Author: Archie Campbell

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Preprints

Early life predictors of cerebral small vessel disease in four prospective cohort studies.

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SNP and Haplotype Regional Heritability Mapping (SNHap-RHM): joint mapping of common and rare variation affecting complex traits

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Breast cancer risks associated with missense variants in breast cancer susceptibility genes

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The genetic structure of the world's first farmers

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  • Site-wide: 306
  • In genetics: 4
• Year to date:
  • Site-wide: 2,934
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  • Site-wide: 73,729

A time-resolved proteomic and diagnostic map characterizes COVID-19 disease progression and predicts outcome

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  • Site-wide: 1,767
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• Year to date:
  • Site-wide: 3,482
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  • Site-wide: 73,788

Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics

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  • Site-wide: 1,874
  • In infectious diseases: 484
• Year to date:
  • Site-wide: 8,506
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  • Site-wide: 8,073

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 4,487
  • In genetics: 171
• Year to date:
  • Site-wide: 37,499
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  • Site-wide: 105,638

Mental health during the COVID-19 pandemic in two longitudinal UK population cohorts

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  • Site-wide: 4,595
  • In psychiatry and clinical psychology: 17
• Year to date:
  • Site-wide: 2,722
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  • Site-wide: 34,833

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

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  • Site-wide: 8,541
  • In genetics: 371
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Genetic insights into the biological mechanisms governing human ovarian ageing

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  • Site-wide: 10,281
  • In sexual and reproductive health: 10
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  • Site-wide: 287

Within-sibship GWAS improve estimates of direct genetic effects

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  • Site-wide: 14,923
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  • Site-wide: 2,098
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  • Site-wide: 67,476

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • Site-wide: 17,141
  • In genomics: 1,677
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  • Site-wide: 17,557

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • Site-wide: 17,935
  • In genetics: 830
• Year to date:
  • Site-wide: 87,761
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  • Site-wide: 54,999

Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility

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  • Site-wide: 19,264
  • In genetic and genomic medicine: 82
• Year to date:
  • Site-wide: 23,813
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  • Site-wide: 43,987

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 20,632
  • In genetics: 943
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  • Site-wide: 9,164
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  • Site-wide: 7,075

Epigenetic prediction of complex traits and death

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  • Site-wide: 23,942
  • In genomics: 2,247
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  • Site-wide: 102,558
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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 25,192
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Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

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  • Site-wide: 25,367
  • In genomics: 2,355
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Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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  • Site-wide: 30,905
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  • Site-wide: 92,372

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

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  • Site-wide: 34,947
  • In genomics: 2,951
• Year to date:
  • Site-wide: 48,871
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  • Site-wide: 131,690

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 35,091
  • In genomics: 2,963
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  • Site-wide: 106,725
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  • Site-wide: 51,706

Quantifying the extent to which index event biases influence large genetic association studies

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  • Site-wide: 40,956
  • In genetics: 1,842
• Year to date:
  • Site-wide: 146,777
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Electronic Health Record and Genome-wide Genetic Data in Generation Scotland Participants

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  • Site-wide: 42,635
  • In genomics: 3,428
• Year to date:
  • Site-wide: 121,648
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  • Site-wide: 120,812

Epigenetic scores for the circulating proteome as tools for disease prediction

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  • Site-wide: 44,193
  • In genomics: 3,514
• Year to date:
  • Site-wide: 8,313
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  • Site-wide: 6,507

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

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  • Site-wide: 49,768
  • In genetics: 2,198
• Year to date:
  • Site-wide: 98,945
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  • Site-wide: 62,869

A meta-analysis of genome-wide association studies of epigenetic age acceleration

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  • Site-wide: 50,714
  • In genetics: 2,244
• Year to date:
  • Site-wide: 136,884
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  • Site-wide: 63,786

DNA methylation age acceleration and risk factors for Alzheimer's disease

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  • Site-wide: 52,383
  • In genomics: 3,982
• Year to date:
  • Site-wide: 144,093
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  • Site-wide: None

Insight into the genetic aetiology of retinal detachment by combining small clinical and large population-based datasets

• Downloaded 556 times
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  • Site-wide: 55,244
  • In genetics: 2,434
• Year to date:
  • Site-wide: 89,233
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  • Site-wide: 37,257

VEP-G2P: A Tool for Efficient, Flexible and Scalable Diagnostic Filtering of Genomic Variants

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  • Site-wide: 57,094
  • In genetics: 2,534
• Year to date:
  • Site-wide: 113,944
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  • Site-wide: 79,432

Face covering adherence is positively associated with better mental health and wellbeing: a longitudinal analysis of the CovidLife surveys

• Downloaded 534 times
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  • Site-wide: 57,933
  • In psychiatry and clinical psychology: 203
• Year to date:
  • Site-wide: 22,402
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  • Site-wide: 67,426

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

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  • Site-wide: 58,846
  • In epidemiology: 2,659
• Year to date:
  • Site-wide: 117,399
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  • Site-wide: 50,640

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 483 times
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  • Site-wide: 64,862
  • In genetics: 2,855
• Year to date:
  • Site-wide: 150,511
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  • Site-wide: None

Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

• Downloaded 471 times
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  • Site-wide: 66,708
  • In genomics: 4,708
• Year to date:
  • Site-wide: 108,018
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  • Site-wide: 36,896

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

• Downloaded 438 times
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  • Site-wide: 72,012
  • In genetics: 3,165
• Year to date:
  • Site-wide: 141,161
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  • Site-wide: 105,631

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

• Downloaded 411 times
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  • Site-wide: 76,763
  • In genomics: 5,146
• Year to date:
  • Site-wide: 140,143
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  • Site-wide: 115,222

Epigenome-wide analyses identify DNA methylation signatures of dementia risk

• Downloaded 389 times
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  • Site-wide: 80,708
  • In genetic and genomic medicine: 348
• Year to date:
  • Site-wide: 94,213
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  • Site-wide: 82,861

Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2

• Downloaded 382 times
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  • Site-wide: 82,084
  • In genetics: 3,566
• Year to date:
  • Site-wide: 96,950
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  • Site-wide: None

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 363 times
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  • Site-wide: 85,846
  • In genetics: 3,736
• Year to date:
  • Site-wide: 145,094
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  • Site-wide: 80,028

An epigenome-wide association study of sex-specific chronological ageing

• Downloaded 336 times
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  • Site-wide: 91,583
  • In genomics: 5,741
• Year to date:
  • Site-wide: 152,960
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  • Site-wide: None

Creating and validating a DNA methylation-based proxy for Interleukin-6

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  • Site-wide: 98,848
  • In genetic and genomic medicine: 469
• Year to date:
  • Site-wide: 61,612
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  • Site-wide: 54,520

Epigenetic signatures of starting and stopping smoking

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  • Site-wide: 99,693
  • In genomics: 6,043
• Year to date:
  • Site-wide: 150,236
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  • Site-wide: 79,733

Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

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  • Site-wide: 101,228
  • In epidemiology: 4,279
• Year to date:
  • Site-wide: 53,894
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  • Site-wide: 60,492

Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression

• Downloaded 280 times
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  • Site-wide: 104,710
  • In genetics: 4,432
• Year to date:
  • Site-wide: 148,533
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DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

• Downloaded 276 times
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  • Site-wide: 105,574
  • In genetics: 4,477
• Year to date:
  • Site-wide: 100,865
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  • Site-wide: 53,540

Assessment of Dried Blood Spots for DNA Methylation Profiling

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  • Site-wide: 106,468
  • In genomics: 6,249
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  • Site-wide: 151,350
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DNA methylation signatures of C-reactive protein associations with structural neuroimaging measures and major depressive disorder

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  • Site-wide: 108,028
  • In psychiatry and clinical psychology: 466
• Year to date:
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  • Site-wide: 64,479

Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

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  • Site-wide: 109,109
  • In genomics: 6,353
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  • Site-wide: 140,242
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  • Site-wide: 51,582

DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health

• Downloaded 226 times
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  • Site-wide: 117,947
  • In neuroscience: 17,805
• Year to date:
  • Site-wide: 149,766
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  • Site-wide: 115,790

A proteomic survival predictor for COVID-19 patients in intensive care

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  • Site-wide: 122,015
  • In infectious diseases: 4,979
• Year to date:
  • Site-wide: 31,220
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  • Site-wide: 104,756

Genome-wide methylation data improves dissection of the effect of smoking on body mass index.

• Downloaded 206 times
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  • Site-wide: 123,011
  • In genomics: 6,812
• Year to date:
  • Site-wide: 50,846
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  • Site-wide: 85,013

Genome-Wide Association Study of Non-Alcoholic Fatty Liver Disease Identifies Association with Apolipoprotein E

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  • Site-wide: 124,568
  • In gastroenterology: 173
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  • Site-wide: 18,456

Blood-based epigenome-wide analyses of cognitive abilities

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  • Site-wide: 124,594
  • In genetic and genomic medicine: 669
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  • Site-wide: 33,358
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  • Site-wide: 103,546

Subthreshold psychosis symptoms associated with molecular genetic risk in a population-based cohort: Findings from Generation Scotland

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  • Site-wide: 127,143
  • In genetics: 5,205
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  • Site-wide: 152,629
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  • Site-wide: 116,361

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

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  • Site-wide: 130,428
  • In genetic and genomic medicine: 709
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  • Site-wide: 38,902
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  • Site-wide: 14,994

Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk

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  • Site-wide: 133,881
  • In genetic and genomic medicine: 738
• Year to date:
  • Site-wide: 43,121
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  • Site-wide: 124,745

Genome-wide Analysis Identifies Novel Gallstone-susceptibility Loci Including Genes Regulating Gastrointestinal Motility

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  • Site-wide: 136,111
  • In gastroenterology: 203
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  • Site-wide: 46,432
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  • Site-wide: 5,078

Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome

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  • Site-wide: 150,925
  • In genetics: 5,891
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  • Site-wide: 95,379
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  • Site-wide: 14,019

Epigenome and phenome study reveals circulating markers pertinent to brain health

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  • Site-wide: 153,140
  • In genetic and genomic medicine: 930
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  • Site-wide: 131,761
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  • Site-wide: 13,392