67,580

Leveraging polygenic functional enrichment to improve GWAS power

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  • Site-wide: 6,219 out of 67,580
  • In genetics: 492 out of 3,796
• Year to date:
  • Site-wide: 10,627 out of 67,580
• Since beginning of last month:
  • Site-wide: 1,587 out of 67,580

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • Site-wide: 6,612 out of 67,580
  • In genomics: 1,073 out of 4,580
• Year to date:
  • Site-wide: 45,793 out of 67,580
• Since beginning of last month:
  • Site-wide: 64,891 out of 67,580

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

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  • Site-wide: 6,908 out of 67,580
  • In genetics: 543 out of 3,796
• Year to date:
  • Site-wide: 1,728 out of 67,580
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  • Site-wide: 4,821 out of 67,580

Shared Genetic Architecture Of Asthma With Allergic Diseases: A Genome-wide Cross Trait Analysis Of 112,000 Individuals From UK Biobank

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  • In genetics: 548 out of 3,796
• Year to date:
  • Site-wide: 29,655 out of 67,580
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  • Site-wide: 44,908 out of 67,580

Subtle stratification confounds estimates of heritability from rare variants

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  • In genetics: 622 out of 3,796
• Year to date:
  • Site-wide: 40,396 out of 67,580
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  • Site-wide: 46,123 out of 67,580

Monogenic and polygenic inheritance become instruments for clonal selection

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  • Site-wide: 8,702 out of 67,580
  • In genetics: 652 out of 3,796
• Year to date:
  • Site-wide: 2,230 out of 67,580
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  • Site-wide: 4,356 out of 67,580

Two variance component model improves genetic prediction in family data sets

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  • Site-wide: 9,428 out of 67,580
  • In genetics: 695 out of 3,796
• Year to date:
  • Site-wide: 57,487 out of 67,580
• Since beginning of last month:
  • Site-wide: 52,201 out of 67,580

Low-frequency variant functional architectures reveal strength of negative selection across coding and non-coding annotations

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  • Site-wide: 9,611 out of 67,580
  • In genetics: 710 out of 3,796
• Year to date:
  • Site-wide: 29,193 out of 67,580
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  • Site-wide: 19,746 out of 67,580

Correcting subtle stratification in summary association statistics

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  • Site-wide: 11,059 out of 67,580
  • In genetics: 801 out of 3,796
• Year to date:
  • Site-wide: 31,503 out of 67,580
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  • Site-wide: 32,972 out of 67,580

Quantification of genetic components of population differentiation in UK Biobank traits reveals signals of polygenic selection

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  • Site-wide: 11,402 out of 67,580
  • In genetics: 812 out of 3,796
• Year to date:
  • Site-wide: 21,941 out of 67,580
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  • Site-wide: 18,924 out of 67,580

Genes with high network connectivity are enriched for disease heritability

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  • Site-wide: 12,154 out of 67,580
  • In genetics: 851 out of 3,796
• Year to date:
  • Site-wide: 7,292 out of 67,580
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  • Site-wide: 34,126 out of 67,580

Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits

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  • In genetics: 889 out of 3,796
• Year to date:
  • Site-wide: 48,731 out of 67,580
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  • Site-wide: 56,806 out of 67,580

Combining case-control status and family history of disease increases association power

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  • Site-wide: 24,280 out of 67,580
  • In genetics: 1,600 out of 3,796
• Year to date:
  • Site-wide: 7,882 out of 67,580
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  • Site-wide: 9,163 out of 67,580

Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability

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  • In genetics: 1,665 out of 3,796
• Year to date:
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  • Site-wide: 20,242 out of 67,580

Mixed Model Association with Family-Biased Case-Control Ascertainment

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  • In genetics: 1,702 out of 3,796
• Year to date:
  • Site-wide: 59,606 out of 67,580
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  • Site-wide: 63,706 out of 67,580

The genomic landscape of clonal hematopoiesis in Japan

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  • In genetics: 2,125 out of 3,796
• Year to date:
  • Site-wide: 13,195 out of 67,580
• Since beginning of last month:
  • Site-wide: 20,146 out of 67,580