Author: Archie Campbell

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Preprints

The genetic structure of the world's first farmers

• Downloaded 24,865 times
• Download rankings, all-time:
  • Site-wide: 273
  • In genetics: 4
• Year to date:
  • Site-wide: 2,348
• Since beginning of last month:
  • Site-wide: 2,803

A time-resolved proteomic and diagnostic map characterizes COVID-19 disease progression and predicts outcome

• Downloaded 5,995 times
• Download rankings, all-time:
  • Site-wide: 1,591
  • In infectious diseases: 401
• Year to date:
  • Site-wide: 2,440
• Since beginning of last month:
  • Site-wide: 4,247

Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics

• Downloaded 5,801 times
• Download rankings, all-time:
  • Site-wide: 1,685
  • In infectious diseases: 420
• Year to date:
  • Site-wide: 7,902
• Since beginning of last month:
  • Site-wide: 5,734

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,089 times
• Download rankings, all-time:
  • Site-wide: 4,094
  • In genetics: 170
• Year to date:
  • Site-wide: 59,138
• Since beginning of last month:
  • Site-wide: 71,364

Mental health during the COVID-19 pandemic in two longitudinal UK population cohorts

• Downloaded 2,860 times
• Download rankings, all-time:
  • Site-wide: 4,539
  • In psychiatry and clinical psychology: 15
• Year to date:
  • Site-wide: 1,772
• Since beginning of last month:
  • Site-wide: 1,813

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

• Downloaded 2,039 times
• Download rankings, all-time:
  • Site-wide: 7,466
  • In genetics: 345
• Year to date:
  • Site-wide: 122,461
• Since beginning of last month:
  • Site-wide: 124,284

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,245 times
• Download rankings, all-time:
  • Site-wide: 15,653
  • In genomics: 1,600
• Year to date:
  • Site-wide: 95,642
• Since beginning of last month:
  • Site-wide: 120,214

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

• Downloaded 1,217 times
• Download rankings, all-time:
  • Site-wide: 16,162
  • In genetics: 781
• Year to date:
  • Site-wide: 72,795
• Since beginning of last month:
  • Site-wide: 94,209

Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility

• Downloaded 1,117 times
• Download rankings, all-time:
  • Site-wide: 18,359
  • In genetic and genomic medicine: 68
• Year to date:
  • Site-wide: 15,923
• Since beginning of last month:
  • Site-wide: 17,122

Epigenetic prediction of complex traits and death

• Downloaded 1,009 times
• Download rankings, all-time:
  • Site-wide: 21,320
  • In genomics: 2,099
• Year to date:
  • Site-wide: 70,397
• Since beginning of last month:
  • Site-wide: 55,616

Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

• Downloaded 976 times
• Download rankings, all-time:
  • Site-wide: 22,320
  • In genomics: 2,171
• Year to date:
  • Site-wide: 95,320
• Since beginning of last month:
  • Site-wide: 71,773

Within-sibship GWAS improve estimates of direct genetic effects

• Downloaded 920 times
• Download rankings, all-time:
  • Site-wide: 24,413
  • In genetics: 1,170
• Year to date:
  • Site-wide: 1,610
• Since beginning of last month:
  • Site-wide: 1,103

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 908 times
• Download rankings, all-time:
  • Site-wide: 24,872
  • In genetics: 1,187
• Year to date:
  • Site-wide: 19,202
• Since beginning of last month:
  • Site-wide: 10,087

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 895 times
• Download rankings, all-time:
  • Site-wide: 25,371
  • In genetics: 1,216
• Year to date:
  • Site-wide: 9,724
• Since beginning of last month:
  • Site-wide: 3,925

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 829 times
• Download rankings, all-time:
  • Site-wide: 28,178
  • In genetics: 1,357
• Year to date:
  • Site-wide: 69,432
• Since beginning of last month:
  • Site-wide: 93,279

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 753 times
• Download rankings, all-time:
  • Site-wide: 32,258
  • In genomics: 2,846
• Year to date:
  • Site-wide: 102,780
• Since beginning of last month:
  • Site-wide: 120,275

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

• Downloaded 749 times
• Download rankings, all-time:
  • Site-wide: 32,476
  • In genomics: 2,863
• Year to date:
  • Site-wide: 31,586
• Since beginning of last month:
  • Site-wide: 40,464

Quantifying the extent to which index event biases influence large genetic association studies

• Downloaded 692 times
• Download rankings, all-time:
  • Site-wide: 36,237
  • In genetics: 1,715
• Year to date:
  • Site-wide: 122,451
• Since beginning of last month:
  • Site-wide: 94,057

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 688 times
• Download rankings, all-time:
  • Site-wide: 36,527
  • In sexual and reproductive health: 17
• Year to date:
  • Site-wide: 2,469
• Since beginning of last month:
  • Site-wide: 4,404

Electronic Health Record and Genome-wide Genetic Data in Generation Scotland Participants

• Downloaded 665 times
• Download rankings, all-time:
  • Site-wide: 38,184
  • In genomics: 3,207
• Year to date:
  • Site-wide: 91,996
• Since beginning of last month:
  • Site-wide: 97,769

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

• Downloaded 588 times
• Download rankings, all-time:
  • Site-wide: 44,639
  • In genetics: 2,078
• Year to date:
  • Site-wide: 63,615
• Since beginning of last month:
  • Site-wide: 45,340

DNA methylation age acceleration and risk factors for Alzheimer's disease

• Downloaded 573 times
• Download rankings, all-time:
  • Site-wide: 46,119
  • In genomics: 3,665
• Year to date:
  • Site-wide: 109,510
• Since beginning of last month:
  • Site-wide: 63,267

A meta-analysis of genome-wide association studies of epigenetic age acceleration

• Downloaded 573 times
• Download rankings, all-time:
  • Site-wide: 46,096
  • In genetics: 2,147
• Year to date:
  • Site-wide: 131,365
• Since beginning of last month:
  • Site-wide: 107,303

VEP-G2P: A Tool for Efficient, Flexible and Scalable Diagnostic Filtering of Genomic Variants

• Downloaded 521 times
• Download rankings, all-time:
  • Site-wide: 51,642
  • In genetics: 2,387
• Year to date:
  • Site-wide: 86,533
• Since beginning of last month:
  • Site-wide: 82,127

Insight into the genetic aetiology of retinal detachment by combining small clinical and large population-based datasets

• Downloaded 517 times
• Download rankings, all-time:
  • Site-wide: 52,102
  • In genetics: 2,406
• Year to date:
  • Site-wide: 81,169
• Since beginning of last month:
  • Site-wide: 51,050

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

• Downloaded 496 times
• Download rankings, all-time:
  • Site-wide: 54,718
  • In epidemiology: 2,417
• Year to date:
  • Site-wide: 119,857
• Since beginning of last month:
  • Site-wide: 81,133

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 480 times
• Download rankings, all-time:
  • Site-wide: 56,863
  • In genetics: 2,623
• Year to date:
  • Site-wide: 117,054
• Since beginning of last month:
  • Site-wide: 94,032

Face covering adherence is positively associated with better mental health and wellbeing: a longitudinal analysis of the CovidLife surveys

• Downloaded 478 times
• Download rankings, all-time:
  • Site-wide: 57,091
  • In psychiatry and clinical psychology: 183
• Year to date:
  • Site-wide: 12,869
• Since beginning of last month:
  • Site-wide: 20,996

Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

• Downloaded 436 times
• Download rankings, all-time:
  • Site-wide: 62,778
  • In genomics: 4,540
• Year to date:
  • Site-wide: 108,670
• Since beginning of last month:
  • Site-wide: 91,992

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

• Downloaded 425 times
• Download rankings, all-time:
  • Site-wide: 64,494
  • In genetics: 2,965
• Year to date:
  • Site-wide: 119,731
• Since beginning of last month:
  • Site-wide: 93,873

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

• Downloaded 399 times
• Download rankings, all-time:
  • Site-wide: 68,590
  • In genomics: 4,800
• Year to date:
  • Site-wide: 115,809
• Since beginning of last month:
  • Site-wide: 100,457

Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2

• Downloaded 368 times
• Download rankings, all-time:
  • Site-wide: 73,974
  • In genetics: 3,357
• Year to date:
  • Site-wide: 59,771
• Since beginning of last month:
  • Site-wide: 48,468

Epigenome-wide analyses identify DNA methylation signatures of dementia risk

• Downloaded 358 times
• Download rankings, all-time:
  • Site-wide: 75,860
  • In genetic and genomic medicine: 268
• Year to date:
  • Site-wide: 76,037
• Since beginning of last month:
  • Site-wide: 80,154

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 350 times
• Download rankings, all-time:
  • Site-wide: 77,438
  • In genetics: 3,515
• Year to date:
  • Site-wide: 128,078
• Since beginning of last month:
  • Site-wide: 106,657

An epigenome-wide association study of sex-specific chronological ageing

• Downloaded 328 times
• Download rankings, all-time:
  • Site-wide: 81,597
  • In genomics: 5,325
• Year to date:
  • Site-wide: 135,105
• Since beginning of last month:
  • Site-wide: 89,306

Epigenetic signatures of starting and stopping smoking

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 90,266
  • In genomics: 5,650
• Year to date:
  • Site-wide: 136,667
• Since beginning of last month:
  • Site-wide: 123,540

Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression

• Downloaded 273 times
• Download rankings, all-time:
  • Site-wide: 93,260
  • In genetics: 4,157
• Year to date:
  • Site-wide: 119,625
• Since beginning of last month:
  • Site-wide: 80,741

Assessment of Dried Blood Spots for DNA Methylation Profiling

• Downloaded 263 times
• Download rankings, all-time:
  • Site-wide: 95,560
  • In genomics: 5,837
• Year to date:
  • Site-wide: 132,821
• Since beginning of last month:
  • Site-wide: 136,047

Creating and validating a DNA methylation-based proxy for Interleukin-6

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 97,079
  • In genetic and genomic medicine: 397
• Year to date:
  • Site-wide: 49,097
• Since beginning of last month:
  • Site-wide: 41,483

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

• Downloaded 252 times
• Download rankings, all-time:
  • Site-wide: 97,795
  • In genetics: 4,333
• Year to date:
  • Site-wide: 75,891
• Since beginning of last month:
  • Site-wide: 128,112

Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

• Downloaded 246 times
• Download rankings, all-time:
  • Site-wide: 99,211
  • In genomics: 5,941
• Year to date:
  • Site-wide: 121,192
• Since beginning of last month:
  • Site-wide: 117,847

Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

• Downloaded 231 times
• Download rankings, all-time:
  • Site-wide: 102,682
  • In epidemiology: 4,197
• Year to date:
  • Site-wide: 48,349
• Since beginning of last month:
  • Site-wide: 43,729

Epigenetic scores for the circulating proteome replicate protein-disease predictions as tools for biomarker discovery

• Downloaded 223 times
• Download rankings, all-time:
  • Site-wide: 104,387
  • In genomics: 6,120
• Year to date:
  • Site-wide: 31,305
• Since beginning of last month:
  • Site-wide: None

DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health

• Downloaded 215 times
• Download rankings, all-time:
  • Site-wide: 106,336
  • In neuroscience: 16,407
• Year to date:
  • Site-wide: 132,213
• Since beginning of last month:
  • Site-wide: 131,592

DNA methylation signatures of C-reactive protein associations with structural neuroimaging measures and major depressive disorder

• Downloaded 210 times
• Download rankings, all-time:
  • Site-wide: 107,547
  • In psychiatry and clinical psychology: 439
• Year to date:
  • Site-wide: 63,219
• Since beginning of last month:
  • Site-wide: 60,360

Subthreshold psychosis symptoms associated with molecular genetic risk in a population-based cohort: Findings from Generation Scotland

• Downloaded 182 times
• Download rankings, all-time:
  • Site-wide: 113,747
  • In genetics: 4,914
• Year to date:
  • Site-wide: 132,442
• Since beginning of last month:
  • Site-wide: 128,826

Genome-wide methylation data improves dissection of the effect of smoking on body mass index.

• Downloaded 155 times
• Download rankings, all-time:
  • Site-wide: 119,595
  • In genomics: 6,578
• Year to date:
  • Site-wide: 37,731
• Since beginning of last month:
  • Site-wide: 14,446

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

• Downloaded 117 times
• Download rankings, all-time:
  • Site-wide: 127,300
  • In genetic and genomic medicine: 636
• Year to date:
  • Site-wide: 27,489
• Since beginning of last month:
  • Site-wide: 33,837