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Author: Hilary K Finucane

Rankings

  • All-time downloads: 113,859 (rank: 1,714 )
  • Categories:
    • bioinformatics: 8,139 (rank: 1,866 )
    • genetic and genomic medicine: 15,560 (rank: 49 )
    • genetics: 62,071 (rank: 73 )
    • genomics: 27,169 (rank: 536 )

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Preprints

An Atlas of Genetic Correlations across Human Diseases and Traits

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    • Site-wide: 776
    • In genomics: 32
  • Year to date:
    • Site-wide: 146,436
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    • Site-wide: 5,990

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Downloaded 9,843 times
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    • Site-wide: 1,393
    • In genetics: 27
  • Year to date:
    • Site-wide: 19,327
  • Since beginning of last month:
    • Site-wide: 21,453

Partitioning heritability by functional category using GWAS summary statistics

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  • Downloaded 9,002 times
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    • Site-wide: 1,578
    • In genetics: 34
  • Year to date:
    • Site-wide: 28,092
  • Since beginning of last month:
    • Site-wide: 5,988

Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

genetic and genomic medicine more details view paper
  • Downloaded 7,728 times
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    • Site-wide: 1,925
    • In genetic and genomic medicine: 11
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    • Site-wide: 456
  • Since beginning of last month:
    • Site-wide: 1,070

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

bioinformatics more details view paper
  • Downloaded 7,602 times
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    • Site-wide: 1,967
    • In bioinformatics: 107
  • Year to date:
    • Site-wide: 27,663
  • Since beginning of last month:
    • Site-wide: 152,219

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

genetics more details view paper
  • Downloaded 4,512 times
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    • Site-wide: 4,010
    • In genetics: 112
  • Year to date:
    • Site-wide: 145,359
  • Since beginning of last month:
    • Site-wide: 147,901

Genome-wide maps of enhancer regulation connect risk variants to disease genes

genetics more details view paper
  • Downloaded 3,555 times
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    • Site-wide: 5,692
    • In genetics: 187
  • Year to date:
    • Site-wide: 17,401
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    • Site-wide: 27,087

Interrogation of human hematopoiesis at single-cell and single-variant resolution

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  • Downloaded 3,397 times
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    • Site-wide: 6,095
    • In genetics: 201
  • Year to date:
    • Site-wide: 85,812
  • Since beginning of last month:
    • Site-wide: 148,099

Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

genetics more details view paper
  • Downloaded 3,375 times
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    • Site-wide: 6,166
    • In genetics: 205
  • Year to date:
    • Site-wide: 23,555
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    • Site-wide: 141,986

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.

genetic and genomic medicine more details view paper
  • Downloaded 3,367 times
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    • Site-wide: 6,190
    • In genetic and genomic medicine: 34
  • Year to date:
    • Site-wide: 7,827
  • Since beginning of last month:
    • Site-wide: 10,179

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

genetics more details view paper
  • Downloaded 3,127 times
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    • Site-wide: 6,888
    • In genetics: 249
  • Year to date:
    • Site-wide: 83,448
  • Since beginning of last month:
    • Site-wide: 117,451

HCR-FlowFISH: A flexible CRISPR screening method to identify cis-regulatory elements and their target genes

genomics more details view paper
  • Downloaded 3,095 times
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    • Site-wide: 6,985
    • In genomics: 654
  • Year to date:
    • Site-wide: 7,729
  • Since beginning of last month:
    • Site-wide: 14,993

Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

genetics more details view paper
  • Downloaded 3,040 times
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    • Site-wide: 7,154
    • In genetics: 260
  • Year to date:
    • Site-wide: 79,542
  • Since beginning of last month:
    • Site-wide: 198,267

Functionally-informed fine-mapping and polygenic localization of complex trait heritability

genetics more details view paper
  • Downloaded 2,965 times
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    • Site-wide: 7,428
    • In genetics: 265
  • Year to date:
    • Site-wide: 84,617
  • Since beginning of last month:
    • Site-wide: 45,969

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

genetics more details view paper
  • Downloaded 2,761 times
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    • Site-wide: 8,237
    • In genetics: 308
  • Year to date:
    • Site-wide: 183,852
  • Since beginning of last month:
    • Site-wide: 174,996

Insights from complex trait fine-mapping across diverse populations

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  • Downloaded 2,734 times
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    • Site-wide: 8,370
    • In genetic and genomic medicine: 49
  • Year to date:
    • Site-wide: 4,344
  • Since beginning of last month:
    • Site-wide: 4,962

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

genomics more details view paper
  • Downloaded 2,689 times
  • Download rankings, all-time:
    • Site-wide: 8,582
    • In genomics: 805
  • Year to date:
    • Site-wide: 87,623
  • Since beginning of last month:
    • Site-wide: 205,113

Efficient Bayesian mixed model analysis increases association power in large cohorts

genetics more details view paper
  • Downloaded 2,453 times
  • Download rankings, all-time:
    • Site-wide: 9,851
    • In genetics: 375
  • Year to date:
    • Site-wide: 144,176
  • Since beginning of last month:
    • Site-wide: 60,293

Estimating the proportion of disease heritability mediated by gene expression levels

genetics more details view paper
  • Downloaded 2,434 times
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    • Site-wide: 9,961
    • In genetics: 381
  • Year to date:
    • Site-wide: 84,345
  • Since beginning of last month:
    • Site-wide: 60,034

Reference-based phasing using the Haplotype Reference Consortium panel

genetics more details view paper
  • Downloaded 2,089 times
  • Download rankings, all-time:
    • Site-wide: 12,575
    • In genetics: 470
  • Year to date:
    • Site-wide: 23,240
  • Since beginning of last month:
    • Site-wide: 75,697

Reconciling S-LDSC and LDAK models and functional enrichment estimates

genetics more details view paper
  • Downloaded 2,081 times
  • Download rankings, all-time:
    • Site-wide: 12,645
    • In genetics: 472
  • Year to date:
    • Site-wide: 60,295
  • Since beginning of last month:
    • Site-wide: 60,267

Tractor: A framework allowing for improved inclusion of admixed individuals in large-scale association studies.

genomics more details view paper
  • Downloaded 1,914 times
  • Download rankings, all-time:
    • Site-wide: 14,363
    • In genomics: 1,296
  • Year to date:
    • Site-wide: 39,284
  • Since beginning of last month:
    • Site-wide: 122,075

Genome-wide association studies suggest limited immune gene enrichment in schizophrenia compared to five autoimmune diseases

genetics more details view paper
  • Downloaded 1,755 times
  • Download rankings, all-time:
    • Site-wide: 16,423
    • In genetics: 660
  • Year to date:
    • Site-wide: 45,375
  • Since beginning of last month:
    • Site-wide: 115,971

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

genetics more details view paper
  • Downloaded 1,604 times
  • Download rankings, all-time:
    • Site-wide: 18,925
    • In genetics: 766
  • Year to date:
    • Site-wide: 112,551
  • Since beginning of last month:
    • Site-wide: 51,792

Leveraging supervised learning for functionally-informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs

genomics more details view paper
  • Downloaded 1,378 times
  • Download rankings, all-time:
    • Site-wide: 24,135
    • In genomics: 2,074
  • Year to date:
    • Site-wide: 128,453
  • Since beginning of last month:
    • Site-wide: 66,189

Meta-analysis fine-mapping is often miscalibrated at single-variant resolution

genetic and genomic medicine more details view paper
  • Downloaded 1,363 times
  • Download rankings, all-time:
    • Site-wide: 24,556
    • In genetic and genomic medicine: 151
  • Year to date:
    • Site-wide: 13,649
  • Since beginning of last month:
    • Site-wide: 11,868

Mapping the convergence of genes for coronary artery disease onto endothelial cell programs

genomics more details view paper
  • Downloaded 1,260 times
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    • Site-wide: 27,871
    • In genomics: 2,893
  • Year to date:
    • Site-wide: 549
  • Since beginning of last month:
    • Site-wide: 1,623

Low-frequency variant functional architectures reveal strength of negative selection across coding and non-coding annotations

genetics more details view paper
  • Downloaded 1,148 times
  • Download rankings, all-time:
    • Site-wide: 32,250
    • In genetics: 1,284
  • Year to date:
    • Site-wide: 145,962
  • Since beginning of last month:
    • Site-wide: 148,256

Correcting subtle stratification in summary association statistics

genetics more details view paper
  • Downloaded 1,139 times
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    • Site-wide: 32,643
    • In genetics: 1,297
  • Year to date:
    • Site-wide: 144,573
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    • Site-wide: 147,495

Genes with high network connectivity are enriched for disease heritability

genetics more details view paper
  • Downloaded 1,022 times
  • Download rankings, all-time:
    • Site-wide: 38,530
    • In genetics: 1,516
  • Year to date:
    • Site-wide: 161,995
  • Since beginning of last month:
    • Site-wide: 200,896

Functional partitioning of local and distal gene expression regulation in multiple human tissues

genomics more details view paper
  • Downloaded 985 times
  • Download rankings, all-time:
    • Site-wide: 40,826
    • In genomics: 3,121
  • Year to date:
    • Site-wide: 163,786
  • Since beginning of last month:
    • Site-wide: 148,827

Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits

genetics more details view paper
  • Downloaded 968 times
  • Download rankings, all-time:
    • Site-wide: 41,962
    • In genetics: 1,664
  • Year to date:
    • Site-wide: 116,686
  • Since beginning of last month:
    • Site-wide: 143,178

Significance testing for small annotations in stratified LD-Score regression

genetic and genomic medicine more details view paper
  • Downloaded 748 times
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    • Site-wide: 61,915
    • In genetic and genomic medicine: 406
  • Year to date:
    • Site-wide: 18,222
  • Since beginning of last month:
    • Site-wide: 24,875

Shared heritability and functional enrichment across six solid cancers

genomics more details view paper
  • Downloaded 649 times
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    • Site-wide: 75,530
    • In genomics: 5,012
  • Year to date:
    • Site-wide: 161,516
  • Since beginning of last month:
    • Site-wide: 145,355

Improving fine-mapping by modeling infinitesimal effects

bioinformatics more details view paper
  • Downloaded 598 times
  • Download rankings, all-time:
    • Site-wide: 84,065
    • In bioinformatics: 8,216
  • Year to date:
    • Site-wide: 3,535
  • Since beginning of last month:
    • Site-wide: 1,915

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