Author: Archie Campbell

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Preprints

Phenome-wide analysis identifies parent-of-origin effects on the human methylome associated with changes in the rate of aging

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The genetic structure of the world's first farmers

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A time-resolved proteomic and diagnostic map characterizes COVID-19 disease progression and predicts outcome

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  • Site-wide: 1,793
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Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics

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  • Site-wide: 2,490
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A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

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Within-sibship GWAS improve estimates of direct genetic effects

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Mental health during the COVID-19 pandemic in two longitudinal UK population cohorts

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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Genetic insights into the biological mechanisms governing human ovarian ageing

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Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

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Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • Site-wide: 23,740
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Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility

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  • Site-wide: 24,131
  • In genetic and genomic medicine: 143
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  • Site-wide: 101,944

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

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  • Site-wide: 32,598
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  • Site-wide: 15,003

Epigenetic prediction of complex traits and death

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  • Site-wide: 32,856
  • In genomics: 2,691
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  • Site-wide: 107,668
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  • Site-wide: 200,589

Epigenetic scores for the circulating proteome as tools for disease prediction

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  • Site-wide: 35,345
  • In genomics: 2,836
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Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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  • Site-wide: 42,619
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  • Site-wide: 117,102

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

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  • Site-wide: 44,157
  • In genomics: 3,344
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  • Site-wide: 110,598
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  • Site-wide: 122,742

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 48,487
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  • Site-wide: 92,569

Electronic Health Record and Genome-wide Genetic Data in Generation Scotland Participants

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  • Site-wide: 163,130
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  • Site-wide: 209,667

Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease

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  • Site-wide: 58,620
  • In genetic and genomic medicine: 394
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  • Site-wide: 8,400
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  • Site-wide: 7,955

Quantifying the extent to which index event biases influence large genetic association studies

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  • Site-wide: 60,773
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  • Site-wide: 174,603
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  • Site-wide: 149,329

Face covering adherence is positively associated with better mental health and wellbeing: a longitudinal analysis of the CovidLife surveys

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  • Site-wide: 66,794
  • In psychiatry and clinical psychology: 307
• Year to date:
  • Site-wide: 92,886
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  • Site-wide: 68,797

Insight into the genetic aetiology of retinal detachment by combining small clinical and large population-based datasets

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  • Site-wide: 66,832
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• Year to date:
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  • Site-wide: 180,776

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

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  • Site-wide: 72,296
  • In genetics: 2,765
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  • Site-wide: 178,563

A meta-analysis of genome-wide association studies of epigenetic age acceleration

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  • Site-wide: 73,332
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  • Site-wide: 168,755
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  • Site-wide: 207,501

VEP-G2P: A Tool for Efficient, Flexible and Scalable Diagnostic Filtering of Genomic Variants

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  • Site-wide: 202,322

DNA methylation age acceleration and risk factors for Alzheimer's disease

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  • Site-wide: 74,711
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  • Site-wide: 163,056
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  • Site-wide: 200,495

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

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  • Site-wide: 84,451
  • In epidemiology: 3,713
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  • Site-wide: 117,650

Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

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  • Site-wide: 84,846
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• Year to date:
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  • Site-wide: 144,640

Blood-based epigenome-wide analyses of cognitive abilities

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  • Site-wide: 87,023
  • In genetic and genomic medicine: 563
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  • Site-wide: 135,678

Meta-analysis of exome array data identifies six novel genetic loci for lung function

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  • Site-wide: 87,131
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  • Site-wide: 195,257
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  • Site-wide: 178,078

A proteomic survival predictor for COVID-19 patients in intensive care

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  • Site-wide: 89,429
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  • Site-wide: 72,367
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  • Site-wide: 68,844

Refining epigenetic prediction of chronological and biological age

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  • Site-wide: 95,064
  • In genomics: 6,444
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  • Site-wide: 8,017

Breast cancer risks associated with missense variants in breast cancer susceptibility genes

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  • Site-wide: 95,468
  • In genetic and genomic medicine: 617
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  • Site-wide: 86,661

Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health

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  • Site-wide: 96,187
  • In genetic and genomic medicine: 630
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  • Site-wide: 23,146

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

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  • Site-wide: 96,629
  • In genetics: 3,655
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  • Site-wide: 174,756
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  • Site-wide: 178,244

Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2

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  • Site-wide: 99,752
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  • Site-wide: 126,919

Epigenome-wide analyses identify DNA methylation signatures of dementia risk

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  • Site-wide: 101,207
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  • Site-wide: 77,164

Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk

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  • Site-wide: 101,349
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  • Site-wide: 105,092

Creating and validating a DNA methylation-based proxy for Interleukin-6

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  • Site-wide: 102,601
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Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

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  • Site-wide: 103,150
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  • Site-wide: 87,036

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

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  • Site-wide: 103,090
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  • Site-wide: 46,742

Genome-Wide Association Study of Non-Alcoholic Fatty Liver Disease Identifies Association with Apolipoprotein E

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  • Site-wide: 106,622
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Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

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  • Site-wide: 109,335
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  • Site-wide: 176,873
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  • Site-wide: 78,202

DNA methylation signatures of C-reactive protein associations with structural neuroimaging measures and major depressive disorder

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  • Site-wide: 112,076
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• Year to date:
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  • Site-wide: 71,308

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

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  • Site-wide: 122,085
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  • Site-wide: 57,764

Genome-wide methylation data improves dissection of the effect of smoking on body mass index.

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  • Site-wide: 122,544
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  • Site-wide: 184,754

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

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  • Site-wide: 124,805
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  • Site-wide: 168,425
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  • Site-wide: 208,357

Genome-wide Analysis Identifies Novel Gallstone-susceptibility Loci Including Genes Regulating Gastrointestinal Motility

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  • Site-wide: 127,052
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An epigenome-wide association study of sex-specific chronological ageing

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  • Site-wide: 131,208
  • In genomics: 7,183
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  • Site-wide: 147,694

DNA Methylation scores augment 10-year risk prediction of diabetes

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  • Site-wide: 132,218
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  • Site-wide: 30,132
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  • Site-wide: 19,517

Assessment of Dried Blood Spots for DNA Methylation Profiling

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DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

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  • Site-wide: 143,026
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Epigenetic signatures of starting and stopping smoking

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  • Site-wide: 143,850
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  • Site-wide: 166,542
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  • Site-wide: 208,067

Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system

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  • Site-wide: 144,648
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  • Site-wide: 89,270

Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression

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  • Site-wide: 145,692
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  • Site-wide: 201,950

DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health

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  • Site-wide: 152,627
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  • Site-wide: 171,362
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  • Site-wide: 213,586

Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection

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  • Site-wide: 154,949
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Subthreshold psychosis symptoms associated with molecular genetic risk in a population-based cohort: Findings from Generation Scotland

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Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

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  • Site-wide: 159,346
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The influence of biological and statistical properties of CpGs on epigenetic predictions of eighteen traits

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  • Site-wide: 159,933
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Acute COVID-19 severity and 16-month mental morbidity trajectories in patient populations of six nations

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  • Site-wide: 166,048
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  • Site-wide: 113,640

SNP and Haplotype Regional Heritability Mapping (SNHap-RHM): joint mapping of common and rare variation affecting complex traits

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  • Site-wide: 167,795
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Predictive Machine Learning for Personalised Medicine in Major Depressive Disorder

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  • Site-wide: 182,661
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A genome-wide association analysis of 2,622,830 individuals reveals new pathogenic pathways in gout.

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  • Site-wide: 186,375
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  • Site-wide: 1,602

Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome

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  • Site-wide: 187,936
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Early life predictors of cerebral small vessel disease in four prospective cohort studies.

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  • Site-wide: 188,701
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Structural brain correlates of childhood trauma with replication across two large, independent community-based samples.

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  • Site-wide: 195,386
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Blood-based epigenome-wide analyses on the prevalence and incidence of nineteen common disease states

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  • Site-wide: 207,716
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  • Site-wide: 1,276
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Augmenting clinical risk prediction of cardiovascular disease through protein and epigenetic biomarkers

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