Author: Archie Campbell

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Preprints

The genetic structure of the world's first farmers

• Downloaded 24,523 times
• Download rankings, all-time:
  • Site-wide: 256
  • In genetics: 4
• Year to date:
  • Site-wide: 1,721
• Since beginning of last month:
  • Site-wide: 1,721

A time-resolved proteomic and diagnostic map characterizes COVID-19 disease progression and predicts outcome

• Downloaded 5,699 times
• Download rankings, all-time:
  • Site-wide: 1,551
  • In infectious diseases: 383
• Year to date:
  • Site-wide: 1,550
• Since beginning of last month:
  • Site-wide: 1,550

Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics

• Downloaded 5,630 times
• Download rankings, all-time:
  • Site-wide: 1,592
  • In infectious diseases: 390
• Year to date:
  • Site-wide: 6,966
• Since beginning of last month:
  • Site-wide: 6,966

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,069 times
• Download rankings, all-time:
  • Site-wide: 3,724
  • In genetics: 166
• Year to date:
  • Site-wide: 34,847
• Since beginning of last month:
  • Site-wide: 34,847

Mental health during the COVID-19 pandemic in two longitudinal UK population cohorts

• Downloaded 2,397 times
• Download rankings, all-time:
  • Site-wide: 5,331
  • In psychiatry and clinical psychology: 14
• Year to date:
  • Site-wide: 1,543
• Since beginning of last month:
  • Site-wide: 1,543

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

• Downloaded 2,031 times
• Download rankings, all-time:
  • Site-wide: 6,755
  • In genetics: 335
• Year to date:
  • Site-wide: 104,827
• Since beginning of last month:
  • Site-wide: 104,827

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,236 times
• Download rankings, all-time:
  • Site-wide: 14,225
  • In genomics: 1,514
• Year to date:
  • Site-wide: 61,332
• Since beginning of last month:
  • Site-wide: 61,332

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

• Downloaded 1,199 times
• Download rankings, all-time:
  • Site-wide: 14,916
  • In genetics: 767
• Year to date:
  • Site-wide: 50,074
• Since beginning of last month:
  • Site-wide: 50,074

Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility

• Downloaded 1,013 times
• Download rankings, all-time:
  • Site-wide: 19,234
  • In genetic and genomic medicine: 57
• Year to date:
  • Site-wide: 13,719
• Since beginning of last month:
  • Site-wide: 13,719

Epigenetic prediction of complex traits and death

• Downloaded 982 times
• Download rankings, all-time:
  • Site-wide: 20,044
  • In genomics: 2,031
• Year to date:
  • Site-wide: 70,642
• Since beginning of last month:
  • Site-wide: 70,642

Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

• Downloaded 958 times
• Download rankings, all-time:
  • Site-wide: 20,779
  • In genomics: 2,092
• Year to date:
  • Site-wide: 98,952
• Since beginning of last month:
  • Site-wide: 98,952

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 813 times
• Download rankings, all-time:
  • Site-wide: 26,223
  • In genetics: 1,309
• Year to date:
  • Site-wide: 42,568
• Since beginning of last month:
  • Site-wide: 42,568

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 794 times
• Download rankings, all-time:
  • Site-wide: 27,112
  • In genetics: 1,351
• Year to date:
  • Site-wide: 25,949
• Since beginning of last month:
  • Site-wide: 25,949

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 746 times
• Download rankings, all-time:
  • Site-wide: 29,603
  • In genomics: 2,705
• Year to date:
  • Site-wide: 66,556
• Since beginning of last month:
  • Site-wide: 66,556

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

• Downloaded 713 times
• Download rankings, all-time:
  • Site-wide: 31,554
  • In genomics: 2,838
• Year to date:
  • Site-wide: 16,827
• Since beginning of last month:
  • Site-wide: 16,827

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 711 times
• Download rankings, all-time:
  • Site-wide: 31,667
  • In genetics: 1,574
• Year to date:
  • Site-wide: 13,379
• Since beginning of last month:
  • Site-wide: 13,379

Quantifying the extent to which index event biases influence large genetic association studies

• Downloaded 684 times
• Download rankings, all-time:
  • Site-wide: 33,353
  • In genetics: 1,647
• Year to date:
  • Site-wide: 104,776
• Since beginning of last month:
  • Site-wide: 104,776

Electronic Health Record and Genome-wide Genetic Data in Generation Scotland Participants

• Downloaded 655 times
• Download rankings, all-time:
  • Site-wide: 35,326
  • In genomics: 3,075
• Year to date:
  • Site-wide: 58,495
• Since beginning of last month:
  • Site-wide: 58,495

A meta-analysis of genome-wide association studies of epigenetic age acceleration

• Downloaded 564 times
• Download rankings, all-time:
  • Site-wide: 42,698
  • In genetics: 2,067
• Year to date:
  • Site-wide: 121,408
• Since beginning of last month:
  • Site-wide: 121,408

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

• Downloaded 561 times
• Download rankings, all-time:
  • Site-wide: 43,028
  • In genetics: 2,081
• Year to date:
  • Site-wide: 54,020
• Since beginning of last month:
  • Site-wide: 54,020

DNA methylation age acceleration and risk factors for Alzheimer's disease

• Downloaded 558 times
• Download rankings, all-time:
  • Site-wide: 43,261
  • In genomics: 3,554
• Year to date:
  • Site-wide: 113,229
• Since beginning of last month:
  • Site-wide: 113,229

VEP-G2P: A Tool for Efficient, Flexible and Scalable Diagnostic Filtering of Genomic Variants

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 49,222
  • In genetics: 2,365
• Year to date:
  • Site-wide: 82,691
• Since beginning of last month:
  • Site-wide: 82,691

Insight into the genetic aetiology of retinal detachment by combining small clinical and large population-based datasets

• Downloaded 499 times
• Download rankings, all-time:
  • Site-wide: 49,501
  • In genetics: 2,376
• Year to date:
  • Site-wide: 65,585
• Since beginning of last month:
  • Site-wide: 65,585

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

• Downloaded 488 times
• Download rankings, all-time:
  • Site-wide: 50,764
  • In epidemiology: 2,224
• Year to date:
  • Site-wide: 98,027
• Since beginning of last month:
  • Site-wide: 98,027

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 474 times
• Download rankings, all-time:
  • Site-wide: 52,425
  • In genetics: 2,496
• Year to date:
  • Site-wide: 84,282
• Since beginning of last month:
  • Site-wide: 84,282

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 470 times
• Download rankings, all-time:
  • Site-wide: 52,911
  • In sexual and reproductive health: 20
• Year to date:
  • Site-wide: 1,247
• Since beginning of last month:
  • Site-wide: 1,247

Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

• Downloaded 424 times
• Download rankings, all-time:
  • Site-wide: 59,096
  • In genomics: 4,407
• Year to date:
  • Site-wide: 99,420
• Since beginning of last month:
  • Site-wide: 99,420

Face covering adherence is positively associated with better mental health and wellbeing: a longitudinal analysis of the CovidLife surveys

• Downloaded 417 times
• Download rankings, all-time:
  • Site-wide: 60,203
  • In psychiatry and clinical psychology: 178
• Year to date:
  • Site-wide: 5,892
• Since beginning of last month:
  • Site-wide: 5,892

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

• Downloaded 414 times
• Download rankings, all-time:
  • Site-wide: 60,547
  • In genetics: 2,877
• Year to date:
  • Site-wide: 111,752
• Since beginning of last month:
  • Site-wide: 111,752

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

• Downloaded 392 times
• Download rankings, all-time:
  • Site-wide: 63,973
  • In genomics: 4,612
• Year to date:
  • Site-wide: 85,364
• Since beginning of last month:
  • Site-wide: 85,364

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 72,310
  • In genetics: 3,380
• Year to date:
  • Site-wide: 116,217
• Since beginning of last month:
  • Site-wide: 116,217

Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 72,430
  • In genetics: 3,382
• Year to date:
  • Site-wide: 46,643
• Since beginning of last month:
  • Site-wide: 46,643

Epigenome-wide analyses identify DNA methylation signatures of dementia risk

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 72,407
  • In genetic and genomic medicine: 222
• Year to date:
  • Site-wide: 54,839
• Since beginning of last month:
  • Site-wide: 54,839

An epigenome-wide association study of sex-specific chronological ageing

• Downloaded 320 times
• Download rankings, all-time:
  • Site-wide: 76,182
  • In genomics: 5,105
• Year to date:
  • Site-wide: 122,468
• Since beginning of last month:
  • Site-wide: 122,468

Epigenetic signatures of starting and stopping smoking

• Downloaded 282 times
• Download rankings, all-time:
  • Site-wide: 83,645
  • In genomics: 5,390
• Year to date:
  • Site-wide: 121,373
• Since beginning of last month:
  • Site-wide: 121,373

Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression

• Downloaded 264 times
• Download rankings, all-time:
  • Site-wide: 87,491
  • In genetics: 4,015
• Year to date:
  • Site-wide: 104,782
• Since beginning of last month:
  • Site-wide: 104,782

Assessment of Dried Blood Spots for DNA Methylation Profiling

• Downloaded 258 times
• Download rankings, all-time:
  • Site-wide: 88,815
  • In genomics: 5,580
• Year to date:
  • Site-wide: 113,051
• Since beginning of last month:
  • Site-wide: 113,051

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

• Downloaded 247 times
• Download rankings, all-time:
  • Site-wide: 91,229
  • In genetics: 4,171
• Year to date:
  • Site-wide: 35,384
• Since beginning of last month:
  • Site-wide: 35,384

Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

• Downloaded 236 times
• Download rankings, all-time:
  • Site-wide: 93,522
  • In genomics: 5,754
• Year to date:
  • Site-wide: 112,125
• Since beginning of last month:
  • Site-wide: 112,125

Creating and validating a DNA methylation-based proxy for Interleukin-6

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 97,572
  • In genetic and genomic medicine: 367
• Year to date:
  • Site-wide: 41,702
• Since beginning of last month:
  • Site-wide: 41,702

DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health

• Downloaded 210 times
• Download rankings, all-time:
  • Site-wide: 99,189
  • In neuroscience: 15,509
• Year to date:
  • Site-wide: 114,438
• Since beginning of last month:
  • Site-wide: 114,438

Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

• Downloaded 194 times
• Download rankings, all-time:
  • Site-wide: 102,663
  • In epidemiology: 4,192
• Year to date:
  • Site-wide: 38,550
• Since beginning of last month:
  • Site-wide: 38,550

DNA methylation proxies for 16 plasma proteins predict the incidence of 7 leading causes of morbidity

• Downloaded 192 times
• Download rankings, all-time:
  • Site-wide: 103,221
  • In genomics: 6,050
• Year to date:
  • Site-wide: 15,224
• Since beginning of last month:
  • Site-wide: 15,224

DNA methylation signatures of C-reactive protein associations with structural neuroimaging measures and major depressive disorder

• Downloaded 180 times
• Download rankings, all-time:
  • Site-wide: 105,684
  • In psychiatry and clinical psychology: 401
• Year to date:
  • Site-wide: 63,315
• Since beginning of last month:
  • Site-wide: 63,315

Subthreshold psychosis symptoms associated with molecular genetic risk in a population-based cohort: Findings from Generation Scotland

• Downloaded 178 times
• Download rankings, all-time:
  • Site-wide: 105,911
  • In genetics: 4,728
• Year to date:
  • Site-wide: 109,879
• Since beginning of last month:
  • Site-wide: 109,879

Omics versus Questionnaires: Using methylation data to assess the environmental impact of smoking on obesity-related traits

• Downloaded 103 times
• Download rankings, all-time:
  • Site-wide: 120,223
  • In genomics: 6,553
• Year to date:
  • Site-wide: 32,804
• Since beginning of last month:
  • Site-wide: 32,804